diff --git a/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkFiniteDiffOdfMaximaExtractionFilter.cpp b/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkFiniteDiffOdfMaximaExtractionFilter.cpp index 24e2cb589c..d92204518a 100644 --- a/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkFiniteDiffOdfMaximaExtractionFilter.cpp +++ b/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkFiniteDiffOdfMaximaExtractionFilter.cpp @@ -1,512 +1,522 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ #ifndef __itkFiniteDiffOdfMaximaExtractionFilter_cpp #define __itkFiniteDiffOdfMaximaExtractionFilter_cpp #include "itkFiniteDiffOdfMaximaExtractionFilter.h" #include #include #include #include #include #include #include #include #include #include #include #include #include using namespace boost::math; namespace itk { static bool CompareVectors(const vnl_vector_fixed< double, 3 >& v1, const vnl_vector_fixed< double, 3 >& v2) { return (v1.magnitude()>v2.magnitude()); } template< class PixelType, int ShOrder, int NrOdfDirections > FiniteDiffOdfMaximaExtractionFilter< PixelType, ShOrder, NrOdfDirections> ::FiniteDiffOdfMaximaExtractionFilter() : m_Toolkit(FSL) , m_MaxNumPeaks(2) , m_PeakThreshold(0.4) , m_ClusteringThreshold(0.9) , m_AngularThreshold(0.7) , m_NumCoeffs((ShOrder*ShOrder + ShOrder + 2)/2 + ShOrder) , m_NormalizationMethod(MAX_VEC_NORM) , m_AbsolutePeakThreshold(0) { this->SetNumberOfRequiredInputs(1); } template< class PixelType, int ShOrder, int NrOdfDirections > void FiniteDiffOdfMaximaExtractionFilter< PixelType, ShOrder, NrOdfDirections> ::FindCandidatePeaks(OdfType& odf, double thr, std::vector< DirectionType >& container) { double gfa = odf.GetGeneralizedFractionalAnisotropy(); //Find the peaks using a finite difference method bool flag = true; vnl_vector_fixed< bool, NrOdfDirections > used; used.fill(false); //Find the peaks for (int i=0; ithr && val*gfa>m_AbsolutePeakThreshold) // limit to one hemisphere ??? { flag = true; std::vector< int > neighbours = odf.GetNeighbors(i); for (int j=0; j std::vector< vnl_vector_fixed< double, 3 > > FiniteDiffOdfMaximaExtractionFilter< PixelType, ShOrder, NrOdfDirections>::MeanShiftClustering(std::vector< vnl_vector_fixed< double, 3 > >& inDirs) { std::vector< DirectionType > outDirs; if (inDirs.empty()) return inDirs; DirectionType oldMean, currentMean, workingMean; std::vector< int > touched; // initialize touched.resize(inDirs.size(), 0); bool free = true; currentMean = inDirs[0]; // initialize first seed while (free) { oldMean.fill(0.0); // start mean-shift clustering float angle = 0.0; int counter = 0; while ((currentMean-oldMean).magnitude()>0.0001) { counter = 0; oldMean = currentMean; workingMean = oldMean; workingMean.normalize(); currentMean.fill(0.0); for (int i=0; i=m_ClusteringThreshold) { currentMean += inDirs[i]; touched[i] = 1; counter++; } else if (-angle>=m_ClusteringThreshold) { currentMean -= inDirs[i]; touched[i] = 1; counter++; } } } // found stable mean if (counter>0) { float mag = currentMean.magnitude(); if (mag>0) { currentMean /= mag; outDirs.push_back(currentMean); } } // find next unused seed free = false; for (int i=0; i void FiniteDiffOdfMaximaExtractionFilter< PixelType, ShOrder, NrOdfDirections> ::BeforeThreadedGenerateData() { typename CoefficientImageType::Pointer ShCoeffImage = static_cast< CoefficientImageType* >( this->ProcessObject::GetInput(0) ); itk::Vector spacing = ShCoeffImage->GetSpacing(); double minSpacing = spacing[0]; if (spacing[1]GetOrigin(); itk::Matrix direction = ShCoeffImage->GetDirection(); ImageRegion<3> imageRegion = ShCoeffImage->GetLargestPossibleRegion(); + if (m_MaskImage.IsNotNull()) + { + origin = m_MaskImage->GetOrigin(); + direction = m_MaskImage->GetDirection(); + imageRegion = m_MaskImage->GetLargestPossibleRegion(); + } + m_DirectionImageContainer = ItkDirectionImageContainer::New(); for (int i=0; i nullVec; nullVec.Fill(0.0); ItkDirectionImage::Pointer img = ItkDirectionImage::New(); img->SetSpacing( spacing ); img->SetOrigin( origin ); img->SetDirection( direction ); img->SetRegions( imageRegion ); img->Allocate(); img->FillBuffer(nullVec); m_DirectionImageContainer->InsertElement(m_DirectionImageContainer->Size(), img); } if (m_MaskImage.IsNull()) { m_MaskImage = ItkUcharImgType::New(); m_MaskImage->SetSpacing( spacing ); m_MaskImage->SetOrigin( origin ); m_MaskImage->SetDirection( direction ); m_MaskImage->SetRegions( imageRegion ); m_MaskImage->Allocate(); m_MaskImage->FillBuffer(1); } m_NumDirectionsImage = ItkUcharImgType::New(); m_NumDirectionsImage->SetSpacing( spacing ); m_NumDirectionsImage->SetOrigin( origin ); m_NumDirectionsImage->SetDirection( direction ); m_NumDirectionsImage->SetRegions( imageRegion ); m_NumDirectionsImage->Allocate(); m_NumDirectionsImage->FillBuffer(0); this->SetNumberOfOutputs(m_MaxNumPeaks); // calculate SH basis OdfType odf; vnl_matrix_fixed* directions = odf.GetDirections(); vnl_matrix< double > sphCoords; std::vector< DirectionType > dirs; for (int i=0; iget_column(i)); Cart2Sph(dirs, sphCoords); // convert candidate peaks to spherical angles m_ShBasis = CalcShBasis(sphCoords); // evaluate spherical harmonics at each peak MITK_INFO << "Starting finite differences maximum extraction"; MITK_INFO << "ODF sampling points: " << NrOdfDirections; MITK_INFO << "SH order: " << ShOrder; MITK_INFO << "Maximum peaks: " << m_MaxNumPeaks; MITK_INFO << "Relative threshold: " << m_PeakThreshold; MITK_INFO << "Absolute threshold: " << m_AbsolutePeakThreshold; MITK_INFO << "Clustering threshold: " << m_ClusteringThreshold; MITK_INFO << "Angular threshold: " << m_AngularThreshold; } template< class PixelType, int ShOrder, int NrOdfDirections > void FiniteDiffOdfMaximaExtractionFilter< PixelType, ShOrder, NrOdfDirections> ::AfterThreadedGenerateData() { MITK_INFO << "Generating vector field"; vtkSmartPointer m_VtkCellArray = vtkSmartPointer::New(); vtkSmartPointer m_VtkPoints = vtkSmartPointer::New(); typename CoefficientImageType::Pointer ShCoeffImage = static_cast< CoefficientImageType* >( this->ProcessObject::GetInput(0) ); ImageRegionConstIterator< CoefficientImageType > cit(ShCoeffImage, ShCoeffImage->GetLargestPossibleRegion() ); mitk::Vector3D spacing = ShCoeffImage->GetSpacing(); double minSpacing = spacing[0]; if (spacing[1]GetLargestPossibleRegion().GetSize()[0]*ShCoeffImage->GetLargestPossibleRegion().GetSize()[1]*ShCoeffImage->GetLargestPossibleRegion().GetSize()[2]; boost::progress_display disp(maxProgress); while( !cit.IsAtEnd() ) { ++disp; typename CoefficientImageType::IndexType index = cit.GetIndex(); if (m_MaskImage->GetPixel(index)==0) { ++cit; continue; } for (int i=0; iSize(); i++) { ItkDirectionImage::Pointer img = m_DirectionImageContainer->GetElement(i); itk::Vector< float, 3 > pixel = img->GetPixel(index); DirectionType dir; dir[0] = pixel[0]; dir[1] = pixel[1]; dir[2] = pixel[2]; vtkSmartPointer container = vtkSmartPointer::New(); itk::ContinuousIndex center; center[0] = index[0]; center[1] = index[1]; center[2] = index[2]; itk::Point worldCenter; - ShCoeffImage->TransformContinuousIndexToPhysicalPoint( center, worldCenter ); + m_MaskImage->TransformContinuousIndexToPhysicalPoint( center, worldCenter ); itk::Point worldStart; worldStart[0] = worldCenter[0]-dir[0]/2 * minSpacing; worldStart[1] = worldCenter[1]-dir[1]/2 * minSpacing; worldStart[2] = worldCenter[2]-dir[2]/2 * minSpacing; vtkIdType id = m_VtkPoints->InsertNextPoint(worldStart.GetDataPointer()); container->GetPointIds()->InsertNextId(id); itk::Point worldEnd; worldEnd[0] = worldCenter[0]+dir[0]/2 * minSpacing; worldEnd[1] = worldCenter[1]+dir[1]/2 * minSpacing; worldEnd[2] = worldCenter[2]+dir[2]/2 * minSpacing; id = m_VtkPoints->InsertNextPoint(worldEnd.GetDataPointer()); container->GetPointIds()->InsertNextId(id); m_VtkCellArray->InsertNextCell(container); } ++cit; } vtkSmartPointer directionsPolyData = vtkSmartPointer::New(); directionsPolyData->SetPoints(m_VtkPoints); directionsPolyData->SetLines(m_VtkCellArray); m_OutputFiberBundle = mitk::FiberBundleX::New(directionsPolyData); for (int i=0; iSize(); i++) { ItkDirectionImage::Pointer img = m_DirectionImageContainer->GetElement(i); this->SetNthOutput(i, img); } } template< class PixelType, int ShOrder, int NrOdfDirections > void FiniteDiffOdfMaximaExtractionFilter< PixelType, ShOrder, NrOdfDirections> ::ThreadedGenerateData( const OutputImageRegionType& outputRegionForThread, ThreadIdType threadID ) { typename CoefficientImageType::Pointer ShCoeffImage = static_cast< CoefficientImageType* >( this->ProcessObject::GetInput(0) ); ImageRegionConstIterator< CoefficientImageType > cit(ShCoeffImage, outputRegionForThread ); OdfType odf; while( !cit.IsAtEnd() ) { typename CoefficientImageType::IndexType index = cit.GetIndex(); if (m_MaskImage->GetPixel(index)==0) { ++cit; continue; } CoefficientPixelType c = cit.Get(); // calculate ODF double max = 0; odf.Fill(0.0); for (int i=0; imax) max = odf[i]; } if (max<0.0001) { ++cit; continue; } std::vector< DirectionType > candidates, peaks, temp; peaks.clear(); max *= m_PeakThreshold; // relative threshold FindCandidatePeaks(odf, max, candidates); // find all local maxima candidates = MeanShiftClustering(candidates); // cluster maxima vnl_matrix< double > shBasis, sphCoords; Cart2Sph(candidates, sphCoords); // convert candidate peaks to spherical angles shBasis = CalcShBasis(sphCoords); // evaluate spherical harmonics at each peak max = 0.0; for (int i=0; imax) max = val; peaks.push_back(candidates[i]*val); } std::sort( peaks.begin(), peaks.end(), CompareVectors ); // sort peaks // kick out directions to close to a larger direction (too far away to cluster but too close to keep) int m = peaks.size(); if ( m>m_DirectionImageContainer->Size() ) m = m_DirectionImageContainer->Size(); for (int i=0; im_AngularThreshold && valm_DirectionImageContainer->Size() ) num = m_DirectionImageContainer->Size(); for (int i=0; i dir = peaks.at(i); + ItkDirectionImage::Pointer img = m_DirectionImageContainer->GetElement(i); switch (m_NormalizationMethod) { case NO_NORM: break; case SINGLE_VEC_NORM: dir.normalize(); break; case MAX_VEC_NORM: dir /= max; break; } +// dir[0] = -dir[0]; +// dir[2] = -dir[2]; - dir = ShCoeffImage->GetDirection()*dir; + dir = m_MaskImage->GetDirection()*dir; itk::Vector< float, 3 > pixel; pixel.SetElement(0, dir[0]); pixel.SetElement(1, dir[1]); pixel.SetElement(2, dir[2]); img->SetPixel(index, pixel); } m_NumDirectionsImage->SetPixel(index, num); ++cit; } MITK_INFO << "Thread " << threadID << " finished extraction"; } // convert cartesian to spherical coordinates template< class PixelType, int ShOrder, int NrOdfDirections > void FiniteDiffOdfMaximaExtractionFilter< PixelType, ShOrder, NrOdfDirections> ::Cart2Sph(const std::vector< DirectionType >& dir, vnl_matrix& sphCoords) { sphCoords.set_size(dir.size(), 2); for (int i=0; i vnl_matrix FiniteDiffOdfMaximaExtractionFilter< PixelType, ShOrder, NrOdfDirections> ::CalcShBasis(vnl_matrix& sphCoords) { int M = sphCoords.rows(); int j, m; double mag, plm; vnl_matrix shBasis; shBasis.set_size(M, m_NumCoeffs); for (int p=0; p(l,abs(m),cos(sphCoords(p,0))); mag = sqrt((double)(2*l+1)/(4.0*M_PI)*factorial(l-abs(m))/factorial(l+abs(m)))*plm; if (m<0) shBasis(p,j) = sqrt(2.0)*mag*cos(fabs((double)m)*sphCoords(p,1)); else if (m==0) shBasis(p,j) = mag; else shBasis(p,j) = pow(-1.0, m)*sqrt(2.0)*mag*sin(m*sphCoords(p,1)); break; case MRTRIX: plm = legendre_p(l,abs(m),-cos(sphCoords(p,0))); mag = sqrt((double)(2*l+1)/(4.0*M_PI)*factorial(l-abs(m))/factorial(l+abs(m)))*plm; if (m>0) shBasis(p,j) = mag*cos(m*sphCoords(p,1)); else if (m==0) shBasis(p,j) = mag; else shBasis(p,j) = mag*sin(-m*sphCoords(p,1)); break; } j++; } } return shBasis; } } #endif // __itkFiniteDiffOdfMaximaExtractionFilter_cpp diff --git a/Modules/DiffusionImaging/FiberTracking/Algorithms/itkAddArtifactsToDwiImageFilter.cpp b/Modules/DiffusionImaging/FiberTracking/Algorithms/itkAddArtifactsToDwiImageFilter.cpp index 6dc403def6..e9854ebee6 100644 --- a/Modules/DiffusionImaging/FiberTracking/Algorithms/itkAddArtifactsToDwiImageFilter.cpp +++ b/Modules/DiffusionImaging/FiberTracking/Algorithms/itkAddArtifactsToDwiImageFilter.cpp @@ -1,209 +1,208 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ #ifndef __itkAddArtifactsToDwiImageFilter_txx #define __itkAddArtifactsToDwiImageFilter_txx #include #include #include #include "itkAddArtifactsToDwiImageFilter.h" #include #include #include #include +#include #define _USE_MATH_DEFINES #include namespace itk { template< class TPixelType > AddArtifactsToDwiImageFilter< TPixelType > ::AddArtifactsToDwiImageFilter() : m_NoiseModel(NULL) + , m_RingingModel(NULL) + , m_FrequencyMap(NULL) , m_kOffset(0) , m_tLine(1) { this->SetNumberOfRequiredInputs( 1 ); } template< class TPixelType > typename AddArtifactsToDwiImageFilter< TPixelType >::ComplexSliceType::Pointer AddArtifactsToDwiImageFilter< TPixelType >::RearrangeSlice(typename ComplexSliceType::Pointer slice) { ImageRegion<2> region = slice->GetLargestPossibleRegion(); typename ComplexSliceType::Pointer rearrangedSlice = ComplexSliceType::New(); rearrangedSlice->SetLargestPossibleRegion( region ); rearrangedSlice->SetBufferedRegion( region ); rearrangedSlice->SetRequestedRegion( region ); rearrangedSlice->Allocate(); int xHalf = region.GetSize(0)/2; int yHalf = region.GetSize(1)/2; for (int y=0; y pix = slice->GetPixel(idx); if( idx[0] < xHalf ) idx[0] = idx[0] + xHalf; else idx[0] = idx[0] - xHalf; if( idx[1] < yHalf ) idx[1] = idx[1] + yHalf; else idx[1] = idx[1] - yHalf; rearrangedSlice->SetPixel(idx, pix); } return rearrangedSlice; } template< class TPixelType > void AddArtifactsToDwiImageFilter< TPixelType > ::GenerateData() { typename DiffusionImageType::Pointer inputImage = static_cast< DiffusionImageType * >( this->ProcessObject::GetInput(0) ); itk::ImageRegion<3> inputRegion = inputImage->GetLargestPossibleRegion(); - typename DiffusionImageType::Pointer outputImage = DiffusionImageType::New(); - outputImage->SetSpacing( inputImage->GetSpacing() ); - outputImage->SetOrigin( inputImage->GetOrigin() ); - outputImage->SetDirection( inputImage->GetDirection() ); - outputImage->SetLargestPossibleRegion( inputRegion ); - outputImage->SetBufferedRegion( inputRegion ); - outputImage->SetRequestedRegion( inputRegion ); - outputImage->SetVectorLength( inputImage->GetVectorLength() ); - outputImage->Allocate(); + typename itk::ImageDuplicator::Pointer duplicator = itk::ImageDuplicator::New(); + duplicator->SetInputImage( inputImage ); + duplicator->Update(); + typename DiffusionImageType::Pointer outputImage = duplicator->GetOutput(); unsigned int upsampling = 1; if (m_RingingModel!=NULL) - { upsampling = m_RingingModel->GetKspaceCropping(); - } // create slice object typename SliceType::Pointer slice = SliceType::New(); ImageRegion<2> region; region.SetSize(0, inputRegion.GetSize(0)); region.SetSize(1, inputRegion.GetSize(1)); slice->SetLargestPossibleRegion( region ); slice->SetBufferedRegion( region ); slice->SetRequestedRegion( region ); slice->Allocate(); // frequency map slice typename SliceType::Pointer fMap = NULL; if (m_FrequencyMap.IsNotNull()) { fMap = SliceType::New(); ImageRegion<2> region; region.SetSize(0, inputRegion.GetSize(0)); region.SetSize(1, inputRegion.GetSize(1)); fMap->SetLargestPossibleRegion( region ); fMap->SetBufferedRegion( region ); fMap->SetRequestedRegion( region ); fMap->Allocate(); } - boost::progress_display disp(inputImage->GetVectorLength()*inputRegion.GetSize(2)); - for (int g=0; gGetVectorLength(); g++) - for (int z=0; z0.0 || m_RingingModel!=NULL) + { + boost::progress_display disp(inputImage->GetVectorLength()*inputRegion.GetSize(2)); + for (int g=0; gGetVectorLength(); g++) + for (int z=0; zGetPixel(index3D)[g]; + slice->SetPixel(index2D, pix2D); + + if (fMap.IsNotNull()) + fMap->SetPixel(index2D, m_FrequencyMap->GetPixel(index3D)); + } + + // fourier transform slice + typename ComplexSliceType::Pointer fSlice; + typename itk::KspaceImageFilter< SliceType::PixelType >::Pointer idft = itk::KspaceImageFilter< SliceType::PixelType >::New(); + idft->SetInput(slice); + idft->SetkOffset(m_kOffset); + idft->SettLine(m_tLine); + idft->SetFrequencyMap(fMap); + idft->Update(); + + fSlice = idft->GetOutput(); + + if (m_RingingModel!=NULL) { - typename SliceType::IndexType index2D; - index2D[0]=x; index2D[1]=y; - typename DiffusionImageType::IndexType index3D; - index3D[0]=x; index3D[1]=y; index3D[2]=z; - - TPixelType pix2D = inputImage->GetPixel(index3D)[g]; - slice->SetPixel(index2D, pix2D); - - if (fMap.IsNotNull()) - fMap->SetPixel(index2D, m_FrequencyMap->GetPixel(index3D)); + fSlice = RearrangeSlice(fSlice); + fSlice = m_RingingModel->AddArtifact(fSlice); } - // fourier transform slice - typename ComplexSliceType::Pointer fSlice; - typename itk::KspaceImageFilter< SliceType::PixelType >::Pointer idft = itk::KspaceImageFilter< SliceType::PixelType >::New(); - idft->SetInput(slice); - idft->SetkOffset(m_kOffset); - idft->SettLine(m_tLine); - idft->SetFrequencyMap(fMap); - idft->Update(); - - fSlice = idft->GetOutput(); - - if (m_RingingModel!=NULL) - { - fSlice = RearrangeSlice(fSlice); - fSlice = m_RingingModel->AddArtifact(fSlice); + // inverse fourier transform slice + typename SliceType::Pointer newSlice; + typename itk::DftImageFilter< SliceType::PixelType >::Pointer dft = itk::DftImageFilter< SliceType::PixelType >::New(); + dft->SetInput(fSlice); + dft->Update(); + newSlice = dft->GetOutput(); + + // put slice back into channel g + for (int y=0; yGetLargestPossibleRegion().GetSize(1); y++) + for (int x=0; xGetLargestPossibleRegion().GetSize(0); x++) + { + typename DiffusionImageType::IndexType index3D; + index3D[0]=x; index3D[1]=y; index3D[2]=z; + typename DiffusionImageType::PixelType pix3D = outputImage->GetPixel(index3D); + typename SliceType::IndexType index2D; + index2D[0]=x; index2D[1]=y; + + pix3D[g] = newSlice->GetPixel(index2D); + outputImage->SetPixel(index3D, pix3D); + } } - - // inverse fourier transform slice - typename SliceType::Pointer newSlice; - typename itk::DftImageFilter< SliceType::PixelType >::Pointer dft = itk::DftImageFilter< SliceType::PixelType >::New(); - dft->SetInput(fSlice); - dft->Update(); - newSlice = dft->GetOutput(); - - // put slice back into channel g - for (int y=0; yGetLargestPossibleRegion().GetSize(1); y++) - for (int x=0; xGetLargestPossibleRegion().GetSize(0); x++) - { - typename DiffusionImageType::IndexType index3D; - index3D[0]=x; index3D[1]=y; index3D[2]=z; - typename DiffusionImageType::PixelType pix3D = outputImage->GetPixel(index3D); - typename SliceType::IndexType index2D; - index2D[0]=x; index2D[1]=y; - - pix3D[g] = newSlice->GetPixel(index2D); - outputImage->SetPixel(index3D, pix3D); - } - } + } if (m_NoiseModel!=NULL) { ImageRegionIterator it1 (outputImage, outputImage->GetLargestPossibleRegion()); boost::progress_display disp2(outputImage->GetLargestPossibleRegion().GetNumberOfPixels()); while(!it1.IsAtEnd()) { ++disp2; typename DiffusionImageType::PixelType signal = it1.Get(); m_NoiseModel->AddNoise(signal); it1.Set(signal); ++it1; } } this->SetNthOutput(0, outputImage); } } #endif diff --git a/Modules/DiffusionImaging/FiberTracking/Algorithms/itkTractsToDWIImageFilter.cpp b/Modules/DiffusionImaging/FiberTracking/Algorithms/itkTractsToDWIImageFilter.cpp index b3d259f855..00e2761710 100644 --- a/Modules/DiffusionImaging/FiberTracking/Algorithms/itkTractsToDWIImageFilter.cpp +++ b/Modules/DiffusionImaging/FiberTracking/Algorithms/itkTractsToDWIImageFilter.cpp @@ -1,675 +1,697 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ #include "itkTractsToDWIImageFilter.h" #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include namespace itk { TractsToDWIImageFilter::TractsToDWIImageFilter() : m_CircleDummy(false) , m_VolumeAccuracy(10) , m_Upsampling(1) , m_NumberOfRepetitions(1) , m_EnforcePureFiberVoxels(false) , m_InterpolationShrink(10) , m_FiberRadius(20) , m_SignalScale(300) , m_kOffset(0) , m_tLine(1) , m_UseInterpolation(false) { m_Spacing.Fill(2.5); m_Origin.Fill(0.0); m_DirectionMatrix.SetIdentity(); m_ImageRegion.SetSize(0, 10); m_ImageRegion.SetSize(1, 10); m_ImageRegion.SetSize(2, 10); } TractsToDWIImageFilter::~TractsToDWIImageFilter() { } std::vector< TractsToDWIImageFilter::DoubleDwiType::Pointer > TractsToDWIImageFilter::DoKspaceStuff( std::vector< DoubleDwiType::Pointer >& images ) { // create slice object SliceType::Pointer slice = SliceType::New(); ImageRegion<2> region; region.SetSize(0, m_UpsampledImageRegion.GetSize()[0]); region.SetSize(1, m_UpsampledImageRegion.GetSize()[1]); slice->SetLargestPossibleRegion( region ); slice->SetBufferedRegion( region ); slice->SetRequestedRegion( region ); slice->Allocate(); // frequency map slice SliceType::Pointer fMap = NULL; if (m_FrequencyMap.IsNotNull()) { fMap = SliceType::New(); ImageRegion<2> region; region.SetSize(0, m_UpsampledImageRegion.GetSize()[0]); region.SetSize(1, m_UpsampledImageRegion.GetSize()[1]); fMap->SetLargestPossibleRegion( region ); fMap->SetBufferedRegion( region ); fMap->SetRequestedRegion( region ); fMap->Allocate(); } boost::progress_display disp(images.size()*images[0]->GetVectorLength()*images[0]->GetLargestPossibleRegion().GetSize(2)); std::vector< DoubleDwiType::Pointer > outImages; for (int i=0; iSetSpacing( m_Spacing ); newImage->SetOrigin( m_Origin ); newImage->SetDirection( m_DirectionMatrix ); newImage->SetLargestPossibleRegion( m_ImageRegion ); newImage->SetBufferedRegion( m_ImageRegion ); newImage->SetRequestedRegion( m_ImageRegion ); newImage->SetVectorLength( image->GetVectorLength() ); newImage->Allocate(); DiffusionSignalModel* signalModel; if (iGetVectorLength(); g++) for (int z=0; zGetLargestPossibleRegion().GetSize(2); z++) { ++disp; // extract slice from channel g for (int y=0; yGetLargestPossibleRegion().GetSize(1); y++) for (int x=0; xGetLargestPossibleRegion().GetSize(0); x++) { SliceType::IndexType index2D; index2D[0]=x; index2D[1]=y; DoubleDwiType::IndexType index3D; index3D[0]=x; index3D[1]=y; index3D[2]=z; SliceType::PixelType pix2D = image->GetPixel(index3D)[g]; slice->SetPixel(index2D, pix2D); if (fMap.IsNotNull()) fMap->SetPixel(index2D, m_FrequencyMap->GetPixel(index3D)); } // inverse fourier transform slice ComplexSliceType::Pointer fSlice; itk::KspaceImageFilter< SliceType::PixelType >::Pointer idft = itk::KspaceImageFilter< SliceType::PixelType >::New(); idft->SetInput(slice); idft->SetkOffset(m_kOffset); idft->SettLine(m_tLine); idft->SetFrequencyMap(fMap); idft->Update(); fSlice = idft->GetOutput(); fSlice = RearrangeSlice(fSlice); // add artifacts for (int a=0; aSetT2(signalModel->GetT2()); fSlice = m_KspaceArtifacts.at(a)->AddArtifact(fSlice); } // save k-space slice of s0 image if (g==m_FiberModels.at(0)->GetFirstBaselineIndex()) for (int y=0; yGetLargestPossibleRegion().GetSize(1); y++) for (int x=0; xGetLargestPossibleRegion().GetSize(0); x++) { DoubleDwiType::IndexType index3D; index3D[0]=x; index3D[1]=y; index3D[2]=z; SliceType::IndexType index2D; index2D[0]=x; index2D[1]=y; double kpix = sqrt(fSlice->GetPixel(index2D).real()*fSlice->GetPixel(index2D).real()+fSlice->GetPixel(index2D).imag()*fSlice->GetPixel(index2D).imag()); m_KspaceImage->SetPixel(index3D, m_KspaceImage->GetPixel(index3D)+kpix); } // fourier transform slice SliceType::Pointer newSlice; itk::DftImageFilter< SliceType::PixelType >::Pointer dft = itk::DftImageFilter< SliceType::PixelType >::New(); dft->SetInput(fSlice); dft->Update(); newSlice = dft->GetOutput(); // put slice back into channel g for (int y=0; yGetLargestPossibleRegion().GetSize(1); y++) for (int x=0; xGetLargestPossibleRegion().GetSize(0); x++) { DoubleDwiType::IndexType index3D; index3D[0]=x; index3D[1]=y; index3D[2]=z; DoubleDwiType::PixelType pix3D = newImage->GetPixel(index3D); SliceType::IndexType index2D; index2D[0]=x; index2D[1]=y; pix3D[g] = newSlice->GetPixel(index2D); newImage->SetPixel(index3D, pix3D); } } outImages.push_back(newImage); } return outImages; } TractsToDWIImageFilter::ComplexSliceType::Pointer TractsToDWIImageFilter::RearrangeSlice(ComplexSliceType::Pointer slice) { ImageRegion<2> region = slice->GetLargestPossibleRegion(); ComplexSliceType::Pointer rearrangedSlice = ComplexSliceType::New(); rearrangedSlice->SetLargestPossibleRegion( region ); rearrangedSlice->SetBufferedRegion( region ); rearrangedSlice->SetRequestedRegion( region ); rearrangedSlice->Allocate(); int xHalf = region.GetSize(0)/2; int yHalf = region.GetSize(1)/2; for (int y=0; y pix = slice->GetPixel(idx); if( idx[0] < xHalf ) idx[0] = idx[0] + xHalf; else idx[0] = idx[0] - xHalf; if( idx[1] < yHalf ) idx[1] = idx[1] + yHalf; else idx[1] = idx[1] - yHalf; rearrangedSlice->SetPixel(idx, pix); } return rearrangedSlice; } void TractsToDWIImageFilter::GenerateData() { // check input data if (m_FiberBundle.IsNull()) itkExceptionMacro("Input fiber bundle is NULL!"); int numFibers = m_FiberBundle->GetNumFibers(); if (numFibers<=0) itkExceptionMacro("Input fiber bundle contains no fibers!"); if (m_FiberModels.empty()) itkExceptionMacro("No diffusion model for fiber compartments defined!"); if (m_NonFiberModels.empty()) itkExceptionMacro("No diffusion model for non-fiber compartments defined!"); int baselineIndex = m_FiberModels[0]->GetFirstBaselineIndex(); if (baselineIndex<0) itkExceptionMacro("No baseline index found!"); // determine k-space undersampling for (int i=0; i*>(m_KspaceArtifacts.at(i)) ) m_Upsampling = dynamic_cast*>(m_KspaceArtifacts.at(i))->GetKspaceCropping(); if (m_Upsampling<1) m_Upsampling = 1; if (m_TissueMask.IsNotNull()) { // use input tissue mask m_Spacing = m_TissueMask->GetSpacing(); m_Origin = m_TissueMask->GetOrigin(); m_DirectionMatrix = m_TissueMask->GetDirection(); m_ImageRegion = m_TissueMask->GetLargestPossibleRegion(); if (m_Upsampling>1) { ImageRegion<3> region = m_ImageRegion; region.SetSize(0, m_ImageRegion.GetSize(0)*m_Upsampling); region.SetSize(1, m_ImageRegion.GetSize(1)*m_Upsampling); itk::Vector spacing = m_Spacing; spacing[0] /= m_Upsampling; spacing[1] /= m_Upsampling; itk::RescaleIntensityImageFilter::Pointer rescaler = itk::RescaleIntensityImageFilter::New(); rescaler->SetInput(0,m_TissueMask); rescaler->SetOutputMaximum(100); rescaler->SetOutputMinimum(0); rescaler->Update(); itk::ResampleImageFilter::Pointer resampler = itk::ResampleImageFilter::New(); resampler->SetInput(rescaler->GetOutput()); resampler->SetOutputParametersFromImage(m_TissueMask); resampler->SetSize(region.GetSize()); resampler->SetOutputSpacing(spacing); resampler->Update(); m_TissueMask = resampler->GetOutput(); } MITK_INFO << "Using tissue mask"; } // initialize output dwi image OutputImageType::Pointer outImage = OutputImageType::New(); outImage->SetSpacing( m_Spacing ); outImage->SetOrigin( m_Origin ); outImage->SetDirection( m_DirectionMatrix ); outImage->SetLargestPossibleRegion( m_ImageRegion ); outImage->SetBufferedRegion( m_ImageRegion ); outImage->SetRequestedRegion( m_ImageRegion ); outImage->SetVectorLength( m_FiberModels[0]->GetNumGradients() ); outImage->Allocate(); OutputImageType::PixelType temp; temp.SetSize(m_FiberModels[0]->GetNumGradients()); temp.Fill(0.0); outImage->FillBuffer(temp); // is input slize size a power of two? int x=m_ImageRegion.GetSize(0); int y=m_ImageRegion.GetSize(1); if ( x%2 == 1 ) x += 1; if ( y%2 == 1 ) y += 1; // if not, adjust size and dimension (needed for FFT); zero-padding if (x!=m_ImageRegion.GetSize(0)) { MITK_INFO << "Adjusting image width: " << m_ImageRegion.GetSize(0) << " --> " << x << " --> " << x*m_Upsampling; m_ImageRegion.SetSize(0, x); } if (y!=m_ImageRegion.GetSize(1)) { MITK_INFO << "Adjusting image height: " << m_ImageRegion.GetSize(1) << " --> " << y << " --> " << y*m_Upsampling; m_ImageRegion.SetSize(1, y); } // initialize k-space image m_KspaceImage = ItkDoubleImgType::New(); m_KspaceImage->SetSpacing( m_Spacing ); m_KspaceImage->SetOrigin( m_Origin ); m_KspaceImage->SetDirection( m_DirectionMatrix ); m_KspaceImage->SetLargestPossibleRegion( m_ImageRegion ); m_KspaceImage->SetBufferedRegion( m_ImageRegion ); m_KspaceImage->SetRequestedRegion( m_ImageRegion ); m_KspaceImage->Allocate(); m_KspaceImage->FillBuffer(0); // apply undersampling to image parameters m_UpsampledSpacing = m_Spacing; m_UpsampledImageRegion = m_ImageRegion; m_UpsampledSpacing[0] /= m_Upsampling; m_UpsampledSpacing[1] /= m_Upsampling; m_UpsampledImageRegion.SetSize(0, m_ImageRegion.GetSize()[0]*m_Upsampling); m_UpsampledImageRegion.SetSize(1, m_ImageRegion.GetSize()[1]*m_Upsampling); // everything from here on is using the upsampled image parameters!!! if (m_TissueMask.IsNull()) { m_TissueMask = ItkUcharImgType::New(); m_TissueMask->SetSpacing( m_UpsampledSpacing ); m_TissueMask->SetOrigin( m_Origin ); m_TissueMask->SetDirection( m_DirectionMatrix ); m_TissueMask->SetLargestPossibleRegion( m_UpsampledImageRegion ); m_TissueMask->SetBufferedRegion( m_UpsampledImageRegion ); m_TissueMask->SetRequestedRegion( m_UpsampledImageRegion ); m_TissueMask->Allocate(); m_TissueMask->FillBuffer(1); } // resample frequency map if (m_FrequencyMap.IsNotNull()) { itk::ResampleImageFilter::Pointer resampler = itk::ResampleImageFilter::New(); resampler->SetInput(m_FrequencyMap); resampler->SetOutputParametersFromImage(m_FrequencyMap); resampler->SetSize(m_UpsampledImageRegion.GetSize()); resampler->SetOutputSpacing(m_UpsampledSpacing); resampler->Update(); m_FrequencyMap = resampler->GetOutput(); } + // initialize volume fraction images + m_VolumeFractions.clear(); + for (int i=0; iSetSpacing( m_UpsampledSpacing ); + tempimg->SetOrigin( m_Origin ); + tempimg->SetDirection( m_DirectionMatrix ); + tempimg->SetLargestPossibleRegion( m_UpsampledImageRegion ); + tempimg->SetBufferedRegion( m_UpsampledImageRegion ); + tempimg->SetRequestedRegion( m_UpsampledImageRegion ); + tempimg->Allocate(); + tempimg->FillBuffer(0); + m_VolumeFractions.push_back(tempimg); + } + // resample fiber bundle for sufficient voxel coverage double segmentVolume = 0.0001; float minSpacing = 1; if(m_UpsampledSpacing[0]GetDeepCopy(); fiberBundle->ResampleFibers(minSpacing/m_VolumeAccuracy); double mmRadius = m_FiberRadius/1000; if (mmRadius>0) segmentVolume = M_PI*mmRadius*mmRadius*minSpacing/m_VolumeAccuracy; - // generate double images to wokr with because we don't want to lose precision + // generate double images to work with because we don't want to lose precision // we use a separate image for each compartment model std::vector< DoubleDwiType::Pointer > compartments; for (int i=0; iSetSpacing( m_UpsampledSpacing ); doubleDwi->SetOrigin( m_Origin ); doubleDwi->SetDirection( m_DirectionMatrix ); doubleDwi->SetLargestPossibleRegion( m_UpsampledImageRegion ); doubleDwi->SetBufferedRegion( m_UpsampledImageRegion ); doubleDwi->SetRequestedRegion( m_UpsampledImageRegion ); doubleDwi->SetVectorLength( m_FiberModels[0]->GetNumGradients() ); doubleDwi->Allocate(); DoubleDwiType::PixelType pix; pix.SetSize(m_FiberModels[0]->GetNumGradients()); pix.Fill(0.0); doubleDwi->FillBuffer(pix); compartments.push_back(doubleDwi); } double interpFact = 2*atan(-0.5*m_InterpolationShrink); double maxVolume = 0; vtkSmartPointer fiberPolyData = fiberBundle->GetFiberPolyData(); vtkSmartPointer vLines = fiberPolyData->GetLines(); vLines->InitTraversal(); MITK_INFO << "Generating signal of " << m_FiberModels.size() << " fiber compartments"; boost::progress_display disp(numFibers); for( int i=0; iGetNextCell ( numPoints, points ); if (numPoints<2) continue; for( int j=0; jGetPoint(points[j]); itk::Point vertex = GetItkPoint(temp); itk::Vector v = GetItkVector(temp); itk::Vector dir(3); if (jGetPoint(points[j+1]))-v; else dir = v-GetItkVector(fiberPolyData->GetPoint(points[j-1])); itk::Index<3> idx; itk::ContinuousIndex contIndex; m_TissueMask->TransformPhysicalPointToIndex(vertex, idx); m_TissueMask->TransformPhysicalPointToContinuousIndex(vertex, contIndex); if (!m_UseInterpolation) // use nearest neighbour interpolation { if (!m_TissueMask->GetLargestPossibleRegion().IsInside(idx) || m_TissueMask->GetPixel(idx)<=0) continue; // generate signal for each fiber compartment for (int k=0; kSetFiberDirection(dir); DoubleDwiType::PixelType pix = doubleDwi->GetPixel(idx); pix += segmentVolume*m_FiberModels[k]->SimulateMeasurement(); doubleDwi->SetPixel(idx, pix ); if (pix[baselineIndex]>maxVolume) maxVolume = pix[baselineIndex]; } continue; } double frac_x = contIndex[0] - idx[0]; double frac_y = contIndex[1] - idx[1]; double frac_z = contIndex[2] - idx[2]; if (frac_x<0) { idx[0] -= 1; frac_x += 1; } if (frac_y<0) { idx[1] -= 1; frac_y += 1; } if (frac_z<0) { idx[2] -= 1; frac_z += 1; } frac_x = atan((0.5-frac_x)*m_InterpolationShrink)/interpFact + 0.5; frac_y = atan((0.5-frac_y)*m_InterpolationShrink)/interpFact + 0.5; frac_z = atan((0.5-frac_z)*m_InterpolationShrink)/interpFact + 0.5; // use trilinear interpolation itk::Index<3> newIdx; for (int x=0; x<2; x++) { frac_x = 1-frac_x; for (int y=0; y<2; y++) { frac_y = 1-frac_y; for (int z=0; z<2; z++) { frac_z = 1-frac_z; newIdx[0] = idx[0]+x; newIdx[1] = idx[1]+y; newIdx[2] = idx[2]+z; double frac = frac_x*frac_y*frac_z; // is position valid? if (!m_TissueMask->GetLargestPossibleRegion().IsInside(newIdx) || m_TissueMask->GetPixel(newIdx)<=0) continue; // generate signal for each fiber compartment for (int k=0; kSetFiberDirection(dir); DoubleDwiType::PixelType pix = doubleDwi->GetPixel(newIdx); pix += segmentVolume*frac*m_FiberModels[k]->SimulateMeasurement(); doubleDwi->SetPixel(newIdx, pix ); if (pix[baselineIndex]>maxVolume) maxVolume = pix[baselineIndex]; } } } } } } MITK_INFO << "Generating signal of " << m_NonFiberModels.size() << " non-fiber compartments"; ImageRegionIterator it3(m_TissueMask, m_TissueMask->GetLargestPossibleRegion()); boost::progress_display disp3(m_TissueMask->GetLargestPossibleRegion().GetNumberOfPixels()); double voxelVolume = m_UpsampledSpacing[0]*m_UpsampledSpacing[1]*m_UpsampledSpacing[2]; double fact = 1; if (m_FiberRadius<0.0001) fact = voxelVolume/maxVolume; while(!it3.IsAtEnd()) { ++disp3; DoubleDwiType::IndexType index = it3.GetIndex(); if (it3.Get()>0) { // get fiber volume fraction DoubleDwiType::Pointer fiberDwi = compartments.at(0); DoubleDwiType::PixelType fiberPix = fiberDwi->GetPixel(index); // intra axonal compartment if (fact>1) // auto scale intra-axonal if no fiber radius is specified { fiberPix *= fact; fiberDwi->SetPixel(index, fiberPix); } double f = fiberPix[baselineIndex]; if (f>voxelVolume || f>0 && m_EnforcePureFiberVoxels) // more fiber than space in voxel? { fiberDwi->SetPixel(index, fiberPix*voxelVolume/f); for (int i=1; iSetPixel(index, pix); + m_VolumeFractions.at(i)->SetPixel(index, 1); } } else { + m_VolumeFractions.at(0)->SetPixel(index, f); + double nonf = voxelVolume-f; // non-fiber volume double inter = 0; if (m_FiberModels.size()>1) inter = nonf * f/voxelVolume; // intra-axonal fraction of non fiber compartment scales linearly with f double other = nonf - inter; // rest of compartment + double singleinter = inter/(m_FiberModels.size()-1); // adjust non-fiber and intra-axonal signal for (int i=1; iGetPixel(index); if (pix[baselineIndex]>0) pix /= pix[baselineIndex]; - pix *= inter; + pix *= singleinter; doubleDwi->SetPixel(index, pix); + m_VolumeFractions.at(i)->SetPixel(index, singleinter/voxelVolume); } for (int i=0; iGetPixel(index) + m_NonFiberModels[i]->SimulateMeasurement()*other*m_NonFiberModels[i]->GetWeight(); doubleDwi->SetPixel(index, pix); + m_VolumeFractions.at(i+m_FiberModels.size())->SetPixel(index, other/voxelVolume*m_NonFiberModels[i]->GetWeight()); } } } ++it3; } // do k-space stuff - if (!m_KspaceArtifacts.empty()) + if (!m_KspaceArtifacts.empty() || m_kOffset>0) { MITK_INFO << "Adjusting complex signal"; compartments = DoKspaceStuff(compartments); } MITK_INFO << "Summing compartments and adding noise"; unsigned int window = 0; unsigned int min = itk::NumericTraits::max(); ImageRegionIterator it4 (outImage, outImage->GetLargestPossibleRegion()); DoubleDwiType::PixelType signal; signal.SetSize(m_FiberModels[0]->GetNumGradients()); boost::progress_display disp4(outImage->GetLargestPossibleRegion().GetNumberOfPixels()); while(!it4.IsAtEnd()) { ++disp4; DWIImageType::IndexType index = it4.GetIndex(); signal.Fill(0.0); // adjust fiber signal for (int i=0; iGetPixel(index)*m_SignalScale; // adjust non-fiber signal for (int i=0; iGetPixel(index)*m_SignalScale; DoubleDwiType::PixelType accu = signal; accu.Fill(0.0); for (int i=0; iAddNoise(temp); accu += temp; } signal = accu/m_NumberOfRepetitions; for (int i=0; i0) signal[i] = floor(signal[i]+0.5); else signal[i] = ceil(signal[i]-0.5); if (!m_FiberModels.at(0)->IsBaselineIndex(i) && signal[i]>window) window = signal[i]; if (!m_FiberModels.at(0)->IsBaselineIndex(i) && signal[i]SetNthOutput(0, outImage); } itk::Point TractsToDWIImageFilter::GetItkPoint(double point[3]) { itk::Point itkPoint; itkPoint[0] = point[0]; itkPoint[1] = point[1]; itkPoint[2] = point[2]; return itkPoint; } itk::Vector TractsToDWIImageFilter::GetItkVector(double point[3]) { itk::Vector itkVector; itkVector[0] = point[0]; itkVector[1] = point[1]; itkVector[2] = point[2]; return itkVector; } vnl_vector_fixed TractsToDWIImageFilter::GetVnlVector(double point[3]) { vnl_vector_fixed vnlVector; vnlVector[0] = point[0]; vnlVector[1] = point[1]; vnlVector[2] = point[2]; return vnlVector; } vnl_vector_fixed TractsToDWIImageFilter::GetVnlVector(Vector& vector) { vnl_vector_fixed vnlVector; vnlVector[0] = vector[0]; vnlVector[1] = vector[1]; vnlVector[2] = vector[2]; return vnlVector; } } diff --git a/Modules/DiffusionImaging/FiberTracking/Algorithms/itkTractsToDWIImageFilter.h b/Modules/DiffusionImaging/FiberTracking/Algorithms/itkTractsToDWIImageFilter.h index c47e42cc62..2de8201b53 100644 --- a/Modules/DiffusionImaging/FiberTracking/Algorithms/itkTractsToDWIImageFilter.h +++ b/Modules/DiffusionImaging/FiberTracking/Algorithms/itkTractsToDWIImageFilter.h @@ -1,140 +1,144 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ #ifndef __itkTractsToDWIImageFilter_h__ #define __itkTractsToDWIImageFilter_h__ // MITK #include #include #include #include #include #include // ITK #include #include #include #include #include #include typedef itk::VectorImage< short, 3 > DWIImageType; namespace itk { /** * \brief Generates artificial diffusion weighted image volume from the input fiberbundle using a generic multicompartment model. */ class TractsToDWIImageFilter : public ImageSource< DWIImageType > { public: typedef TractsToDWIImageFilter Self; typedef ImageSource< DWIImageType > Superclass; typedef SmartPointer< Self > Pointer; typedef SmartPointer< const Self > ConstPointer; typedef itk::Image ItkDoubleImgType; typedef itk::Image ItkFloatImgType; typedef itk::Image ItkUcharImgType; typedef mitk::FiberBundleX::Pointer FiberBundleType; typedef itk::VectorImage< double, 3 > DoubleDwiType; typedef std::vector< mitk::KspaceArtifact* > KspaceArtifactList; typedef std::vector< mitk::DiffusionSignalModel* > DiffusionModelList; typedef itk::Matrix MatrixType; typedef mitk::DiffusionNoiseModel NoiseModelType; typedef itk::Image< double, 2 > SliceType; typedef itk::VnlForwardFFTImageFilter::OutputImageType ComplexSliceType; itkNewMacro(Self) itkTypeMacro( TractsToDWIImageFilter, ImageToImageFilter ) // input itkSetMacro( SignalScale, double ) itkSetMacro( FiberRadius, double ) itkSetMacro( InterpolationShrink, double ) ///< large values shrink (towards nearest neighbour interpolation), small values strech interpolation function (towards linear interpolation) itkSetMacro( VolumeAccuracy, unsigned int ) ///< determines fiber sampling density and thereby the accuracy of the fiber volume fraction itkSetMacro( FiberBundle, FiberBundleType ) ///< input fiber bundle itkSetMacro( Spacing, mitk::Vector3D ) ///< output image spacing itkSetMacro( Origin, mitk::Point3D ) ///< output image origin itkSetMacro( DirectionMatrix, MatrixType ) ///< output image rotation itkSetMacro( EnforcePureFiberVoxels, bool ) ///< treat all voxels containing at least one fiber as fiber-only (actually disable non-fiber compartments for this voxel). itkSetMacro( ImageRegion, ImageRegion<3> ) ///< output image size itkSetMacro( NumberOfRepetitions, unsigned int ) ///< number of acquisition repetitions to reduce noise (default is no additional repetition) itkSetMacro( TissueMask, ItkUcharImgType::Pointer ) ///< voxels outside of this binary mask contain only noise (are treated as air) - itkGetMacro( KspaceImage, ItkDoubleImgType::Pointer ) void SetNoiseModel(NoiseModelType* noiseModel){ m_NoiseModel = noiseModel; } ///< generates the noise added to the image values void SetFiberModels(DiffusionModelList modelList){ m_FiberModels = modelList; } ///< generate signal of fiber compartments void SetNonFiberModels(DiffusionModelList modelList){ m_NonFiberModels = modelList; } ///< generate signal of non-fiber compartments void SetKspaceArtifacts(KspaceArtifactList artifactList){ m_KspaceArtifacts = artifactList; } mitk::LevelWindow GetLevelWindow(){ return m_LevelWindow; } itkSetMacro( FrequencyMap, ItkDoubleImgType::Pointer ) itkSetMacro( kOffset, double ) itkSetMacro( tLine, double ) itkSetMacro( UseInterpolation, bool ) + // output + itkGetMacro( KspaceImage, ItkDoubleImgType::Pointer ) + std::vector< ItkDoubleImgType::Pointer > GetVolumeFractions(){ return m_VolumeFractions; } + void GenerateData(); protected: TractsToDWIImageFilter(); virtual ~TractsToDWIImageFilter(); itk::Point GetItkPoint(double point[3]); itk::Vector GetItkVector(double point[3]); vnl_vector_fixed GetVnlVector(double point[3]); vnl_vector_fixed GetVnlVector(Vector< float, 3 >& vector); /** Transform generated image compartment by compartment, channel by channel and slice by slice using FFT and add k-space artifacts. */ std::vector< DoubleDwiType::Pointer > DoKspaceStuff(std::vector< DoubleDwiType::Pointer >& images); /** Rearrange FFT output to shift low frequencies to the iamge center (correct itk). */ TractsToDWIImageFilter::ComplexSliceType::Pointer RearrangeSlice(ComplexSliceType::Pointer slice); itk::Vector m_Spacing; ///< output image spacing itk::Vector m_UpsampledSpacing; mitk::Point3D m_Origin; ///< output image origin MatrixType m_DirectionMatrix; ///< output image rotation ImageRegion<3> m_ImageRegion; ///< output image size ImageRegion<3> m_UpsampledImageRegion; ItkUcharImgType::Pointer m_TissueMask; ///< voxels outside of this binary mask contain only noise (are treated as air) ItkDoubleImgType::Pointer m_FrequencyMap; ///< map of the B0 inhomogeneities double m_kOffset; double m_tLine; FiberBundleType m_FiberBundle; ///< input fiber bundle DiffusionModelList m_FiberModels; ///< generate signal of fiber compartments DiffusionModelList m_NonFiberModels; ///< generate signal of non-fiber compartments KspaceArtifactList m_KspaceArtifacts; NoiseModelType* m_NoiseModel; ///< generates the noise added to the image values bool m_CircleDummy; unsigned int m_VolumeAccuracy; ItkDoubleImgType::Pointer m_KspaceImage; unsigned int m_Upsampling; unsigned int m_NumberOfRepetitions; bool m_EnforcePureFiberVoxels; double m_InterpolationShrink; double m_FiberRadius; double m_SignalScale; mitk::LevelWindow m_LevelWindow; bool m_UseInterpolation; + std::vector< ItkDoubleImgType::Pointer > m_VolumeFractions; ///< one double image for each compartment containing the corresponding volume fraction per voxel }; } #include "itkTractsToDWIImageFilter.cpp" #endif diff --git a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkFiberfoxView.cpp b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkFiberfoxView.cpp index 3838047e47..edc4469e1b 100644 --- a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkFiberfoxView.cpp +++ b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkFiberfoxView.cpp @@ -1,1676 +1,1733 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ //misc #define _USE_MATH_DEFINES #include // Blueberry #include #include // Qmitk #include "QmitkFiberfoxView.h" // MITK #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include #include +#include #include #define _USE_MATH_DEFINES #include const std::string QmitkFiberfoxView::VIEW_ID = "org.mitk.views.fiberfoxview"; QmitkFiberfoxView::QmitkFiberfoxView() : QmitkAbstractView() , m_Controls( 0 ) , m_SelectedImage( NULL ) { } // Destructor QmitkFiberfoxView::~QmitkFiberfoxView() { } void QmitkFiberfoxView::CreateQtPartControl( QWidget *parent ) { // build up qt view, unless already done if ( !m_Controls ) { // create GUI widgets from the Qt Designer's .ui file m_Controls = new Ui::QmitkFiberfoxViewControls; m_Controls->setupUi( parent ); m_Controls->m_StickWidget1->setVisible(true); m_Controls->m_StickWidget2->setVisible(false); m_Controls->m_ZeppelinWidget1->setVisible(false); m_Controls->m_ZeppelinWidget2->setVisible(false); m_Controls->m_TensorWidget1->setVisible(false); m_Controls->m_TensorWidget2->setVisible(false); m_Controls->m_BallWidget1->setVisible(true); m_Controls->m_BallWidget2->setVisible(false); m_Controls->m_AstrosticksWidget1->setVisible(false); m_Controls->m_AstrosticksWidget2->setVisible(false); m_Controls->m_DotWidget1->setVisible(false); m_Controls->m_DotWidget2->setVisible(false); m_Controls->m_Comp4FractionFrame->setVisible(false); m_Controls->m_DiffusionPropsMessage->setVisible(false); m_Controls->m_GeometryMessage->setVisible(false); m_Controls->m_AdvancedSignalOptionsFrame->setVisible(false); m_Controls->m_AdvancedFiberOptionsFrame->setVisible(false); m_Controls->m_VarianceBox->setVisible(false); m_Controls->m_GibbsRingingFrame->setVisible(false); m_Controls->m_NoiseFrame->setVisible(true); m_Controls->m_GhostFrame->setVisible(false); m_Controls->m_DistortionsFrame->setVisible(false); m_Controls->m_FrequencyMapBox->SetDataStorage(this->GetDataStorage()); mitk::TNodePredicateDataType::Pointer isMitkImage = mitk::TNodePredicateDataType::New(); mitk::NodePredicateDataType::Pointer isDwi = mitk::NodePredicateDataType::New("DiffusionImage"); mitk::NodePredicateDataType::Pointer isDti = mitk::NodePredicateDataType::New("TensorImage"); mitk::NodePredicateDataType::Pointer isQbi = mitk::NodePredicateDataType::New("QBallImage"); mitk::NodePredicateOr::Pointer isDiffusionImage = mitk::NodePredicateOr::New(isDwi, isDti); isDiffusionImage = mitk::NodePredicateOr::New(isDiffusionImage, isQbi); mitk::NodePredicateNot::Pointer noDiffusionImage = mitk::NodePredicateNot::New(isDiffusionImage); mitk::NodePredicateAnd::Pointer finalPredicate = mitk::NodePredicateAnd::New(isMitkImage, noDiffusionImage); m_Controls->m_FrequencyMapBox->SetPredicate(finalPredicate); connect((QObject*) m_Controls->m_GenerateImageButton, SIGNAL(clicked()), (QObject*) this, SLOT(GenerateImage())); connect((QObject*) m_Controls->m_GenerateFibersButton, SIGNAL(clicked()), (QObject*) this, SLOT(GenerateFibers())); connect((QObject*) m_Controls->m_CircleButton, SIGNAL(clicked()), (QObject*) this, SLOT(OnDrawROI())); connect((QObject*) m_Controls->m_FlipButton, SIGNAL(clicked()), (QObject*) this, SLOT(OnFlipButton())); connect((QObject*) m_Controls->m_JoinBundlesButton, SIGNAL(clicked()), (QObject*) this, SLOT(JoinBundles())); connect((QObject*) m_Controls->m_VarianceBox, SIGNAL(valueChanged(double)), (QObject*) this, SLOT(OnVarianceChanged(double))); connect((QObject*) m_Controls->m_DistributionBox, SIGNAL(currentIndexChanged(int)), (QObject*) this, SLOT(OnDistributionChanged(int))); connect((QObject*) m_Controls->m_FiberDensityBox, SIGNAL(valueChanged(int)), (QObject*) this, SLOT(OnFiberDensityChanged(int))); connect((QObject*) m_Controls->m_FiberSamplingBox, SIGNAL(valueChanged(int)), (QObject*) this, SLOT(OnFiberSamplingChanged(int))); connect((QObject*) m_Controls->m_TensionBox, SIGNAL(valueChanged(double)), (QObject*) this, SLOT(OnTensionChanged(double))); connect((QObject*) m_Controls->m_ContinuityBox, SIGNAL(valueChanged(double)), (QObject*) this, SLOT(OnContinuityChanged(double))); connect((QObject*) m_Controls->m_BiasBox, SIGNAL(valueChanged(double)), (QObject*) this, SLOT(OnBiasChanged(double))); connect((QObject*) m_Controls->m_AddGibbsRinging, SIGNAL(stateChanged(int)), (QObject*) this, SLOT(OnAddGibbsRinging(int))); connect((QObject*) m_Controls->m_AddNoise, SIGNAL(stateChanged(int)), (QObject*) this, SLOT(OnAddNoise(int))); connect((QObject*) m_Controls->m_AddGhosts, SIGNAL(stateChanged(int)), (QObject*) this, SLOT(OnAddGhosts(int))); connect((QObject*) m_Controls->m_AddDistortions, SIGNAL(stateChanged(int)), (QObject*) this, SLOT(OnAddDistortions(int))); connect((QObject*) m_Controls->m_ConstantRadiusBox, SIGNAL(stateChanged(int)), (QObject*) this, SLOT(OnConstantRadius(int))); connect((QObject*) m_Controls->m_CopyBundlesButton, SIGNAL(clicked()), (QObject*) this, SLOT(CopyBundles())); connect((QObject*) m_Controls->m_TransformBundlesButton, SIGNAL(clicked()), (QObject*) this, SLOT(ApplyTransform())); connect((QObject*) m_Controls->m_AlignOnGrid, SIGNAL(clicked()), (QObject*) this, SLOT(AlignOnGrid())); connect((QObject*) m_Controls->m_Compartment1Box, SIGNAL(currentIndexChanged(int)), (QObject*) this, SLOT(Comp1ModelFrameVisibility(int))); connect((QObject*) m_Controls->m_Compartment2Box, SIGNAL(currentIndexChanged(int)), (QObject*) this, SLOT(Comp2ModelFrameVisibility(int))); connect((QObject*) m_Controls->m_Compartment3Box, SIGNAL(currentIndexChanged(int)), (QObject*) this, SLOT(Comp3ModelFrameVisibility(int))); connect((QObject*) m_Controls->m_Compartment4Box, SIGNAL(currentIndexChanged(int)), (QObject*) this, SLOT(Comp4ModelFrameVisibility(int))); connect((QObject*) m_Controls->m_AdvancedOptionsBox, SIGNAL( stateChanged(int)), (QObject*) this, SLOT(ShowAdvancedOptions(int))); connect((QObject*) m_Controls->m_AdvancedOptionsBox_2, SIGNAL( stateChanged(int)), (QObject*) this, SLOT(ShowAdvancedOptions(int))); } } void QmitkFiberfoxView::ShowAdvancedOptions(int state) { if (state) { m_Controls->m_AdvancedFiberOptionsFrame->setVisible(true); m_Controls->m_AdvancedSignalOptionsFrame->setVisible(true); m_Controls->m_AdvancedOptionsBox->setChecked(true); m_Controls->m_AdvancedOptionsBox_2->setChecked(true); } else { m_Controls->m_AdvancedFiberOptionsFrame->setVisible(false); m_Controls->m_AdvancedSignalOptionsFrame->setVisible(false); m_Controls->m_AdvancedOptionsBox->setChecked(false); m_Controls->m_AdvancedOptionsBox_2->setChecked(false); } } void QmitkFiberfoxView::Comp1ModelFrameVisibility(int index) { m_Controls->m_StickWidget1->setVisible(false); m_Controls->m_ZeppelinWidget1->setVisible(false); m_Controls->m_TensorWidget1->setVisible(false); switch (index) { case 0: m_Controls->m_StickWidget1->setVisible(true); break; case 1: m_Controls->m_ZeppelinWidget1->setVisible(true); break; case 2: m_Controls->m_TensorWidget1->setVisible(true); break; } } void QmitkFiberfoxView::Comp2ModelFrameVisibility(int index) { m_Controls->m_StickWidget2->setVisible(false); m_Controls->m_ZeppelinWidget2->setVisible(false); m_Controls->m_TensorWidget2->setVisible(false); switch (index) { case 0: break; case 1: m_Controls->m_StickWidget2->setVisible(true); break; case 2: m_Controls->m_ZeppelinWidget2->setVisible(true); break; case 3: m_Controls->m_TensorWidget2->setVisible(true); break; } } void QmitkFiberfoxView::Comp3ModelFrameVisibility(int index) { m_Controls->m_BallWidget1->setVisible(false); m_Controls->m_AstrosticksWidget1->setVisible(false); m_Controls->m_DotWidget1->setVisible(false); switch (index) { case 0: m_Controls->m_BallWidget1->setVisible(true); break; case 1: m_Controls->m_AstrosticksWidget1->setVisible(true); break; case 2: m_Controls->m_DotWidget1->setVisible(true); break; } } void QmitkFiberfoxView::Comp4ModelFrameVisibility(int index) { m_Controls->m_BallWidget2->setVisible(false); m_Controls->m_AstrosticksWidget2->setVisible(false); m_Controls->m_DotWidget2->setVisible(false); m_Controls->m_Comp4FractionFrame->setVisible(false); switch (index) { case 0: break; case 1: m_Controls->m_BallWidget2->setVisible(true); m_Controls->m_Comp4FractionFrame->setVisible(true); break; case 2: m_Controls->m_AstrosticksWidget2->setVisible(true); m_Controls->m_Comp4FractionFrame->setVisible(true); break; case 3: m_Controls->m_DotWidget2->setVisible(true); m_Controls->m_Comp4FractionFrame->setVisible(true); break; } } void QmitkFiberfoxView::OnConstantRadius(int value) { if (value>0 && m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::OnAddDistortions(int value) { if (value>0) m_Controls->m_DistortionsFrame->setVisible(true); else m_Controls->m_DistortionsFrame->setVisible(false); } void QmitkFiberfoxView::OnAddGhosts(int value) { if (value>0) m_Controls->m_GhostFrame->setVisible(true); else m_Controls->m_GhostFrame->setVisible(false); } void QmitkFiberfoxView::OnAddNoise(int value) { if (value>0) m_Controls->m_NoiseFrame->setVisible(true); else m_Controls->m_NoiseFrame->setVisible(false); } void QmitkFiberfoxView::OnAddGibbsRinging(int value) { if (value>0) m_Controls->m_GibbsRingingFrame->setVisible(true); else m_Controls->m_GibbsRingingFrame->setVisible(false); } void QmitkFiberfoxView::OnDistributionChanged(int value) { if (value==1) m_Controls->m_VarianceBox->setVisible(true); else m_Controls->m_VarianceBox->setVisible(false); if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::OnVarianceChanged(double value) { if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::OnFiberDensityChanged(int value) { if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::OnFiberSamplingChanged(int value) { if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::OnTensionChanged(double value) { if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::OnContinuityChanged(double value) { if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::OnBiasChanged(double value) { if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::AlignOnGrid() { for (int i=0; i(m_SelectedFiducials.at(i)->GetData()); mitk::Point3D wc0 = pe->GetWorldControlPoint(0); mitk::DataStorage::SetOfObjects::ConstPointer parentFibs = GetDataStorage()->GetSources(m_SelectedFiducials.at(i)); for( mitk::DataStorage::SetOfObjects::const_iterator it = parentFibs->begin(); it != parentFibs->end(); ++it ) { mitk::DataNode::Pointer pFibNode = *it; if ( pFibNode.IsNotNull() && dynamic_cast(pFibNode->GetData()) ) { mitk::DataStorage::SetOfObjects::ConstPointer parentImgs = GetDataStorage()->GetSources(pFibNode); for( mitk::DataStorage::SetOfObjects::const_iterator it2 = parentImgs->begin(); it2 != parentImgs->end(); ++it2 ) { mitk::DataNode::Pointer pImgNode = *it2; if ( pImgNode.IsNotNull() && dynamic_cast(pImgNode->GetData()) ) { mitk::Image::Pointer img = dynamic_cast(pImgNode->GetData()); mitk::Geometry3D::Pointer geom = img->GetGeometry(); itk::Index<3> idx; geom->WorldToIndex(wc0, idx); mitk::Point3D cIdx; cIdx[0]=idx[0]; cIdx[1]=idx[1]; cIdx[2]=idx[2]; mitk::Point3D world; geom->IndexToWorld(cIdx,world); mitk::Vector3D trans = world - wc0; pe->GetGeometry()->Translate(trans); break; } } break; } } } for( int i=0; iGetSources(fibNode); for( mitk::DataStorage::SetOfObjects::const_iterator it = sources->begin(); it != sources->end(); ++it ) { mitk::DataNode::Pointer imgNode = *it; if ( imgNode.IsNotNull() && dynamic_cast(imgNode->GetData()) ) { mitk::DataStorage::SetOfObjects::ConstPointer derivations = GetDataStorage()->GetDerivations(fibNode); for( mitk::DataStorage::SetOfObjects::const_iterator it2 = derivations->begin(); it2 != derivations->end(); ++it2 ) { mitk::DataNode::Pointer fiducialNode = *it2; if ( fiducialNode.IsNotNull() && dynamic_cast(fiducialNode->GetData()) ) { mitk::PlanarEllipse::Pointer pe = dynamic_cast(fiducialNode->GetData()); mitk::Point3D wc0 = pe->GetWorldControlPoint(0); mitk::Image::Pointer img = dynamic_cast(imgNode->GetData()); mitk::Geometry3D::Pointer geom = img->GetGeometry(); itk::Index<3> idx; geom->WorldToIndex(wc0, idx); mitk::Point3D cIdx; cIdx[0]=idx[0]; cIdx[1]=idx[1]; cIdx[2]=idx[2]; mitk::Point3D world; geom->IndexToWorld(cIdx,world); mitk::Vector3D trans = world - wc0; pe->GetGeometry()->Translate(trans); } } break; } } } for( int i=0; i(m_SelectedImages.at(i)->GetData()); mitk::DataStorage::SetOfObjects::ConstPointer derivations = GetDataStorage()->GetDerivations(m_SelectedImages.at(i)); for( mitk::DataStorage::SetOfObjects::const_iterator it = derivations->begin(); it != derivations->end(); ++it ) { mitk::DataNode::Pointer fibNode = *it; if ( fibNode.IsNotNull() && dynamic_cast(fibNode->GetData()) ) { mitk::DataStorage::SetOfObjects::ConstPointer derivations2 = GetDataStorage()->GetDerivations(fibNode); for( mitk::DataStorage::SetOfObjects::const_iterator it2 = derivations2->begin(); it2 != derivations2->end(); ++it2 ) { mitk::DataNode::Pointer fiducialNode = *it2; if ( fiducialNode.IsNotNull() && dynamic_cast(fiducialNode->GetData()) ) { mitk::PlanarEllipse::Pointer pe = dynamic_cast(fiducialNode->GetData()); mitk::Point3D wc0 = pe->GetWorldControlPoint(0); mitk::Geometry3D::Pointer geom = img->GetGeometry(); itk::Index<3> idx; geom->WorldToIndex(wc0, idx); mitk::Point3D cIdx; cIdx[0]=idx[0]; cIdx[1]=idx[1]; cIdx[2]=idx[2]; mitk::Point3D world; geom->IndexToWorld(cIdx,world); mitk::Vector3D trans = world - wc0; pe->GetGeometry()->Translate(trans); } } } } } mitk::RenderingManager::GetInstance()->RequestUpdateAll(); if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::OnFlipButton() { if (m_SelectedFiducial.IsNull()) return; std::map::iterator it = m_DataNodeToPlanarFigureData.find(m_SelectedFiducial.GetPointer()); if( it != m_DataNodeToPlanarFigureData.end() ) { QmitkPlanarFigureData& data = it->second; data.m_Flipped += 1; data.m_Flipped %= 2; } if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } QmitkFiberfoxView::GradientListType QmitkFiberfoxView::GenerateHalfShell(int NPoints) { NPoints *= 2; GradientListType pointshell; int numB0 = NPoints/20; if (numB0==0) numB0=1; GradientType g; g.Fill(0.0); for (int i=0; i theta; theta.set_size(NPoints); vnl_vector phi; phi.set_size(NPoints); double C = sqrt(4*M_PI); phi(0) = 0.0; phi(NPoints-1) = 0.0; for(int i=0; i0 && i std::vector > QmitkFiberfoxView::MakeGradientList() { std::vector > retval; vnl_matrix_fixed* U = itk::PointShell >::DistributePointShell(); // Add 0 vector for B0 int numB0 = ndirs/10; if (numB0==0) numB0=1; itk::Vector v; v.Fill(0.0); for (int i=0; i v; v[0] = U->get(0,i); v[1] = U->get(1,i); v[2] = U->get(2,i); retval.push_back(v); } return retval; } void QmitkFiberfoxView::OnAddBundle() { if (m_SelectedImage.IsNull()) return; mitk::DataStorage::SetOfObjects::ConstPointer children = GetDataStorage()->GetDerivations(m_SelectedImage); mitk::FiberBundleX::Pointer bundle = mitk::FiberBundleX::New(); mitk::DataNode::Pointer node = mitk::DataNode::New(); node->SetData( bundle ); QString name = QString("Bundle_%1").arg(children->size()); node->SetName(name.toStdString()); m_SelectedBundles.push_back(node); UpdateGui(); GetDataStorage()->Add(node, m_SelectedImage); } void QmitkFiberfoxView::OnDrawROI() { if (m_SelectedBundles.empty()) OnAddBundle(); if (m_SelectedBundles.empty()) return; mitk::DataStorage::SetOfObjects::ConstPointer children = GetDataStorage()->GetDerivations(m_SelectedBundles.at(0)); mitk::PlanarEllipse::Pointer figure = mitk::PlanarEllipse::New(); mitk::DataNode::Pointer node = mitk::DataNode::New(); node->SetData( figure ); QList nodes = this->GetDataManagerSelection(); for( int i=0; iSetSelected(false); m_SelectedFiducial = node; QString name = QString("Fiducial_%1").arg(children->size()); node->SetName(name.toStdString()); node->SetSelected(true); GetDataStorage()->Add(node, m_SelectedBundles.at(0)); this->DisableCrosshairNavigation(); mitk::PlanarFigureInteractor::Pointer figureInteractor = dynamic_cast(node->GetInteractor()); if(figureInteractor.IsNull()) figureInteractor = mitk::PlanarFigureInteractor::New("PlanarFigureInteractor", node); mitk::GlobalInteraction::GetInstance()->AddInteractor(figureInteractor); UpdateGui(); } bool CompareLayer(mitk::DataNode::Pointer i,mitk::DataNode::Pointer j) { int li = -1; i->GetPropertyValue("layer", li); int lj = -1; j->GetPropertyValue("layer", lj); return liGetSources(m_SelectedFiducial); for( mitk::DataStorage::SetOfObjects::const_iterator it = parents->begin(); it != parents->end(); ++it ) if(dynamic_cast((*it)->GetData())) m_SelectedBundles.push_back(*it); if (m_SelectedBundles.empty()) return; } vector< vector< mitk::PlanarEllipse::Pointer > > fiducials; vector< vector< unsigned int > > fliplist; for (int i=0; iGetDerivations(m_SelectedBundles.at(i)); std::vector< mitk::DataNode::Pointer > childVector; for( mitk::DataStorage::SetOfObjects::const_iterator it = children->begin(); it != children->end(); ++it ) childVector.push_back(*it); sort(childVector.begin(), childVector.end(), CompareLayer); vector< mitk::PlanarEllipse::Pointer > fib; vector< unsigned int > flip; float radius = 1; int count = 0; for( std::vector< mitk::DataNode::Pointer >::const_iterator it = childVector.begin(); it != childVector.end(); ++it ) { mitk::DataNode::Pointer node = *it; if ( node.IsNotNull() && dynamic_cast(node->GetData()) ) { mitk::PlanarEllipse* ellipse = dynamic_cast(node->GetData()); if (m_Controls->m_ConstantRadiusBox->isChecked()) { ellipse->SetTreatAsCircle(true); mitk::Point2D c = ellipse->GetControlPoint(0); mitk::Point2D p = ellipse->GetControlPoint(1); mitk::Vector2D v = p-c; if (count==0) { radius = v.GetVnlVector().magnitude(); ellipse->SetControlPoint(1, p); } else { v.Normalize(); v *= radius; ellipse->SetControlPoint(1, c+v); } } fib.push_back(ellipse); std::map::iterator it = m_DataNodeToPlanarFigureData.find(node.GetPointer()); if( it != m_DataNodeToPlanarFigureData.end() ) { QmitkPlanarFigureData& data = it->second; flip.push_back(data.m_Flipped); } else flip.push_back(0); } count++; } if (fib.size()>1) { fiducials.push_back(fib); fliplist.push_back(flip); } else if (fib.size()>0) m_SelectedBundles.at(i)->SetData( mitk::FiberBundleX::New() ); mitk::RenderingManager::GetInstance()->RequestUpdateAll(); } itk::FibersFromPlanarFiguresFilter::Pointer filter = itk::FibersFromPlanarFiguresFilter::New(); filter->SetFiducials(fiducials); filter->SetFlipList(fliplist); switch(m_Controls->m_DistributionBox->currentIndex()){ case 0: filter->SetFiberDistribution(itk::FibersFromPlanarFiguresFilter::DISTRIBUTE_UNIFORM); break; case 1: filter->SetFiberDistribution(itk::FibersFromPlanarFiguresFilter::DISTRIBUTE_GAUSSIAN); filter->SetVariance(m_Controls->m_VarianceBox->value()); break; } filter->SetDensity(m_Controls->m_FiberDensityBox->value()); filter->SetTension(m_Controls->m_TensionBox->value()); filter->SetContinuity(m_Controls->m_ContinuityBox->value()); filter->SetBias(m_Controls->m_BiasBox->value()); filter->SetFiberSampling(m_Controls->m_FiberSamplingBox->value()); filter->Update(); vector< mitk::FiberBundleX::Pointer > fiberBundles = filter->GetFiberBundles(); for (int i=0; iSetData( fiberBundles.at(i) ); if (fiberBundles.at(i)->GetNumFibers()>50000) m_SelectedBundles.at(i)->SetVisibility(false); } mitk::RenderingManager::GetInstance()->RequestUpdateAll(); } void QmitkFiberfoxView::GenerateImage() { itk::ImageRegion<3> imageRegion; imageRegion.SetSize(0, m_Controls->m_SizeX->value()); imageRegion.SetSize(1, m_Controls->m_SizeY->value()); imageRegion.SetSize(2, m_Controls->m_SizeZ->value()); mitk::Vector3D spacing; spacing[0] = m_Controls->m_SpacingX->value(); spacing[1] = m_Controls->m_SpacingY->value(); spacing[2] = m_Controls->m_SpacingZ->value(); mitk::Point3D origin; origin[0] = spacing[0]/2; origin[1] = spacing[1]/2; origin[2] = spacing[2]/2; itk::Matrix directionMatrix; directionMatrix.SetIdentity(); if (m_SelectedBundles.empty()) { + if (m_SelectedDWI.IsNotNull()) // add artifacts to existing diffusion weighted image + { + for (int i=0; i*>(m_SelectedImages.at(i)->GetData())) + continue; + mitk::DiffusionImage::Pointer diffImg = dynamic_cast*>(m_SelectedImages.at(i)->GetData()); + + double noiseVariance = 0; + if (m_Controls->m_AddNoise->isChecked()) + { + noiseVariance = m_Controls->m_NoiseLevel->value(); + artifactModelString += "_NOISE"; + artifactModelString += QString::number(noiseVariance); + } + mitk::RicianNoiseModel noiseModel; + noiseModel.SetNoiseVariance(noiseVariance); + + itk::AddArtifactsToDwiImageFilter< short >::Pointer filter = itk::AddArtifactsToDwiImageFilter< short >::New(); + filter->SetInput(diffImg->GetVectorImage()); + + // filter->SetkOffset(m_Controls->doubleSpinBox->value()); + filter->SetNoiseModel(&noiseModel); + filter->Update(); + + mitk::DataNode::Pointer resultNode = mitk::DataNode::New(); + mitk::DiffusionImage::Pointer image = mitk::DiffusionImage::New(); + image->SetVectorImage( filter->GetOutput() ); + image->SetB_Value(diffImg->GetB_Value()); + image->SetDirections(diffImg->GetDirections()); + image->InitializeFromVectorImage(); + resultNode->SetData( image ); + resultNode->SetName(m_SelectedImages.at(i)->GetName()+artifactModelString.toStdString()); + GetDataStorage()->Add(resultNode); + } + return; + } mitk::Image::Pointer image = mitk::ImageGenerator::GenerateGradientImage( m_Controls->m_SizeX->value(), m_Controls->m_SizeY->value(), m_Controls->m_SizeZ->value(), m_Controls->m_SpacingX->value(), m_Controls->m_SpacingY->value(), m_Controls->m_SpacingZ->value()); mitk::Geometry3D* geom = image->GetGeometry(); geom->SetOrigin(origin); mitk::DataNode::Pointer node = mitk::DataNode::New(); node->SetData( image ); node->SetName("Dummy"); unsigned int window = m_Controls->m_SizeX->value()*m_Controls->m_SizeY->value()*m_Controls->m_SizeZ->value(); unsigned int level = window/2; mitk::LevelWindow lw; lw.SetLevelWindow(level, window); node->SetProperty( "levelwindow", mitk::LevelWindowProperty::New( lw ) ); GetDataStorage()->Add(node); m_SelectedImage = node; mitk::BaseData::Pointer basedata = node->GetData(); if (basedata.IsNotNull()) { mitk::RenderingManager::GetInstance()->InitializeViews( basedata->GetTimeSlicedGeometry(), mitk::RenderingManager::REQUEST_UPDATE_ALL, true ); mitk::RenderingManager::GetInstance()->RequestUpdateAll(); } UpdateGui(); return; } if (m_SelectedImage.IsNotNull()) { mitk::Image* img = dynamic_cast(m_SelectedImage->GetData()); itk::Image< float, 3 >::Pointer itkImg = itk::Image< float, 3 >::New(); CastToItkImage< itk::Image< float, 3 > >(img, itkImg); imageRegion = itkImg->GetLargestPossibleRegion(); spacing = itkImg->GetSpacing(); origin = itkImg->GetOrigin(); directionMatrix = itkImg->GetDirection(); } DiffusionSignalModel::GradientListType gradientList; double bVal = 1000; if (m_SelectedDWI.IsNull()) { gradientList = GenerateHalfShell(m_Controls->m_NumGradientsBox->value());; bVal = m_Controls->m_BvalueBox->value(); } else { mitk::DiffusionImage::Pointer dwi = dynamic_cast*>(m_SelectedDWI->GetData()); imageRegion = dwi->GetVectorImage()->GetLargestPossibleRegion(); spacing = dwi->GetVectorImage()->GetSpacing(); origin = dwi->GetVectorImage()->GetOrigin(); directionMatrix = dwi->GetVectorImage()->GetDirection(); bVal = dwi->GetB_Value(); mitk::DiffusionImage::GradientDirectionContainerType::Pointer dirs = dwi->GetDirections(); for (int i=0; iSize(); i++) { DiffusionSignalModel::GradientType g; g[0] = dirs->at(i)[0]; g[1] = dirs->at(i)[1]; g[2] = dirs->at(i)[2]; gradientList.push_back(g); } } for (int i=0; im_Compartment4Box->currentIndex()>0) { comp4Weight = m_Controls->m_Comp4FractionBox->value(); comp3Weight -= comp4Weight; } mitk::StickModel stickModel1; mitk::StickModel stickModel2; mitk::TensorModel zeppelinModel1; mitk::TensorModel zeppelinModel2; mitk::TensorModel tensorModel1; mitk::TensorModel tensorModel2; mitk::BallModel ballModel1; mitk::BallModel ballModel2; mitk::AstroStickModel astrosticksModel1; mitk::AstroStickModel astrosticksModel2; mitk::DotModel dotModel1; mitk::DotModel dotModel2; // compartment 1 switch (m_Controls->m_Compartment1Box->currentIndex()) { case 0: MITK_INFO << "Using stick model"; stickModel1.SetGradientList(gradientList); stickModel1.SetDiffusivity(m_Controls->m_StickWidget1->GetD()); stickModel1.SetT2(m_Controls->m_StickWidget1->GetT2()); fiberModelList.push_back(&stickModel1); signalModelString += "Stick"; resultNode->AddProperty("Fiberfox.Compartment1.Description", StringProperty::New("Intra-axonal compartment") ); resultNode->AddProperty("Fiberfox.Compartment1.Model", StringProperty::New("Stick") ); resultNode->AddProperty("Fiberfox.Compartment1.D", DoubleProperty::New(m_Controls->m_StickWidget1->GetD()) ); resultNode->AddProperty("Fiberfox.Compartment1.T2", DoubleProperty::New(stickModel1.GetT2()) ); break; case 1: MITK_INFO << "Using zeppelin model"; zeppelinModel1.SetGradientList(gradientList); zeppelinModel1.SetBvalue(bVal); zeppelinModel1.SetDiffusivity1(m_Controls->m_ZeppelinWidget1->GetD1()); zeppelinModel1.SetDiffusivity2(m_Controls->m_ZeppelinWidget1->GetD2()); zeppelinModel1.SetDiffusivity3(m_Controls->m_ZeppelinWidget1->GetD2()); zeppelinModel1.SetT2(m_Controls->m_ZeppelinWidget1->GetT2()); fiberModelList.push_back(&zeppelinModel1); signalModelString += "Zeppelin"; resultNode->AddProperty("Fiberfox.Compartment1.Description", StringProperty::New("Intra-axonal compartment") ); resultNode->AddProperty("Fiberfox.Compartment1.Model", StringProperty::New("Zeppelin") ); resultNode->AddProperty("Fiberfox.Compartment1.D1", DoubleProperty::New(m_Controls->m_ZeppelinWidget1->GetD1()) ); resultNode->AddProperty("Fiberfox.Compartment1.D2", DoubleProperty::New(m_Controls->m_ZeppelinWidget1->GetD2()) ); resultNode->AddProperty("Fiberfox.Compartment1.T2", DoubleProperty::New(zeppelinModel1.GetT2()) ); break; case 2: MITK_INFO << "Using tensor model"; tensorModel1.SetGradientList(gradientList); tensorModel1.SetBvalue(bVal); tensorModel1.SetDiffusivity1(m_Controls->m_TensorWidget1->GetD1()); tensorModel1.SetDiffusivity2(m_Controls->m_TensorWidget1->GetD2()); tensorModel1.SetDiffusivity3(m_Controls->m_TensorWidget1->GetD3()); tensorModel1.SetT2(m_Controls->m_TensorWidget1->GetT2()); fiberModelList.push_back(&tensorModel1); signalModelString += "Tensor"; resultNode->AddProperty("Fiberfox.Compartment1.Description", StringProperty::New("Intra-axonal compartment") ); resultNode->AddProperty("Fiberfox.Compartment1.Model", StringProperty::New("Tensor") ); resultNode->AddProperty("Fiberfox.Compartment1.D1", DoubleProperty::New(m_Controls->m_TensorWidget1->GetD1()) ); resultNode->AddProperty("Fiberfox.Compartment1.D2", DoubleProperty::New(m_Controls->m_TensorWidget1->GetD2()) ); resultNode->AddProperty("Fiberfox.Compartment1.D3", DoubleProperty::New(m_Controls->m_TensorWidget1->GetD3()) ); resultNode->AddProperty("Fiberfox.Compartment1.T2", DoubleProperty::New(zeppelinModel1.GetT2()) ); break; } // compartment 2 switch (m_Controls->m_Compartment2Box->currentIndex()) { case 0: break; case 1: stickModel2.SetGradientList(gradientList); stickModel2.SetDiffusivity(m_Controls->m_StickWidget2->GetD()); stickModel2.SetT2(m_Controls->m_StickWidget2->GetT2()); fiberModelList.push_back(&stickModel2); signalModelString += "Stick"; resultNode->AddProperty("Fiberfox.Compartment2.Description", StringProperty::New("Inter-axonal compartment") ); resultNode->AddProperty("Fiberfox.Compartment2.Model", StringProperty::New("Stick") ); resultNode->AddProperty("Fiberfox.Compartment2.D", DoubleProperty::New(m_Controls->m_StickWidget2->GetD()) ); resultNode->AddProperty("Fiberfox.Compartment2.T2", DoubleProperty::New(stickModel2.GetT2()) ); break; case 2: zeppelinModel2.SetGradientList(gradientList); zeppelinModel2.SetBvalue(bVal); zeppelinModel2.SetDiffusivity1(m_Controls->m_ZeppelinWidget2->GetD1()); zeppelinModel2.SetDiffusivity2(m_Controls->m_ZeppelinWidget2->GetD2()); zeppelinModel2.SetDiffusivity3(m_Controls->m_ZeppelinWidget2->GetD2()); zeppelinModel2.SetT2(m_Controls->m_ZeppelinWidget2->GetT2()); fiberModelList.push_back(&zeppelinModel2); signalModelString += "Zeppelin"; resultNode->AddProperty("Fiberfox.Compartment2.Description", StringProperty::New("Inter-axonal compartment") ); resultNode->AddProperty("Fiberfox.Compartment2.Model", StringProperty::New("Zeppelin") ); resultNode->AddProperty("Fiberfox.Compartment2.D1", DoubleProperty::New(m_Controls->m_ZeppelinWidget2->GetD1()) ); resultNode->AddProperty("Fiberfox.Compartment2.D2", DoubleProperty::New(m_Controls->m_ZeppelinWidget2->GetD2()) ); resultNode->AddProperty("Fiberfox.Compartment2.T2", DoubleProperty::New(zeppelinModel2.GetT2()) ); break; case 3: tensorModel2.SetGradientList(gradientList); tensorModel2.SetBvalue(bVal); tensorModel2.SetDiffusivity1(m_Controls->m_TensorWidget2->GetD1()); tensorModel2.SetDiffusivity2(m_Controls->m_TensorWidget2->GetD2()); tensorModel2.SetDiffusivity3(m_Controls->m_TensorWidget2->GetD3()); tensorModel2.SetT2(m_Controls->m_TensorWidget2->GetT2()); fiberModelList.push_back(&tensorModel2); signalModelString += "Tensor"; resultNode->AddProperty("Fiberfox.Compartment2.Description", StringProperty::New("Inter-axonal compartment") ); resultNode->AddProperty("Fiberfox.Compartment2.Model", StringProperty::New("Tensor") ); resultNode->AddProperty("Fiberfox.Compartment2.D1", DoubleProperty::New(m_Controls->m_TensorWidget2->GetD1()) ); resultNode->AddProperty("Fiberfox.Compartment2.D2", DoubleProperty::New(m_Controls->m_TensorWidget2->GetD2()) ); resultNode->AddProperty("Fiberfox.Compartment2.D3", DoubleProperty::New(m_Controls->m_TensorWidget2->GetD3()) ); resultNode->AddProperty("Fiberfox.Compartment2.T2", DoubleProperty::New(zeppelinModel2.GetT2()) ); break; } // compartment 3 switch (m_Controls->m_Compartment3Box->currentIndex()) { case 0: ballModel1.SetGradientList(gradientList); ballModel1.SetBvalue(bVal); ballModel1.SetDiffusivity(m_Controls->m_BallWidget1->GetD()); ballModel1.SetT2(m_Controls->m_BallWidget1->GetT2()); ballModel1.SetWeight(comp3Weight); nonFiberModelList.push_back(&ballModel1); signalModelString += "Ball"; resultNode->AddProperty("Fiberfox.Compartment3.Description", StringProperty::New("Extra-axonal compartment 1") ); resultNode->AddProperty("Fiberfox.Compartment3.Model", StringProperty::New("Ball") ); resultNode->AddProperty("Fiberfox.Compartment3.D", DoubleProperty::New(m_Controls->m_BallWidget1->GetD()) ); resultNode->AddProperty("Fiberfox.Compartment3.T2", DoubleProperty::New(ballModel1.GetT2()) ); break; case 1: astrosticksModel1.SetGradientList(gradientList); astrosticksModel1.SetBvalue(bVal); astrosticksModel1.SetDiffusivity(m_Controls->m_AstrosticksWidget1->GetD()); astrosticksModel1.SetT2(m_Controls->m_AstrosticksWidget1->GetT2()); astrosticksModel1.SetRandomizeSticks(m_Controls->m_AstrosticksWidget1->GetRandomizeSticks()); astrosticksModel1.SetWeight(comp3Weight); nonFiberModelList.push_back(&astrosticksModel1); signalModelString += "Astrosticks"; resultNode->AddProperty("Fiberfox.Compartment3.Description", StringProperty::New("Extra-axonal compartment 1") ); resultNode->AddProperty("Fiberfox.Compartment3.Model", StringProperty::New("Astrosticks") ); resultNode->AddProperty("Fiberfox.Compartment3.D", DoubleProperty::New(m_Controls->m_AstrosticksWidget1->GetD()) ); resultNode->AddProperty("Fiberfox.Compartment3.T2", DoubleProperty::New(astrosticksModel1.GetT2()) ); resultNode->AddProperty("Fiberfox.Compartment3.RandomSticks", BoolProperty::New(m_Controls->m_AstrosticksWidget1->GetRandomizeSticks()) ); break; case 2: dotModel1.SetGradientList(gradientList); dotModel1.SetT2(m_Controls->m_DotWidget1->GetT2()); dotModel1.SetWeight(comp3Weight); nonFiberModelList.push_back(&dotModel1); signalModelString += "Dot"; resultNode->AddProperty("Fiberfox.Compartment3.Description", StringProperty::New("Extra-axonal compartment 1") ); resultNode->AddProperty("Fiberfox.Compartment3.Model", StringProperty::New("Dot") ); resultNode->AddProperty("Fiberfox.Compartment3.T2", DoubleProperty::New(dotModel1.GetT2()) ); break; } // compartment 4 switch (m_Controls->m_Compartment4Box->currentIndex()) { case 0: break; case 1: ballModel2.SetGradientList(gradientList); ballModel2.SetBvalue(bVal); ballModel2.SetDiffusivity(m_Controls->m_BallWidget2->GetD()); ballModel2.SetT2(m_Controls->m_BallWidget2->GetT2()); ballModel2.SetWeight(comp4Weight); nonFiberModelList.push_back(&ballModel2); signalModelString += "Ball"; resultNode->AddProperty("Fiberfox.Compartment4.Description", StringProperty::New("Extra-axonal compartment 2") ); resultNode->AddProperty("Fiberfox.Compartment4.Model", StringProperty::New("Ball") ); resultNode->AddProperty("Fiberfox.Compartment4.D", DoubleProperty::New(m_Controls->m_BallWidget2->GetD()) ); resultNode->AddProperty("Fiberfox.Compartment4.T2", DoubleProperty::New(ballModel2.GetT2()) ); break; case 2: astrosticksModel2.SetGradientList(gradientList); astrosticksModel2.SetBvalue(bVal); astrosticksModel2.SetDiffusivity(m_Controls->m_AstrosticksWidget2->GetD()); astrosticksModel2.SetT2(m_Controls->m_AstrosticksWidget2->GetT2()); astrosticksModel2.SetRandomizeSticks(m_Controls->m_AstrosticksWidget2->GetRandomizeSticks()); astrosticksModel2.SetWeight(comp4Weight); nonFiberModelList.push_back(&astrosticksModel2); signalModelString += "Astrosticks"; resultNode->AddProperty("Fiberfox.Compartment4.Description", StringProperty::New("Extra-axonal compartment 2") ); resultNode->AddProperty("Fiberfox.Compartment4.Model", StringProperty::New("Astrosticks") ); resultNode->AddProperty("Fiberfox.Compartment4.D", DoubleProperty::New(m_Controls->m_AstrosticksWidget2->GetD()) ); resultNode->AddProperty("Fiberfox.Compartment4.T2", DoubleProperty::New(astrosticksModel2.GetT2()) ); resultNode->AddProperty("Fiberfox.Compartment4.RandomSticks", BoolProperty::New(m_Controls->m_AstrosticksWidget2->GetRandomizeSticks()) ); break; case 3: dotModel2.SetGradientList(gradientList); dotModel2.SetT2(m_Controls->m_DotWidget2->GetT2()); dotModel2.SetWeight(comp4Weight); nonFiberModelList.push_back(&dotModel2); signalModelString += "Dot"; resultNode->AddProperty("Fiberfox.Compartment4.Description", StringProperty::New("Extra-axonal compartment 2") ); resultNode->AddProperty("Fiberfox.Compartment4.Model", StringProperty::New("Dot") ); resultNode->AddProperty("Fiberfox.Compartment4.T2", DoubleProperty::New(dotModel2.GetT2()) ); break; } itk::TractsToDWIImageFilter::KspaceArtifactList artifactList; // artifact models QString artifactModelString(""); double noiseVariance = 0; if (m_Controls->m_AddNoise->isChecked()) { noiseVariance = m_Controls->m_NoiseLevel->value(); artifactModelString += "_NOISE"; artifactModelString += QString::number(noiseVariance); resultNode->AddProperty("Fiberfox.Noise-Variance", DoubleProperty::New(noiseVariance)); } mitk::RicianNoiseModel noiseModel; noiseModel.SetNoiseVariance(noiseVariance); mitk::GibbsRingingArtifact gibbsModel; if (m_Controls->m_AddGibbsRinging->isChecked()) { artifactModelString += "_RINGING"; resultNode->AddProperty("Fiberfox.k-Space-Undersampling", IntProperty::New(m_Controls->m_KspaceUndersamplingBox->currentText().toInt())); gibbsModel.SetKspaceCropping((double)m_Controls->m_KspaceUndersamplingBox->currentText().toInt()); artifactList.push_back(&gibbsModel); } if ( this->m_Controls->m_TEbox->value() < imageRegion.GetSize(1)*m_Controls->m_LineReadoutTimeBox->value() ) { this->m_Controls->m_TEbox->setValue( imageRegion.GetSize(1)*m_Controls->m_LineReadoutTimeBox->value() ); QMessageBox::information( NULL, "Warning", "Echo time is too short! Time not sufficient to read slice. Automaticall adjusted to "+QString::number(this->m_Controls->m_TEbox->value())+" ms"); } double lineReadoutTime = m_Controls->m_LineReadoutTimeBox->value(); // adjusting line readout time to the adapted image size needed for the DFT int y = imageRegion.GetSize(1); if ( y%2 == 1 ) y += 1; if ( y>imageRegion.GetSize(1) ) lineReadoutTime *= (double)imageRegion.GetSize(1)/y; // add signal contrast model mitk::SignalDecay contrastModel; if (m_Controls->m_RelaxationBox->isChecked()) { contrastModel.SetTinhom(this->m_Controls->m_T2starBox->value()); contrastModel.SetTE(this->m_Controls->m_TEbox->value()); contrastModel.SetTline(lineReadoutTime); artifactList.push_back(&contrastModel); artifactModelString += "_RELAX"; } // add N/2 ghosting double kOffset = 0; if (m_Controls->m_AddGhosts->isChecked()) { artifactModelString += "_GHOST"; kOffset = m_Controls->m_kOffsetBox->value(); resultNode->AddProperty("Fiberfox.Line-Offset", DoubleProperty::New(kOffset)); } // add distortions if (m_Controls->m_AddDistortions->isChecked() && m_Controls->m_FrequencyMapBox->GetSelectedNode().IsNotNull()) { mitk::DataNode::Pointer fMapNode = m_Controls->m_FrequencyMapBox->GetSelectedNode(); mitk::Image* img = dynamic_cast(fMapNode->GetData()); ItkDoubleImgType::Pointer itkImg = ItkDoubleImgType::New(); CastToItkImage< ItkDoubleImgType >(img, itkImg); if (imageRegion.GetSize(0)==itkImg->GetLargestPossibleRegion().GetSize(0) && - imageRegion.GetSize(1)==itkImg->GetLargestPossibleRegion().GetSize(1) && - imageRegion.GetSize(2)==itkImg->GetLargestPossibleRegion().GetSize(2)) + imageRegion.GetSize(1)==itkImg->GetLargestPossibleRegion().GetSize(1) && + imageRegion.GetSize(2)==itkImg->GetLargestPossibleRegion().GetSize(2)) tractsToDwiFilter->SetFrequencyMap(itkImg); } mitk::FiberBundleX::Pointer fiberBundle = dynamic_cast(m_SelectedBundles.at(i)->GetData()); if (fiberBundle->GetNumFibers()<=0) continue; tractsToDwiFilter->SetImageRegion(imageRegion); tractsToDwiFilter->SetSpacing(spacing); tractsToDwiFilter->SetOrigin(origin); tractsToDwiFilter->SetDirectionMatrix(directionMatrix); tractsToDwiFilter->SetFiberBundle(fiberBundle); tractsToDwiFilter->SetFiberModels(fiberModelList); tractsToDwiFilter->SetNonFiberModels(nonFiberModelList); tractsToDwiFilter->SetNoiseModel(&noiseModel); tractsToDwiFilter->SetKspaceArtifacts(artifactList); tractsToDwiFilter->SetkOffset(kOffset); tractsToDwiFilter->SettLine(m_Controls->m_LineReadoutTimeBox->value()); tractsToDwiFilter->SetNumberOfRepetitions(m_Controls->m_RepetitionsBox->value()); tractsToDwiFilter->SetEnforcePureFiberVoxels(m_Controls->m_EnforcePureFiberVoxelsBox->isChecked()); tractsToDwiFilter->SetInterpolationShrink(m_Controls->m_InterpolationShrink->value()); tractsToDwiFilter->SetFiberRadius(m_Controls->m_FiberRadius->value()); tractsToDwiFilter->SetSignalScale(m_Controls->m_SignalScaleBox->value()); if (m_Controls->m_InterpolationShrink->value()<1000) tractsToDwiFilter->SetUseInterpolation(true); if (m_TissueMask.IsNotNull()) { ItkUcharImgType::Pointer mask = ItkUcharImgType::New(); mitk::CastToItkImage(m_TissueMask, mask); tractsToDwiFilter->SetTissueMask(mask); } tractsToDwiFilter->Update(); mitk::DiffusionImage::Pointer image = mitk::DiffusionImage::New(); image->SetVectorImage( tractsToDwiFilter->GetOutput() ); image->SetB_Value(bVal); image->SetDirections(gradientList); image->InitializeFromVectorImage(); resultNode->SetData( image ); resultNode->SetName(m_SelectedBundles.at(i)->GetName() +"_D"+QString::number(imageRegion.GetSize(0)).toStdString() +"-"+QString::number(imageRegion.GetSize(1)).toStdString() +"-"+QString::number(imageRegion.GetSize(2)).toStdString() +"_S"+QString::number(spacing[0]).toStdString() +"-"+QString::number(spacing[1]).toStdString() +"-"+QString::number(spacing[2]).toStdString() +"_b"+QString::number(bVal).toStdString() +"_"+signalModelString.toStdString() +artifactModelString.toStdString()); GetDataStorage()->Add(resultNode, m_SelectedBundles.at(i)); resultNode->AddProperty("Fiberfox.InterpolationShrink", IntProperty::New(m_Controls->m_InterpolationShrink->value())); resultNode->AddProperty("Fiberfox.SignalScale", IntProperty::New(m_Controls->m_SignalScaleBox->value())); resultNode->AddProperty("Fiberfox.FiberRadius", IntProperty::New(m_Controls->m_FiberRadius->value())); resultNode->AddProperty("Fiberfox.Tinhom", IntProperty::New(m_Controls->m_T2starBox->value())); resultNode->AddProperty("Fiberfox.Repetitions", IntProperty::New(m_Controls->m_RepetitionsBox->value())); resultNode->AddProperty("Fiberfox.b-value", DoubleProperty::New(bVal)); resultNode->AddProperty("Fiberfox.Model", StringProperty::New(signalModelString.toStdString())); resultNode->AddProperty("Fiberfox.PureFiberVoxels", BoolProperty::New(m_Controls->m_EnforcePureFiberVoxelsBox->isChecked())); resultNode->AddProperty("binary", BoolProperty::New(false)); resultNode->SetProperty( "levelwindow", mitk::LevelWindowProperty::New(tractsToDwiFilter->GetLevelWindow()) ); if (m_Controls->m_KspaceImageBox->isChecked()) { - itk::Image::Pointer kspace = tractsToDwiFilter->GetKspaceImage(); + itk::TractsToDWIImageFilter::ItkDoubleImgType::Pointer kspace = tractsToDwiFilter->GetKspaceImage(); mitk::Image::Pointer image = mitk::Image::New(); image->InitializeByItk(kspace.GetPointer()); image->SetVolume(kspace->GetBufferPointer()); mitk::DataNode::Pointer node = mitk::DataNode::New(); node->SetData( image ); node->SetName(m_SelectedBundles.at(i)->GetName()+"_k-space"); GetDataStorage()->Add(node, m_SelectedBundles.at(i)); } + if (m_Controls->m_VolumeFractionsBox->isChecked()) + { + std::vector< itk::TractsToDWIImageFilter::ItkDoubleImgType::Pointer > volumeFractions = tractsToDwiFilter->GetVolumeFractions(); + for (int k=0; kInitializeByItk(volumeFractions.at(k).GetPointer()); + image->SetVolume(volumeFractions.at(k)->GetBufferPointer()); + + mitk::DataNode::Pointer node = mitk::DataNode::New(); + node->SetData( image ); + node->SetName(m_SelectedBundles.at(i)->GetName()+"_CompartmentVolume-"+QString::number(k).toStdString()); + GetDataStorage()->Add(node, m_SelectedBundles.at(i)); + } + } + mitk::BaseData::Pointer basedata = resultNode->GetData(); if (basedata.IsNotNull()) { mitk::RenderingManager::GetInstance()->InitializeViews( basedata->GetTimeSlicedGeometry(), mitk::RenderingManager::REQUEST_UPDATE_ALL, true ); mitk::RenderingManager::GetInstance()->RequestUpdateAll(); } } } void QmitkFiberfoxView::ApplyTransform() { vector< mitk::DataNode::Pointer > selectedBundles; for( int i=0; iGetDerivations(m_SelectedImages.at(i)); for( mitk::DataStorage::SetOfObjects::const_iterator it = derivations->begin(); it != derivations->end(); ++it ) { mitk::DataNode::Pointer fibNode = *it; if ( fibNode.IsNotNull() && dynamic_cast(fibNode->GetData()) ) selectedBundles.push_back(fibNode); } } if (selectedBundles.empty()) selectedBundles = m_SelectedBundles2; if (!selectedBundles.empty()) { std::vector::const_iterator it = selectedBundles.begin(); for (it; it!=selectedBundles.end(); ++it) { mitk::FiberBundleX::Pointer fib = dynamic_cast((*it)->GetData()); fib->RotateAroundAxis(m_Controls->m_XrotBox->value(), m_Controls->m_YrotBox->value(), m_Controls->m_ZrotBox->value()); fib->TranslateFibers(m_Controls->m_XtransBox->value(), m_Controls->m_YtransBox->value(), m_Controls->m_ZtransBox->value()); fib->ScaleFibers(m_Controls->m_XscaleBox->value(), m_Controls->m_YscaleBox->value(), m_Controls->m_ZscaleBox->value()); // handle child fiducials if (m_Controls->m_IncludeFiducials->isChecked()) { mitk::DataStorage::SetOfObjects::ConstPointer derivations = GetDataStorage()->GetDerivations(*it); for( mitk::DataStorage::SetOfObjects::const_iterator it2 = derivations->begin(); it2 != derivations->end(); ++it2 ) { mitk::DataNode::Pointer fiducialNode = *it2; if ( fiducialNode.IsNotNull() && dynamic_cast(fiducialNode->GetData()) ) { mitk::PlanarEllipse* pe = dynamic_cast(fiducialNode->GetData()); mitk::Geometry3D* geom = pe->GetGeometry(); // translate mitk::Vector3D world; world[0] = m_Controls->m_XtransBox->value(); world[1] = m_Controls->m_YtransBox->value(); world[2] = m_Controls->m_ZtransBox->value(); geom->Translate(world); // calculate rotation matrix double x = m_Controls->m_XrotBox->value()*M_PI/180; double y = m_Controls->m_YrotBox->value()*M_PI/180; double z = m_Controls->m_ZrotBox->value()*M_PI/180; itk::Matrix< float, 3, 3 > rotX; rotX.SetIdentity(); rotX[1][1] = cos(x); rotX[2][2] = rotX[1][1]; rotX[1][2] = -sin(x); rotX[2][1] = -rotX[1][2]; itk::Matrix< float, 3, 3 > rotY; rotY.SetIdentity(); rotY[0][0] = cos(y); rotY[2][2] = rotY[0][0]; rotY[0][2] = sin(y); rotY[2][0] = -rotY[0][2]; itk::Matrix< float, 3, 3 > rotZ; rotZ.SetIdentity(); rotZ[0][0] = cos(z); rotZ[1][1] = rotZ[0][0]; rotZ[0][1] = -sin(z); rotZ[1][0] = -rotZ[0][1]; itk::Matrix< float, 3, 3 > rot = rotZ*rotY*rotX; // transform control point coordinate into geometry translation geom->SetOrigin(pe->GetWorldControlPoint(0)); mitk::Point2D cp; cp.Fill(0.0); pe->SetControlPoint(0, cp); // rotate fiducial geom->GetIndexToWorldTransform()->SetMatrix(rot*geom->GetIndexToWorldTransform()->GetMatrix()); // implicit translation mitk::Vector3D trans; trans[0] = geom->GetOrigin()[0]-fib->GetGeometry()->GetCenter()[0]; trans[1] = geom->GetOrigin()[1]-fib->GetGeometry()->GetCenter()[1]; trans[2] = geom->GetOrigin()[2]-fib->GetGeometry()->GetCenter()[2]; mitk::Vector3D newWc = rot*trans; newWc = newWc-trans; geom->Translate(newWc); } } } } } else { for (int i=0; i(m_SelectedFiducials.at(i)->GetData()); mitk::Geometry3D* geom = pe->GetGeometry(); // translate mitk::Vector3D world; world[0] = m_Controls->m_XtransBox->value(); world[1] = m_Controls->m_YtransBox->value(); world[2] = m_Controls->m_ZtransBox->value(); geom->Translate(world); // calculate rotation matrix double x = m_Controls->m_XrotBox->value()*M_PI/180; double y = m_Controls->m_YrotBox->value()*M_PI/180; double z = m_Controls->m_ZrotBox->value()*M_PI/180; itk::Matrix< float, 3, 3 > rotX; rotX.SetIdentity(); rotX[1][1] = cos(x); rotX[2][2] = rotX[1][1]; rotX[1][2] = -sin(x); rotX[2][1] = -rotX[1][2]; itk::Matrix< float, 3, 3 > rotY; rotY.SetIdentity(); rotY[0][0] = cos(y); rotY[2][2] = rotY[0][0]; rotY[0][2] = sin(y); rotY[2][0] = -rotY[0][2]; itk::Matrix< float, 3, 3 > rotZ; rotZ.SetIdentity(); rotZ[0][0] = cos(z); rotZ[1][1] = rotZ[0][0]; rotZ[0][1] = -sin(z); rotZ[1][0] = -rotZ[0][1]; itk::Matrix< float, 3, 3 > rot = rotZ*rotY*rotX; // transform control point coordinate into geometry translation geom->SetOrigin(pe->GetWorldControlPoint(0)); mitk::Point2D cp; cp.Fill(0.0); pe->SetControlPoint(0, cp); // rotate fiducial geom->GetIndexToWorldTransform()->SetMatrix(rot*geom->GetIndexToWorldTransform()->GetMatrix()); } if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } mitk::RenderingManager::GetInstance()->RequestUpdateAll(); } void QmitkFiberfoxView::CopyBundles() { if ( m_SelectedBundles.size()<1 ){ QMessageBox::information( NULL, "Warning", "Select at least one fiber bundle!"); MITK_WARN("QmitkFiberProcessingView") << "Select at least one fiber bundle!"; return; } std::vector::const_iterator it = m_SelectedBundles.begin(); for (it; it!=m_SelectedBundles.end(); ++it) { // find parent image mitk::DataNode::Pointer parentNode; mitk::DataStorage::SetOfObjects::ConstPointer parentImgs = GetDataStorage()->GetSources(*it); for( mitk::DataStorage::SetOfObjects::const_iterator it2 = parentImgs->begin(); it2 != parentImgs->end(); ++it2 ) { mitk::DataNode::Pointer pImgNode = *it2; if ( pImgNode.IsNotNull() && dynamic_cast(pImgNode->GetData()) ) { parentNode = pImgNode; break; } } mitk::FiberBundleX::Pointer fib = dynamic_cast((*it)->GetData()); mitk::FiberBundleX::Pointer newBundle = fib->GetDeepCopy(); QString name((*it)->GetName().c_str()); name += "_copy"; mitk::DataNode::Pointer fbNode = mitk::DataNode::New(); fbNode->SetData(newBundle); fbNode->SetName(name.toStdString()); fbNode->SetVisibility(true); if (parentNode.IsNotNull()) GetDataStorage()->Add(fbNode, parentNode); else GetDataStorage()->Add(fbNode); // copy child fiducials if (m_Controls->m_IncludeFiducials->isChecked()) { mitk::DataStorage::SetOfObjects::ConstPointer derivations = GetDataStorage()->GetDerivations(*it); for( mitk::DataStorage::SetOfObjects::const_iterator it2 = derivations->begin(); it2 != derivations->end(); ++it2 ) { mitk::DataNode::Pointer fiducialNode = *it2; if ( fiducialNode.IsNotNull() && dynamic_cast(fiducialNode->GetData()) ) { mitk::PlanarEllipse::Pointer pe = mitk::PlanarEllipse::New(); pe->DeepCopy(dynamic_cast(fiducialNode->GetData())); mitk::DataNode::Pointer newNode = mitk::DataNode::New(); newNode->SetData(pe); newNode->SetName(fiducialNode->GetName()); GetDataStorage()->Add(newNode, fbNode); } } } } mitk::RenderingManager::GetInstance()->RequestUpdateAll(); } void QmitkFiberfoxView::JoinBundles() { if ( m_SelectedBundles.size()<2 ){ QMessageBox::information( NULL, "Warning", "Select at least two fiber bundles!"); MITK_WARN("QmitkFiberProcessingView") << "Select at least two fiber bundles!"; return; } std::vector::const_iterator it = m_SelectedBundles.begin(); mitk::FiberBundleX::Pointer newBundle = dynamic_cast((*it)->GetData()); QString name(""); name += QString((*it)->GetName().c_str()); ++it; for (it; it!=m_SelectedBundles.end(); ++it) { newBundle = newBundle->AddBundle(dynamic_cast((*it)->GetData())); name += "+"+QString((*it)->GetName().c_str()); } mitk::DataNode::Pointer fbNode = mitk::DataNode::New(); fbNode->SetData(newBundle); fbNode->SetName(name.toStdString()); fbNode->SetVisibility(true); GetDataStorage()->Add(fbNode); mitk::RenderingManager::GetInstance()->RequestUpdateAll(); } void QmitkFiberfoxView::UpdateGui() { m_Controls->m_FiberBundleLabel->setText("mandatory"); m_Controls->m_GeometryFrame->setEnabled(true); m_Controls->m_GeometryMessage->setVisible(false); m_Controls->m_DiffusionPropsMessage->setVisible(false); m_Controls->m_FiberGenMessage->setVisible(true); m_Controls->m_TransformBundlesButton->setEnabled(false); m_Controls->m_CopyBundlesButton->setEnabled(false); m_Controls->m_GenerateFibersButton->setEnabled(false); m_Controls->m_FlipButton->setEnabled(false); m_Controls->m_CircleButton->setEnabled(false); m_Controls->m_BvalueBox->setEnabled(true); m_Controls->m_NumGradientsBox->setEnabled(true); m_Controls->m_JoinBundlesButton->setEnabled(false); m_Controls->m_AlignOnGrid->setEnabled(false); if (m_SelectedFiducial.IsNotNull()) { m_Controls->m_TransformBundlesButton->setEnabled(true); m_Controls->m_FlipButton->setEnabled(true); m_Controls->m_AlignOnGrid->setEnabled(true); } if (m_SelectedImage.IsNotNull() || !m_SelectedBundles.empty()) { m_Controls->m_TransformBundlesButton->setEnabled(true); m_Controls->m_CircleButton->setEnabled(true); m_Controls->m_FiberGenMessage->setVisible(false); m_Controls->m_AlignOnGrid->setEnabled(true); } if (m_TissueMask.IsNotNull() || m_SelectedImage.IsNotNull()) { m_Controls->m_GeometryMessage->setVisible(true); m_Controls->m_GeometryFrame->setEnabled(false); } if (m_SelectedDWI.IsNotNull()) { m_Controls->m_DiffusionPropsMessage->setVisible(true); m_Controls->m_BvalueBox->setEnabled(false); m_Controls->m_NumGradientsBox->setEnabled(false); m_Controls->m_GeometryMessage->setVisible(true); m_Controls->m_GeometryFrame->setEnabled(false); } if (!m_SelectedBundles.empty()) { m_Controls->m_CopyBundlesButton->setEnabled(true); m_Controls->m_GenerateFibersButton->setEnabled(true); m_Controls->m_FiberBundleLabel->setText(m_SelectedBundles.at(0)->GetName().c_str()); if (m_SelectedBundles.size()>1) m_Controls->m_JoinBundlesButton->setEnabled(true); } } void QmitkFiberfoxView::OnSelectionChanged( berry::IWorkbenchPart::Pointer, const QList& nodes ) { m_SelectedBundles2.clear(); m_SelectedImages.clear(); m_SelectedFiducials.clear(); m_SelectedFiducial = NULL; m_TissueMask = NULL; m_SelectedBundles.clear(); m_SelectedImage = NULL; m_SelectedDWI = NULL; m_Controls->m_TissueMaskLabel->setText("optional"); // iterate all selected objects, adjust warning visibility for( int i=0; i*>(node->GetData()) ) { m_SelectedDWI = node; m_SelectedImage = node; m_SelectedImages.push_back(node); } else if( node.IsNotNull() && dynamic_cast(node->GetData()) ) { m_SelectedImages.push_back(node); m_SelectedImage = node; bool isBinary = false; node->GetPropertyValue("binary", isBinary); if (isBinary) { m_TissueMask = dynamic_cast(node->GetData()); m_Controls->m_TissueMaskLabel->setText(node->GetName().c_str()); } } else if ( node.IsNotNull() && dynamic_cast(node->GetData()) ) { m_SelectedBundles2.push_back(node); if (m_Controls->m_RealTimeFibers->isChecked()) { m_SelectedBundles.push_back(node); mitk::FiberBundleX::Pointer newFib = dynamic_cast(node->GetData()); if (newFib->GetNumFibers()!=m_Controls->m_FiberDensityBox->value()) GenerateFibers(); } else m_SelectedBundles.push_back(node); } else if ( node.IsNotNull() && dynamic_cast(node->GetData()) ) { m_SelectedFiducials.push_back(node); m_SelectedFiducial = node; m_SelectedBundles.clear(); mitk::DataStorage::SetOfObjects::ConstPointer parents = GetDataStorage()->GetSources(node); for( mitk::DataStorage::SetOfObjects::const_iterator it = parents->begin(); it != parents->end(); ++it ) { mitk::DataNode::Pointer pNode = *it; if ( pNode.IsNotNull() && dynamic_cast(pNode->GetData()) ) m_SelectedBundles.push_back(pNode); } } } UpdateGui(); } void QmitkFiberfoxView::EnableCrosshairNavigation() { MITK_DEBUG << "EnableCrosshairNavigation"; // enable the crosshair navigation if (mitk::ILinkedRenderWindowPart* linkedRenderWindow = dynamic_cast(this->GetRenderWindowPart())) { MITK_DEBUG << "enabling linked navigation"; linkedRenderWindow->EnableLinkedNavigation(true); // linkedRenderWindow->EnableSlicingPlanes(true); } if (m_Controls->m_RealTimeFibers->isChecked()) GenerateFibers(); } void QmitkFiberfoxView::DisableCrosshairNavigation() { MITK_DEBUG << "DisableCrosshairNavigation"; // disable the crosshair navigation during the drawing if (mitk::ILinkedRenderWindowPart* linkedRenderWindow = dynamic_cast(this->GetRenderWindowPart())) { MITK_DEBUG << "disabling linked navigation"; linkedRenderWindow->EnableLinkedNavigation(false); // linkedRenderWindow->EnableSlicingPlanes(false); } } void QmitkFiberfoxView::NodeRemoved(const mitk::DataNode* node) { mitk::DataNode* nonConstNode = const_cast(node); std::map::iterator it = m_DataNodeToPlanarFigureData.find(nonConstNode); if( it != m_DataNodeToPlanarFigureData.end() ) { QmitkPlanarFigureData& data = it->second; // remove observers data.m_Figure->RemoveObserver( data.m_EndPlacementObserverTag ); data.m_Figure->RemoveObserver( data.m_SelectObserverTag ); data.m_Figure->RemoveObserver( data.m_StartInteractionObserverTag ); data.m_Figure->RemoveObserver( data.m_EndInteractionObserverTag ); m_DataNodeToPlanarFigureData.erase( it ); } } void QmitkFiberfoxView::NodeAdded( const mitk::DataNode* node ) { // add observer for selection in renderwindow mitk::PlanarFigure* figure = dynamic_cast(node->GetData()); bool isPositionMarker (false); node->GetBoolProperty("isContourMarker", isPositionMarker); if( figure && !isPositionMarker ) { MITK_DEBUG << "figure added. will add interactor if needed."; mitk::PlanarFigureInteractor::Pointer figureInteractor = dynamic_cast(node->GetInteractor()); mitk::DataNode* nonConstNode = const_cast( node ); if(figureInteractor.IsNull()) { figureInteractor = mitk::PlanarFigureInteractor::New("PlanarFigureInteractor", nonConstNode); } else { // just to be sure that the interactor is not added twice mitk::GlobalInteraction::GetInstance()->RemoveInteractor(figureInteractor); } MITK_DEBUG << "adding interactor to globalinteraction"; mitk::GlobalInteraction::GetInstance()->AddInteractor(figureInteractor); MITK_DEBUG << "will now add observers for planarfigure"; QmitkPlanarFigureData data; data.m_Figure = figure; // // add observer for event when figure has been placed typedef itk::SimpleMemberCommand< QmitkFiberfoxView > SimpleCommandType; // SimpleCommandType::Pointer initializationCommand = SimpleCommandType::New(); // initializationCommand->SetCallbackFunction( this, &QmitkFiberfoxView::PlanarFigureInitialized ); // data.m_EndPlacementObserverTag = figure->AddObserver( mitk::EndPlacementPlanarFigureEvent(), initializationCommand ); // add observer for event when figure is picked (selected) typedef itk::MemberCommand< QmitkFiberfoxView > MemberCommandType; MemberCommandType::Pointer selectCommand = MemberCommandType::New(); selectCommand->SetCallbackFunction( this, &QmitkFiberfoxView::PlanarFigureSelected ); data.m_SelectObserverTag = figure->AddObserver( mitk::SelectPlanarFigureEvent(), selectCommand ); // add observer for event when interaction with figure starts SimpleCommandType::Pointer startInteractionCommand = SimpleCommandType::New(); startInteractionCommand->SetCallbackFunction( this, &QmitkFiberfoxView::DisableCrosshairNavigation); data.m_StartInteractionObserverTag = figure->AddObserver( mitk::StartInteractionPlanarFigureEvent(), startInteractionCommand ); // add observer for event when interaction with figure starts SimpleCommandType::Pointer endInteractionCommand = SimpleCommandType::New(); endInteractionCommand->SetCallbackFunction( this, &QmitkFiberfoxView::EnableCrosshairNavigation); data.m_EndInteractionObserverTag = figure->AddObserver( mitk::EndInteractionPlanarFigureEvent(), endInteractionCommand ); m_DataNodeToPlanarFigureData[nonConstNode] = data; } } void QmitkFiberfoxView::PlanarFigureSelected( itk::Object* object, const itk::EventObject& ) { mitk::TNodePredicateDataType::Pointer isPf = mitk::TNodePredicateDataType::New(); mitk::DataStorage::SetOfObjects::ConstPointer allPfs = this->GetDataStorage()->GetSubset( isPf ); for ( mitk::DataStorage::SetOfObjects::const_iterator it = allPfs->begin(); it!=allPfs->end(); ++it) { mitk::DataNode* node = *it; if( node->GetData() == object ) { node->SetSelected(true); m_SelectedFiducial = node; } else node->SetSelected(false); } UpdateGui(); this->RequestRenderWindowUpdate(); } void QmitkFiberfoxView::SetFocus() { m_Controls->m_CircleButton->setFocus(); } diff --git a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkFiberfoxViewControls.ui b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkFiberfoxViewControls.ui index 942a3ba281..1e9af9ab77 100644 --- a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkFiberfoxViewControls.ui +++ b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkFiberfoxViewControls.ui @@ -1,2153 +1,2166 @@ QmitkFiberfoxViewControls 0 0 493 - 1504 + 1532 Form 0 Fiber Definition Qt::Vertical 20 40 color: rgb(255, 0, 0); Please select an image or an existing fiber bundle to draw the fiber fiducials. If you can't provide a suitable image, generate one using the "Signal Generation" tab. Qt::AutoText Qt::AlignJustify|Qt::AlignVCenter true Fiducial Options All fiducials are treated as circles with the same radius as the first fiducial. Use Constant Fiducial Radius false false Align selected fiducials with voxel grid. Shifts selected fiducials to nearest voxel center. Align With Grid Operations false Copy Bundles false Transform Selection QFrame::NoFrame QFrame::Raised 0 Y false Rotation angle (in degree) around x-axis. -360.000000000000000 360.000000000000000 0.100000000000000 Axis: false Rotation angle (in degree) around y-axis. -360.000000000000000 360.000000000000000 0.100000000000000 Translation: false Translation (in mm) in direction of the z-axis. -1000.000000000000000 1000.000000000000000 0.100000000000000 Translation (in mm) in direction of the y-axis. -1000.000000000000000 1000.000000000000000 0.100000000000000 X false Rotation: false Z false Rotation angle (in degree) around z-axis. -360.000000000000000 360.000000000000000 0.100000000000000 Translation (in mm) in direction of the x-axis. -1000.000000000000000 1000.000000000000000 0.100000000000000 Scaling: false Scaling factor for selected fiber bundle along the x-axis. 0.010000000000000 10.000000000000000 0.010000000000000 1.000000000000000 Scaling factor for selected fiber bundle along the y-axis. 0.010000000000000 10.000000000000000 0.010000000000000 1.000000000000000 Scaling factor for selected fiber bundle along the z-axis. 0.010000000000000 10.000000000000000 0.010000000000000 1.000000000000000 false Join Bundles If checked, the fiducials belonging to the modified bundle are also modified. Include Fiducials true Fiber Options QFrame::NoFrame QFrame::Raised 0 QFrame::NoFrame QFrame::Raised 0 Tension: false Fiber Sampling: false 3 -1.000000000000000 1.000000000000000 0.100000000000000 0.000000000000000 Fiber sampling points (per cm) 1 100 1 10 3 -1.000000000000000 1.000000000000000 0.100000000000000 0.000000000000000 Bias: false Continuity: false 3 -1.000000000000000 1.000000000000000 0.100000000000000 0.000000000000000 QFrame::NoFrame QFrame::Raised 0 6 #Fibers: false Specify number of fibers to generate for the selected bundle. 1 1000000 100 100 false Generate Fibers QFrame::NoFrame QFrame::Raised 0 Select fiber distribution inside of the fiducials. Uniform Gaussian Fiber Distribution: false Variance of the gaussian 3 0.001000000000000 10.000000000000000 0.010000000000000 0.100000000000000 QFrame::NoFrame QFrame::Raised 0 Disable to only generate fibers if "Generate Fibers" button is pressed. Real Time Fibers true Disable to only generate fibers if "Generate Fibers" button is pressed. Advanced Options false QFrame::NoFrame QFrame::Raised 0 false 30 30 Draw elliptical fiducial. :/QmitkDiffusionImaging/circle.png:/QmitkDiffusionImaging/circle.png 32 32 false true false 30 30 Flip fiber waypoints of selcted fiducial around one axis. :/QmitkDiffusionImaging/refresh.xpm:/QmitkDiffusionImaging/refresh.xpm 32 32 false true Qt::Horizontal 40 20 Signal Generation Intra-axonal Compartment Select signal model for intra-axonal compartment. Stick Model Zeppelin Model Tensor Model Data Fiber Bundle: false <html><head/><body><p><span style=" color:#ff0000;">mandatory</span></p></body></html> true Tissue Mask: false <html><head/><body><p><span style=" color:#969696;">optional</span></p></body></html> true Extra-axonal Compartments Select signal model for extra-axonal compartment. Ball Model Astrosticks Model Dot Model Select signal model for extra-axonal compartment. -- Ball Model Astrosticks Model Dot Model Qt::Horizontal QFrame::NoFrame QFrame::Raised 0 Weighting factor between the two extra-axonal compartments. 1.000000000000000 0.100000000000000 0.300000000000000 Compartment Fraction: true Start DWI generation from selected fiebr bundle. If no fiber bundle is selected, a grayscale image containing a simple gradient is generated. Generate Image Image Settings QFrame::NoFrame QFrame::Raised 0 6 Signal Scale: Interpolation Shrink: Line Readout Time: false Fiber radius used to calculate volume fractions (in µm). Set to 0 for automatic radius estimation. 0 1000 0 T2* relaxation time (in milliseconds). 100.000000000000000 0.100000000000000 1.000000000000000 Fiber Radius: Relaxation time due to magnetic field inhomogeneities (T2', in milliseconds). 1 10000 1 50 TE in milliseconds 1 10000 1 100 Number of signal averages. Increase to reduce noise. 1 100 1 1 <html><head/><body><p>Large values shrink (towards nearest neighbour interpolation), small values strech interpolation function (towards linear interpolation). 1000 equals nearest neighbour interpolation.</p></body></html> 1 1000 1000 TE in milliseconds 1 10000 1 100 Repetitions: Output k-Space Image false <html><head/><body><p>Echo Time <span style=" font-style:italic;">TE</span>: </p></body></html> false Disable partial volume. Treat voxel content as fiber-only if at least one fiber is present. Disable Partial Volume Effects false <html><head/><body><p><span style=" font-style:italic;">T</span><span style=" font-style:italic; vertical-align:sub;">inhom</span> Relaxation: </p></body></html> false <html><head/><body><p><span style=" font-style:italic;">TE</span>, <span style=" font-style:italic;">T</span><span style=" font-style:italic; vertical-align:sub;">inhom</span> and <span style=" font-style:italic;">T2</span> will have no effect if unchecked.</p></body></html> Simulate Signal Relaxation true + + + + Output one image per compartment containing the corresponding volume fractions per voxel. + + + Output Volume Fractions + + + false + + + color: rgb(255, 0, 0); Using geometry of selected image! color: rgb(255, 0, 0); Using gradients of selected DWI! QFrame::NoFrame QFrame::Raised 0 3 0.100000000000000 50.000000000000000 0.100000000000000 2.000000000000000 Image Spacing: 3 0.100000000000000 50.000000000000000 0.100000000000000 2.000000000000000 3 0.100000000000000 50.000000000000000 0.100000000000000 2.000000000000000 Image Dimensions: Fiber sampling factor which determines the accuracy of the calculated fiber and non-fiber volume fractions. 1 1000 1 11 Fiber sampling factor which determines the accuracy of the calculated fiber and non-fiber volume fractions. 1 1000 1 11 Fiber sampling factor which determines the accuracy of the calculated fiber and non-fiber volume fractions. 1 1000 1 3 QFrame::NoFrame QFrame::Raised 0 6 Gradient Directions: Number of gradient directions distributed over the half sphere. 0 10000 1 30 b-Value: false b-value in mm/s² 0 10000 100 1000 Advanced Options Qt::Vertical 20 40 Noise and other Artifacts true QFrame::NoFrame QFrame::Raised 6 0 k-Space Undersampling: false Image is upsampled using this factor, afterwards fourier transformed, cropped to the original size and then inverse fourier transformed. 0 2 4 8 16 32 64 128 256 Add Distortions false Add Gibbs Ringing false Add Rician Noise true QFrame::NoFrame QFrame::Raised 0 Variance: Variance of Rician noise model. 4 0.000000000000000 100000.000000000000000 0.001000000000000 25.000000000000000 Add N/2 Ghosts false true QFrame::NoFrame QFrame::Raised 6 0 K-Space Line Offset: false A larger offset increases the inensity of the ghost image. 3 1.000000000000000 0.010000000000000 0.100000000000000 true QFrame::NoFrame QFrame::Raised 6 0 Frequency Map: false Select image specifying the frequency inhomogeneities (in Hz). Inter-axonal Compartment Select signal model for intra-axonal compartment. -- Stick Model Zeppelin Model Tensor Model QmitkTensorModelParametersWidget QWidget
QmitkTensorModelParametersWidget.h
1 QmitkStickModelParametersWidget QWidget
QmitkStickModelParametersWidget.h
1 QmitkZeppelinModelParametersWidget QWidget
QmitkZeppelinModelParametersWidget.h
1 QmitkBallModelParametersWidget QWidget
QmitkBallModelParametersWidget.h
1 QmitkAstrosticksModelParametersWidget QWidget
QmitkAstrosticksModelParametersWidget.h
1 QmitkDotModelParametersWidget QWidget
QmitkDotModelParametersWidget.h
1 QmitkDataStorageComboBox QComboBox
QmitkDataStorageComboBox.h
 m_CircleButton m_FlipButton m_RealTimeFibers m_AdvancedOptionsBox m_DistributionBox m_VarianceBox m_FiberDensityBox m_FiberSamplingBox m_TensionBox m_ContinuityBox m_BiasBox m_GenerateFibersButton m_ConstantRadiusBox m_AlignOnGrid m_XrotBox m_YrotBox m_ZrotBox m_XtransBox m_YtransBox m_ZtransBox m_XscaleBox m_YscaleBox m_ZscaleBox m_TransformBundlesButton m_CopyBundlesButton m_JoinBundlesButton m_IncludeFiducials m_GenerateImageButton m_SizeX m_SizeY m_SizeZ m_SpacingX m_SpacingY m_SpacingZ m_NumGradientsBox m_BvalueBox m_AdvancedOptionsBox_2 m_RepetitionsBox m_SignalScaleBox m_TEbox m_LineReadoutTimeBox m_T2starBox m_FiberRadius m_InterpolationShrink m_EnforcePureFiberVoxelsBox m_KspaceImageBox m_Compartment1Box m_Compartment2Box m_Compartment3Box m_Compartment4Box m_Comp4FractionBox m_AddNoise m_NoiseLevel m_AddGhosts m_kOffsetBox m_AddDistortions m_FrequencyMapBox m_AddGibbsRinging m_KspaceUndersamplingBox tabWidget diff --git a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkOdfMaximaExtractionView.cpp b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkOdfMaximaExtractionView.cpp index 2f26f69ef9..88c5bc24ac 100644 --- a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkOdfMaximaExtractionView.cpp +++ b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkOdfMaximaExtractionView.cpp @@ -1,751 +1,753 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ //misc #define _USE_MATH_DEFINES #include #include // Blueberry #include #include // Qmitk #include "QmitkOdfMaximaExtractionView.h" // MITK #include #include #include #include #include #include // ITK #include #include #include #include #include #include #include const std::string QmitkOdfMaximaExtractionView::VIEW_ID = "org.mitk.views.odfmaximaextractionview"; using namespace mitk; QmitkOdfMaximaExtractionView::QmitkOdfMaximaExtractionView() : QmitkFunctionality() , m_Controls( 0 ) , m_MultiWidget( NULL ) { } // Destructor QmitkOdfMaximaExtractionView::~QmitkOdfMaximaExtractionView() { } void QmitkOdfMaximaExtractionView::CreateQtPartControl( QWidget *parent ) { // build up qt view, unless already done if ( !m_Controls ) { // create GUI widgets from the Qt Designer's .ui file m_Controls = new Ui::QmitkOdfMaximaExtractionViewControls; m_Controls->setupUi( parent ); connect((QObject*) m_Controls->m_StartTensor, SIGNAL(clicked()), (QObject*) this, SLOT(StartTensor())); connect((QObject*) m_Controls->m_StartFiniteDiff, SIGNAL(clicked()), (QObject*) this, SLOT(StartFiniteDiff())); connect((QObject*) m_Controls->m_GenerateImageButton, SIGNAL(clicked()), (QObject*) this, SLOT(GenerateImage())); connect((QObject*) m_Controls->m_ImportPeaks, SIGNAL(clicked()), (QObject*) this, SLOT(ConvertPeaks())); connect((QObject*) m_Controls->m_ImportShCoeffs, SIGNAL(clicked()), (QObject*) this, SLOT(ConvertShCoeffs())); } } void QmitkOdfMaximaExtractionView::UpdateGui() { m_Controls->m_GenerateImageButton->setEnabled(false); m_Controls->m_StartFiniteDiff->setEnabled(false); m_Controls->m_StartTensor->setEnabled(false); m_Controls->m_CoeffImageFrame->setEnabled(false); if (!m_ImageNodes.empty() || !m_TensorImageNodes.empty()) { m_Controls->m_InputData->setTitle("Input Data"); if (!m_TensorImageNodes.empty()) { m_Controls->m_DwiFibLabel->setText(m_TensorImageNodes.front()->GetName().c_str()); m_Controls->m_StartTensor->setEnabled(true); } else { m_Controls->m_DwiFibLabel->setText(m_ImageNodes.front()->GetName().c_str()); m_Controls->m_StartFiniteDiff->setEnabled(true); m_Controls->m_GenerateImageButton->setEnabled(true); m_Controls->m_CoeffImageFrame->setEnabled(true); m_Controls->m_ShOrderBox->setEnabled(true); m_Controls->m_MaxNumPeaksBox->setEnabled(true); m_Controls->m_PeakThresholdBox->setEnabled(true); m_Controls->m_AbsoluteThresholdBox->setEnabled(true); } } else m_Controls->m_DwiFibLabel->setText("mandatory"); if (m_ImageNodes.empty()) { m_Controls->m_ImportPeaks->setEnabled(false); m_Controls->m_ImportShCoeffs->setEnabled(false); } else { m_Controls->m_ImportPeaks->setEnabled(true); m_Controls->m_ImportShCoeffs->setEnabled(true); } if (!m_BinaryImageNodes.empty()) { m_Controls->m_MaskLabel->setText(m_BinaryImageNodes.front()->GetName().c_str()); } else { m_Controls->m_MaskLabel->setText("optional"); } } template void QmitkOdfMaximaExtractionView::TemplatedConvertShCoeffs(mitk::Image* mitkImg) { typedef itk::ShCoefficientImageImporter< float, shOrder > FilterType; typedef mitk::ImageToItk< itk::Image< float, 4 > > CasterType; CasterType::Pointer caster = CasterType::New(); caster->SetInput(mitkImg); caster->Update(); typename FilterType::Pointer filter = FilterType::New(); switch (m_Controls->m_ToolkitBox->currentIndex()) { case 0: filter->SetToolkit(FilterType::FSL); break; case 1: filter->SetToolkit(FilterType::MRTRIX); break; default: filter->SetToolkit(FilterType::FSL); } filter->SetInputImage(caster->GetOutput()); filter->GenerateData(); typename FilterType::QballImageType::Pointer itkQbi = filter->GetQballImage(); typename FilterType::CoefficientImageType::Pointer itkCi = filter->GetCoefficientImage(); { mitk::Image::Pointer img = mitk::Image::New(); img->InitializeByItk( itkCi.GetPointer() ); img->SetVolume( itkCi->GetBufferPointer() ); DataNode::Pointer node = DataNode::New(); node->SetData(img); node->SetName("_ShCoefficientImage"); + node->SetVisibility(false); GetDataStorage()->Add(node); } { mitk::QBallImage::Pointer img = mitk::QBallImage::New(); img->InitializeByItk( itkQbi.GetPointer() ); img->SetVolume( itkQbi->GetBufferPointer() ); DataNode::Pointer node = DataNode::New(); node->SetData(img); node->SetName("_QballImage"); GetDataStorage()->Add(node); } } void QmitkOdfMaximaExtractionView::ConvertShCoeffs() { if (m_ImageNodes.empty()) return; mitk::Image::Pointer mitkImg = dynamic_cast(m_ImageNodes.at(0)->GetData()); if (mitkImg->GetDimension()!=4) { MITK_INFO << "wrong image type (need 4 dimensions)"; return; } int nrCoeffs = mitkImg->GetLargestPossibleRegion().GetSize()[3]; // solve bx² + cx + d = 0 = shOrder² + 2*shOrder + 2-2*neededCoeffs; int c=3, d=2-2*nrCoeffs; double D = c*c-4*d; int shOrder; if (D>0) { shOrder = (-c+sqrt(D))/2.0; if (shOrder<0) shOrder = (-c-sqrt(D))/2.0; } else if (D==0) shOrder = -c/2.0; MITK_INFO << "using SH-order " << shOrder; switch (shOrder) { case 4: TemplatedConvertShCoeffs<4>(mitkImg); break; case 6: TemplatedConvertShCoeffs<6>(mitkImg); break; case 8: TemplatedConvertShCoeffs<8>(mitkImg); break; case 10: TemplatedConvertShCoeffs<10>(mitkImg); break; case 12: TemplatedConvertShCoeffs<12>(mitkImg); break; default: MITK_INFO << "SH-order " << shOrder << " not supported"; } } void QmitkOdfMaximaExtractionView::ConvertPeaks() { if (m_ImageNodes.empty()) return; switch (m_Controls->m_ToolkitBox->currentIndex()) { case 0: { typedef itk::Image< float, 4 > ItkImageType; typedef itk::FslPeakImageConverter< float > FilterType; FilterType::Pointer filter = FilterType::New(); FilterType::InputType::Pointer inputVec = FilterType::InputType::New(); mitk::Geometry3D::Pointer geom; for (int i=0; i(m_ImageNodes.at(i)->GetData()); geom = mitkImg->GetGeometry(); typedef mitk::ImageToItk< FilterType::InputImageType > CasterType; CasterType::Pointer caster = CasterType::New(); caster->SetInput(mitkImg); caster->Update(); FilterType::InputImageType::Pointer itkImg = caster->GetOutput(); inputVec->InsertElement(inputVec->Size(), itkImg); } filter->SetInputImages(inputVec); filter->GenerateData(); mitk::Vector3D outImageSpacing = geom->GetSpacing(); float maxSpacing = 1; if(outImageSpacing[0]>outImageSpacing[1] && outImageSpacing[0]>outImageSpacing[2]) maxSpacing = outImageSpacing[0]; else if (outImageSpacing[1] > outImageSpacing[2]) maxSpacing = outImageSpacing[1]; else maxSpacing = outImageSpacing[2]; mitk::FiberBundleX::Pointer directions = filter->GetOutputFiberBundle(); // directions->SetGeometry(geom); DataNode::Pointer node = DataNode::New(); node->SetData(directions); node->SetName("_VectorField"); node->SetProperty("Fiber2DSliceThickness", mitk::FloatProperty::New(maxSpacing)); node->SetProperty("Fiber2DfadeEFX", mitk::BoolProperty::New(false)); GetDataStorage()->Add(node); typedef FilterType::DirectionImageContainerType DirectionImageContainerType; DirectionImageContainerType::Pointer container = filter->GetDirectionImageContainer(); for (int i=0; iSize(); i++) { ItkDirectionImage3DType::Pointer itkImg = container->GetElement(i); mitk::Image::Pointer img = mitk::Image::New(); img->InitializeByItk( itkImg.GetPointer() ); img->SetVolume( itkImg->GetBufferPointer() ); DataNode::Pointer node = DataNode::New(); node->SetData(img); QString name(m_ImageNodes.at(i)->GetName().c_str()); name += "_Direction"; name += QString::number(i+1); node->SetName(name.toStdString().c_str()); GetDataStorage()->Add(node); } break; } case 1: { typedef itk::Image< float, 4 > ItkImageType; typedef itk::MrtrixPeakImageConverter< float > FilterType; FilterType::Pointer filter = FilterType::New(); // cast to itk mitk::Image::Pointer mitkImg = dynamic_cast(m_ImageNodes.at(0)->GetData()); mitk::Geometry3D::Pointer geom = mitkImg->GetGeometry(); typedef mitk::ImageToItk< FilterType::InputImageType > CasterType; CasterType::Pointer caster = CasterType::New(); caster->SetInput(mitkImg); caster->Update(); FilterType::InputImageType::Pointer itkImg = caster->GetOutput(); filter->SetInputImage(itkImg); filter->GenerateData(); mitk::Vector3D outImageSpacing = geom->GetSpacing(); float maxSpacing = 1; if(outImageSpacing[0]>outImageSpacing[1] && outImageSpacing[0]>outImageSpacing[2]) maxSpacing = outImageSpacing[0]; else if (outImageSpacing[1] > outImageSpacing[2]) maxSpacing = outImageSpacing[1]; else maxSpacing = outImageSpacing[2]; mitk::FiberBundleX::Pointer directions = filter->GetOutputFiberBundle(); //directions->SetGeometry(geom); DataNode::Pointer node = DataNode::New(); node->SetData(directions); QString name(m_ImageNodes.at(0)->GetName().c_str()); name += "_VectorField"; node->SetName(name.toStdString().c_str()); node->SetProperty("Fiber2DSliceThickness", mitk::FloatProperty::New(maxSpacing)); node->SetProperty("Fiber2DfadeEFX", mitk::BoolProperty::New(false)); GetDataStorage()->Add(node); typedef FilterType::DirectionImageContainerType DirectionImageContainerType; DirectionImageContainerType::Pointer container = filter->GetDirectionImageContainer(); for (int i=0; iSize(); i++) { ItkDirectionImage3DType::Pointer itkImg = container->GetElement(i); mitk::Image::Pointer img = mitk::Image::New(); img->InitializeByItk( itkImg.GetPointer() ); img->SetVolume( itkImg->GetBufferPointer() ); DataNode::Pointer node = DataNode::New(); node->SetData(img); QString name(m_ImageNodes.at(0)->GetName().c_str()); name += "_Direction"; name += QString::number(i+1); node->SetName(name.toStdString().c_str()); GetDataStorage()->Add(node); } break; } } } void QmitkOdfMaximaExtractionView::GenerateImage() { if (!m_ImageNodes.empty()) GenerateDataFromDwi(); } void QmitkOdfMaximaExtractionView::StartTensor() { if (m_TensorImageNodes.empty()) return; typedef itk::DiffusionTensorPrincipalDirectionImageFilter< float, float > MaximaExtractionFilterType; MaximaExtractionFilterType::Pointer filter = MaximaExtractionFilterType::New(); mitk::Geometry3D::Pointer geometry; try{ TensorImage::Pointer img = dynamic_cast(m_TensorImageNodes.at(0)->GetData()); ItkTensorImage::Pointer itkImage = ItkTensorImage::New(); CastToItkImage(img, itkImage); filter->SetInput(itkImage); geometry = img->GetGeometry(); } catch(itk::ExceptionObject &e) { MITK_INFO << "wrong image type: " << e.what(); throw e; } if (!m_BinaryImageNodes.empty()) { ItkUcharImgType::Pointer itkMaskImage = ItkUcharImgType::New(); Image::Pointer mitkMaskImg = dynamic_cast(m_BinaryImageNodes.at(0)->GetData()); CastToItkImage(mitkMaskImg, itkMaskImage); filter->SetMaskImage(itkMaskImage); } if (m_Controls->m_NormalizationBox->currentIndex()==0) filter->SetNormalizeVectors(false); filter->Update(); if (m_Controls->m_OutputDirectionImagesBox->isChecked()) { MaximaExtractionFilterType::OutputImageType::Pointer itkImg = filter->GetOutput(); mitk::Image::Pointer img = mitk::Image::New(); img->InitializeByItk( itkImg.GetPointer() ); img->SetVolume( itkImg->GetBufferPointer() ); DataNode::Pointer node = DataNode::New(); node->SetData(img); QString name(m_TensorImageNodes.at(0)->GetName().c_str()); name += "_PrincipalDirection"; node->SetName(name.toStdString().c_str()); GetDataStorage()->Add(node); } if (m_Controls->m_OutputNumDirectionsBox->isChecked()) { ItkUcharImgType::Pointer numDirImage = filter->GetNumDirectionsImage(); mitk::Image::Pointer image2 = mitk::Image::New(); image2->InitializeByItk( numDirImage.GetPointer() ); image2->SetVolume( numDirImage->GetBufferPointer() ); DataNode::Pointer node2 = DataNode::New(); node2->SetData(image2); QString name(m_TensorImageNodes.at(0)->GetName().c_str()); name += "_NumDirections"; node2->SetName(name.toStdString().c_str()); GetDataStorage()->Add(node2); } if (m_Controls->m_OutputVectorFieldBox->isChecked()) { mitk::Vector3D outImageSpacing = geometry->GetSpacing(); float minSpacing = 1; if(outImageSpacing[0]GetOutputFiberBundle(); // directions->SetGeometry(geometry); DataNode::Pointer node = DataNode::New(); node->SetData(directions); QString name(m_TensorImageNodes.at(0)->GetName().c_str()); name += "_VectorField"; node->SetName(name.toStdString().c_str()); node->SetProperty("Fiber2DSliceThickness", mitk::FloatProperty::New(minSpacing)); node->SetProperty("Fiber2DfadeEFX", mitk::BoolProperty::New(false)); GetDataStorage()->Add(node); } } template void QmitkOdfMaximaExtractionView::StartMaximaExtraction() { typedef itk::FiniteDiffOdfMaximaExtractionFilter< float, shOrder, 20242 > MaximaExtractionFilterType; typename MaximaExtractionFilterType::Pointer filter = MaximaExtractionFilterType::New(); switch (m_Controls->m_ToolkitBox->currentIndex()) { case 0: filter->SetToolkit(MaximaExtractionFilterType::FSL); break; case 1: filter->SetToolkit(MaximaExtractionFilterType::MRTRIX); break; default: filter->SetToolkit(MaximaExtractionFilterType::FSL); } mitk::Geometry3D::Pointer geometry; try{ Image::Pointer img = dynamic_cast(m_ImageNodes.at(0)->GetData()); typedef ImageToItk< typename MaximaExtractionFilterType::CoefficientImageType > CasterType; typename CasterType::Pointer caster = CasterType::New(); caster->SetInput(img); caster->Update(); filter->SetInput(caster->GetOutput()); geometry = img->GetGeometry(); } catch(itk::ExceptionObject &e) { MITK_INFO << "wrong image type: " << e.what(); throw; } filter->SetAngularThreshold(cos((float)m_Controls->m_AngularThreshold->value()*M_PI/180)); filter->SetClusteringThreshold(cos((float)m_Controls->m_ClusteringAngleBox->value()*M_PI/180)); filter->SetMaxNumPeaks(m_Controls->m_MaxNumPeaksBox->value()); filter->SetPeakThreshold(m_Controls->m_PeakThresholdBox->value()); filter->SetAbsolutePeakThreshold(m_Controls->m_AbsoluteThresholdBox->value()); if (!m_BinaryImageNodes.empty()) { ItkUcharImgType::Pointer itkMaskImage = ItkUcharImgType::New(); Image::Pointer mitkMaskImg = dynamic_cast(m_BinaryImageNodes.at(0)->GetData()); CastToItkImage(mitkMaskImg, itkMaskImage); filter->SetMaskImage(itkMaskImage); } switch (m_Controls->m_NormalizationBox->currentIndex()) { case 0: filter->SetNormalizationMethod(MaximaExtractionFilterType::NO_NORM); break; case 1: filter->SetNormalizationMethod(MaximaExtractionFilterType::MAX_VEC_NORM); break; case 2: filter->SetNormalizationMethod(MaximaExtractionFilterType::SINGLE_VEC_NORM); break; } filter->Update(); if (m_Controls->m_OutputDirectionImagesBox->isChecked()) { typedef typename MaximaExtractionFilterType::ItkDirectionImageContainer ItkDirectionImageContainer; typename ItkDirectionImageContainer::Pointer container = filter->GetDirectionImageContainer(); for (int i=0; iSize(); i++) { typename MaximaExtractionFilterType::ItkDirectionImage::Pointer itkImg = container->GetElement(i); mitk::Image::Pointer img = mitk::Image::New(); img->InitializeByItk( itkImg.GetPointer() ); img->SetVolume( itkImg->GetBufferPointer() ); DataNode::Pointer node = DataNode::New(); node->SetData(img); QString name(m_ImageNodes.at(0)->GetName().c_str()); name += "_Direction"; name += QString::number(i+1); node->SetName(name.toStdString().c_str()); + node->SetVisibility(false); GetDataStorage()->Add(node); } } if (m_Controls->m_OutputNumDirectionsBox->isChecked()) { ItkUcharImgType::Pointer numDirImage = filter->GetNumDirectionsImage(); mitk::Image::Pointer image2 = mitk::Image::New(); image2->InitializeByItk( numDirImage.GetPointer() ); image2->SetVolume( numDirImage->GetBufferPointer() ); DataNode::Pointer node2 = DataNode::New(); node2->SetData(image2); QString name(m_ImageNodes.at(0)->GetName().c_str()); name += "_NumDirections"; node2->SetName(name.toStdString().c_str()); GetDataStorage()->Add(node2); } if (m_Controls->m_OutputVectorFieldBox->isChecked()) { mitk::Vector3D outImageSpacing = geometry->GetSpacing(); float minSpacing = 1; if(outImageSpacing[0]GetOutputFiberBundle(); // directions->SetGeometry(geometry); DataNode::Pointer node = DataNode::New(); node->SetData(directions); QString name(m_ImageNodes.at(0)->GetName().c_str()); name += "_VectorField"; node->SetName(name.toStdString().c_str()); node->SetProperty("Fiber2DSliceThickness", mitk::FloatProperty::New(minSpacing)); node->SetProperty("Fiber2DfadeEFX", mitk::BoolProperty::New(false)); GetDataStorage()->Add(node); } } void QmitkOdfMaximaExtractionView::StartFiniteDiff() { if (m_ImageNodes.empty()) return; switch (m_Controls->m_ShOrderBox->currentIndex()) { case 0: StartMaximaExtraction<2>(); break; case 1: StartMaximaExtraction<4>(); break; case 2: StartMaximaExtraction<6>(); break; case 3: StartMaximaExtraction<8>(); break; case 4: StartMaximaExtraction<10>(); break; case 5: StartMaximaExtraction<12>(); break; } } void QmitkOdfMaximaExtractionView::GenerateDataFromDwi() { typedef itk::OdfMaximaExtractionFilter< float > MaximaExtractionFilterType; MaximaExtractionFilterType::Pointer filter = MaximaExtractionFilterType::New(); mitk::Geometry3D::Pointer geometry; if (!m_ImageNodes.empty()) { try{ Image::Pointer img = dynamic_cast(m_ImageNodes.at(0)->GetData()); typedef ImageToItk< MaximaExtractionFilterType::CoefficientImageType > CasterType; CasterType::Pointer caster = CasterType::New(); caster->SetInput(img); caster->Update(); filter->SetShCoeffImage(caster->GetOutput()); geometry = img->GetGeometry(); } catch(itk::ExceptionObject &e) { MITK_INFO << "wrong image type: " << e.what(); return; } } else return; filter->SetMaxNumPeaks(m_Controls->m_MaxNumPeaksBox->value()); filter->SetPeakThreshold(m_Controls->m_PeakThresholdBox->value()); if (!m_BinaryImageNodes.empty()) { ItkUcharImgType::Pointer itkMaskImage = ItkUcharImgType::New(); Image::Pointer mitkMaskImg = dynamic_cast(m_BinaryImageNodes.at(0)->GetData()); CastToItkImage(mitkMaskImg, itkMaskImage); filter->SetMaskImage(itkMaskImage); } switch (m_Controls->m_NormalizationBox->currentIndex()) { case 0: filter->SetNormalizationMethod(MaximaExtractionFilterType::NO_NORM); break; case 1: filter->SetNormalizationMethod(MaximaExtractionFilterType::MAX_VEC_NORM); break; case 2: filter->SetNormalizationMethod(MaximaExtractionFilterType::SINGLE_VEC_NORM); break; } filter->GenerateData(); ItkUcharImgType::Pointer numDirImage = filter->GetNumDirectionsImage(); if (m_Controls->m_OutputDirectionImagesBox->isChecked()) { typedef MaximaExtractionFilterType::ItkDirectionImageContainer ItkDirectionImageContainer; ItkDirectionImageContainer::Pointer container = filter->GetDirectionImageContainer(); for (int i=0; iSize(); i++) { MaximaExtractionFilterType::ItkDirectionImage::Pointer itkImg = container->GetElement(i); mitk::Image::Pointer img = mitk::Image::New(); img->InitializeByItk( itkImg.GetPointer() ); img->SetVolume( itkImg->GetBufferPointer() ); DataNode::Pointer node = DataNode::New(); node->SetData(img); QString name(m_ImageNodes.at(0)->GetName().c_str()); name += "_Direction"; name += QString::number(i+1); node->SetName(name.toStdString().c_str()); GetDataStorage()->Add(node); } } if (m_Controls->m_OutputNumDirectionsBox->isChecked()) { mitk::Image::Pointer image2 = mitk::Image::New(); image2->InitializeByItk( numDirImage.GetPointer() ); image2->SetVolume( numDirImage->GetBufferPointer() ); DataNode::Pointer node = DataNode::New(); node->SetData(image2); QString name(m_ImageNodes.at(0)->GetName().c_str()); name += "_NumDirections"; node->SetName(name.toStdString().c_str()); GetDataStorage()->Add(node); } if (m_Controls->m_OutputVectorFieldBox->isChecked()) { mitk::Vector3D outImageSpacing = geometry->GetSpacing(); float minSpacing = 1; if(outImageSpacing[0]GetOutputFiberBundle(); // directions->SetGeometry(geometry); DataNode::Pointer node = DataNode::New(); node->SetData(directions); QString name(m_ImageNodes.at(0)->GetName().c_str()); name += "_VectorField"; node->SetName(name.toStdString().c_str()); node->SetProperty("Fiber2DSliceThickness", mitk::FloatProperty::New(minSpacing)); node->SetProperty("Fiber2DfadeEFX", mitk::BoolProperty::New(false)); GetDataStorage()->Add(node); } } void QmitkOdfMaximaExtractionView::StdMultiWidgetAvailable (QmitkStdMultiWidget &stdMultiWidget) { m_MultiWidget = &stdMultiWidget; } void QmitkOdfMaximaExtractionView::StdMultiWidgetNotAvailable() { m_MultiWidget = NULL; } void QmitkOdfMaximaExtractionView::OnSelectionChanged( std::vector nodes ) { m_Controls->m_InputData->setTitle("Please Select Input Data"); m_Controls->m_DwiFibLabel->setText("mandatory"); m_Controls->m_MaskLabel->setText("optional"); m_BinaryImageNodes.clear(); m_ImageNodes.clear(); m_TensorImageNodes.clear(); // iterate all selected objects, adjust warning visibility for( std::vector::iterator it = nodes.begin(); it != nodes.end(); ++it ) { mitk::DataNode::Pointer node = *it; if ( node.IsNotNull() && dynamic_cast(node->GetData()) ) { m_TensorImageNodes.push_back(node); } else if( node.IsNotNull() && dynamic_cast(node->GetData()) ) { bool isBinary = false; node->GetPropertyValue("binary", isBinary); if (isBinary) m_BinaryImageNodes.push_back(node); else m_ImageNodes.push_back(node); } } UpdateGui(); } diff --git a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkQBallReconstructionView.cpp b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkQBallReconstructionView.cpp index 961a581783..1576d6c260 100644 --- a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkQBallReconstructionView.cpp +++ b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkQBallReconstructionView.cpp @@ -1,1061 +1,1062 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ //#define MBILOG_ENABLE_DEBUG #include "QmitkQBallReconstructionView.h" #include "mitkDiffusionImagingConfigure.h" // qt includes #include // itk includes #include "itkTimeProbe.h" // mitk includes #include "mitkProgressBar.h" #include "mitkStatusBar.h" #include "mitkNodePredicateDataType.h" #include "QmitkDataStorageComboBox.h" #include "QmitkStdMultiWidget.h" #include "itkDiffusionQballReconstructionImageFilter.h" #include "itkAnalyticalDiffusionQballReconstructionImageFilter.h" #include "itkDiffusionMultiShellQballReconstructionImageFilter.h" #include "itkVectorContainer.h" #include "mitkQBallImage.h" #include "mitkProperties.h" #include "mitkVtkResliceInterpolationProperty.h" #include "mitkLookupTable.h" #include "mitkLookupTableProperty.h" #include "mitkTransferFunction.h" #include "mitkTransferFunctionProperty.h" #include "mitkDataNodeObject.h" #include "mitkOdfNormalizationMethodProperty.h" #include "mitkOdfScaleByProperty.h" #include "berryIStructuredSelection.h" #include "berryIWorkbenchWindow.h" #include "berryISelectionService.h" #include const std::string QmitkQBallReconstructionView::VIEW_ID = "org.mitk.views.qballreconstruction"; typedef float TTensorPixelType; const int QmitkQBallReconstructionView::nrconvkernels = 252; struct QbrShellSelection { QmitkQBallReconstructionView* m_View; mitk::DataNode * m_Node; std::string m_NodeName; std::vector m_CheckBoxes; QLabel * m_Label; mitk::DiffusionImage * m_Image; typedef mitk::DiffusionImage::BValueMap BValueMap; QbrShellSelection(QmitkQBallReconstructionView* view, mitk::DataNode * node) : m_View(view), m_Node(node), m_NodeName(node->GetName()) { m_Image = dynamic_cast * > (node->GetData()); if(!m_Image){MITK_INFO << "QmitkQBallReconstructionView::QbrShellSelection : fail to initialize DiffusionImage "; return;} GenerateCheckboxes(); } void GenerateCheckboxes() { BValueMap origMap = m_Image->GetB_ValueMap(); BValueMap::iterator itStart = origMap.begin(); itStart++; BValueMap::iterator itEnd = origMap.end(); m_Label = new QLabel(m_NodeName.c_str()); m_Label->setVisible(true); m_View->m_Controls->m_QBallSelectionBox->layout()->addWidget(m_Label); for(BValueMap::iterator it = itStart ; it!= itEnd; it++) { QCheckBox * box = new QCheckBox(QString::number(it->first)); m_View->m_Controls->m_QBallSelectionBox->layout()->addWidget(box); box->setChecked(true); box->setCheckable(true); // box->setVisible(true); m_CheckBoxes.push_back(box); } } void SetVisible(bool vis) { foreach(QCheckBox * box, m_CheckBoxes) { box->setVisible(vis); } } BValueMap GetBValueSelctionMap() { BValueMap inputMap = m_Image->GetB_ValueMap(); BValueMap outputMap; double val = 0; if(inputMap.find(0) == inputMap.end()){ MITK_INFO << "QbrShellSelection: return empty BValueMap from GUI Selection"; return outputMap; }else{ outputMap[val] = inputMap[val]; MITK_INFO << val; } foreach(QCheckBox * box, m_CheckBoxes) { if(box->isChecked()){ val = box->text().toDouble(); outputMap[val] = inputMap[val]; MITK_INFO << val; } } return outputMap; } ~QbrShellSelection() { m_View->m_Controls->m_QBallSelectionBox->layout()->removeWidget(m_Label); delete m_Label; for(std::vector::iterator it = m_CheckBoxes.begin() ; it!= m_CheckBoxes.end(); it++) { m_View->m_Controls->m_QBallSelectionBox->layout()->removeWidget((*it)); delete (*it); } m_CheckBoxes.clear(); } }; using namespace berry; struct QbrSelListener : ISelectionListener { berryObjectMacro(QbrSelListener); QbrSelListener(QmitkQBallReconstructionView* view) { m_View = view; } void DoSelectionChanged(ISelection::ConstPointer selection) { // save current selection in member variable m_View->m_CurrentSelection = selection.Cast(); // do something with the selected items if(m_View->m_CurrentSelection) { bool foundDwiVolume = false; m_View->m_Controls->m_DiffusionImageLabel->setText("mandatory"); m_View->m_Controls->m_InputData->setTitle("Please Select Input Data"); QString selected_images = ""; mitk::DataStorage::SetOfObjects::Pointer set = mitk::DataStorage::SetOfObjects::New(); int at = 0; // iterate selection for (IStructuredSelection::iterator i = m_View->m_CurrentSelection->Begin(); i != m_View->m_CurrentSelection->End(); ++i) { // extract datatree node if (mitk::DataNodeObject::Pointer nodeObj = i->Cast()) { mitk::DataNode::Pointer node = nodeObj->GetDataNode(); mitk::DiffusionImage* diffusionImage; // only look at interesting types if(diffusionImage = dynamic_cast * >(node->GetData())) { foundDwiVolume = true; selected_images += QString(node->GetName().c_str()); if(i + 1 != m_View->m_CurrentSelection->End()) selected_images += "\n"; set->InsertElement(at++, node); } } } m_View->GenerateShellSelectionUI(set); m_View->m_Controls->m_DiffusionImageLabel->setText(selected_images); m_View->m_Controls->m_ButtonStandard->setEnabled(foundDwiVolume); if (foundDwiVolume) m_View->m_Controls->m_InputData->setTitle("Input Data"); else m_View->m_Controls->m_DiffusionImageLabel->setText("mandatory"); } } void SelectionChanged(IWorkbenchPart::Pointer part, ISelection::ConstPointer selection) { // check, if selection comes from datamanager if (part) { QString partname(part->GetPartName().c_str()); if(partname.compare("Datamanager")==0) { // apply selection DoSelectionChanged(selection); } } } QmitkQBallReconstructionView* m_View; }; // --------------- QmitkQBallReconstructionView----------------- // QmitkQBallReconstructionView::QmitkQBallReconstructionView() : QmitkFunctionality(), m_Controls(NULL), m_MultiWidget(NULL) { } QmitkQBallReconstructionView::QmitkQBallReconstructionView(const QmitkQBallReconstructionView& other) { Q_UNUSED(other); throw std::runtime_error("Copy constructor not implemented"); } QmitkQBallReconstructionView::~QmitkQBallReconstructionView() { this->GetSite()->GetWorkbenchWindow()->GetSelectionService()->RemovePostSelectionListener(/*"org.mitk.views.datamanager",*/ m_SelListener); } void QmitkQBallReconstructionView::CreateQtPartControl(QWidget *parent) { if (!m_Controls) { // create GUI widgets m_Controls = new Ui::QmitkQBallReconstructionViewControls; m_Controls->setupUi(parent); this->CreateConnections(); m_Controls->m_DiffusionImageLabel->setText("mandatory"); QStringList items; items << "2" << "4" << "6" << "8" << "10" << "12"; m_Controls->m_QBallReconstructionMaxLLevelComboBox->addItems(items); m_Controls->m_QBallReconstructionMaxLLevelComboBox->setCurrentIndex(1); MethodChoosen(m_Controls->m_QBallReconstructionMethodComboBox->currentIndex()); #ifndef DIFFUSION_IMAGING_EXTENDED m_Controls->m_QBallReconstructionMethodComboBox->removeItem(3); #endif AdvancedCheckboxClicked(); } m_SelListener = berry::ISelectionListener::Pointer(new QbrSelListener(this)); this->GetSite()->GetWorkbenchWindow()->GetSelectionService()->AddPostSelectionListener(/*"org.mitk.views.datamanager",*/ m_SelListener); berry::ISelection::ConstPointer sel( this->GetSite()->GetWorkbenchWindow()->GetSelectionService()->GetSelection("org.mitk.views.datamanager")); m_CurrentSelection = sel.Cast(); m_SelListener.Cast()->DoSelectionChanged(sel); } void QmitkQBallReconstructionView::StdMultiWidgetAvailable (QmitkStdMultiWidget &stdMultiWidget) { m_MultiWidget = &stdMultiWidget; } void QmitkQBallReconstructionView::StdMultiWidgetNotAvailable() { m_MultiWidget = NULL; } void QmitkQBallReconstructionView::CreateConnections() { if ( m_Controls ) { connect( (QObject*)(m_Controls->m_ButtonStandard), SIGNAL(clicked()), this, SLOT(ReconstructStandard()) ); connect( (QObject*)(m_Controls->m_AdvancedCheckbox), SIGNAL(clicked()), this, SLOT(AdvancedCheckboxClicked()) ); connect( (QObject*)(m_Controls->m_QBallReconstructionMethodComboBox), SIGNAL(currentIndexChanged(int)), this, SLOT(MethodChoosen(int)) ); } } void QmitkQBallReconstructionView::OnSelectionChanged( std::vector nodes ) { } void QmitkQBallReconstructionView::Activated() { QmitkFunctionality::Activated(); berry::ISelection::ConstPointer sel( this->GetSite()->GetWorkbenchWindow()->GetSelectionService()->GetSelection("org.mitk.views.datamanager")); m_CurrentSelection = sel.Cast(); m_SelListener.Cast()->DoSelectionChanged(sel); } void QmitkQBallReconstructionView::Deactivated() { QmitkFunctionality::Deactivated(); } void QmitkQBallReconstructionView::ReconstructStandard() { int index = m_Controls->m_QBallReconstructionMethodComboBox->currentIndex(); #ifndef DIFFUSION_IMAGING_EXTENDED if(index>=3) { index = index + 1; } #endif switch(index) { case 0: { // Numerical Reconstruct(0,0); break; } case 1: { // Standard Reconstruct(1,0); break; } case 2: { // Solid Angle Reconstruct(1,6); break; } case 3: { // Constrained Solid Angle Reconstruct(1,7); break; } case 4: { // ADC Reconstruct(1,4); break; } case 5: { // Raw Signal Reconstruct(1,5); break; } case 6: { // Q-Ball reconstruction Reconstruct(2,0); break; } } } void QmitkQBallReconstructionView::MethodChoosen(int method) { #ifndef DIFFUSION_IMAGING_EXTENDED if(method>=3) { method = method + 1; } #endif m_Controls->m_QBallSelectionBox->setHidden(true); m_Controls->m_OutputCoeffsImage->setHidden(true); if (method==0) m_Controls->m_ShFrame->setVisible(false); else m_Controls->m_ShFrame->setVisible(true); switch(method) { case 0: m_Controls->m_Description->setText("Numerical recon. (Tuch 2004)"); break; case 1: m_Controls->m_Description->setText("Spherical harmonics recon. (Descoteaux 2007)"); m_Controls->m_OutputCoeffsImage->setHidden(false); break; case 2: m_Controls->m_Description->setText("SH recon. with solid angle consideration (Aganj 2009)"); m_Controls->m_OutputCoeffsImage->setHidden(false); break; case 3: m_Controls->m_Description->setText("SH solid angle with non-neg. constraint (Goh 2009)"); break; case 4: m_Controls->m_Description->setText("SH recon. of the plain ADC-profiles"); break; case 5: m_Controls->m_Description->setText("SH recon. of the raw diffusion signal"); break; case 6: m_Controls->m_Description->setText("SH recon. of the multi shell diffusion signal (Aganj 2010)"); m_Controls->m_QBallSelectionBox->setHidden(false); m_Controls->m_OutputCoeffsImage->setHidden(false); break; } } void QmitkQBallReconstructionView::AdvancedCheckboxClicked() { bool check = m_Controls->m_AdvancedCheckbox->isChecked(); m_Controls->m_QBallReconstructionMaxLLevelTextLabel_2->setVisible(check); m_Controls->m_QBallReconstructionMaxLLevelComboBox->setVisible(check); m_Controls->m_QBallReconstructionLambdaTextLabel_2->setVisible(check); m_Controls->m_QBallReconstructionLambdaLineEdit->setVisible(check); m_Controls->m_QBallReconstructionThresholdLabel_2->setVisible(check); m_Controls->m_QBallReconstructionThreasholdEdit->setVisible(check); m_Controls->label_2->setVisible(check); m_Controls->frame_2->setVisible(check); } void QmitkQBallReconstructionView::Reconstruct(int method, int normalization) { if (m_CurrentSelection) { mitk::DataStorage::SetOfObjects::Pointer set = mitk::DataStorage::SetOfObjects::New(); int at = 0; for (IStructuredSelection::iterator i = m_CurrentSelection->Begin(); i != m_CurrentSelection->End(); ++i) { if (mitk::DataNodeObject::Pointer nodeObj = i->Cast()) { mitk::DataNode::Pointer node = nodeObj->GetDataNode(); if(QString("DiffusionImage").compare(node->GetData()->GetNameOfClass())==0) { set->InsertElement(at++, node); } } } if(method == 0) { NumericalQBallReconstruction(set, normalization); } else { #if BOOST_VERSION / 100000 > 0 #if BOOST_VERSION / 100 % 1000 > 34 if(method == 1) { AnalyticalQBallReconstruction(set, normalization); } if(method == 2) { MultiQBallReconstruction(set); } #else std::cout << "ERROR: Boost 1.35 minimum required" << std::endl; QMessageBox::warning(NULL,"ERROR","Boost 1.35 minimum required"); #endif #else std::cout << "ERROR: Boost 1.35 minimum required" << std::endl; QMessageBox::warning(NULL,"ERROR","Boost 1.35 minimum required"); #endif } } } void QmitkQBallReconstructionView::NumericalQBallReconstruction (mitk::DataStorage::SetOfObjects::Pointer inImages, int normalization) { try { itk::TimeProbe clock; int nrFiles = inImages->size(); if (!nrFiles) return; QString status; mitk::ProgressBar::GetInstance()->AddStepsToDo(nrFiles); mitk::DataStorage::SetOfObjects::const_iterator itemiter( inImages->begin() ); mitk::DataStorage::SetOfObjects::const_iterator itemiterend( inImages->end() ); std::vector nodes; while ( itemiter != itemiterend ) // for all items { mitk::DiffusionImage* vols = static_cast*>( (*itemiter)->GetData()); std::string nodename; (*itemiter)->GetStringProperty("name", nodename); ++itemiter; // QBALL RECONSTRUCTION clock.Start(); MITK_INFO << "QBall reconstruction "; mitk::StatusBar::GetInstance()->DisplayText(status.sprintf( "QBall reconstruction for %s", nodename.c_str()).toAscii()); typedef itk::DiffusionQballReconstructionImageFilter QballReconstructionImageFilterType; QballReconstructionImageFilterType::Pointer filter = QballReconstructionImageFilterType::New(); filter->SetGradientImage( vols->GetDirections(), vols->GetVectorImage() ); filter->SetBValue(vols->GetB_Value()); filter->SetThreshold( m_Controls->m_QBallReconstructionThreasholdEdit->value() ); switch(normalization) { case 0: { filter->SetNormalizationMethod(QballReconstructionImageFilterType::QBR_STANDARD); break; } case 1: { filter->SetNormalizationMethod(QballReconstructionImageFilterType::QBR_B_ZERO_B_VALUE); break; } case 2: { filter->SetNormalizationMethod(QballReconstructionImageFilterType::QBR_B_ZERO); break; } case 3: { filter->SetNormalizationMethod(QballReconstructionImageFilterType::QBR_NONE); break; } default: { filter->SetNormalizationMethod(QballReconstructionImageFilterType::QBR_STANDARD); } } filter->Update(); clock.Stop(); MITK_DEBUG << "took " << clock.GetMeanTime() << "s." ; // ODFs TO DATATREE mitk::QBallImage::Pointer image = mitk::QBallImage::New(); image->InitializeByItk( filter->GetOutput() ); //image->SetImportVolume( filter->GetOutput()->GetBufferPointer(), 0, 0, mitk::Image::ImportMemoryManagementType::ManageMemory ); image->SetVolume( filter->GetOutput()->GetBufferPointer() ); mitk::DataNode::Pointer node=mitk::DataNode::New(); node->SetData( image ); QString newname; newname = newname.append(nodename.c_str()); newname = newname.append("_QN%1").arg(normalization); SetDefaultNodeProperties(node, newname.toStdString()); nodes.push_back(node); mitk::ProgressBar::GetInstance()->Progress(); } std::vector::iterator nodeIt; for(nodeIt = nodes.begin(); nodeIt != nodes.end(); ++nodeIt) GetDefaultDataStorage()->Add(*nodeIt); mitk::StatusBar::GetInstance()->DisplayText(status.sprintf("Finished Processing %d Files", nrFiles).toAscii()); m_MultiWidget->RequestUpdate(); } catch (itk::ExceptionObject &ex) { MITK_INFO << ex ; QMessageBox::information(0, "Reconstruction not possible:", ex.GetDescription()); return ; } } void QmitkQBallReconstructionView::AnalyticalQBallReconstruction( mitk::DataStorage::SetOfObjects::Pointer inImages, int normalization) { try { itk::TimeProbe clock; int nrFiles = inImages->size(); if (!nrFiles) return; std::vector lambdas; float minLambda = m_Controls->m_QBallReconstructionLambdaLineEdit->value(); lambdas.push_back(minLambda); int nLambdas = lambdas.size(); QString status; mitk::ProgressBar::GetInstance()->AddStepsToDo(nrFiles*nLambdas); mitk::DataStorage::SetOfObjects::const_iterator itemiter( inImages->begin() ); mitk::DataStorage::SetOfObjects::const_iterator itemiterend( inImages->end() ); std::vector* nodes = new std::vector(); while ( itemiter != itemiterend ) // for all items { mitk::DiffusionImage* vols = static_cast*>( (*itemiter)->GetData()); std::string nodename; (*itemiter)->GetStringProperty("name",nodename); itemiter++; // QBALL RECONSTRUCTION clock.Start(); MITK_INFO << "QBall reconstruction "; mitk::StatusBar::GetInstance()->DisplayText(status.sprintf( "QBall reconstruction for %s", nodename.c_str()).toAscii()); for(int i=0; im_QBallReconstructionMaxLLevelComboBox->currentIndex()) { case 0: { TemplatedAnalyticalQBallReconstruction<2>(vols, currentLambda, nodename, nodes, normalization); break; } case 1: { TemplatedAnalyticalQBallReconstruction<4>(vols, currentLambda, nodename, nodes, normalization); break; } case 2: { TemplatedAnalyticalQBallReconstruction<6>(vols, currentLambda, nodename, nodes, normalization); break; } case 3: { TemplatedAnalyticalQBallReconstruction<8>(vols, currentLambda, nodename, nodes, normalization); break; } case 4: { TemplatedAnalyticalQBallReconstruction<10>(vols, currentLambda, nodename, nodes, normalization); break; } case 5: { TemplatedAnalyticalQBallReconstruction<12>(vols, currentLambda, nodename, nodes, normalization); break; } } clock.Stop(); MITK_DEBUG << "took " << clock.GetMeanTime() << "s." ; mitk::ProgressBar::GetInstance()->Progress(); } } std::vector::iterator nodeIt; for(nodeIt = nodes->begin(); nodeIt != nodes->end(); ++nodeIt) GetDefaultDataStorage()->Add(*nodeIt); m_MultiWidget->RequestUpdate(); mitk::StatusBar::GetInstance()->DisplayText(status.sprintf("Finished Processing %d Files", nrFiles).toAscii()); } catch (itk::ExceptionObject &ex) { MITK_INFO << ex; QMessageBox::information(0, "Reconstruction not possible:", ex.GetDescription()); return; } } template void QmitkQBallReconstructionView::TemplatedAnalyticalQBallReconstruction( mitk::DiffusionImage* vols, float lambda, std::string nodename, std::vector* nodes, int normalization) { typedef itk::AnalyticalDiffusionQballReconstructionImageFilter FilterType; typename FilterType::Pointer filter = FilterType::New(); filter->SetGradientImage( vols->GetDirections(), vols->GetVectorImage() ); filter->SetBValue(vols->GetB_Value()); filter->SetThreshold( m_Controls->m_QBallReconstructionThreasholdEdit->value() ); filter->SetLambda(lambda); switch(normalization) { case 0: { filter->SetNormalizationMethod(FilterType::QBAR_STANDARD); break; } case 1: { filter->SetNormalizationMethod(FilterType::QBAR_B_ZERO_B_VALUE); break; } case 2: { filter->SetNormalizationMethod(FilterType::QBAR_B_ZERO); break; } case 3: { filter->SetNormalizationMethod(FilterType::QBAR_NONE); break; } case 4: { filter->SetNormalizationMethod(FilterType::QBAR_ADC_ONLY); break; } case 5: { filter->SetNormalizationMethod(FilterType::QBAR_RAW_SIGNAL); break; } case 6: { filter->SetNormalizationMethod(FilterType::QBAR_SOLID_ANGLE); break; } case 7: { filter->SetNormalizationMethod(FilterType::QBAR_NONNEG_SOLID_ANGLE); break; } default: { filter->SetNormalizationMethod(FilterType::QBAR_STANDARD); } } filter->Update(); // ODFs TO DATATREE mitk::QBallImage::Pointer image = mitk::QBallImage::New(); image->InitializeByItk( filter->GetOutput() ); image->SetVolume( filter->GetOutput()->GetBufferPointer() ); mitk::DataNode::Pointer node=mitk::DataNode::New(); node->SetData( image ); QString newname; newname = newname.append(nodename.c_str()); newname = newname.append("_QA%1").arg(normalization); SetDefaultNodeProperties(node, newname.toStdString()); nodes->push_back(node); if(m_Controls->m_OutputCoeffsImage->isChecked()) { mitk::Image::Pointer coeffsImage = mitk::Image::New(); coeffsImage->InitializeByItk( filter->GetCoefficientImage().GetPointer() ); coeffsImage->SetVolume( filter->GetCoefficientImage()->GetBufferPointer() ); mitk::DataNode::Pointer coeffsNode=mitk::DataNode::New(); coeffsNode->SetData( coeffsImage ); coeffsNode->SetProperty( "name", mitk::StringProperty::New( QString(nodename.c_str()).append("_coeffs").toStdString()) ); + coeffsNode->SetVisibility(false); nodes->push_back(coeffsNode); } } void QmitkQBallReconstructionView::MultiQBallReconstruction( mitk::DataStorage::SetOfObjects::Pointer inImages) { try { itk::TimeProbe clock; int nrFiles = inImages->size(); if (!nrFiles) return; std::vector lambdas; float minLambda = m_Controls->m_QBallReconstructionLambdaLineEdit->value(); lambdas.push_back(minLambda); int nLambdas = lambdas.size(); QString status; mitk::ProgressBar::GetInstance()->AddStepsToDo(nrFiles*nLambdas); mitk::DataStorage::SetOfObjects::const_iterator itemiter( inImages->begin() ); mitk::DataStorage::SetOfObjects::const_iterator itemiterend( inImages->end() ); std::vector* nodes = new std::vector(); while ( itemiter != itemiterend ) // for all items { mitk::DiffusionImage* vols = static_cast*>( (*itemiter)->GetData()); const mitk::DataNode * nodePointer = (*itemiter).GetPointer(); std::string nodename; (*itemiter)->GetStringProperty("name",nodename); itemiter++; // QBALL RECONSTRUCTION clock.Start(); MITK_INFO << "QBall reconstruction "; mitk::StatusBar::GetInstance()->DisplayText(status.sprintf( "QBall reconstruction for %s", nodename.c_str()).toAscii()); for(int i=0; im_QBallReconstructionMaxLLevelComboBox->currentIndex()) { case 0: { TemplatedMultiQBallReconstruction<2>(vols, currentLambda, nodePointer, nodes); break; } case 1: { TemplatedMultiQBallReconstruction<4>(vols, currentLambda, nodePointer, nodes); break; } case 2: { TemplatedMultiQBallReconstruction<6>(vols, currentLambda, nodePointer, nodes); break; } case 3: { TemplatedMultiQBallReconstruction<8>(vols, currentLambda, nodePointer, nodes); break; } case 4: { TemplatedMultiQBallReconstruction<10>(vols, currentLambda, nodePointer, nodes); break; } case 5: { TemplatedMultiQBallReconstruction<12>(vols, currentLambda, nodePointer, nodes); break; } } clock.Stop(); MITK_DEBUG << "took " << clock.GetMeanTime() << "s." ; mitk::ProgressBar::GetInstance()->Progress(); } } std::vector::iterator nodeIt; for(nodeIt = nodes->begin(); nodeIt != nodes->end(); ++nodeIt) GetDefaultDataStorage()->Add(*nodeIt); m_MultiWidget->RequestUpdate(); mitk::StatusBar::GetInstance()->DisplayText(status.sprintf("Finished Processing %d Files", nrFiles).toAscii()); } catch (itk::ExceptionObject &ex) { MITK_INFO << ex ; QMessageBox::information(0, "Reconstruction not possible:", ex.GetDescription()); return ; } } template void QmitkQBallReconstructionView::TemplatedMultiQBallReconstruction( mitk::DiffusionImage* vols, float lambda, const mitk::DataNode * dataNodePointer, std::vector* nodes) { typedef itk::DiffusionMultiShellQballReconstructionImageFilter FilterType; typename FilterType::Pointer filter = FilterType::New(); std::string nodename; dataNodePointer->GetStringProperty("name",nodename); filter->SetBValueMap(m_ShellSelectorMap[dataNodePointer]->GetBValueSelctionMap()); filter->SetGradientImage( vols->GetDirections(), vols->GetVectorImage(), vols->GetB_Value() ); filter->SetThreshold( m_Controls->m_QBallReconstructionThreasholdEdit->value() ); filter->SetLambda(lambda); filter->Update(); // ODFs TO DATATREE mitk::QBallImage::Pointer image = mitk::QBallImage::New(); image->InitializeByItk( filter->GetOutput() ); image->SetVolume( filter->GetOutput()->GetBufferPointer() ); mitk::DataNode::Pointer node=mitk::DataNode::New(); node->SetData( image ); QString newname; newname = newname.append(nodename.c_str()); newname = newname.append("_QAMultiShell"); SetDefaultNodeProperties(node, newname.toStdString()); nodes->push_back(node); if(m_Controls->m_OutputCoeffsImage->isChecked()) { mitk::Image::Pointer coeffsImage = mitk::Image::New(); coeffsImage->InitializeByItk( filter->GetCoefficientImage().GetPointer() ); coeffsImage->SetVolume( filter->GetCoefficientImage()->GetBufferPointer() ); mitk::DataNode::Pointer coeffsNode=mitk::DataNode::New(); coeffsNode->SetData( coeffsImage ); coeffsNode->SetProperty( "name", mitk::StringProperty::New( QString(nodename.c_str()).append("_coeffs").toStdString()) ); nodes->push_back(coeffsNode); } } void QmitkQBallReconstructionView::SetDefaultNodeProperties(mitk::DataNode::Pointer node, std::string name) { node->SetProperty( "ShowMaxNumber", mitk::IntProperty::New( 500 ) ); node->SetProperty( "Scaling", mitk::FloatProperty::New( 1.0 ) ); node->SetProperty( "Normalization", mitk::OdfNormalizationMethodProperty::New()); node->SetProperty( "ScaleBy", mitk::OdfScaleByProperty::New()); node->SetProperty( "IndexParam1", mitk::FloatProperty::New(2)); node->SetProperty( "IndexParam2", mitk::FloatProperty::New(1)); node->SetProperty( "visible", mitk::BoolProperty::New( true ) ); node->SetProperty( "VisibleOdfs", mitk::BoolProperty::New( false ) ); node->SetProperty ("layer", mitk::IntProperty::New(100)); node->SetProperty( "DoRefresh", mitk::BoolProperty::New( true ) ); //node->SetProperty( "opacity", mitk::FloatProperty::New(1.0f) ); node->SetProperty( "name", mitk::StringProperty::New(name) ); } //node->SetProperty( "volumerendering", mitk::BoolProperty::New( false ) ); //node->SetProperty( "use color", mitk::BoolProperty::New( true ) ); //node->SetProperty( "texture interpolation", mitk::BoolProperty::New( true ) ); //node->SetProperty( "reslice interpolation", mitk::VtkResliceInterpolationProperty::New() ); //node->SetProperty( "layer", mitk::IntProperty::New(0)); //node->SetProperty( "in plane resample extent by geometry", mitk::BoolProperty::New( false ) ); //node->SetOpacity(1.0f); //node->SetColor(1.0,1.0,1.0); //node->SetVisibility(true); //node->SetProperty( "IsQBallVolume", mitk::BoolProperty::New( true ) ); //mitk::LevelWindowProperty::Pointer levWinProp = mitk::LevelWindowProperty::New(); //mitk::LevelWindow levelwindow; //// levelwindow.SetAuto( image ); //levWinProp->SetLevelWindow( levelwindow ); //node->GetPropertyList()->SetPropertx( "levelwindow", levWinProp ); //// add a default rainbow lookup table for color mapping //if(!node->GetProperty("LookupTable")) //{ // mitk::LookupTable::Pointer mitkLut = mitk::LookupTable::New(); // vtkLookupTable* vtkLut = mitkLut->GetVtkLookupTable(); // vtkLut->SetHueRange(0.6667, 0.0); // vtkLut->SetTableRange(0.0, 20.0); // vtkLut->Build(); // mitk::LookupTableProperty::Pointer mitkLutProp = mitk::LookupTableProperty::New(); // mitkLutProp->SetLookupTable(mitkLut); // node->SetProperty( "LookupTable", mitkLutProp ); //} //if(!node->GetProperty("binary")) // node->SetProperty( "binary", mitk::BoolProperty::New( false ) ); //// add a default transfer function //mitk::TransferFunction::Pointer tf = mitk::TransferFunction::New(); //node->SetProperty ( "TransferFunction", mitk::TransferFunctionProperty::New ( tf.GetPointer() ) ); //// set foldername as string property //mitk::StringProperty::Pointer nameProp = mitk::StringProperty::New( name ); //node->SetProperty( "name", nameProp ); void QmitkQBallReconstructionView::GenerateShellSelectionUI(mitk::DataStorage::SetOfObjects::Pointer set) { std::map tempMap; const mitk::DataStorage::SetOfObjects::iterator setEnd( set->end() ); mitk::DataStorage::SetOfObjects::iterator NodeIt( set->begin() ); while(NodeIt != setEnd) { if(m_ShellSelectorMap.find( (*NodeIt).GetPointer() ) != m_ShellSelectorMap.end()) { tempMap[(*NodeIt).GetPointer()] = m_ShellSelectorMap[(*NodeIt).GetPointer()]; m_ShellSelectorMap.erase((*NodeIt).GetPointer()); }else { tempMap[(*NodeIt).GetPointer()] = new QbrShellSelection(this, (*NodeIt) ); tempMap[(*NodeIt).GetPointer()]->SetVisible(true); } NodeIt++; } for(std::map::iterator it = m_ShellSelectorMap.begin(); it != m_ShellSelectorMap.end();it ++) { delete it->second; } m_ShellSelectorMap.clear(); m_ShellSelectorMap = tempMap; } diff --git a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkQBallReconstructionViewControls.ui b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkQBallReconstructionViewControls.ui index a8afb2c9a2..b803eb8448 100644 --- a/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkQBallReconstructionViewControls.ui +++ b/Plugins/org.mitk.gui.qt.diffusionimaging/src/internal/QmitkQBallReconstructionViewControls.ui @@ -1,349 +1,326 @@ QmitkQBallReconstructionViewControls 0 0 372 844 0 0 true QmitkQBallReconstructionViewControls Please Select Input Data Input for Q-Ball reconstruction. Raw DWI: Input for Q-Ball reconstruction. <font color='red'>mandatory</font> true Parameters Advanced Settings QFrame::StyledPanel QFrame::Raised QFrame::NoFrame QFrame::Raised - - 0 - - - 0 - - - 0 - - + 0 true B0 Threshold false - + + + 10000 + + QFrame::NoFrame QFrame::Raised - - 0 - - - 0 - - - 0 - - + 0 QFrame::NoFrame QFrame::Raised - - 0 - - - 0 - - - 0 - - + 0 true Regularization Parameter Lambda: false true Maximum l-Level: false true -1 true Spherical Harmonics: 3 1.000000000000000 0.001000000000000 0.006000000000000 Output SH-Coefficient Image 2 Numerical Standard Solid Angle Constraint Solid Angle ADC-Profile only Raw Signal only Multi-Shell TextLabel false Start Reconstruction true Qt::LeftToRight false Multi-Shell Reconstruction Qt::Vertical 20 0