diff --git a/Modules/QtPython/CMakeLists.txt b/Modules/QtPython/CMakeLists.txt
index 4089449246..d497d472ef 100644
--- a/Modules/QtPython/CMakeLists.txt
+++ b/Modules/QtPython/CMakeLists.txt
@@ -1,19 +1,18 @@
 if(MITK_USE_Python3)
   mitkFunctionCheckCompilerFlags("/wd4273" CMAKE_CXX_FLAGS)
 
   set(OpenCV_DEP )
   if(MITK_USE_OpenCV)
     set(OpenCV_DEP OpenCV)
   endif()
 
   mitk_create_module(
     DEPENDS MitkCore MitkQtWidgets MitkPython
     PACKAGE_DEPENDS
     PUBLIC Qt5|Widgets CTK|CTKScriptingPythonCore+CTKScriptingPythonWidgets
     )
 
-  # temporarily disabled, bug-19153
-  if(UNIX)
+  if(BUILD_TESTING)
     add_subdirectory(Testing)
   endif()
 endif()
diff --git a/Modules/QtPython/Testing/CMakeLists.txt b/Modules/QtPython/Testing/CMakeLists.txt
index f84c5188fa..e9cde47bc8 100644
--- a/Modules/QtPython/Testing/CMakeLists.txt
+++ b/Modules/QtPython/Testing/CMakeLists.txt
@@ -1,3 +1,19 @@
 set(package_deps PACKAGE_DEPENDS PRIVATE)
 
 MITK_CREATE_MODULE_TESTS(${package_deps})
+
+if(UNIX AND NOT APPLE)
+  #[[ The PythonQt library (dependency of MitkQtPython module) depends on Qt
+      libraries without absolute paths. Use LD_LIBRARY_PATH as workaround.
+      See T26955. ]]
+  if(TARGET ${TESTDRIVER})
+    get_target_property(ld_library_path Qt5::Core IMPORTED_LOCATION_RELEASE)
+    get_filename_component(ld_library_path "${ld_library_path}" DIRECTORY)
+
+    add_test(
+      NAME mitkPythonTest
+      COMMAND ${CMAKE_COMMAND} -E env "LD_LIBRARY_PATH=${ld_library_path}"
+        ${CMAKE_RUNTIME_OUTPUT_DIRECTORY}/${TESTDRIVER} mitkPythonTest
+    )
+  endif()
+endif()
diff --git a/Modules/QtPython/Testing/files.cmake b/Modules/QtPython/Testing/files.cmake
index d4301946da..2be97879a7 100644
--- a/Modules/QtPython/Testing/files.cmake
+++ b/Modules/QtPython/Testing/files.cmake
@@ -1,3 +1,10 @@
-set(MODULE_TESTS
-  mitkPythonTest.cpp
-)
+if(UNIX AND NOT APPLE)
+  # See T26955.
+  set(MODULE_CUSTOM_TESTS
+    mitkPythonTest.cpp
+  )
+else()
+  set(MODULE_TESTS
+    mitkPythonTest.cpp
+  )
+endif()