diff --git a/Modules/Pharmacokinetics/include/mitkConcentrationCurveGenerator.h b/Modules/Pharmacokinetics/include/mitkConcentrationCurveGenerator.h index d3bbcf0a67..1889ef0280 100644 --- a/Modules/Pharmacokinetics/include/mitkConcentrationCurveGenerator.h +++ b/Modules/Pharmacokinetics/include/mitkConcentrationCurveGenerator.h @@ -1,157 +1,167 @@ /*============================================================================ The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center (DKFZ) All rights reserved. Use of this source code is governed by a 3-clause BSD license that can be found in the LICENSE file. ============================================================================*/ #ifndef mitkConcentrationCurveGenerator_h #define mitkConcentrationCurveGenerator_h #include #include #include "mitkConvertToConcentrationAbsoluteFunctor.h" #include "mitkConvertToConcentrationRelativeFunctor.h" #include "MitkPharmacokineticsExports.h" namespace mitk { /** \class ConcentrationCurveGenerator * \brief Converts a given 4D mitk::Image with MR signal values into a 4D mitk::Image with corresponding contrast agent concentration values * * From a given 4D image, the Generator takes the 3D image of the first time point as baseline image. It then loops over all time steps, casts * the current 3D image to itk and passes it to the ConvertToconcentrationFunctor. The returned 3D image has now values of concentration type and is stored at its timepoint * in the return image. */ class MITKPHARMACOKINETICS_EXPORT ConcentrationCurveGenerator : public itk::Object { public: mitkClassMacroItkParent(ConcentrationCurveGenerator, itk::Object); itkNewMacro(Self); //typedef itk::Image ImageType; typedef itk::Image ConvertedImageType; /** Getter and Setter for 4D mitk::Image*/ itkSetConstObjectMacro(DynamicImage,Image); itkGetConstObjectMacro(DynamicImage,Image); /** Parameters Relevant for conversion Calculation; Have to be Set externally (Sequence Dependend)*/ itkSetMacro(RelaxationTime, double); itkGetConstReferenceMacro(RelaxationTime, double); itkSetMacro(Relaxivity, double); itkGetConstReferenceMacro(Relaxivity, double); itkSetMacro(RecoveryTime, double); itkGetConstReferenceMacro(RecoveryTime, double); + itkSetMacro(RepetitionTime, double); + itkGetConstReferenceMacro(RepetitionTime, double); + itkSetMacro(FlipAngle, double); itkGetConstReferenceMacro(FlipAngle, double); + itkSetMacro(FlipAnglePDW, double); + itkGetConstReferenceMacro(FlipAnglePDW, double); + itkSetMacro(Factor, double); itkGetConstReferenceMacro(Factor, double); - /** Getter and Setter for T10 Map image*/ - itkSetConstObjectMacro(T10Image,Image); - itkGetConstObjectMacro(T10Image,Image); + /** Getter and Setter for PDW Map image*/ + itkSetConstObjectMacro(PDWImage,Image); + itkGetConstObjectMacro(PDWImage,Image); itkSetMacro(T2Factor, double); itkGetConstReferenceMacro(T2Factor, double); itkSetMacro(T2EchoTime, double); itkGetConstReferenceMacro(T2EchoTime, double); /** @brief Calls Convert and returns the 4D mitk::image in Concentration units*/ itkSetMacro(BaselineStartTimeStep, unsigned int); itkGetConstReferenceMacro(BaselineStartTimeStep, unsigned int); itkSetMacro(BaselineEndTimeStep, unsigned int); itkGetConstReferenceMacro(BaselineEndTimeStep, unsigned int); itkSetMacro(isTurboFlashSequence,bool); itkGetConstReferenceMacro(isTurboFlashSequence,bool); itkSetMacro(AbsoluteSignalEnhancement,bool); itkGetConstReferenceMacro(AbsoluteSignalEnhancement,bool); itkSetMacro(RelativeSignalEnhancement,bool); itkGetConstReferenceMacro(RelativeSignalEnhancement,bool); itkSetMacro(UsingT1Map,bool); itkGetConstReferenceMacro(UsingT1Map,bool); itkSetMacro(isT2weightedImage,bool); itkGetConstReferenceMacro(isT2weightedImage,bool); Image::Pointer GetConvertedImage(); protected: ConcentrationCurveGenerator(); ~ConcentrationCurveGenerator() override; template mitk::Image::Pointer convertToConcentration(const itk::Image *itkInputImage, const itk::Image *itkBaselineImage); /** Calls ConvertToconcentrationFunctor for passed 3D itk::image*/ mitk::Image::Pointer ConvertSignalToConcentrationCurve(const mitk::Image* inputImage, const mitk::Image* baselineImage); /** @brief Takes the 3D image of the first timepoint to set as baseline image*/ void PrepareBaselineImage(); template void CalculateAverageBaselineImage(const itk::Image *itkBaselineImage); /** @brief loops over all timepoints, casts the current timepoint 3D mitk::image to itk and passes it to ConvertSignalToConcentrationCurve */ virtual void Convert(); private: Image::ConstPointer m_DynamicImage; Image::ConstPointer m_BaselineImage; - Image::ConstPointer m_T10Image; + Image::ConstPointer m_PDWImage; Image::Pointer m_ConvertSignalToConcentrationCurve_OutputImage; Image::Pointer m_ConvertedImage; bool m_isT2weightedImage; bool m_isTurboFlashSequence; bool m_AbsoluteSignalEnhancement; bool m_RelativeSignalEnhancement; bool m_UsingT1Map; double m_Factor; - //=Repetition Time TR + //=Recovery Time double m_RecoveryTime; + //=Repetition Time TR + double m_RepetitionTime; //= pre-CA T1 time double m_RelaxationTime; //= contrast agent relaxivity double m_Relaxivity; double m_FlipAngle; + double m_FlipAnglePDW; + double m_T2Factor; double m_T2EchoTime; // The baseline image is averaged from the signal within time step range [m_BaselineStartTimeStep, m_BaselineEndTimeStep]. // m_BaselineStartTimeStep is the first time frame, that is included into the baseline averaging (starting with 0). unsigned int m_BaselineStartTimeStep; // m_BaselinStopTimeStep is the last time frame, that is included into the baseline averaging. unsigned int m_BaselineEndTimeStep; }; } #endif diff --git a/Modules/Pharmacokinetics/include/mitkConvertToConcentrationViaT1Functor.h b/Modules/Pharmacokinetics/include/mitkConvertToConcentrationViaT1Functor.h index f39d68cbcc..0d4d9b6650 100644 --- a/Modules/Pharmacokinetics/include/mitkConvertToConcentrationViaT1Functor.h +++ b/Modules/Pharmacokinetics/include/mitkConvertToConcentrationViaT1Functor.h @@ -1,79 +1,83 @@ /*============================================================================ The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center (DKFZ) All rights reserved. Use of this source code is governed by a 3-clause BSD license that can be found in the LICENSE file. ============================================================================*/ #ifndef mitkConvertToConcentrationViaT1Functor_h #define mitkConvertToConcentrationViaT1Functor_h #include "itkMath.h" #include "MitkPharmacokineticsExports.h" namespace mitk { template class MITKPHARMACOKINETICS_EXPORT ConvertToConcentrationViaT1CalcFunctor { public: - ConvertToConcentrationViaT1CalcFunctor(): m_relaxivity(0.0), m_TR(0.0), m_flipangle(0.0) {}; - ~ConvertToConcentrationViaT1CalcFunctor() {}; + ConvertToConcentrationViaT1CalcFunctor(): m_relaxivity(0.0), m_TR(0.0), m_flipangle(0.0), m_flipanglePDW(0.0) {}; + ~ConvertToConcentrationViaT1CalcFunctor() {}; - void initialize(double relaxivity, double TR, double flipangle) + void initialize(double relaxivity, double TR, double flipangle, double flipanglePDW) { - - m_relaxivity = relaxivity; - m_TR = TR; - m_flipangle = flipangle; + m_relaxivity = relaxivity; + m_TR = TR; + m_flipangle = flipangle; + m_flipanglePDW = flipanglePDW; } bool operator!=( const ConvertToConcentrationViaT1CalcFunctor & other) const { return !(*this == other); } bool operator==( const ConvertToConcentrationViaT1CalcFunctor & other) const { - return (this->m_relaxivity == other.m_relaxivity) && (this->m_TR == other.m_TR) && (this->m_flipangle == other.m_flipangle); + return (this->m_relaxivity == other.m_relaxivity) && (this->m_TR == other.m_TR) && (this->m_flipangle == other.m_flipangle) && (this->m_flipanglePDW == other.m_flipanglePDW); } - inline TOutputpixel operator()( const TInputPixel1 & value, const TInputPixel2 & baseline, const TInputPixel3 & nativeT1) + inline TOutputpixel operator()( const TInputPixel1 & value, const TInputPixel2 & baseline, const TInputPixel3 & pdw) { - TOutputpixel concentration(0); - double R10, R1; - if (baseline !=0 && nativeT1 != 0 && value != 0) - { - double s = (double) value/baseline; - R10 = (double) 1/nativeT1; - double tmp1 = log(1-s + s*exp(-R10*m_TR) - exp(-R10*m_TR)* cos(m_flipangle)); - double tmp2 = (1-s*cos(m_flipangle) + s*exp(-R10*m_TR)*cos(m_flipangle) - exp(-R10*m_TR)* cos(m_flipangle)); - - R1 = (double) -1/m_TR * tmp1/tmp2 ; - - concentration = (double) (R1 - R10)/ m_relaxivity; - } - else - { - concentration = 0; - } - - return concentration; + TOutputpixel concentration(0.0); + if (baseline != 0 && pdw != 0 && value != 0) + { + // calculate signal scaling factor S0 and pre-contrast T1 relaxation time T10 + double a = pdw * sin(m_flipangle) / (baseline * sin(m_flipanglePDW)); + double b = (a - 1) / (a * cos(m_flipanglePDW) - cos(m_flipangle)); + double T10 = (double)(-1.0) * m_TR / log(b); + double lambda = exp((-1) * m_TR / T10); + double S0 = pdw * (1-lambda * cos(m_flipanglePDW)) / ((1 - lambda) * sin(m_flipanglePDW)); + + // calculate T1 + double c = (value - S0 * sin(m_flipangle)) / (value * cos(m_flipangle) - S0 * sin(m_flipangle)); + double T1 = (double)(-1) * m_TR / log(c); + + //calculate concentration + concentration = (double)(1 / T1 - 1 / T10) / (m_relaxivity/1000.0); + } + else + { + concentration = 0.0; + } + + return concentration; } private: - double m_relaxivity; - double m_TR; - double m_flipangle; - + double m_relaxivity; + double m_TR; + double m_flipangle; + double m_flipanglePDW; }; } #endif diff --git a/Modules/Pharmacokinetics/src/Common/mitkConcentrationCurveGenerator.cpp b/Modules/Pharmacokinetics/src/Common/mitkConcentrationCurveGenerator.cpp index f19254394b..7e528c00e0 100644 --- a/Modules/Pharmacokinetics/src/Common/mitkConcentrationCurveGenerator.cpp +++ b/Modules/Pharmacokinetics/src/Common/mitkConcentrationCurveGenerator.cpp @@ -1,324 +1,326 @@ /*============================================================================ The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center (DKFZ) All rights reserved. Use of this source code is governed by a 3-clause BSD license that can be found in the LICENSE file. ============================================================================*/ #include "mitkConcentrationCurveGenerator.h" #include "mitkConvertToConcentrationTurboFlashFunctor.h" #include "mitkConvertT2ConcentrationFunctor.h" #include "mitkConvertToConcentrationViaT1Functor.h" #include "mitkImageTimeSelector.h" #include "mitkImageCast.h" #include "mitkITKImageImport.h" #include "mitkModelBase.h" #include "mitkExtractTimeGrid.h" #include "mitkArbitraryTimeGeometry.h" #include "itkNaryAddImageFilter.h" #include "mitkImageAccessByItk.h" #include "itkImageIOBase.h" #include "itkBinaryFunctorImageFilter.h" #include "itkTernaryFunctorImageFilter.h" #include #include "itkMeanProjectionImageFilter.h" mitk::ConcentrationCurveGenerator::ConcentrationCurveGenerator() : m_isT2weightedImage(false), m_isTurboFlashSequence(false), m_AbsoluteSignalEnhancement(false), m_RelativeSignalEnhancement(0.0), m_UsingT1Map(false), m_Factor(0.0), m_RecoveryTime(0.0), m_RelaxationTime(0.0), - m_Relaxivity(0.0), m_FlipAngle(0.0), m_T2Factor(0.0), m_T2EchoTime(0.0) + m_Relaxivity(0.0), m_FlipAngle(0.0), m_FlipAnglePDW(0.0), m_T2Factor(0.0), m_T2EchoTime(0.0) { } mitk::ConcentrationCurveGenerator::~ConcentrationCurveGenerator() { } mitk::Image::Pointer mitk::ConcentrationCurveGenerator::GetConvertedImage() { if(this->m_DynamicImage.IsNull()) { itkExceptionMacro( << "Dynamic Image not set!"); } else { Convert(); } return m_ConvertedImage; } void mitk::ConcentrationCurveGenerator::Convert() { mitk::Image::Pointer tempImage = mitk::Image::New(); mitk::PixelType pixeltype = mitk::MakeScalarPixelType(); tempImage->Initialize(pixeltype,*this->m_DynamicImage->GetTimeGeometry()); mitk::TimeGeometry::Pointer timeGeometry = (this->m_DynamicImage->GetTimeGeometry())->Clone(); tempImage->SetTimeGeometry(timeGeometry); PrepareBaselineImage(); mitk::ImageTimeSelector::Pointer imageTimeSelector = mitk::ImageTimeSelector::New(); imageTimeSelector->SetInput(this->m_DynamicImage); for(unsigned int i = 0; i< this->m_DynamicImage->GetTimeSteps(); ++i) { imageTimeSelector->SetTimeNr(i); imageTimeSelector->UpdateLargestPossibleRegion(); mitk::Image::Pointer mitkInputImage = imageTimeSelector->GetOutput(); mitk::Image::Pointer outputImage = mitk::Image::New(); outputImage = ConvertSignalToConcentrationCurve(mitkInputImage,this->m_BaselineImage); mitk::ImageReadAccessor accessor(outputImage); tempImage->SetVolume(accessor.GetData(), i); } this->m_ConvertedImage = tempImage; } void mitk::ConcentrationCurveGenerator::PrepareBaselineImage() { mitk::ImageTimeSelector::Pointer imageTimeSelector = mitk::ImageTimeSelector::New(); imageTimeSelector->SetInput(this->m_DynamicImage); imageTimeSelector->SetTimeNr(0); imageTimeSelector->UpdateLargestPossibleRegion(); mitk::Image::Pointer baselineImage; baselineImage = imageTimeSelector->GetOutput(); if (m_BaselineStartTimeStep == m_BaselineEndTimeStep) { this->m_BaselineImage = imageTimeSelector->GetOutput(); } else { try { AccessFixedDimensionByItk(this->m_DynamicImage, mitk::ConcentrationCurveGenerator::CalculateAverageBaselineImage, 4); } catch (itk::ExceptionObject & err) { std::cerr << "ExceptionObject in ConcentrationCurveGenerator::CalculateAverageBaselineImage caught!" << std::endl; std::cerr << err << std::endl; } } } template void mitk::ConcentrationCurveGenerator::CalculateAverageBaselineImage(const itk::Image *itkBaselineImage) { if (itkBaselineImage == NULL) { mitkThrow() << "Error in ConcentrationCurveGenerator::CalculateAverageBaselineImage. Input image is NULL."; } if (m_BaselineStartTimeStep > m_BaselineEndTimeStep) { mitkThrow() << "Error in ConcentrationCurveGenerator::CalculateAverageBaselineImage. End time point is before start time point."; } typedef itk::Image TPixel4DImageType; typedef itk::Image Double3DImageType; typedef itk::Image Double4DImageType; typedef itk::ExtractImageFilter ExtractImageFilterType; typedef itk::ExtractImageFilter Extract3DImageFilterType; typedef itk::MeanProjectionImageFilter MeanProjectionImageFilterType; typename MeanProjectionImageFilterType::Pointer MeanProjectionImageFilter = MeanProjectionImageFilterType::New(); typename Extract3DImageFilterType::Pointer Extract3DImageFilter = Extract3DImageFilterType::New(); typename TPixel4DImageType::RegionType region_input = itkBaselineImage->GetLargestPossibleRegion(); + MITK_INFO << "m_BaselineStartTimeStep: " << m_BaselineStartTimeStep; + MITK_INFO << "m_BaselineEndTimeStep: " << m_BaselineEndTimeStep; if (m_BaselineEndTimeStep > region_input.GetSize()[3]) { mitkThrow() << "Error in ConcentrationCurveGenerator::CalculateAverageBaselineImage. End time point is larger than total number of time points."; } typename ExtractImageFilterType::Pointer ExtractFilter = ExtractImageFilterType::New(); typename TPixel4DImageType::Pointer baselineTimeFrameImage = TPixel4DImageType::New(); typename TPixel4DImageType::RegionType extractionRegion; typename TPixel4DImageType::SizeType size_input_aux = region_input.GetSize(); size_input_aux[3] = m_BaselineEndTimeStep - m_BaselineStartTimeStep + 1; typename TPixel4DImageType::IndexType start_input_aux = region_input.GetIndex(); start_input_aux[3] = m_BaselineStartTimeStep; extractionRegion.SetSize(size_input_aux); extractionRegion.SetIndex(start_input_aux); ExtractFilter->SetExtractionRegion(extractionRegion); ExtractFilter->SetInput(itkBaselineImage); ExtractFilter->SetDirectionCollapseToSubmatrix(); try { ExtractFilter->Update(); } catch (itk::ExceptionObject & err) { std::cerr << "ExceptionObject caught!" << std::endl; std::cerr << err << std::endl; } baselineTimeFrameImage = ExtractFilter->GetOutput(); MeanProjectionImageFilter->SetProjectionDimension(3); MeanProjectionImageFilter->SetInput(baselineTimeFrameImage); try { MeanProjectionImageFilter->Update(); } catch (itk::ExceptionObject & err) { std::cerr << "ExceptionObject caught!" << std::endl; std::cerr << err << std::endl; } Extract3DImageFilter->SetInput(MeanProjectionImageFilter->GetOutput()); size_input_aux[3] = 0; start_input_aux[3] = 0; extractionRegion.SetSize(size_input_aux); extractionRegion.SetIndex(start_input_aux); Extract3DImageFilter->SetExtractionRegion(extractionRegion); Extract3DImageFilter->SetDirectionCollapseToSubmatrix(); try { Extract3DImageFilter->Update(); } catch (itk::ExceptionObject & err) { std::cerr << "ExceptionObject caught!" << std::endl; std::cerr << err << std::endl; } Image::Pointer mitkBaselineImage = Image::New(); CastToMitkImage(Extract3DImageFilter->GetOutput(), mitkBaselineImage); this->m_BaselineImage = mitkBaselineImage; } mitk::Image::Pointer mitk::ConcentrationCurveGenerator::ConvertSignalToConcentrationCurve(const mitk::Image* inputImage,const mitk::Image* baselineImage) { mitk::PixelType m_PixelType = inputImage->GetPixelType(); AccessTwoImagesFixedDimensionByItk(inputImage, baselineImage, mitk::ConcentrationCurveGenerator::convertToConcentration, 3); return m_ConvertSignalToConcentrationCurve_OutputImage; } template mitk::Image::Pointer mitk::ConcentrationCurveGenerator::convertToConcentration(const itk::Image *itkInputImage, const itk::Image *itkBaselineImage) { typedef itk::Image InputImageType; typedef itk::Image BaselineImageType; if (this->m_isT2weightedImage) { typedef mitk::ConvertT2ConcentrationFunctor ConversionFunctorT2Type; typedef itk::BinaryFunctorImageFilter FilterT2Type; ConversionFunctorT2Type ConversionT2Functor; ConversionT2Functor.initialize(this->m_T2Factor, this->m_T2EchoTime); typename FilterT2Type::Pointer ConversionT2Filter = FilterT2Type::New(); ConversionT2Filter->SetFunctor(ConversionT2Functor); ConversionT2Filter->SetInput1(itkInputImage); ConversionT2Filter->SetInput2(itkBaselineImage); ConversionT2Filter->Update(); m_ConvertSignalToConcentrationCurve_OutputImage = mitk::ImportItkImage(ConversionT2Filter->GetOutput())->Clone(); } else { if(this->m_isTurboFlashSequence) { typedef mitk::ConvertToConcentrationTurboFlashFunctor ConversionFunctorTurboFlashType; typedef itk::BinaryFunctorImageFilter FilterTurboFlashType; ConversionFunctorTurboFlashType ConversionTurboFlashFunctor; ConversionTurboFlashFunctor.initialize(this->m_RelaxationTime, this->m_Relaxivity, this->m_RecoveryTime); typename FilterTurboFlashType::Pointer ConversionTurboFlashFilter = FilterTurboFlashType::New(); ConversionTurboFlashFilter->SetFunctor(ConversionTurboFlashFunctor); ConversionTurboFlashFilter->SetInput1(itkInputImage); ConversionTurboFlashFilter->SetInput2(itkBaselineImage); ConversionTurboFlashFilter->Update(); m_ConvertSignalToConcentrationCurve_OutputImage = mitk::ImportItkImage(ConversionTurboFlashFilter->GetOutput())->Clone(); } else if(this->m_UsingT1Map) { - typename ConvertedImageType::Pointer itkT10Image = ConvertedImageType::New(); - mitk::CastToItkImage(m_T10Image, itkT10Image); + typename BaselineImageType::Pointer itkPDWImage = BaselineImageType::New(); + mitk::CastToItkImage(m_PDWImage, itkPDWImage); typedef mitk::ConvertToConcentrationViaT1CalcFunctor ConvertToConcentrationViaT1CalcFunctorType; - typedef itk::TernaryFunctorImageFilter FilterT1MapType; + typedef itk::TernaryFunctorImageFilter FilterT1MapType; ConvertToConcentrationViaT1CalcFunctorType ConversionT1MapFunctor; - ConversionT1MapFunctor.initialize(this->m_Relaxivity, this->m_RecoveryTime, this->m_FlipAngle); + ConversionT1MapFunctor.initialize(this->m_Relaxivity, this->m_RepetitionTime, this->m_FlipAngle, this->m_FlipAnglePDW); typename FilterT1MapType::Pointer ConversionT1MapFilter = FilterT1MapType::New(); ConversionT1MapFilter->SetFunctor(ConversionT1MapFunctor); ConversionT1MapFilter->SetInput1(itkInputImage); ConversionT1MapFilter->SetInput2(itkBaselineImage); - ConversionT1MapFilter->SetInput3(itkT10Image); + ConversionT1MapFilter->SetInput3(itkPDWImage); ConversionT1MapFilter->Update(); m_ConvertSignalToConcentrationCurve_OutputImage = mitk::ImportItkImage(ConversionT1MapFilter->GetOutput())->Clone(); } else if(this->m_AbsoluteSignalEnhancement) { typedef mitk::ConvertToConcentrationAbsoluteFunctor ConversionFunctorAbsoluteType; typedef itk::BinaryFunctorImageFilter FilterAbsoluteType; ConversionFunctorAbsoluteType ConversionAbsoluteFunctor; ConversionAbsoluteFunctor.initialize(this->m_Factor); typename FilterAbsoluteType::Pointer ConversionAbsoluteFilter = FilterAbsoluteType::New(); ConversionAbsoluteFilter->SetFunctor(ConversionAbsoluteFunctor); ConversionAbsoluteFilter->SetInput1(itkInputImage); ConversionAbsoluteFilter->SetInput2(itkBaselineImage); ConversionAbsoluteFilter->Update(); m_ConvertSignalToConcentrationCurve_OutputImage = mitk::ImportItkImage(ConversionAbsoluteFilter->GetOutput())->Clone(); } else if(this->m_RelativeSignalEnhancement) { typedef mitk::ConvertToConcentrationRelativeFunctor ConversionFunctorRelativeType; typedef itk::BinaryFunctorImageFilter FilterRelativeType; ConversionFunctorRelativeType ConversionRelativeFunctor; ConversionRelativeFunctor.initialize(this->m_Factor); typename FilterRelativeType::Pointer ConversionRelativeFilter = FilterRelativeType::New(); ConversionRelativeFilter->SetFunctor(ConversionRelativeFunctor); ConversionRelativeFilter->SetInput1(itkInputImage); ConversionRelativeFilter->SetInput2(itkBaselineImage); ConversionRelativeFilter->Update(); m_ConvertSignalToConcentrationCurve_OutputImage = mitk::ImportItkImage(ConversionRelativeFilter->GetOutput())->Clone(); } } return m_ConvertSignalToConcentrationCurve_OutputImage; } diff --git a/Modules/Pharmacokinetics/test/mitkConvertSignalToConcentrationTest.cpp b/Modules/Pharmacokinetics/test/mitkConvertSignalToConcentrationTest.cpp index 771d25e57b..b0828f387f 100644 --- a/Modules/Pharmacokinetics/test/mitkConvertSignalToConcentrationTest.cpp +++ b/Modules/Pharmacokinetics/test/mitkConvertSignalToConcentrationTest.cpp @@ -1,217 +1,217 @@ /*============================================================================ The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center (DKFZ) All rights reserved. Use of this source code is governed by a 3-clause BSD license that can be found in the LICENSE file. ============================================================================*/ // Testing #include "mitkTestingMacros.h" #include "mitkTestFixture.h" //MITK includes #include "mitkConcentrationCurveGenerator.h" #include "mitkTestDynamicImageGenerator.h" #include "mitkImagePixelReadAccessor.h" class mitkConvertSignalToConcentrationTestSuite : public mitk::TestFixture { CPPUNIT_TEST_SUITE(mitkConvertSignalToConcentrationTestSuite); MITK_TEST(GetConvertedImageAbsoluteEnhancementTest); MITK_TEST(GetConvertedImageAbsoluteEnhancementAveragedBaselineTest); MITK_TEST(GetConvertedImageRelativeEnhancementTest); MITK_TEST(GetConvertedImageturboFLASHTest); MITK_TEST(GetConvertedImageVFATest); MITK_TEST(GetConvertedImageT2Test); CPPUNIT_TEST_SUITE_END(); private: mitk::Image::Pointer m_dynamicImage; mitk::Image::Pointer m_convertedImage; mitk::ConcentrationCurveGenerator::Pointer m_concentrationGen; std::vector > m_testIndices; public: void setUp() override { m_dynamicImage = mitk::GenerateDynamicTestImageMITK(); m_concentrationGen = mitk::ConcentrationCurveGenerator::New(); m_concentrationGen->SetDynamicImage(m_dynamicImage); itk::Index<4> testIndex0 = { { 0, 0, 0, 0 } }; itk::Index<4> testIndex1 = { { 0, 2, 2, 3 } }; itk::Index<4> testIndex2 = { { 2, 2, 1, 9 } }; itk::Index<4> testIndex3 = { { 0, 3, 2, 1 } }; itk::Index<4> testIndex4 = { { 2, 2, 2, 4 } }; m_testIndices.push_back(testIndex0); m_testIndices.push_back(testIndex1); m_testIndices.push_back(testIndex2); m_testIndices.push_back(testIndex3); m_testIndices.push_back(testIndex4); } void tearDown() override { } void GetConvertedImageAbsoluteEnhancementTest() { m_concentrationGen->SetAbsoluteSignalEnhancement(true); m_concentrationGen->SetFactor(1.0); m_concentrationGen->SetBaselineStartTimeStep(0); m_concentrationGen->SetBaselineEndTimeStep(0); m_convertedImage = m_concentrationGen->GetConvertedImage(); mitk::ImagePixelReadAccessor readAccess(m_convertedImage, m_convertedImage->GetSliceData(4)); std::vector refValues; refValues.push_back(0.0); refValues.push_back(90.0); refValues.push_back(360.0); refValues.push_back(0.0); refValues.push_back(160.0); std::stringstream ss; for (long unsigned int i = 0; i < m_testIndices.size(); i++) { ss << "Checking value of image converted using absolute enhancement at test index " << i << "."; std::string message = ss.str(); CPPUNIT_ASSERT_MESSAGE(message, mitk::Equal(refValues.at(i), readAccess.GetPixelByIndex(m_testIndices.at(i)), 1e-6, true) == true); } } void GetConvertedImageAbsoluteEnhancementAveragedBaselineTest() { m_concentrationGen->SetAbsoluteSignalEnhancement(true); m_concentrationGen->SetFactor(1.0); m_concentrationGen->SetBaselineStartTimeStep(1); m_concentrationGen->SetBaselineEndTimeStep(3); m_convertedImage = m_concentrationGen->GetConvertedImage(); mitk::ImagePixelReadAccessor readAccess(m_convertedImage, m_convertedImage->GetSliceData(4)); std::vector refValues; refValues.push_back(0.0); refValues.push_back(30.0); refValues.push_back(280.0); refValues.push_back(0.0); refValues.push_back(80.0); std::stringstream ss; for (long unsigned int i = 0; i < m_testIndices.size(); i++) { ss << "Checking value of image converted using absolute enhancement with averaged baseline at test index " << i << "."; std::string message = ss.str(); CPPUNIT_ASSERT_MESSAGE(message, mitk::Equal(refValues.at(i), readAccess.GetPixelByIndex(m_testIndices.at(i)), 1e-6, true) == true); } } void GetConvertedImageRelativeEnhancementTest() { m_concentrationGen->SetRelativeSignalEnhancement(true); m_concentrationGen->SetFactor(1.0); m_concentrationGen->SetBaselineStartTimeStep(0); m_concentrationGen->SetBaselineEndTimeStep(0); m_convertedImage = m_concentrationGen->GetConvertedImage(); mitk::ImagePixelReadAccessor readAccess(m_convertedImage, m_convertedImage->GetSliceData(4)); std::vector refValues; refValues.push_back(0.0); refValues.push_back(3.461538); refValues.push_back(20.0); refValues.push_back(0.0); refValues.push_back(5.714286); std::stringstream ss; for (long unsigned int i = 0; i < m_testIndices.size(); i++) { ss << "Checking value of image converted using relative enhancement at test index " << i << "."; std::string message = ss.str(); CPPUNIT_ASSERT_MESSAGE(message, mitk::Equal(refValues.at(i), readAccess.GetPixelByIndex(m_testIndices.at(i)), 1e-6, true) == true); } } void GetConvertedImageturboFLASHTest() { m_concentrationGen->SetisTurboFlashSequence(true); m_concentrationGen->SetRecoveryTime(1.0); m_concentrationGen->SetRelaxationTime(1.0); m_concentrationGen->SetRelaxivity(1.0); m_concentrationGen->SetBaselineStartTimeStep(0); m_concentrationGen->SetBaselineEndTimeStep(0); m_convertedImage = m_concentrationGen->GetConvertedImage(); mitk::ImagePixelReadAccessor readAccess(m_convertedImage, m_convertedImage->GetSliceData(4)); std::vector refValues; refValues.push_back(0.0); refValues.push_back(0.0); refValues.push_back(0.0); refValues.push_back(0.0); refValues.push_back(0.0); std::stringstream ss; for (long unsigned int i = 0; i < m_testIndices.size(); i++) { ss << "Checking value of image converted using the turboFLASH model at test index " << i << "."; std::string message = ss.str(); CPPUNIT_ASSERT_MESSAGE(message, mitk::Equal(refValues.at(i), readAccess.GetPixelByIndex(m_testIndices.at(i)), 1e-6, true) == true); } } void GetConvertedImageVFATest() { mitk::Image::Pointer PDWImage; PDWImage = mitk::GenerateTestFrame(1.0); m_concentrationGen->SetUsingT1Map(true); m_concentrationGen->SetRecoveryTime(1.0); m_concentrationGen->SetRelaxivity(1.0); - m_concentrationGen->SetT10Image(PDWImage); + m_concentrationGen->SetPDWImage(PDWImage); m_concentrationGen->SetFlipAngle(1.0); m_concentrationGen->SetBaselineStartTimeStep(0); m_concentrationGen->SetBaselineEndTimeStep(0); m_convertedImage = m_concentrationGen->GetConvertedImage(); mitk::ImagePixelReadAccessor readAccess(m_convertedImage, m_convertedImage->GetSliceData(4)); std::vector refValues; refValues.push_back(0.0); refValues.push_back(2.956868); refValues.push_back(0.0); refValues.push_back(0.0); refValues.push_back(3.989374); std::stringstream ss; for (long unsigned int i = 0; i < m_testIndices.size(); i++) { ss << "Checking value of image converted using the VFA method at test index " << i << "."; std::string message = ss.str(); CPPUNIT_ASSERT_MESSAGE(message, mitk::Equal(refValues.at(i), readAccess.GetPixelByIndex(m_testIndices.at(i)), 1e-6, true) == true); } } void GetConvertedImageT2Test() { m_concentrationGen->SetisT2weightedImage(true); m_concentrationGen->SetT2Factor(1.0); m_concentrationGen->SetT2EchoTime(1.0); m_concentrationGen->SetBaselineStartTimeStep(0); m_concentrationGen->SetBaselineEndTimeStep(0); m_convertedImage = m_concentrationGen->GetConvertedImage(); mitk::ImagePixelReadAccessor readAccess(m_convertedImage, m_convertedImage->GetSliceData(4)); std::vector refValues; refValues.push_back(0.0); refValues.push_back(-1.495494); refValues.push_back(-3.044522); refValues.push_back(0.0); refValues.push_back(-1.904237); std::stringstream ss; for (long unsigned int i = 0; i < m_testIndices.size(); i++) { ss << "Checking value of converted T2 image at test index " << i << "."; std::string message = ss.str(); CPPUNIT_ASSERT_MESSAGE(message, mitk::Equal(refValues.at(i), readAccess.GetPixelByIndex(m_testIndices.at(i)), 1e-6, true) == true); } } }; MITK_TEST_SUITE_REGISTRATION(mitkConvertSignalToConcentration) diff --git a/Plugins/org.mitk.gui.qt.pharmacokinetics.concentration.mri/src/internal/ConcentrationCurveConverterView.cpp b/Plugins/org.mitk.gui.qt.pharmacokinetics.concentration.mri/src/internal/ConcentrationCurveConverterView.cpp index 1ec7c9c470..d05859526a 100644 --- a/Plugins/org.mitk.gui.qt.pharmacokinetics.concentration.mri/src/internal/ConcentrationCurveConverterView.cpp +++ b/Plugins/org.mitk.gui.qt.pharmacokinetics.concentration.mri/src/internal/ConcentrationCurveConverterView.cpp @@ -1,551 +1,553 @@ /*============================================================================ The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center (DKFZ) All rights reserved. Use of this source code is governed by a 3-clause BSD license that can be found in the LICENSE file. ============================================================================*/ #include #include "mitkWorkbenchUtil.h" #include "ConcentrationCurveConverterView.h" #include "mitkConcentrationCurveGenerator.h" #include "mitkNodePredicateDataType.h" #include "mitkConvertToConcentrationTurboFlashFunctor.h" #include "mitkConvertToConcentrationAbsoluteFunctor.h" #include "mitkConvertToConcentrationRelativeFunctor.h" #include "itkBinaryFunctorImageFilter.h" #include "boost/math/constants/constants.hpp" #include #include #include #include #include #include #include "mitkNodePredicateFunction.h" #include #include // Includes for image casting between ITK and MITK #include "mitkImageTimeSelector.h" #include "mitkImageCast.h" #include "mitkITKImageImport.h" #include #include const std::string ConcentrationCurveConverterView::VIEW_ID = "org.mitk.views.pharmacokinetics.concentration.mri"; void ConcentrationCurveConverterView::SetFocus() { m_Controls.btnConvertToConcentration->setFocus(); } void ConcentrationCurveConverterView::CreateQtPartControl(QWidget* parent) { m_Controls.setupUi(parent); m_Controls.btnConvertToConcentration->setEnabled(false); connect(m_Controls.btnConvertToConcentration, SIGNAL(clicked()), this, SLOT(OnConvertToConcentrationButtonClicked())); m_Controls.timeSeriesNodeSelector->SetNodePredicate(this->m_isValidTimeSeriesImagePredicate); m_Controls.timeSeriesNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.timeSeriesNodeSelector->SetSelectionIsOptional(false); m_Controls.timeSeriesNodeSelector->SetInvalidInfo("Please select time series."); m_Controls.image3DNodeSelector->SetNodePredicate(this->m_isValidPDWImagePredicate); m_Controls.image3DNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.image3DNodeSelector->SetSelectionIsOptional(false); m_Controls.image3DNodeSelector->SetInvalidInfo("Please select 3D image."); m_Controls.baselineImageNodeSelector->SetNodePredicate(this->m_isValidPDWImagePredicate); m_Controls.baselineImageNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.baselineImageNodeSelector->SetSelectionIsOptional(false); m_Controls.baselineImageNodeSelector->SetInvalidInfo("Please select baseline image."); m_Controls.t2TimeSeriesNodeSelector->SetNodePredicate(this->m_isValidTimeSeriesImagePredicate); m_Controls.t2TimeSeriesNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.t2TimeSeriesNodeSelector->SetSelectionIsOptional(false); m_Controls.t2TimeSeriesNodeSelector->SetInvalidInfo("Please select time series."); m_Controls.PDWImageNodeSelector->SetNodePredicate(m_isValidPDWImagePredicate); m_Controls.PDWImageNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.PDWImageNodeSelector->SetInvalidInfo("Please select PDW Image."); m_Controls.PDWImageNodeSelector->setEnabled(false); m_Controls.groupBox_T1->hide(); m_Controls.groupBox_T2->hide(); m_Controls.groupBox3D->hide(); m_Controls.groupBox4D->hide(); m_Controls.groupBoxTurboFlash->hide(); m_Controls.groupConcentration->hide(); connect(m_Controls.radioButton_T1, SIGNAL(toggled(bool)),this, SLOT(OnSettingChanged())); connect(m_Controls.radioButton_T2, SIGNAL(toggled(bool)),this, SLOT(OnSettingChanged())); connect(m_Controls.radioButton3D, SIGNAL(toggled(bool)),this, SLOT(OnSettingChanged())); connect(m_Controls.radioButton4D, SIGNAL(toggled(bool)),this, SLOT(OnSettingChanged())); //Concentration m_Controls.groupConcentration->hide(); m_Controls.groupBoxEnhancement->hide(); m_Controls.groupBoxTurboFlash->hide(); m_Controls.groupBox_T1MapviaVFA->hide(); m_Controls.spinBox_baselineStartTimeStep->setValue(0); m_Controls.spinBox_baselineEndTimeStep->setValue(0); m_Controls.spinBox_baselineEndTimeStep->setMinimum(0); m_Controls.spinBox_baselineStartTimeStep->setMinimum(0); m_Controls.spinBox_baselineStartTimeStepT2->setValue(0); m_Controls.spinBox_baselineEndTimeStepT2->setValue(0); m_Controls.spinBox_baselineEndTimeStepT2->setMinimum(0); m_Controls.spinBox_baselineStartTimeStepT2->setMinimum(0); connect(m_Controls.radioButtonTurboFlash, SIGNAL(toggled(bool)), m_Controls.groupBoxTurboFlash, SLOT(setVisible(bool))); connect(m_Controls.radioButtonTurboFlash, SIGNAL(toggled(bool)), this, SLOT(OnSettingChanged())); connect(m_Controls.relaxationtime, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.recoverytime, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.relaxivity, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.timeSeriesNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &ConcentrationCurveConverterView::OnNodeSelectionChanged); connect(m_Controls.image3DNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &ConcentrationCurveConverterView::OnNodeSelectionChanged); connect(m_Controls.baselineImageNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &ConcentrationCurveConverterView::OnNodeSelectionChanged); connect(m_Controls.t2TimeSeriesNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &ConcentrationCurveConverterView::OnNodeSelectionChanged); connect(m_Controls.PDWImageNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &ConcentrationCurveConverterView::OnSettingChanged); connect(m_Controls.radioButton_absoluteEnhancement, SIGNAL(toggled(bool)), this, SLOT(OnSettingChanged())); connect(m_Controls.radioButton_relativeEnchancement, SIGNAL(toggled(bool)), this, SLOT(OnSettingChanged())); connect(m_Controls.radioButton_absoluteEnhancement, SIGNAL(toggled(bool)), m_Controls.groupBoxEnhancement, SLOT(setVisible(bool))); connect(m_Controls.radioButton_relativeEnchancement, SIGNAL(toggled(bool)), m_Controls.groupBoxEnhancement, SLOT(setVisible(bool))); connect(m_Controls.factorSpinBox, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.spinBox_baselineStartTimeStep, SIGNAL(valueChanged(int)), this, SLOT(OnSettingChanged())); connect(m_Controls.spinBox_baselineEndTimeStep, SIGNAL(valueChanged(int)), this, SLOT(OnSettingChanged())); connect(m_Controls.spinBox_baselineStartTimeStepT2, SIGNAL(valueChanged(int)), this, SLOT(OnSettingChanged())); connect(m_Controls.spinBox_baselineEndTimeStepT2, SIGNAL(valueChanged(int)), this, SLOT(OnSettingChanged())); connect(m_Controls.radioButtonUsingT1viaVFA, SIGNAL(toggled(bool)), m_Controls.groupBox_T1MapviaVFA, SLOT(setVisible(bool))); connect(m_Controls.radioButtonUsingT1viaVFA, SIGNAL(toggled(bool)), this, SLOT(OnSettingChanged())); connect(m_Controls.FlipangleSpinBox, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.RelaxivitySpinBox, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.TRSpinBox, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.T2EchoTimeSpinBox, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.T2FactorSpinBox, SIGNAL(valueChanged(double)), this, SLOT(OnSettingChanged())); connect(m_Controls.radioButtonUsingT1viaVFA, SIGNAL(toggled(bool)), m_Controls.PDWImageNodeSelector, SLOT(setEnabled(bool))); } void ConcentrationCurveConverterView::OnSettingChanged() { bool ok = false; m_Controls.groupBox_T1->setVisible(m_Controls.radioButton_T1->isChecked()); m_Controls.groupBox_T2->setVisible(m_Controls.radioButton_T2->isChecked()); if(m_Controls.radioButton_T1->isChecked()) { m_Controls.groupBox3D->setVisible(m_Controls.radioButton3D->isChecked()); m_Controls.groupBox4D->setVisible(m_Controls.radioButton4D->isChecked()); if(m_Controls.radioButton4D->isChecked()) { m_Controls.groupConcentration->setVisible(true); ok = m_selectedImage.IsNotNull() && CheckSettings(); } else if(m_Controls.radioButton3D->isChecked()) { m_Controls.groupConcentration->setVisible(true); ok = m_selectedImage.IsNotNull() && m_selectedBaselineImage.IsNotNull() && CheckSettings(); } } else if (m_Controls.radioButton_T2->isChecked()) { m_Controls.groupConcentration->setVisible(false); ok = m_selectedImage.IsNotNull() && CheckSettings(); } m_Controls.btnConvertToConcentration->setEnabled(ok); } bool ConcentrationCurveConverterView::CheckSettings() const { bool ok = true; if (m_Controls.radioButton_T1->isChecked()) { if (this->m_Controls.radioButtonTurboFlash->isChecked()) { ok = ok && (m_Controls.recoverytime->value() > 0); ok = ok && (m_Controls.relaxationtime->value() > 0); ok = ok && (m_Controls.relaxivity->value() > 0); ok = ok && (m_Controls.AifRecoverytime->value() > 0); ok = ok && CheckBaselineSelectionSettings(); } else if (this->m_Controls.radioButton_absoluteEnhancement->isChecked() || this->m_Controls.radioButton_relativeEnchancement->isChecked()) { ok = ok && (m_Controls.factorSpinBox->value() > 0); ok = ok && CheckBaselineSelectionSettings(); } else if (this->m_Controls.radioButtonUsingT1viaVFA->isChecked()) { ok = ok && (m_Controls.FlipangleSpinBox->value() > 0); ok = ok && (m_Controls.TRSpinBox->value() > 0); ok = ok && (m_Controls.RelaxivitySpinBox->value() > 0); ok = ok && (m_Controls.PDWImageNodeSelector->GetSelectedNode().IsNotNull()); ok = ok && CheckBaselineSelectionSettings(); } else { ok = false; } } else if (this->m_Controls.radioButton_T2->isChecked()) { ok = ok && m_Controls.T2EchoTimeSpinBox->value() > 0; ok = ok && m_Controls.T2FactorSpinBox->value() > 0; ok = ok && CheckBaselineSelectionSettings(); } else { ok = false; } return ok; } bool ConcentrationCurveConverterView::CheckBaselineSelectionSettings() const { if (this->m_Controls.radioButton_T1->isChecked()) { return m_Controls.spinBox_baselineStartTimeStep->value() <= m_Controls.spinBox_baselineEndTimeStep->value(); } else if (this->m_Controls.radioButton_T2->isChecked()) { return m_Controls.spinBox_baselineStartTimeStepT2->value() <= m_Controls.spinBox_baselineEndTimeStepT2->value(); } else { return 0; } } void ConcentrationCurveConverterView::OnConvertToConcentrationButtonClicked() { mitk::Image::Pointer concentrationImage; mitk::DataNode::Pointer concentrationNode; if(m_Controls.radioButton_T1->isChecked()) { if(m_Controls.radioButton4D->isChecked()) { concentrationImage = this->Convert4DConcentrationImage(this->m_selectedImage); } else if(m_Controls.radioButton3D->isChecked()) { concentrationImage = Convert3DConcentrationImage(this->m_selectedImage, this->m_selectedBaselineImage); } } else if(m_Controls.radioButton_T2->isChecked()) { concentrationImage = this->ConvertT2ConcentrationImgage(this->m_selectedImage); } std::string nameOfResultImage = m_selectedNode->GetName(); nameOfResultImage.append("_Concentration"); concentrationNode = AddConcentrationImage(concentrationImage,nameOfResultImage); } mitk::Image::Pointer ConcentrationCurveConverterView::Convert3DConcentrationImage(mitk::Image::Pointer inputImage,mitk::Image::Pointer baselineImage) { typedef itk::Image InputImageType; InputImageType::Pointer itkInputImage = InputImageType::New(); InputImageType::Pointer itkBaselineImage = InputImageType::New(); mitk::CastToItkImage(inputImage, itkInputImage ); mitk::CastToItkImage(baselineImage, itkBaselineImage ); mitk::Image::Pointer outputImage; if(this->m_Controls.radioButtonTurboFlash->isChecked()) { typedef mitk::ConvertToConcentrationTurboFlashFunctor ConversionFunctorTurboFlashType; typedef itk::BinaryFunctorImageFilter FilterTurboFlashType; ConversionFunctorTurboFlashType ConversionTurboFlashFunctor; ConversionTurboFlashFunctor.initialize(m_Controls.relaxationtime->value(), m_Controls.relaxivity->value(), m_Controls.recoverytime->value()); FilterTurboFlashType::Pointer ConversionTurboFlashFilter = FilterTurboFlashType::New(); ConversionTurboFlashFilter->SetFunctor(ConversionTurboFlashFunctor); ConversionTurboFlashFilter->SetInput1(itkInputImage); ConversionTurboFlashFilter->SetInput2(itkBaselineImage); ConversionTurboFlashFilter->Update(); outputImage = mitk::ImportItkImage(ConversionTurboFlashFilter->GetOutput())->Clone(); } else if(this->m_Controls.radioButton_absoluteEnhancement->isChecked()) { typedef mitk::ConvertToConcentrationAbsoluteFunctor ConversionFunctorAbsoluteType; typedef itk::BinaryFunctorImageFilter FilterAbsoluteType; ConversionFunctorAbsoluteType ConversionAbsoluteFunctor; ConversionAbsoluteFunctor.initialize(m_Controls.factorSpinBox->value()); FilterAbsoluteType::Pointer ConversionAbsoluteFilter = FilterAbsoluteType::New(); ConversionAbsoluteFilter->SetFunctor(ConversionAbsoluteFunctor); ConversionAbsoluteFilter->SetInput1(itkInputImage); ConversionAbsoluteFilter->SetInput2(itkBaselineImage); ConversionAbsoluteFilter->Update(); outputImage = mitk::ImportItkImage(ConversionAbsoluteFilter->GetOutput())->Clone(); } else if(m_Controls.radioButton_relativeEnchancement->isChecked()) { typedef mitk::ConvertToConcentrationRelativeFunctor ConversionFunctorRelativeType; typedef itk::BinaryFunctorImageFilter FilterRelativeType; ConversionFunctorRelativeType ConversionRelativeFunctor; ConversionRelativeFunctor.initialize(m_Controls.factorSpinBox->value()); FilterRelativeType::Pointer ConversionRelativeFilter = FilterRelativeType::New(); ConversionRelativeFilter->SetFunctor(ConversionRelativeFunctor); ConversionRelativeFilter->SetInput1(itkInputImage); ConversionRelativeFilter->SetInput2(itkBaselineImage); ConversionRelativeFilter->Update(); outputImage = mitk::ImportItkImage(ConversionRelativeFilter->GetOutput())->Clone(); } return outputImage; } mitk::DataNode::Pointer ConcentrationCurveConverterView::AddConcentrationImage(mitk::Image* image, std::string nodeName) const { if (!image) { mitkThrow() << "Cannot generate concentration node. Passed image is null. parameter name: "; } mitk::DataNode::Pointer result = mitk::DataNode::New(); result->SetData(image); result->SetName(nodeName); result->SetVisibility(true); this->GetDataStorage()->Add(result, m_selectedNode); return result; }; mitk::Image::Pointer ConcentrationCurveConverterView::Convert4DConcentrationImage(mitk::Image::Pointer inputImage) { //Compute Concentration image mitk::ConcentrationCurveGenerator::Pointer concentrationGen = mitk::ConcentrationCurveGenerator::New(); concentrationGen->SetDynamicImage(inputImage); concentrationGen->SetisTurboFlashSequence(m_Controls.radioButtonTurboFlash->isChecked()); concentrationGen->SetAbsoluteSignalEnhancement(m_Controls.radioButton_absoluteEnhancement->isChecked()); concentrationGen->SetRelativeSignalEnhancement(m_Controls.radioButton_relativeEnchancement->isChecked()); concentrationGen->SetUsingT1Map(m_Controls.radioButtonUsingT1viaVFA->isChecked()); concentrationGen->SetBaselineStartTimeStep(m_Controls.spinBox_baselineStartTimeStepT2->value()); concentrationGen->SetBaselineEndTimeStep(m_Controls.spinBox_baselineEndTimeStepT2->value()); concentrationGen->SetisT2weightedImage(false); if (m_Controls.radioButtonTurboFlash->isChecked()) { concentrationGen->SetRecoveryTime(m_Controls.recoverytime->value()); concentrationGen->SetRelaxationTime(m_Controls.relaxationtime->value()); concentrationGen->SetRelaxivity(m_Controls.relaxivity->value()); concentrationGen->SetBaselineStartTimeStep(m_Controls.spinBox_baselineStartTimeStep->value()); concentrationGen->SetBaselineEndTimeStep(m_Controls.spinBox_baselineEndTimeStep->value()); } else if (this->m_Controls.radioButtonUsingT1viaVFA->isChecked()) { - concentrationGen->SetRecoveryTime(m_Controls.TRSpinBox->value()); + concentrationGen->SetRepetitionTime(m_Controls.TRSpinBox->value()); concentrationGen->SetRelaxivity(m_Controls.RelaxivitySpinBox->value()); - concentrationGen->SetT10Image(dynamic_cast(m_Controls.PDWImageNodeSelector->GetSelectedNode()->GetData())); + concentrationGen->SetPDWImage(dynamic_cast(m_Controls.PDWImageNodeSelector->GetSelectedNode()->GetData())); concentrationGen->SetBaselineStartTimeStep(m_Controls.spinBox_baselineStartTimeStep->value()); concentrationGen->SetBaselineEndTimeStep(m_Controls.spinBox_baselineEndTimeStep->value()); //Convert Flipangle from degree to radiant - double alpha = m_Controls.FlipangleSpinBox->value()/360*2* boost::math::constants::pi(); - concentrationGen->SetFlipAngle(alpha); + double alpha = m_Controls.FlipangleSpinBox->value()/360*2* boost::math::constants::pi(); + concentrationGen->SetFlipAngle(alpha); + double alphaPDW = m_Controls.FlipanglePDWSpinBox->value() / 360 * 2 * boost::math::constants::pi(); + concentrationGen->SetFlipAnglePDW(alphaPDW); } else { concentrationGen->SetFactor(m_Controls.factorSpinBox->value()); concentrationGen->SetBaselineStartTimeStep(m_Controls.spinBox_baselineStartTimeStep->value()); concentrationGen->SetBaselineEndTimeStep(m_Controls.spinBox_baselineEndTimeStep->value()); } mitk::Image::Pointer concentrationImage = concentrationGen->GetConvertedImage(); return concentrationImage; } mitk::Image::Pointer ConcentrationCurveConverterView::ConvertT2ConcentrationImgage(mitk::Image::Pointer inputImage) { //Compute Concentration image mitk::ConcentrationCurveGenerator::Pointer concentrationGen = mitk::ConcentrationCurveGenerator::New(); concentrationGen->SetDynamicImage(inputImage); concentrationGen->SetisTurboFlashSequence(false); concentrationGen->SetAbsoluteSignalEnhancement(false); concentrationGen->SetRelativeSignalEnhancement(false); concentrationGen->SetisT2weightedImage(true); concentrationGen->SetT2Factor(m_Controls.T2FactorSpinBox->value()); concentrationGen->SetT2EchoTime(m_Controls.T2EchoTimeSpinBox->value()); concentrationGen->SetBaselineStartTimeStep(m_Controls.spinBox_baselineStartTimeStep->value()); concentrationGen->SetBaselineEndTimeStep(m_Controls.spinBox_baselineEndTimeStep->value()); mitk::Image::Pointer concentrationImage = concentrationGen->GetConvertedImage(); return concentrationImage; } void ConcentrationCurveConverterView::OnNodeSelectionChanged(QList/*nodes*/) { m_selectedNode = nullptr; m_selectedImage = nullptr; m_selectedBaselineNode = nullptr; m_selectedBaselineImage = nullptr; if (m_Controls.radioButton_T1->isChecked()) { if (m_Controls.radioButton4D->isChecked()) { if (m_Controls.timeSeriesNodeSelector->GetSelectedNode().IsNotNull()) { this->m_selectedNode = m_Controls.timeSeriesNodeSelector->GetSelectedNode(); m_selectedImage = dynamic_cast(m_selectedNode->GetData()); } else { this->m_selectedNode = nullptr; this->m_selectedImage = nullptr; } } else if (m_Controls.radioButton3D->isChecked()) { if (m_Controls.image3DNodeSelector->GetSelectedNode().IsNotNull() && m_Controls.baselineImageNodeSelector->GetSelectedNode().IsNotNull()) { this->m_selectedNode = m_Controls.image3DNodeSelector->GetSelectedNode(); m_selectedImage = dynamic_cast(m_selectedNode->GetData()); this->m_selectedBaselineNode = m_Controls.baselineImageNodeSelector->GetSelectedNode(); m_selectedBaselineImage = dynamic_cast(m_selectedBaselineNode->GetData()); } else { this->m_selectedNode = nullptr; this->m_selectedImage = nullptr; m_selectedBaselineNode = nullptr; m_selectedBaselineImage = nullptr; } } if (this->m_selectedImage.IsNotNull()) { m_Controls.spinBox_baselineStartTimeStep->setMaximum((this->m_selectedImage->GetDimension(3)) - 1); m_Controls.spinBox_baselineEndTimeStep->setMaximum((this->m_selectedImage->GetDimension(3)) - 1); } } if (m_Controls.radioButton_T2->isChecked()) { if (m_Controls.t2TimeSeriesNodeSelector->GetSelectedNode().IsNotNull()) { this->m_selectedNode = m_Controls.t2TimeSeriesNodeSelector->GetSelectedNode(); m_selectedImage = dynamic_cast(m_selectedNode->GetData()); } else { this->m_selectedNode = nullptr; this->m_selectedImage = nullptr; } if (this->m_selectedImage.IsNotNull()) { m_Controls.spinBox_baselineStartTimeStepT2->setMaximum((this->m_selectedImage->GetDimension(3)) - 1); m_Controls.spinBox_baselineEndTimeStepT2->setMaximum((this->m_selectedImage->GetDimension(3)) - 1); } } m_Controls.btnConvertToConcentration->setEnabled(m_selectedImage.IsNotNull() && CheckSettings()); } ConcentrationCurveConverterView::ConcentrationCurveConverterView() { mitk::NodePredicateDataType::Pointer isLabelSet = mitk::NodePredicateDataType::New("LabelSetImage"); mitk::NodePredicateDataType::Pointer isImage = mitk::NodePredicateDataType::New("Image"); mitk::NodePredicateProperty::Pointer isBinary = mitk::NodePredicateProperty::New("binary", mitk::BoolProperty::New(true)); mitk::NodePredicateAnd::Pointer isLegacyMask = mitk::NodePredicateAnd::New(isImage, isBinary); mitk::NodePredicateDimension::Pointer is3D = mitk::NodePredicateDimension::New(3); mitk::NodePredicateOr::Pointer isMask = mitk::NodePredicateOr::New(isLegacyMask, isLabelSet); mitk::NodePredicateAnd::Pointer isNoMask = mitk::NodePredicateAnd::New(isImage, mitk::NodePredicateNot::New(isMask)); mitk::NodePredicateAnd::Pointer is3DImage = mitk::NodePredicateAnd::New(isImage, is3D, isNoMask); this->m_IsMaskPredicate = mitk::NodePredicateAnd::New(isMask, mitk::NodePredicateNot::New(mitk::NodePredicateProperty::New("helper object"))).GetPointer(); this->m_IsNoMaskImagePredicate = mitk::NodePredicateAnd::New(isNoMask, mitk::NodePredicateNot::New(mitk::NodePredicateProperty::New("helper object"))).GetPointer(); auto isDynamicData = mitk::NodePredicateFunction::New([](const mitk::DataNode* node) { return (node && node->GetData() && node->GetData()->GetTimeSteps() > 1); }); auto modelFitResultRelationRule = mitk::ModelFitResultRelationRule::New(); auto isNoModelFitNodePredicate = mitk::NodePredicateNot::New(modelFitResultRelationRule->GetConnectedSourcesDetector()); this->m_isValidPDWImagePredicate = mitk::NodePredicateAnd::New(is3DImage, isNoModelFitNodePredicate); this->m_isValidTimeSeriesImagePredicate = mitk::NodePredicateAnd::New(isDynamicData, isImage, isNoMask); } diff --git a/Plugins/org.mitk.gui.qt.pharmacokinetics.mri/src/internal/MRPerfusionView.cpp b/Plugins/org.mitk.gui.qt.pharmacokinetics.mri/src/internal/MRPerfusionView.cpp index 95b4584c78..c863870692 100644 --- a/Plugins/org.mitk.gui.qt.pharmacokinetics.mri/src/internal/MRPerfusionView.cpp +++ b/Plugins/org.mitk.gui.qt.pharmacokinetics.mri/src/internal/MRPerfusionView.cpp @@ -1,1362 +1,1362 @@ /*============================================================================ The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center (DKFZ) All rights reserved. Use of this source code is governed by a 3-clause BSD license that can be found in the LICENSE file. ============================================================================*/ #include "MRPerfusionView.h" #include "boost/tokenizer.hpp" #include "boost/math/constants/constants.hpp" #include #include "mitkWorkbenchUtil.h" #include "mitkAterialInputFunctionGenerator.h" #include "mitkConcentrationCurveGenerator.h" #include #include #include #include #include #include #include #include "mitkTwoCompartmentExchangeModelFactory.h" #include "mitkTwoCompartmentExchangeModelParameterizer.h" #include #include #include #include #include #include #include #include "mitkNodePredicateFunction.h" #include #include #include #include #include #include #include #include #include #include #include #include #include #include // Includes for image casting between ITK and MITK #include #include "mitkImageCast.h" #include "mitkITKImageImport.h" #include #include const std::string MRPerfusionView::VIEW_ID = "org.mitk.views.pharmacokinetics.mri"; inline double convertToDouble(const std::string& data) { std::istringstream stepStream(data); stepStream.imbue(std::locale("C")); double value = 0.0; if (!(stepStream >> value) || !(stepStream.eof())) { mitkThrow() << "Cannot convert string to double. String: " << data; } return value; } void MRPerfusionView::SetFocus() { m_Controls.btnModelling->setFocus(); } void MRPerfusionView::CreateQtPartControl(QWidget* parent) { m_Controls.setupUi(parent); m_Controls.btnModelling->setEnabled(false); this->InitModelComboBox(); m_Controls.timeSeriesNodeSelector->SetNodePredicate(this->m_isValidTimeSeriesImagePredicate); m_Controls.timeSeriesNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.timeSeriesNodeSelector->SetSelectionIsOptional(false); m_Controls.timeSeriesNodeSelector->SetInvalidInfo("Please select time series."); m_Controls.timeSeriesNodeSelector->SetAutoSelectNewNodes(true); m_Controls.maskNodeSelector->SetNodePredicate(this->m_IsMaskPredicate); m_Controls.maskNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.maskNodeSelector->SetSelectionIsOptional(true); m_Controls.maskNodeSelector->SetEmptyInfo("Please select (optional) mask."); connect(m_Controls.btnModelling, SIGNAL(clicked()), this, SLOT(OnModellingButtonClicked())); connect(m_Controls.comboModel, SIGNAL(currentIndexChanged(int)), this, SLOT(OnModellSet(int))); connect(m_Controls.radioPixelBased, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.timeSeriesNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &MRPerfusionView::OnNodeSelectionChanged); connect(m_Controls.maskNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &MRPerfusionView::OnNodeSelectionChanged); connect(m_Controls.AIFMaskNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &MRPerfusionView::UpdateGUIControls); connect(m_Controls.AIFImageNodeSelector, &QmitkAbstractNodeSelectionWidget::CurrentSelectionChanged, this, &MRPerfusionView::UpdateGUIControls); //AIF setting m_Controls.groupAIF->hide(); m_Controls.btnAIFFile->setEnabled(false); m_Controls.btnAIFFile->setEnabled(false); m_Controls.radioAIFImage->setChecked(true); m_Controls.AIFMaskNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.AIFMaskNodeSelector->SetNodePredicate(m_IsMaskPredicate); m_Controls.AIFMaskNodeSelector->setVisible(true); m_Controls.AIFMaskNodeSelector->setEnabled(true); m_Controls.AIFMaskNodeSelector->SetAutoSelectNewNodes(true); m_Controls.AIFImageNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.AIFImageNodeSelector->SetNodePredicate(this->m_isValidTimeSeriesImagePredicate); m_Controls.AIFImageNodeSelector->setEnabled(false); m_Controls.checkDedicatedAIFImage->setEnabled(true); m_Controls.HCLSpinBox->setValue(mitk::AterialInputFunctionGenerator::DEFAULT_HEMATOCRIT_LEVEL); m_Controls.spinBox_baselineEndTimeStep->setMinimum(0); m_Controls.spinBox_baselineStartTimeStep->setMinimum(0); connect(m_Controls.radioAIFImage, SIGNAL(toggled(bool)), m_Controls.AIFMaskNodeSelector, SLOT(setVisible(bool))); connect(m_Controls.radioAIFImage, SIGNAL(toggled(bool)), m_Controls.labelAIFMask, SLOT(setVisible(bool))); connect(m_Controls.radioAIFImage, SIGNAL(toggled(bool)), m_Controls.checkDedicatedAIFImage, SLOT(setVisible(bool))); connect(m_Controls.radioAIFImage, SIGNAL(toggled(bool)), m_Controls.AIFMaskNodeSelector, SLOT(setEnabled(bool))); connect(m_Controls.radioAIFImage, SIGNAL(toggled(bool)), m_Controls.checkDedicatedAIFImage, SLOT(setEnabled(bool))); connect(m_Controls.radioAIFImage, SIGNAL(toggled(bool)), m_Controls.checkDedicatedAIFImage, SLOT(setVisible(bool))); connect(m_Controls.radioAIFImage, SIGNAL(toggled(bool)), m_Controls.AIFImageNodeSelector, SLOT(setVisible(bool))); connect(m_Controls.checkDedicatedAIFImage, SIGNAL(toggled(bool)), m_Controls.AIFImageNodeSelector, SLOT(setEnabled(bool))); connect(m_Controls.radioAIFImage, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.radioAIFFile, SIGNAL(toggled(bool)), m_Controls.btnAIFFile, SLOT(setEnabled(bool))); connect(m_Controls.radioAIFFile, SIGNAL(toggled(bool)), m_Controls.aifFilePath, SLOT(setEnabled(bool))); connect(m_Controls.radioAIFFile, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.btnAIFFile, SIGNAL(clicked()), this, SLOT(LoadAIFfromFile())); //Brix setting m_Controls.groupDescBrix->hide(); connect(m_Controls.injectiontime, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); //Num2CX setting m_Controls.groupNum2CXM->hide(); connect(m_Controls.odeStepSize, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); //Model fit configuration m_Controls.groupBox_FitConfiguration->hide(); m_Controls.checkBox_Constraints->setEnabled(false); m_Controls.constraintManager->setEnabled(false); m_Controls.initialValuesManager->setEnabled(false); m_Controls.initialValuesManager->setDataStorage(this->GetDataStorage()); connect(m_Controls.radioButton_StartParameters, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.checkBox_Constraints, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.initialValuesManager, SIGNAL(initialValuesChanged(void)), this, SLOT(UpdateGUIControls())); connect(m_Controls.radioButton_StartParameters, SIGNAL(toggled(bool)), m_Controls.initialValuesManager, SLOT(setEnabled(bool))); connect(m_Controls.checkBox_Constraints, SIGNAL(toggled(bool)), m_Controls.constraintManager, SLOT(setEnabled(bool))); connect(m_Controls.checkBox_Constraints, SIGNAL(toggled(bool)), m_Controls.constraintManager, SLOT(setVisible(bool))); //Concentration m_Controls.groupConcentration->hide(); m_Controls.groupBoxEnhancement->hide(); m_Controls.groupBoxTurboFlash->hide(); m_Controls.radioButtonNoConversion->setChecked(true); m_Controls.groupBox_T1MapviaVFA->hide(); m_Controls.spinBox_baselineStartTimeStep->setValue(0); m_Controls.spinBox_baselineEndTimeStep->setValue(0); connect(m_Controls.radioButtonTurboFlash, SIGNAL(toggled(bool)), m_Controls.groupBoxTurboFlash, SLOT(setVisible(bool))); connect(m_Controls.radioButtonTurboFlash, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.relaxationtime, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); connect(m_Controls.recoverytime, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); connect(m_Controls.relaxivity, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); connect(m_Controls.radioButton_absoluteEnhancement, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.radioButton_relativeEnchancement, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.radioButton_absoluteEnhancement, SIGNAL(toggled(bool)), m_Controls.groupBoxEnhancement, SLOT(setVisible(bool))); connect(m_Controls.radioButton_relativeEnchancement, SIGNAL(toggled(bool)), m_Controls.groupBoxEnhancement, SLOT(setVisible(bool))); connect(m_Controls.factorSpinBox, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); connect(m_Controls.spinBox_baselineStartTimeStep, SIGNAL(valueChanged(int)), this, SLOT(UpdateGUIControls())); connect(m_Controls.spinBox_baselineEndTimeStep, SIGNAL(valueChanged(int)), this, SLOT(UpdateGUIControls())); connect(m_Controls.radioButtonUsingT1viaVFA, SIGNAL(toggled(bool)), m_Controls.groupBox_T1MapviaVFA, SLOT(setVisible(bool))); connect(m_Controls.radioButtonUsingT1viaVFA, SIGNAL(toggled(bool)), this, SLOT(UpdateGUIControls())); connect(m_Controls.FlipangleSpinBox, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); connect(m_Controls.RelaxivitySpinBox, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); connect(m_Controls.TRSpinBox, SIGNAL(valueChanged(double)), this, SLOT(UpdateGUIControls())); m_Controls.PDWImageNodeSelector->SetNodePredicate(m_isValidPDWImagePredicate); m_Controls.PDWImageNodeSelector->SetDataStorage(this->GetDataStorage()); m_Controls.PDWImageNodeSelector->SetInvalidInfo("Please select PDW Image."); m_Controls.PDWImageNodeSelector->setEnabled(false); connect(m_Controls.radioButtonUsingT1viaVFA, SIGNAL(toggled(bool)), m_Controls.PDWImageNodeSelector, SLOT(setEnabled(bool))); UpdateGUIControls(); } bool MRPerfusionView::IsTurboFlashSequenceFlag() const { return this->m_Controls.radioButtonTurboFlash->isChecked(); }; void MRPerfusionView::UpdateGUIControls() { m_Controls.lineFitName->setPlaceholderText(QString::fromStdString(this->GetDefaultFitName())); m_Controls.lineFitName->setEnabled(!m_FittingInProgress); m_Controls.checkBox_Constraints->setEnabled(m_modelConstraints.IsNotNull()); bool isDescBrixFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; bool isToftsFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr || dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; bool is2CXMFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; m_Controls.groupAIF->setVisible(isToftsFactory || is2CXMFactory); m_Controls.groupDescBrix->setVisible(isDescBrixFactory); m_Controls.groupConcentration->setVisible(isToftsFactory || is2CXMFactory ); m_Controls.groupBox_FitConfiguration->setVisible(m_selectedModelFactory); m_Controls.groupBox->setEnabled(!m_FittingInProgress); m_Controls.comboModel->setEnabled(!m_FittingInProgress); m_Controls.groupAIF->setEnabled(!m_FittingInProgress); m_Controls.groupDescBrix->setEnabled(!m_FittingInProgress); m_Controls.groupNum2CXM->setEnabled(!m_FittingInProgress); m_Controls.groupConcentration->setEnabled(!m_FittingInProgress); m_Controls.groupBox_FitConfiguration->setEnabled(!m_FittingInProgress); m_Controls.radioROIbased->setEnabled(m_selectedMask.IsNotNull()); m_Controls.btnModelling->setEnabled(m_selectedImage.IsNotNull() && m_selectedModelFactory.IsNotNull() && !m_FittingInProgress && CheckModelSettings()); m_Controls.spinBox_baselineStartTimeStep->setEnabled(m_Controls.radioButtonTurboFlash->isChecked() || m_Controls.radioButton_absoluteEnhancement->isChecked() || m_Controls.radioButton_relativeEnchancement->isChecked() || m_Controls.radioButtonUsingT1viaVFA->isChecked()); m_Controls.spinBox_baselineEndTimeStep->setEnabled(m_Controls.radioButton_absoluteEnhancement->isChecked() || m_Controls.radioButton_relativeEnchancement->isChecked() || m_Controls.radioButtonUsingT1viaVFA->isChecked() || m_Controls.radioButtonTurboFlash->isChecked()); } void MRPerfusionView::OnModellSet(int index) { m_selectedModelFactory = nullptr; if (index > 0) { if (static_cast(index) <= m_FactoryStack.size() ) { m_selectedModelFactory = m_FactoryStack[index - 1]; } else { MITK_WARN << "Invalid model index. Index outside of the factory stack. Factory stack size: "<< m_FactoryStack.size() << "; invalid index: "<< index; } } if (m_selectedModelFactory) { this->m_modelConstraints = dynamic_cast (m_selectedModelFactory->CreateDefaultConstraints().GetPointer()); m_Controls.initialValuesManager->setInitialValues(m_selectedModelFactory->GetParameterNames(), m_selectedModelFactory->GetDefaultInitialParameterization()); if (this->m_modelConstraints.IsNull()) { this->m_modelConstraints = mitk::SimpleBarrierConstraintChecker::New(); } m_Controls.constraintManager->setChecker(this->m_modelConstraints, this->m_selectedModelFactory->GetParameterNames()); } UpdateGUIControls(); } std::string MRPerfusionView::GetFitName() const { std::string fitName = m_Controls.lineFitName->text().toStdString(); if (fitName.empty()) { fitName = m_Controls.lineFitName->placeholderText().toStdString(); } return fitName; } std::string MRPerfusionView::GetDefaultFitName() const { std::string defaultName = "undefined model"; if (this->m_selectedModelFactory.IsNotNull()) { defaultName = this->m_selectedModelFactory->GetClassID(); } if (this->m_Controls.radioPixelBased->isChecked()) { defaultName += "_pixel"; } else { defaultName += "_roi"; } return defaultName; } void MRPerfusionView::OnModellingButtonClicked() { //check if all static parameters set if (m_selectedModelFactory.IsNotNull() && CheckModelSettings()) { m_HasGeneratedNewInput = false; m_HasGeneratedNewInputAIF = false; mitk::ParameterFitImageGeneratorBase::Pointer generator = nullptr; mitk::modelFit::ModelFitInfo::Pointer fitSession = nullptr; bool isDescBrixFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; bool isExtToftsFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; bool isStanToftsFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; bool is2CXMFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; if (isDescBrixFactory) { if (this->m_Controls.radioPixelBased->isChecked()) { GenerateDescriptiveBrixModel_PixelBased(fitSession, generator); } else { GenerateDescriptiveBrixModel_ROIBased(fitSession, generator); } } else if (isStanToftsFactory) { if (this->m_Controls.radioPixelBased->isChecked()) { GenerateAIFbasedModelFit_PixelBased(fitSession, generator); } else { GenerateAIFbasedModelFit_ROIBased(fitSession, generator); } } else if (isExtToftsFactory) { if (this->m_Controls.radioPixelBased->isChecked()) { GenerateAIFbasedModelFit_PixelBased(fitSession, generator); } else { GenerateAIFbasedModelFit_ROIBased(fitSession, generator); } } else if (is2CXMFactory) { if (this->m_Controls.radioPixelBased->isChecked()) { GenerateAIFbasedModelFit_PixelBased(fitSession, generator); } else { GenerateAIFbasedModelFit_ROIBased(fitSession, generator); } } //add other models with else if if (generator.IsNotNull() && fitSession.IsNotNull()) { m_FittingInProgress = true; UpdateGUIControls(); DoFit(fitSession, generator); } else { QMessageBox box; box.setText("Fitting error!"); box.setInformativeText("Could not establish fitting job. Error when setting ab generator, model parameterizer or session info."); box.setStandardButtons(QMessageBox::Ok); box.setDefaultButton(QMessageBox::Ok); box.setIcon(QMessageBox::Warning); box.exec(); } } else { QMessageBox box; box.setText("Static parameters for model are not set!"); box.setInformativeText("Some static parameters, that are needed for calculation are not set and equal to zero. Modeling not possible"); box.setStandardButtons(QMessageBox::Ok); box.setDefaultButton(QMessageBox::Ok); box.setIcon(QMessageBox::Warning); box.exec(); } } void MRPerfusionView::OnNodeSelectionChanged(QList/*nodes*/) { m_selectedMaskNode = nullptr; m_selectedMask = nullptr; if (m_Controls.timeSeriesNodeSelector->GetSelectedNode().IsNotNull()) { this->m_selectedNode = m_Controls.timeSeriesNodeSelector->GetSelectedNode(); m_selectedImage = dynamic_cast(m_selectedNode->GetData()); if (m_selectedImage) { this->m_Controls.initialValuesManager->setReferenceImageGeometry(m_selectedImage->GetGeometry()); } else { this->m_Controls.initialValuesManager->setReferenceImageGeometry(nullptr); } } else { this->m_selectedNode = nullptr; this->m_selectedImage = nullptr; this->m_Controls.initialValuesManager->setReferenceImageGeometry(nullptr); } if (m_Controls.maskNodeSelector->GetSelectedNode().IsNotNull()) { this->m_selectedMaskNode = m_Controls.maskNodeSelector->GetSelectedNode(); this->m_selectedMask = dynamic_cast(m_selectedMaskNode->GetData()); if (this->m_selectedMask.IsNotNull() && this->m_selectedMask->GetTimeSteps() > 1) { MITK_INFO << "Selected mask has multiple timesteps. Only use first timestep to mask model fit. Mask name: " << m_Controls.maskNodeSelector->GetSelectedNode()->GetName(); mitk::ImageTimeSelector::Pointer maskedImageTimeSelector = mitk::ImageTimeSelector::New(); maskedImageTimeSelector->SetInput(this->m_selectedMask); maskedImageTimeSelector->SetTimeNr(0); maskedImageTimeSelector->UpdateLargestPossibleRegion(); this->m_selectedMask = maskedImageTimeSelector->GetOutput(); } } if (m_selectedMask.IsNull()) { this->m_Controls.radioPixelBased->setChecked(true); } if (this->m_selectedImage.IsNotNull()) { m_Controls.spinBox_baselineStartTimeStep->setMaximum((this->m_selectedImage->GetDimension(3))-1); m_Controls.spinBox_baselineEndTimeStep->setMaximum((this->m_selectedImage->GetDimension(3)) - 1); } UpdateGUIControls(); } bool MRPerfusionView::CheckModelSettings() const { bool ok = true; //check whether any model is set at all. Otherwise exit with false if (m_selectedModelFactory.IsNotNull()) { bool isDescBrixFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; bool isToftsFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr|| dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; bool is2CXMFactory = dynamic_cast (m_selectedModelFactory.GetPointer()) != nullptr; if (isDescBrixFactory) { //if all static parameters for this model are set, exit with true, Otherwise exit with false ok = m_Controls.injectiontime->value() > 0; } else if (isToftsFactory || is2CXMFactory) { if (this->m_Controls.radioAIFImage->isChecked()) { ok = ok && m_Controls.AIFMaskNodeSelector->GetSelectedNode().IsNotNull(); if (this->m_Controls.checkDedicatedAIFImage->isChecked()) { ok = ok && m_Controls.AIFImageNodeSelector->GetSelectedNode().IsNotNull(); } } else if (this->m_Controls.radioAIFFile->isChecked()) { ok = ok && (this->AIFinputGrid.size() != 0) && (this->AIFinputFunction.size() != 0); } else { ok = false; } if (this->m_Controls.radioButtonTurboFlash->isChecked() ) { ok = ok && (m_Controls.recoverytime->value() > 0); ok = ok && (m_Controls.relaxationtime->value() > 0); ok = ok && (m_Controls.relaxivity->value() > 0); ok = ok && (m_Controls.AifRecoverytime->value() > 0); ok = ok && CheckBaselineSelectionSettings(); } else if (this->m_Controls.radioButton_absoluteEnhancement->isChecked() || this->m_Controls.radioButton_relativeEnchancement->isChecked() ) { ok = ok && (m_Controls.factorSpinBox->value() > 0); ok = ok && CheckBaselineSelectionSettings(); } else if (this->m_Controls.radioButtonUsingT1viaVFA->isChecked() ) { ok = ok && (m_Controls.FlipangleSpinBox->value() > 0); ok = ok && (m_Controls.TRSpinBox->value() > 0); ok = ok && (m_Controls.RelaxivitySpinBox->value() > 0); ok = ok && (m_Controls.PDWImageNodeSelector->GetSelectedNode().IsNotNull()); ok = ok && CheckBaselineSelectionSettings(); } else if (this->m_Controls.radioButtonNoConversion->isChecked()) { ok = ok && true; } else { ok = false; } } //add other models as else if and check whether all needed static parameters are set else { ok = false; } if (this->m_Controls.radioButton_StartParameters->isChecked() && !this->m_Controls.initialValuesManager->hasValidInitialValues()) { std::string warning = "Warning. Invalid start parameters. At least one parameter as an invalid image setting as source."; MITK_ERROR << warning; m_Controls.infoBox->append(QString("") + QString::fromStdString(warning) + QString("")); ok = false; }; } else { ok = false; } return ok; } bool MRPerfusionView::CheckBaselineSelectionSettings() const { return m_Controls.spinBox_baselineStartTimeStep->value() <= m_Controls.spinBox_baselineEndTimeStep->value(); } void MRPerfusionView::ConfigureInitialParametersOfParameterizer(mitk::ModelParameterizerBase* parameterizer) const { if (m_Controls.radioButton_StartParameters->isChecked()) { //use user defined initial parameters mitk::InitialParameterizationDelegateBase::Pointer paramDelegate = m_Controls.initialValuesManager->getInitialParametrizationDelegate(); parameterizer->SetInitialParameterizationDelegate(paramDelegate); } } void MRPerfusionView::GenerateDescriptiveBrixModel_PixelBased(mitk::modelFit::ModelFitInfo::Pointer& modelFitInfo, mitk::ParameterFitImageGeneratorBase::Pointer& generator) { mitk::PixelBasedParameterFitImageGenerator::Pointer fitGenerator = mitk::PixelBasedParameterFitImageGenerator::New(); mitk::DescriptivePharmacokineticBrixModelParameterizer::Pointer modelParameterizer = mitk::DescriptivePharmacokineticBrixModelParameterizer::New(); //Model configuration (static parameters) can be done now modelParameterizer->SetTau(m_Controls.injectiontime->value()); mitk::ImageTimeSelector::Pointer imageTimeSelector = mitk::ImageTimeSelector::New(); imageTimeSelector->SetInput(this->m_selectedImage); imageTimeSelector->SetTimeNr(0); imageTimeSelector->UpdateLargestPossibleRegion(); mitk::DescriptivePharmacokineticBrixModelParameterizer::BaseImageType::Pointer baseImage; mitk::CastToItkImage(imageTimeSelector->GetOutput(), baseImage); modelParameterizer->SetBaseImage(baseImage); this->ConfigureInitialParametersOfParameterizer(modelParameterizer); //Specify fitting strategy and criterion parameters mitk::ModelFitFunctorBase::Pointer fitFunctor = CreateDefaultFitFunctor(modelParameterizer); //Parametrize fit generator fitGenerator->SetModelParameterizer(modelParameterizer); std::string roiUID = ""; if (m_selectedMask.IsNotNull()) { fitGenerator->SetMask(m_selectedMask); roiUID = m_selectedMask->GetUID(); } fitGenerator->SetDynamicImage(m_selectedImage); fitGenerator->SetFitFunctor(fitFunctor); generator = fitGenerator.GetPointer(); //Create model info modelFitInfo = mitk::modelFit::CreateFitInfoFromModelParameterizer(modelParameterizer, m_selectedNode->GetData(), mitk::ModelFitConstants::FIT_TYPE_VALUE_PIXELBASED(), this->GetFitName(), roiUID); } void MRPerfusionView::GenerateDescriptiveBrixModel_ROIBased(mitk::modelFit::ModelFitInfo::Pointer& modelFitInfo, mitk::ParameterFitImageGeneratorBase::Pointer& generator) { if (m_selectedMask.IsNull()) { return; } mitk::ROIBasedParameterFitImageGenerator::Pointer fitGenerator = mitk::ROIBasedParameterFitImageGenerator::New(); mitk::DescriptivePharmacokineticBrixModelValueBasedParameterizer::Pointer modelParameterizer = mitk::DescriptivePharmacokineticBrixModelValueBasedParameterizer::New(); //Compute ROI signal mitk::MaskedDynamicImageStatisticsGenerator::Pointer signalGenerator = mitk::MaskedDynamicImageStatisticsGenerator::New(); signalGenerator->SetMask(m_selectedMask); signalGenerator->SetDynamicImage(m_selectedImage); signalGenerator->Generate(); mitk::MaskedDynamicImageStatisticsGenerator::ResultType roiSignal = signalGenerator->GetMean(); //Model configuration (static parameters) can be done now modelParameterizer->SetTau(m_Controls.injectiontime->value()); modelParameterizer->SetBaseValue(roiSignal[0]); this->ConfigureInitialParametersOfParameterizer(modelParameterizer); //Specify fitting strategy and criterion parameters mitk::ModelFitFunctorBase::Pointer fitFunctor = CreateDefaultFitFunctor(modelParameterizer); //Parametrize fit generator fitGenerator->SetModelParameterizer(modelParameterizer); fitGenerator->SetMask(m_selectedMask); fitGenerator->SetFitFunctor(fitFunctor); fitGenerator->SetSignal(roiSignal); fitGenerator->SetTimeGrid(mitk::ExtractTimeGrid(m_selectedImage)); generator = fitGenerator.GetPointer(); std::string roiUID = this->m_selectedMask->GetUID(); //Create model info modelFitInfo = mitk::modelFit::CreateFitInfoFromModelParameterizer(modelParameterizer, m_selectedNode->GetData(), mitk::ModelFitConstants::FIT_TYPE_VALUE_ROIBASED(), this->GetFitName(), roiUID); mitk::ScalarListLookupTable::ValueType infoSignal; for (mitk::MaskedDynamicImageStatisticsGenerator::ResultType::const_iterator pos = roiSignal.begin(); pos != roiSignal.end(); ++pos) { infoSignal.push_back(*pos); } modelFitInfo->inputData.SetTableValue("ROI", infoSignal); } template void MRPerfusionView::GenerateLinearModelFit_PixelBased(mitk::modelFit::ModelFitInfo::Pointer& modelFitInfo, mitk::ParameterFitImageGeneratorBase::Pointer& generator) { mitk::PixelBasedParameterFitImageGenerator::Pointer fitGenerator = mitk::PixelBasedParameterFitImageGenerator::New(); typename TParameterizer::Pointer modelParameterizer = TParameterizer::New(); this->ConfigureInitialParametersOfParameterizer(modelParameterizer); //Specify fitting strategy and criterion parameters mitk::ModelFitFunctorBase::Pointer fitFunctor = CreateDefaultFitFunctor(modelParameterizer); //Parametrize fit generator fitGenerator->SetModelParameterizer(modelParameterizer); std::string roiUID = ""; if (m_selectedMask.IsNotNull()) { fitGenerator->SetMask(m_selectedMask); roiUID = this->m_selectedMask->GetUID(); } fitGenerator->SetDynamicImage(m_selectedImage); fitGenerator->SetFitFunctor(fitFunctor); generator = fitGenerator.GetPointer(); //Create model info modelFitInfo = mitk::modelFit::CreateFitInfoFromModelParameterizer(modelParameterizer, m_selectedNode->GetData(), mitk::ModelFitConstants::FIT_TYPE_VALUE_PIXELBASED(), this->GetFitName(), roiUID); } template void MRPerfusionView::GenerateLinearModelFit_ROIBased(mitk::modelFit::ModelFitInfo::Pointer& modelFitInfo, mitk::ParameterFitImageGeneratorBase::Pointer& generator) { if (m_selectedMask.IsNull()) { return; } mitk::ROIBasedParameterFitImageGenerator::Pointer fitGenerator = mitk::ROIBasedParameterFitImageGenerator::New(); typename TParameterizer::Pointer modelParameterizer = TParameterizer::New(); //Compute ROI signal mitk::MaskedDynamicImageStatisticsGenerator::Pointer signalGenerator = mitk::MaskedDynamicImageStatisticsGenerator::New(); signalGenerator->SetMask(m_selectedMask); signalGenerator->SetDynamicImage(m_selectedImage); signalGenerator->Generate(); mitk::MaskedDynamicImageStatisticsGenerator::ResultType roiSignal = signalGenerator->GetMean(); //Model configuration (static parameters) can be done now this->ConfigureInitialParametersOfParameterizer(modelParameterizer); //Specify fitting strategy and criterion parameters mitk::ModelFitFunctorBase::Pointer fitFunctor = CreateDefaultFitFunctor(modelParameterizer); //Parametrize fit generator fitGenerator->SetModelParameterizer(modelParameterizer); fitGenerator->SetMask(m_selectedMask); fitGenerator->SetFitFunctor(fitFunctor); fitGenerator->SetSignal(roiSignal); fitGenerator->SetTimeGrid(mitk::ExtractTimeGrid(m_selectedImage)); generator = fitGenerator.GetPointer(); std::string roiUID = this->m_selectedMask->GetUID(); //Create model info modelFitInfo = mitk::modelFit::CreateFitInfoFromModelParameterizer(modelParameterizer, m_selectedNode->GetData(), mitk::ModelFitConstants::FIT_TYPE_VALUE_ROIBASED(), this->GetFitName(), roiUID); mitk::ScalarListLookupTable::ValueType infoSignal; for (mitk::MaskedDynamicImageStatisticsGenerator::ResultType::const_iterator pos = roiSignal.begin(); pos != roiSignal.end(); ++pos) { infoSignal.push_back(*pos); } modelFitInfo->inputData.SetTableValue("ROI", infoSignal); } template void MRPerfusionView::GenerateAIFbasedModelFit_PixelBased(mitk::modelFit::ModelFitInfo::Pointer& modelFitInfo, mitk::ParameterFitImageGeneratorBase::Pointer& generator) { mitk::PixelBasedParameterFitImageGenerator::Pointer fitGenerator = mitk::PixelBasedParameterFitImageGenerator::New(); typename TParameterizer::Pointer modelParameterizer = TParameterizer::New(); PrepareConcentrationImage(); mitk::AIFBasedModelBase::AterialInputFunctionType aif; mitk::AIFBasedModelBase::AterialInputFunctionType aifTimeGrid; GetAIF(aif, aifTimeGrid); modelParameterizer->SetAIF(aif); modelParameterizer->SetAIFTimeGrid(aifTimeGrid); this->ConfigureInitialParametersOfParameterizer(modelParameterizer); //Specify fitting strategy and criterion parameters mitk::ModelFitFunctorBase::Pointer fitFunctor = CreateDefaultFitFunctor(modelParameterizer); //Parametrize fit generator fitGenerator->SetModelParameterizer(modelParameterizer); std::string roiUID = ""; if (m_selectedMask.IsNotNull()) { fitGenerator->SetMask(m_selectedMask); roiUID = this->m_selectedMask->GetUID(); } fitGenerator->SetDynamicImage(this->m_inputImage); fitGenerator->SetFitFunctor(fitFunctor); generator = fitGenerator.GetPointer(); //Create model info modelFitInfo = mitk::modelFit::CreateFitInfoFromModelParameterizer(modelParameterizer, this->m_inputImage, mitk::ModelFitConstants::FIT_TYPE_VALUE_PIXELBASED(), this->GetFitName(), roiUID); mitk::ScalarListLookupTable::ValueType infoSignal; for (mitk::AIFBasedModelBase::AterialInputFunctionType::const_iterator pos = aif.begin(); pos != aif.end(); ++pos) { infoSignal.push_back(*pos); } modelFitInfo->inputData.SetTableValue("AIF", infoSignal); } template void MRPerfusionView::GenerateAIFbasedModelFit_ROIBased( mitk::modelFit::ModelFitInfo::Pointer& modelFitInfo, mitk::ParameterFitImageGeneratorBase::Pointer& generator) { if (m_selectedMask.IsNull()) { return; } mitk::ROIBasedParameterFitImageGenerator::Pointer fitGenerator = mitk::ROIBasedParameterFitImageGenerator::New(); typename TParameterizer::Pointer modelParameterizer = TParameterizer::New(); PrepareConcentrationImage(); mitk::AIFBasedModelBase::AterialInputFunctionType aif; mitk::AIFBasedModelBase::AterialInputFunctionType aifTimeGrid; GetAIF(aif, aifTimeGrid); modelParameterizer->SetAIF(aif); modelParameterizer->SetAIFTimeGrid(aifTimeGrid); this->ConfigureInitialParametersOfParameterizer(modelParameterizer); //Compute ROI signal mitk::MaskedDynamicImageStatisticsGenerator::Pointer signalGenerator = mitk::MaskedDynamicImageStatisticsGenerator::New(); signalGenerator->SetMask(m_selectedMask); signalGenerator->SetDynamicImage(this->m_inputImage); signalGenerator->Generate(); mitk::MaskedDynamicImageStatisticsGenerator::ResultType roiSignal = signalGenerator->GetMean(); //Specify fitting strategy and criterion parameters mitk::ModelFitFunctorBase::Pointer fitFunctor = CreateDefaultFitFunctor(modelParameterizer); //Parametrize fit generator fitGenerator->SetModelParameterizer(modelParameterizer); fitGenerator->SetMask(m_selectedMask); fitGenerator->SetFitFunctor(fitFunctor); fitGenerator->SetSignal(roiSignal); fitGenerator->SetTimeGrid(mitk::ExtractTimeGrid(this->m_inputImage)); generator = fitGenerator.GetPointer(); std::string roiUID = this->m_selectedMask->GetUID(); //Create model info modelFitInfo = mitk::modelFit::CreateFitInfoFromModelParameterizer(modelParameterizer, this->m_inputImage, mitk::ModelFitConstants::FIT_TYPE_VALUE_ROIBASED(), this->GetFitName(), roiUID); mitk::ScalarListLookupTable::ValueType infoSignal; for (mitk::MaskedDynamicImageStatisticsGenerator::ResultType::const_iterator pos = roiSignal.begin(); pos != roiSignal.end(); ++pos) { infoSignal.push_back(*pos); } modelFitInfo->inputData.SetTableValue("ROI", infoSignal); infoSignal.clear(); for (mitk::AIFBasedModelBase::AterialInputFunctionType::const_iterator pos = aif.begin(); pos != aif.end(); ++pos) { infoSignal.push_back(*pos); } modelFitInfo->inputData.SetTableValue("AIF", infoSignal); } void MRPerfusionView::DoFit(const mitk::modelFit::ModelFitInfo* fitSession, mitk::ParameterFitImageGeneratorBase* generator) { this->m_Controls.infoBox->append(QString("" + QString("Fitting Data Set . . .") + QString (""))); ///////////////////////// //create job and put it into the thread pool mitk::modelFit::ModelFitResultNodeVectorType additionalNodes; if (m_HasGeneratedNewInput) { additionalNodes.push_back(m_inputNode); } if (m_HasGeneratedNewInputAIF) { additionalNodes.push_back(m_inputAIFNode); } ParameterFitBackgroundJob* pJob = new ParameterFitBackgroundJob(generator, fitSession, this->m_selectedNode, additionalNodes); pJob->setAutoDelete(true); connect(pJob, SIGNAL(Error(QString)), this, SLOT(OnJobError(QString))); connect(pJob, SIGNAL(Finished()), this, SLOT(OnJobFinished())); connect(pJob, SIGNAL(ResultsAreAvailable(mitk::modelFit::ModelFitResultNodeVectorType, const ParameterFitBackgroundJob*)), this, SLOT(OnJobResultsAreAvailable(mitk::modelFit::ModelFitResultNodeVectorType, const ParameterFitBackgroundJob*)), Qt::BlockingQueuedConnection); connect(pJob, SIGNAL(JobProgress(double)), this, SLOT(OnJobProgress(double))); connect(pJob, SIGNAL(JobStatusChanged(QString)), this, SLOT(OnJobStatusChanged(QString))); QThreadPool* threadPool = QThreadPool::globalInstance(); threadPool->start(pJob); } MRPerfusionView::MRPerfusionView() : m_FittingInProgress(false), m_HasGeneratedNewInput(false), m_HasGeneratedNewInputAIF(false) { m_selectedImage = nullptr; m_selectedMask = nullptr; mitk::ModelFactoryBase::Pointer factory = mitk::DescriptivePharmacokineticBrixModelFactory::New().GetPointer(); m_FactoryStack.push_back(factory); factory = mitk::StandardToftsModelFactory::New().GetPointer(); m_FactoryStack.push_back(factory); factory = mitk::ExtendedToftsModelFactory::New().GetPointer(); m_FactoryStack.push_back(factory); factory = mitk::TwoCompartmentExchangeModelFactory::New().GetPointer(); m_FactoryStack.push_back(factory); mitk::NodePredicateDataType::Pointer isLabelSet = mitk::NodePredicateDataType::New("LabelSetImage"); mitk::NodePredicateDataType::Pointer isImage = mitk::NodePredicateDataType::New("Image"); mitk::NodePredicateProperty::Pointer isBinary = mitk::NodePredicateProperty::New("binary", mitk::BoolProperty::New(true)); mitk::NodePredicateAnd::Pointer isLegacyMask = mitk::NodePredicateAnd::New(isImage, isBinary); mitk::NodePredicateDimension::Pointer is3D = mitk::NodePredicateDimension::New(3); mitk::NodePredicateOr::Pointer isMask = mitk::NodePredicateOr::New(isLegacyMask, isLabelSet); mitk::NodePredicateAnd::Pointer isNoMask = mitk::NodePredicateAnd::New(isImage, mitk::NodePredicateNot::New(isMask)); mitk::NodePredicateAnd::Pointer is3DImage = mitk::NodePredicateAnd::New(isImage, is3D, isNoMask); this->m_IsMaskPredicate = mitk::NodePredicateAnd::New(isMask, mitk::NodePredicateNot::New(mitk::NodePredicateProperty::New("helper object"))).GetPointer(); this->m_IsNoMaskImagePredicate = mitk::NodePredicateAnd::New(isNoMask, mitk::NodePredicateNot::New(mitk::NodePredicateProperty::New("helper object"))).GetPointer(); auto isDynamicData = mitk::NodePredicateFunction::New([](const mitk::DataNode* node) { return (node && node->GetData() && node->GetData()->GetTimeSteps() > 1); }); auto modelFitResultRelationRule = mitk::ModelFitResultRelationRule::New(); auto isNoModelFitNodePredicate = mitk::NodePredicateNot::New(modelFitResultRelationRule->GetConnectedSourcesDetector()); this->m_isValidPDWImagePredicate = mitk::NodePredicateAnd::New(is3DImage, isNoModelFitNodePredicate); this->m_isValidTimeSeriesImagePredicate = mitk::NodePredicateAnd::New(isDynamicData, isImage, isNoMask); } void MRPerfusionView::OnJobFinished() { this->m_Controls.infoBox->append(QString("Fitting finished.")); this->m_FittingInProgress = false; this->UpdateGUIControls(); }; void MRPerfusionView::OnJobError(QString err) { MITK_ERROR << err.toStdString().c_str(); m_Controls.infoBox->append(QString("") + err + QString("")); }; void MRPerfusionView::OnJobResultsAreAvailable(mitk::modelFit::ModelFitResultNodeVectorType results, const ParameterFitBackgroundJob* pJob) { //Store the resulting parameter fit image via convenience helper function in data storage //(handles the correct generation of the nodes and their properties) mitk::modelFit::StoreResultsInDataStorage(this->GetDataStorage(), results, pJob->GetParentNode()); //this stores the concentration image and AIF concentration image, if generated for this fit in the storage. //if not generated for this fit, relevant nodes are empty. mitk::modelFit::StoreResultsInDataStorage(this->GetDataStorage(), pJob->GetAdditionalRelevantNodes(), pJob->GetParentNode()); }; void MRPerfusionView::OnJobProgress(double progress) { QString report = QString("Progress. ") + QString::number(progress); this->m_Controls.infoBox->append(report); }; void MRPerfusionView::OnJobStatusChanged(QString info) { this->m_Controls.infoBox->append(info); } void MRPerfusionView::InitModelComboBox() const { this->m_Controls.comboModel->clear(); this->m_Controls.comboModel->addItem(tr("No model selected")); for (ModelFactoryStackType::const_iterator pos = m_FactoryStack.begin(); pos != m_FactoryStack.end(); ++pos) { this->m_Controls.comboModel->addItem(QString::fromStdString((*pos)->GetClassID())); } this->m_Controls.comboModel->setCurrentIndex(0); }; mitk::DataNode::Pointer MRPerfusionView::GenerateConcentrationNode(mitk::Image* image, const std::string& nodeName) const { if (!image) { mitkThrow() << "Cannot generate concentration node. Passed image is null. parameter name: "; } mitk::DataNode::Pointer result = mitk::DataNode::New(); result->SetData(image); result->SetName(nodeName); result->SetVisibility(true); return result; }; mitk::Image::Pointer MRPerfusionView::ConvertConcentrationImage(bool AIFMode) { //Compute Concentration image mitk::ConcentrationCurveGenerator::Pointer concentrationGen = mitk::ConcentrationCurveGenerator::New(); if (m_Controls.checkDedicatedAIFImage->isChecked() && AIFMode) { concentrationGen->SetDynamicImage(this->m_selectedAIFImage); } else { concentrationGen->SetDynamicImage(this->m_selectedImage); } concentrationGen->SetisTurboFlashSequence(IsTurboFlashSequenceFlag()); concentrationGen->SetAbsoluteSignalEnhancement(m_Controls.radioButton_absoluteEnhancement->isChecked()); concentrationGen->SetRelativeSignalEnhancement(m_Controls.radioButton_relativeEnchancement->isChecked()); concentrationGen->SetUsingT1Map(m_Controls.radioButtonUsingT1viaVFA->isChecked()); if (IsTurboFlashSequenceFlag()) { if (AIFMode) { concentrationGen->SetRecoveryTime(m_Controls.AifRecoverytime->value()); } else { concentrationGen->SetRecoveryTime(m_Controls.recoverytime->value()); } concentrationGen->SetRelaxationTime(m_Controls.relaxationtime->value()); concentrationGen->SetRelaxivity(m_Controls.relaxivity->value()); concentrationGen->SetBaselineStartTimeStep(m_Controls.spinBox_baselineStartTimeStep->value()); concentrationGen->SetBaselineEndTimeStep(m_Controls.spinBox_baselineEndTimeStep->value()); } else if (this->m_Controls.radioButtonUsingT1viaVFA->isChecked()) { concentrationGen->SetRecoveryTime(m_Controls.TRSpinBox->value()); concentrationGen->SetRelaxivity(m_Controls.RelaxivitySpinBox->value()); - concentrationGen->SetT10Image(dynamic_cast(m_Controls.PDWImageNodeSelector->GetSelectedNode()->GetData())); + concentrationGen->SetPDWImage(dynamic_cast(m_Controls.PDWImageNodeSelector->GetSelectedNode()->GetData())); concentrationGen->SetBaselineStartTimeStep(m_Controls.spinBox_baselineStartTimeStep->value()); concentrationGen->SetBaselineEndTimeStep(m_Controls.spinBox_baselineEndTimeStep->value()); //Convert Flipangle from degree to radiant double alpha = m_Controls.FlipangleSpinBox->value()/360*2* boost::math::constants::pi(); concentrationGen->SetFlipAngle(alpha); } else { concentrationGen->SetFactor(m_Controls.factorSpinBox->value()); concentrationGen->SetBaselineStartTimeStep(m_Controls.spinBox_baselineStartTimeStep->value()); concentrationGen->SetBaselineEndTimeStep(m_Controls.spinBox_baselineEndTimeStep->value()); } mitk::Image::Pointer concentrationImage = concentrationGen->GetConvertedImage(); return concentrationImage; } void MRPerfusionView::GetAIF(mitk::AIFBasedModelBase::AterialInputFunctionType& aif, mitk::AIFBasedModelBase::AterialInputFunctionType& aifTimeGrid) { if (this->m_Controls.radioAIFFile->isChecked()) { aif.clear(); aifTimeGrid.clear(); aif.SetSize(AIFinputFunction.size()); aifTimeGrid.SetSize(AIFinputGrid.size()); aif.fill(0.0); aifTimeGrid.fill(0.0); itk::Array::iterator aifPos = aif.begin(); for (std::vector::const_iterator pos = AIFinputFunction.begin(); pos != AIFinputFunction.end(); ++pos, ++aifPos) { *aifPos = *pos; } itk::Array::iterator gridPos = aifTimeGrid.begin(); for (std::vector::const_iterator pos = AIFinputGrid.begin(); pos != AIFinputGrid.end(); ++pos, ++gridPos) { *gridPos = *pos; } } else if (this->m_Controls.radioAIFImage->isChecked()) { aif.clear(); aifTimeGrid.clear(); mitk::AterialInputFunctionGenerator::Pointer aifGenerator = mitk::AterialInputFunctionGenerator::New(); //Hematocrit level aifGenerator->SetHCL(this->m_Controls.HCLSpinBox->value()); //mask settings this->m_selectedAIFMaskNode = m_Controls.AIFMaskNodeSelector->GetSelectedNode(); this->m_selectedAIFMask = dynamic_cast(this->m_selectedAIFMaskNode->GetData()); if (this->m_selectedAIFMask->GetTimeSteps() > 1) { MITK_INFO << "Selected AIF mask has multiple timesteps. Only use first timestep to mask model fit. AIF Mask name: " << m_selectedAIFMaskNode->GetName() ; mitk::ImageTimeSelector::Pointer maskedImageTimeSelector = mitk::ImageTimeSelector::New(); maskedImageTimeSelector->SetInput(this->m_selectedAIFMask); maskedImageTimeSelector->SetTimeNr(0); maskedImageTimeSelector->UpdateLargestPossibleRegion(); this->m_selectedAIFMask = maskedImageTimeSelector->GetOutput(); } if (this->m_selectedAIFMask.IsNotNull()) { aifGenerator->SetMask(this->m_selectedAIFMask); } //image settings if (this->m_Controls.checkDedicatedAIFImage->isChecked()) { this->m_selectedAIFImageNode = m_Controls.AIFImageNodeSelector->GetSelectedNode(); this->m_selectedAIFImage = dynamic_cast(this->m_selectedAIFImageNode->GetData()); } else { this->m_selectedAIFImageNode = m_selectedNode; this->m_selectedAIFImage = m_selectedImage; } this->PrepareAIFConcentrationImage(); aifGenerator->SetDynamicImage(this->m_inputAIFImage); aif = aifGenerator->GetAterialInputFunction(); aifTimeGrid = aifGenerator->GetAterialInputFunctionTimeGrid(); } else { mitkThrow() << "Cannot generate AIF. View is in a invalid state. No AIF mode selected."; } } void MRPerfusionView::LoadAIFfromFile() { QFileDialog dialog; dialog.setNameFilter(tr("Images (*.csv")); QString fileName = dialog.getOpenFileName(); m_Controls.aifFilePath->setText(fileName); std::string m_aifFilePath = fileName.toStdString(); //Read Input typedef boost::tokenizer< boost::escaped_list_separator > Tokenizer; ///////////////////////////////////////////////////////////////////////////////////////////////// //AIF Data std::ifstream in1(m_aifFilePath.c_str()); if (!in1.is_open()) { this->m_Controls.infoBox->append(QString("Could not open AIF File!")); } std::vector< std::string > vec1; std::string line1; while (getline(in1, line1)) { Tokenizer tok(line1); vec1.assign(tok.begin(), tok.end()); this->AIFinputGrid.push_back(convertToDouble(vec1[0])); this->AIFinputFunction.push_back(convertToDouble(vec1[1])); } } void MRPerfusionView::PrepareConcentrationImage() { mitk::Image::Pointer concentrationImage = this->m_selectedImage; mitk::DataNode::Pointer concentrationNode = this->m_selectedNode; m_HasGeneratedNewInput = false; if (!this->m_Controls.radioButtonNoConversion->isChecked()) { concentrationImage = this->ConvertConcentrationImage(false); concentrationNode = GenerateConcentrationNode(concentrationImage, "Concentration"); m_HasGeneratedNewInput = true; } m_inputImage = concentrationImage; m_inputNode = concentrationNode; } void MRPerfusionView::PrepareAIFConcentrationImage() { mitk::Image::Pointer concentrationImage = this->m_selectedImage; mitk::DataNode::Pointer concentrationNode = this->m_selectedNode; m_HasGeneratedNewInputAIF = false; if (this->m_Controls.checkDedicatedAIFImage->isChecked()) { concentrationImage = this->m_selectedAIFImage; concentrationNode = this->m_selectedAIFImageNode; } if (!this->m_Controls.radioButtonNoConversion->isChecked()) { if (!IsTurboFlashSequenceFlag() && !this->m_Controls.checkDedicatedAIFImage->isChecked()) { if (m_inputImage.IsNull()) { mitkThrow() << "Cannot get AIF concentration image. Invalid view state. Input image is not defined yet, but should be."; } //we can directly use the concentration input image/node (generated by GetConcentrationImage) also for the AIF concentrationImage = this->m_inputImage; concentrationNode = this->m_inputNode; } else { concentrationImage = this->ConvertConcentrationImage(true); concentrationNode = GenerateConcentrationNode(concentrationImage, "AIF Concentration"); m_HasGeneratedNewInputAIF = true; } } m_inputAIFImage = concentrationImage; m_inputAIFNode = concentrationNode; } mitk::ModelFitFunctorBase::Pointer MRPerfusionView::CreateDefaultFitFunctor( const mitk::ModelParameterizerBase* parameterizer) const { mitk::LevenbergMarquardtModelFitFunctor::Pointer fitFunctor = mitk::LevenbergMarquardtModelFitFunctor::New(); mitk::NormalizedSumOfSquaredDifferencesFitCostFunction::Pointer chi2 = mitk::NormalizedSumOfSquaredDifferencesFitCostFunction::New(); fitFunctor->RegisterEvaluationParameter("Chi^2", chi2); if (m_Controls.checkBox_Constraints->isChecked()) { fitFunctor->SetConstraintChecker(m_modelConstraints); } mitk::ModelBase::Pointer refModel = parameterizer->GenerateParameterizedModel(); ::itk::LevenbergMarquardtOptimizer::ScalesType scales; scales.SetSize(refModel->GetNumberOfParameters()); scales.Fill(1.0); fitFunctor->SetScales(scales); fitFunctor->SetDebugParameterMaps(m_Controls.checkDebug->isChecked()); return fitFunctor.GetPointer(); }