diff --git a/CMake/BuildConfigurations/DiffusionAll.cmake b/CMake/BuildConfigurations/DiffusionAll.cmake
index 79807ee352..703d668914 100644
--- a/CMake/BuildConfigurations/DiffusionAll.cmake
+++ b/CMake/BuildConfigurations/DiffusionAll.cmake
@@ -1,33 +1,35 @@
 message(STATUS "Configuring MITK Diffusion with all Plugins")
 
 # Enable non-optional external dependencies
 set(MITK_USE_Vigra ON CACHE BOOL "MITK Use Vigra Library" FORCE)
 set(MITK_USE_HDF5 ON CACHE BOOL "MITK Use HDF5 Library" FORCE)
 set(MITK_USE_MatchPoint ON CACHE BOOL "" FORCE)
+set(MITK_USE_Python ON CACHE BOOL "" FORCE)
+set(MITK_USE_SYSTEM_PYTHON ON CACHE BOOL "" FORCE)
 
 # Disable all apps but MITK Diffusion
 set(MITK_BUILD_ALL_APPS OFF CACHE BOOL "Build all MITK applications" FORCE)
 set(MITK_BUILD_APP_CoreApp OFF CACHE BOOL "Build the MITK CoreApp" FORCE)
 set(MITK_BUILD_APP_Diffusion ON CACHE BOOL "Build MITK Diffusion" FORCE)
 
 # Activate Diffusion Mini Apps
 set(BUILD_DiffusionCoreCmdApps ON CACHE BOOL "Build commandline tools for diffusion" FORCE)
 set(BUILD_DiffusionFiberProcessingCmdApps ON CACHE BOOL "Build commandline tools for diffusion fiber processing" FORCE)
 set(BUILD_DiffusionFiberfoxCmdApps ON CACHE BOOL "Build commandline tools for diffusion data simulation (Fiberfox)" FORCE)
 set(BUILD_DiffusionMiscCmdApps ON CACHE BOOL "Build miscellaneous commandline tools for diffusion" FORCE)
 set(BUILD_DiffusionQuantificationCmdApps ON CACHE BOOL "Build commandline tools for diffusion quantification (IVIM, ADC, ...)" FORCE)
 set(BUILD_DiffusionTractographyCmdApps ON CACHE BOOL "Build commandline tools for diffusion fiber tractography" FORCE)
 set(BUILD_DiffusionTractographyEvaluationCmdApps ON CACHE BOOL "Build commandline tools for diffusion fiber tractography evaluation" FORCE)
 set(BUILD_DiffusionConnectomicsCmdApps ON CACHE BOOL "Build commandline tools for diffusion connectomics" FORCE)
 
 # Build neither all plugins nor examples
 set(MITK_BUILD_ALL_PLUGINS OFF CACHE BOOL "Build all MITK plugins" FORCE)
 set(MITK_BUILD_EXAMPLES OFF CACHE BOOL "Build the MITK examples" FORCE)
 set(BUILD_TESTING ON CACHE BOOL "Build the MITK tests" FORCE)
 
 # Activate in-application help generation
 set(MITK_DOXYGEN_GENERATE_QCH_FILES ON CACHE BOOL "Use doxygen to generate Qt compressed help files for MITK docs" FORCE)
 set(BLUEBERRY_USE_QT_HELP ON CACHE BOOL "Enable support for integrating bundle documentation into Qt Help" FORCE)
 
 # Disable console window
 set(MITK_SHOW_CONSOLE_WINDOW ON CACHE BOOL "Use this to enable or disable the console window when starting MITK GUI Applications" FORCE)
diff --git a/Plugins/org.mitk.gui.qt.diffusionimaging.preprocessing/CMakeLists.txt b/Plugins/org.mitk.gui.qt.diffusionimaging.preprocessing/CMakeLists.txt
index 7ce2b4e7cc..b80f3e0fb3 100644
--- a/Plugins/org.mitk.gui.qt.diffusionimaging.preprocessing/CMakeLists.txt
+++ b/Plugins/org.mitk.gui.qt.diffusionimaging.preprocessing/CMakeLists.txt
@@ -1,10 +1,14 @@
+if(MITK_USE_Python)
+
 # The project name must correspond to the directory name of your plug-in
 # and must not contain periods.
 project(org_mitk_gui_qt_diffusionimaging_preprocessing)
 
 mitk_create_plugin(
   EXPORT_DIRECTIVE DIFFUSIONIMAGING_PREPROCESSING_EXPORT
   EXPORTED_INCLUDE_SUFFIXES src
   MODULE_DEPENDS MitkDiffusionCore MitkPython MitkQtPython
   PACKAGE_DEPENDS Qt5|Network
 )
+
+endif()