diff --git a/Plugins/org.mitk.gui.qt.segmentation/src/QmitkSegmentationPreferencePage.cpp b/Plugins/org.mitk.gui.qt.segmentation/src/QmitkSegmentationPreferencePage.cpp
index 808a40582c..f77ebd2f21 100644
--- a/Plugins/org.mitk.gui.qt.segmentation/src/QmitkSegmentationPreferencePage.cpp
+++ b/Plugins/org.mitk.gui.qt.segmentation/src/QmitkSegmentationPreferencePage.cpp
@@ -1,134 +1,135 @@
 /*============================================================================
 
 The Medical Imaging Interaction Toolkit (MITK)
 
 Copyright (c) German Cancer Research Center (DKFZ)
 All rights reserved.
 
 Use of this source code is governed by a 3-clause BSD license that can be
 found in the LICENSE file.
 
 ============================================================================*/
 
 #include "QmitkSegmentationPreferencePage.h"
 
-#include <QLabel>
-#include <QPushButton>
-#include <QFormLayout>
-#include <QHBoxLayout>
-#include <QCheckBox>
-#include <QGroupBox>
-#include <QRadioButton>
-#include <QMessageBox>
-#include <QDoubleSpinBox>
-#include <QLineEdit>
-#include <QToolButton>
-#include <QFileDialog>
-
 #include <berryIPreferencesService.h>
 #include <berryPlatform.h>
 
+#include <mitkBaseApplication.h>
+
+#include <QFileDialog>
+
 #include <ui_QmitkSegmentationPreferencePageControls.h>
 
 QmitkSegmentationPreferencePage::QmitkSegmentationPreferencePage()
   : m_Ui(new Ui::QmitkSegmentationPreferencePageControls),
     m_Control(nullptr),
     m_Initializing(false)
 {
 }
 
 QmitkSegmentationPreferencePage::~QmitkSegmentationPreferencePage()
 {
 }
 
 void QmitkSegmentationPreferencePage::Init(berry::IWorkbench::Pointer)
 {
 }
 
 void QmitkSegmentationPreferencePage::CreateQtControl(QWidget* parent)
 {
   m_Initializing = true;
   berry::IPreferencesService* prefService = berry::Platform::GetPreferencesService();
 
   m_SegmentationPreferencesNode = prefService->GetSystemPreferences()->Node("/org.mitk.views.segmentation");
 
   m_Control = new QWidget(parent);
   m_Ui->setupUi(m_Control);
 
   connect(m_Ui->smoothingCheckBox, SIGNAL(stateChanged(int)), this, SLOT(OnSmoothingCheckboxChecked(int)));
   connect(m_Ui->labelSetPresetToolButton, SIGNAL(clicked()), this, SLOT(OnLabelSetPresetButtonClicked()));
 
   this->Update();
   m_Initializing = false;
 }
 
 QWidget* QmitkSegmentationPreferencePage::GetQtControl() const
 {
   return m_Control;
 }
 
 bool QmitkSegmentationPreferencePage::PerformOk()
 {
   m_SegmentationPreferencesNode->PutBool("slim view", m_Ui->slimViewCheckBox->isChecked());
   m_SegmentationPreferencesNode->PutBool("draw outline", m_Ui->outlineRadioButton->isChecked());
   m_SegmentationPreferencesNode->PutBool("selection mode", m_Ui->selectionModeCheckBox->isChecked());
   m_SegmentationPreferencesNode->PutBool("smoothing hint", m_Ui->smoothingCheckBox->isChecked());
   m_SegmentationPreferencesNode->PutDouble("smoothing value", m_Ui->smoothingSpinBox->value());
   m_SegmentationPreferencesNode->PutDouble("decimation rate", m_Ui->decimationSpinBox->value());
   m_SegmentationPreferencesNode->PutDouble("closing ratio", m_Ui->closingSpinBox->value());
   m_SegmentationPreferencesNode->Put("label set preset", m_Ui->labelSetPresetLineEdit->text());
   return true;
 }
 
 void QmitkSegmentationPreferencePage::PerformCancel()
 {
 }
 
 void QmitkSegmentationPreferencePage::Update()
 {
   m_Ui->slimViewCheckBox->setChecked(m_SegmentationPreferencesNode->GetBool("slim view", false));
 
   if (m_SegmentationPreferencesNode->GetBool("draw outline", true))
   {
     m_Ui->outlineRadioButton->setChecked(true);
   }
   else
   {
     m_Ui->overlayRadioButton->setChecked(true);
   }
 
   m_Ui->selectionModeCheckBox->setChecked(m_SegmentationPreferencesNode->GetBool("selection mode", false));
 
   if (m_SegmentationPreferencesNode->GetBool("smoothing hint", true))
   {
     m_Ui->smoothingCheckBox->setChecked(true);
     m_Ui->smoothingSpinBox->setDisabled(true);
   }
   else
   {
     m_Ui->smoothingCheckBox->setChecked(false);
     m_Ui->smoothingSpinBox->setEnabled(true);
   }
 
   m_Ui->smoothingSpinBox->setValue(m_SegmentationPreferencesNode->GetDouble("smoothing value", 1.0));
   m_Ui->decimationSpinBox->setValue(m_SegmentationPreferencesNode->GetDouble("decimation rate", 0.5));
   m_Ui->closingSpinBox->setValue(m_SegmentationPreferencesNode->GetDouble("closing ratio", 0.0));
 
-  m_Ui->labelSetPresetLineEdit->setText(m_SegmentationPreferencesNode->Get("label set preset", ""));
+  auto labelSetPreset = mitk::BaseApplication::instance().config().getString(mitk::BaseApplication::ARG_SEGMENTATION_LABELSET_PRESET.toStdString(), "");
+  bool isOverridenByCmdLineArg = !labelSetPreset.empty();
+
+  if (!isOverridenByCmdLineArg)
+    labelSetPreset = m_SegmentationPreferencesNode->Get("label set preset", "").toStdString();
+
+  m_Ui->labelSetPresetLineEdit->setDisabled(isOverridenByCmdLineArg);
+  m_Ui->labelSetPresetToolButton->setDisabled(isOverridenByCmdLineArg);
+  m_Ui->labelSetPresetCmdLineArgLabel->setVisible(isOverridenByCmdLineArg);
+
+  m_Ui->labelSetPresetLineEdit->setText(QString::fromStdString(labelSetPreset));
 }
 
 void QmitkSegmentationPreferencePage::OnSmoothingCheckboxChecked(int state)
 {
   if (state != Qt::Unchecked)
     m_Ui->smoothingSpinBox->setDisabled(true);
   else
     m_Ui->smoothingSpinBox->setEnabled(true);
 }
 
 void QmitkSegmentationPreferencePage::OnLabelSetPresetButtonClicked()
 {
   const auto filename = QFileDialog::getOpenFileName(m_Control, QStringLiteral("Load Label Set Preset"), QString(), QStringLiteral("Label set preset (*.lsetp)"));
 
   if (!filename.isEmpty())
     m_Ui->labelSetPresetLineEdit->setText(filename);
 }
diff --git a/Plugins/org.mitk.gui.qt.segmentation/src/QmitkSegmentationPreferencePageControls.ui b/Plugins/org.mitk.gui.qt.segmentation/src/QmitkSegmentationPreferencePageControls.ui
index d0c13ebe70..7728e50e20 100644
--- a/Plugins/org.mitk.gui.qt.segmentation/src/QmitkSegmentationPreferencePageControls.ui
+++ b/Plugins/org.mitk.gui.qt.segmentation/src/QmitkSegmentationPreferencePageControls.ui
@@ -1,198 +1,205 @@
 <?xml version="1.0" encoding="UTF-8"?>
 <ui version="4.0">
  <class>QmitkSegmentationPreferencePageControls</class>
  <widget class="QWidget" name="QmitkSegmentationPreferencePageControls">
   <property name="geometry">
    <rect>
     <x>0</x>
     <y>0</y>
     <width>640</width>
     <height>480</height>
    </rect>
   </property>
   <property name="windowTitle">
    <string>Form</string>
   </property>
   <layout class="QFormLayout" name="formLayout">
-   <property name="horizontalSpacing">
-    <number>8</number>
-   </property>
-   <property name="verticalSpacing">
-    <number>24</number>
-   </property>
    <item row="0" column="0">
     <widget class="QLabel" name="slimViewLabel">
      <property name="text">
       <string>Slim view</string>
      </property>
     </widget>
    </item>
    <item row="0" column="1">
     <widget class="QCheckBox" name="slimViewCheckBox">
      <property name="text">
       <string>Hide tool button texts and increase icon size</string>
      </property>
     </widget>
    </item>
    <item row="1" column="0">
     <widget class="QLabel" name="displayLabel">
      <property name="text">
       <string>2D display</string>
      </property>
     </widget>
    </item>
    <item row="1" column="1">
     <layout class="QVBoxLayout" name="displayOptionsLayout">
      <item>
       <widget class="QRadioButton" name="outlineRadioButton">
        <property name="text">
         <string>Draw as outline</string>
        </property>
       </widget>
      </item>
      <item>
       <widget class="QRadioButton" name="overlayRadioButton">
        <property name="text">
         <string>Draw as transparent overlay</string>
        </property>
       </widget>
      </item>
     </layout>
    </item>
    <item row="2" column="0">
     <widget class="QLabel" name="selectionModeLabel">
      <property name="text">
       <string>Data node selection mode</string>
      </property>
     </widget>
    </item>
    <item row="2" column="1">
     <widget class="QCheckBox" name="selectionModeCheckBox">
      <property name="toolTip">
       <string>If checked the segmentation plugin ensures that only the selected segmentation and the reference image are visible at one time.</string>
      </property>
      <property name="text">
       <string>Show only selected nodes</string>
      </property>
     </widget>
    </item>
    <item row="3" column="0">
     <widget class="QLabel" name="surfaceCreationLabel">
      <property name="text">
       <string>Smoothed surface creation</string>
      </property>
     </widget>
    </item>
    <item row="3" column="1">
     <layout class="QFormLayout" name="surfaceLayout">
      <property name="horizontalSpacing">
       <number>8</number>
      </property>
      <property name="verticalSpacing">
       <number>8</number>
      </property>
      <item row="1" column="0">
       <widget class="QLabel" name="smoothingLabel">
        <property name="text">
         <string>Smoothing value (mm)</string>
        </property>
       </widget>
      </item>
      <item row="1" column="1">
       <widget class="QDoubleSpinBox" name="smoothingSpinBox">
        <property name="toolTip">
         <string>The Smoothing value is used as variance for a gaussian blur.</string>
        </property>
        <property name="singleStep">
         <double>0.500000000000000</double>
        </property>
        <property name="value">
         <double>1.000000000000000</double>
        </property>
       </widget>
      </item>
      <item row="2" column="0">
       <widget class="QLabel" name="decimationLabel">
        <property name="text">
         <string>Decimation rate</string>
        </property>
       </widget>
      </item>
      <item row="2" column="1">
       <widget class="QDoubleSpinBox" name="decimationSpinBox">
        <property name="toolTip">
         <string>Valid range is [0, 1). High values increase decimation, especially when very close to 1. A value of 0 disables decimation.</string>
        </property>
        <property name="maximum">
         <double>0.990000000000000</double>
        </property>
        <property name="singleStep">
         <double>0.100000000000000</double>
        </property>
        <property name="value">
         <double>0.500000000000000</double>
        </property>
       </widget>
      </item>
      <item row="3" column="0">
       <widget class="QLabel" name="closingLabel">
        <property name="text">
         <string>Closing Ratio</string>
        </property>
       </widget>
      </item>
      <item row="3" column="1">
       <widget class="QDoubleSpinBox" name="closingSpinBox">
        <property name="toolTip">
         <string>Valid range is [0, 1]. Higher values increase closing. A value of 0 disables closing.</string>
        </property>
        <property name="maximum">
         <double>1.000000000000000</double>
        </property>
        <property name="singleStep">
         <double>0.100000000000000</double>
        </property>
       </widget>
      </item>
      <item row="0" column="0" colspan="2">
       <widget class="QCheckBox" name="smoothingCheckBox">
        <property name="toolTip">
         <string>If checked the segmentation plugin ensures that only the selected segmentation and the reference image are visible at one time.</string>
        </property>
        <property name="text">
         <string>Use image spacing as smoothing value hint</string>
        </property>
       </widget>
      </item>
     </layout>
    </item>
    <item row="4" column="0">
     <widget class="QLabel" name="labelSetPresetLabel">
      <property name="text">
       <string>Default label set preset</string>
      </property>
     </widget>
    </item>
    <item row="4" column="1">
-    <layout class="QHBoxLayout" name="horizontalLayout">
-     <item>
+    <layout class="QGridLayout" name="gridLayout">
+     <item row="0" column="0">
       <widget class="QLineEdit" name="labelSetPresetLineEdit">
        <property name="clearButtonEnabled">
         <bool>true</bool>
        </property>
       </widget>
      </item>
-     <item>
+     <item row="0" column="1">
       <widget class="QToolButton" name="labelSetPresetToolButton">
        <property name="text">
         <string>...</string>
        </property>
       </widget>
      </item>
+     <item row="1" column="0" colspan="2">
+      <widget class="QLabel" name="labelSetPresetCmdLineArgLabel">
+       <property name="text">
+        <string>&lt;html&gt;&lt;head/&gt;&lt;body&gt;&lt;p&gt;&lt;span style=&quot; color:#ff0000;&quot;&gt;The default label set preset is currently overriden by the &lt;/span&gt;&lt;span style=&quot; font-family:'Courier New'; color:#ff0000;&quot;&gt;Segmentation.labelSetPreset&lt;/span&gt;&lt;span style=&quot; color:#ff0000;&quot;&gt; command-line argument.&lt;/span&gt;&lt;/p&gt;&lt;/body&gt;&lt;/html&gt;</string>
+       </property>
+       <property name="textFormat">
+        <enum>Qt::RichText</enum>
+       </property>
+       <property name="wordWrap">
+        <bool>true</bool>
+       </property>
+      </widget>
+     </item>
     </layout>
    </item>
   </layout>
  </widget>
  <resources/>
  <connections/>
 </ui>