diff --git a/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorGUIControls.ui b/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorGUIControls.ui
index 46bf777f20..1cd3dcd9f0 100644
--- a/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorGUIControls.ui
+++ b/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorGUIControls.ui
@@ -1,293 +1,293 @@
 <?xml version="1.0" encoding="UTF-8"?>
 <ui version="4.0">
  <class>QmitkTotalSegmentatorToolGUIControls</class>
  <widget class="QWidget" name="QmitkTotalSegmentatorToolGUIControls">
   <property name="geometry">
    <rect>
     <x>0</x>
     <y>0</y>
     <width>699</width>
     <height>352</height>
    </rect>
   </property>
   <property name="sizePolicy">
    <sizepolicy hsizetype="Ignored" vsizetype="Minimum">
     <horstretch>0</horstretch>
     <verstretch>0</verstretch>
    </sizepolicy>
   </property>
   <property name="minimumSize">
    <size>
     <width>100</width>
     <height>0</height>
    </size>
   </property>
   <property name="maximumSize">
    <size>
     <width>100000</width>
     <height>100000</height>
    </size>
   </property>
   <property name="windowTitle">
    <string>QmitkTotalSegmentatorToolWidget</string>
   </property>
   <layout class="QVBoxLayout" name="verticalLayout">
    <property name="leftMargin">
     <number>0</number>
    </property>
    <property name="topMargin">
     <number>0</number>
    </property>
    <property name="rightMargin">
     <number>0</number>
    </property>
    <property name="bottomMargin">
     <number>0</number>
    </property>
    <item>
     <layout class="QGridLayout" name="basicSettingsLayout">
      <item row="0" column="0" colspan="4">
       <widget class="QLabel" name="welcomeNote">
        <property name="sizePolicy">
         <sizepolicy hsizetype="Preferred" vsizetype="Minimum">
          <horstretch>0</horstretch>
          <verstretch>0</verstretch>
         </sizepolicy>
        </property>
        <property name="text">
         <string>&lt;html&gt;&lt;head/&gt;&lt;body&gt;&lt;p&gt;Welcome to Total Segmentator tool in MITK. [Experimental]&lt;/p&gt;&lt;p&gt;Please note that this is only an interface to Total Segmentator. MITK does not ship with Total Segmentator. Make sure to have a working Python environment with TotalSegmentator set up beforehand. Choose that environment in the Python Path before inferencing. &lt;/p&gt;&lt;p&gt;Refer to &lt;a href=&quot;https://github.com/wasserth/TotalSegmentator&quot;&gt;&lt;span style=&quot; text-decoration: underline; color:#0000ff;&quot;&gt;https://github.com/wasserth/TotalSegmentator&lt;/span&gt;&lt;/a&gt; to learn everything about the Total Segmentator.&lt;/p&gt;&lt;p&gt;&lt;br/&gt;&lt;/p&gt;&lt;/body&gt;&lt;/html&gt;</string>
        </property>
        <property name="textFormat">
         <enum>Qt::RichText</enum>
        </property>
        <property name="wordWrap">
         <bool>true</bool>
        </property>
       </widget>
      </item>
 	 <item row ="1" colspan="4">
 	  <widget class="QPushButton" name="installButton">
 	   <property name="sizePolicy">
 		<sizepolicy hsizetype="Minimum" vsizetype="Fixed">
 		 <horstretch>0</horstretch>
 		 <verstretch>0</verstretch>
 		</sizepolicy>
 	   </property>
 	   <property name="maximumSize">
 		<size>
 		 <width>100000</width>
 		 <height>16777215</height>
 		</size>
 	   </property>
 	   <property name="text">
 		<string>Install Total Segmentator</string>
 	   </property>
 	  </widget>
 	 </item>	
 	 <item row="2" column="0">
 	  <widget class="QLabel" name="subtaskLabel">
 	   <property name="sizePolicy">
 		<sizepolicy hsizetype="Preferred" vsizetype="Preferred">
 		 <horstretch>0</horstretch>
 		 <verstretch>0</verstretch>
 		</sizepolicy>
 	   </property>
 	   <property name="text">
 		<string>Task:</string>
 	   </property>
 	  </widget>
 	 </item>
 	 <item row="2" column="1" colspan="3">
 	  <widget class="ctkComboBox" name="subtaskComboBox"/>
 	 </item>
     </layout>
    </item>
    <item>
     <widget class="ctkCollapsibleGroupBox" name="inputGroupBox" native="true">
      <property name="minimumSize">
       <size>
        <width>0</width>
        <height>0</height>
       </size>
      </property>
      <property name="title" stdset="0">
       <string>Advanced</string>
      </property>
      <property name="flat" stdset="0">
       <bool>true</bool>
      </property>
      <property name="collapsedHeight" stdset="0">
       <number>5</number>
      </property>
      <property name="collapsed" stdset="0">
       <bool>true</bool>
      </property>
      <layout class="QVBoxLayout" name="verticalLayout_4">
       <item>
        <layout class="QGridLayout" name="_2">
         <property name="leftMargin">
          <number>0</number>
         </property>
         <property name="topMargin">
          <number>0</number>
         </property>
         <property name="rightMargin">
          <number>0</number>
         </property>
         <property name="bottomMargin">
          <number>0</number>
         </property>
         <property name="spacing">
          <number>6</number>
         </property>
 		<item row="0" column="0">
 	     <widget class="QLabel" name="fastLabel">
 		  <property name="sizePolicy">
 		   <sizepolicy hsizetype="Preferred" vsizetype="Preferred">
 			<horstretch>0</horstretch>
 			<verstretch>0</verstretch>
 		   </sizepolicy>
 		  </property>
 		  <property name="text">
 	       <string>Fast</string>
 		  </property>
 		 </widget>
 		</item>  
 		<item row="0" column="1">
 	     <widget class="ctkCheckBox" name="fastBox" native="true">
 		  <property name="checked" stdset="0">
 		   <bool>true</bool>
 		  </property>
 		 </widget>
 		</item>
 		<item row="0" column="2">
 		 <widget class="QLabel" name="OverrideLabel">
 		  <property name="sizePolicy">
 		   <sizepolicy hsizetype="Preferred" vsizetype="Preferred">
 			<horstretch>0</horstretch>
 			<verstretch>0</verstretch>
 		   </sizepolicy>
 		  </property>
 		  <property name="text">
-		   <string>Override install</string>
+		   <string>Use Custom Installation</string>
 		  </property>
 		 </widget>
 		</item>
 		<item row="0" column="3">
 		 <widget class="ctkCheckBox" name="overrideBox" native="true">
 		  <property name="checked" stdset="0">
 		   <bool>false</bool>
 		  </property>
 		 </widget>
 		</item>
         <item row="2" column="0">
          <widget class="QLabel" name="gpuSpinLabel">
           <property name="sizePolicy">
            <sizepolicy hsizetype="Preferred" vsizetype="Preferred">
             <horstretch>0</horstretch>
             <verstretch>0</verstretch>
            </sizepolicy>
           </property>
           <property name="text">
            <string>GPU Id:</string>
           </property>
          </widget>
         </item>
         <item row="2" column="1" colspan="3">
          <widget class="ctkComboBox" name="gpuComboBox"/>
         </item>
         
 		<item row="1" column="0">
 		 <widget class="QLabel" name="pythonEnvLabel">
 		  <property name="sizePolicy">
 		   <sizepolicy hsizetype="Preferred" vsizetype="Preferred">
 			<horstretch>0</horstretch>
 			<verstretch>0</verstretch>
 		   </sizepolicy>
 		  </property>
 		  <property name="text">
-		   <string>Override Python:</string>
+		   <string>Custom Env. Path:</string>
 		  </property>
 		 </widget>
 		</item>
 		<item row="1" column="1" colspan="3">
 	     <widget class="ctkComboBox" name="pythonEnvComboBox"/>
 		</item>
 		<item row="3" column="0">
 		 <widget class="QLabel" name="sysPythonLabel">
 		  <property name="sizePolicy">
 		   <sizepolicy hsizetype="Preferred" vsizetype="Preferred">
 			<horstretch>0</horstretch>
 			<verstretch>0</verstretch>
 		   </sizepolicy>
 		  </property>
 		  <property name="text">
 		   <string>System Python:</string>
 		  </property>
 		 </widget>
 		</item>
 		<item row="3" column="1" colspan="3">
 		 <widget class="ctkComboBox" name="sysPythonComboBox"/>
 		</item>      
        </layout>
       </item>
      </layout>
     </widget>
    </item>
    <item>
     <widget class="QPushButton" name="previewButton">
      <property name="sizePolicy">
       <sizepolicy hsizetype="Minimum" vsizetype="Fixed">
        <horstretch>0</horstretch>
        <verstretch>0</verstretch>
       </sizepolicy>
      </property>
      <property name="maximumSize">
       <size>
        <width>100000</width>
        <height>16777215</height>
       </size>
      </property>
      <property name="text">
       <string>Run Total Segmentator</string>
      </property>
     </widget>
    </item>
    <item>
     <widget class="QLabel" name="statusLabel">
      <property name="sizePolicy">
       <sizepolicy hsizetype="Preferred" vsizetype="Preferred">
        <horstretch>0</horstretch>
        <verstretch>0</verstretch>
       </sizepolicy>
      </property>
      <property name="wordWrap">
       <bool>true</bool>
      </property>
     </widget>
    </item>
   </layout>
  </widget>
  <layoutdefault spacing="6" margin="11"/>
   <customwidgets>
   <customwidget>
    <class>ctkComboBox</class>
    <extends>QComboBox</extends>
    <header location="global">ctkComboBox.h</header>
    <container>1</container>
   </customwidget>
   <customwidget>
    <class>ctkCollapsibleGroupBox</class>
    <extends>QWidget</extends>
    <header>ctkCollapsibleGroupBox.h</header>
   </customwidget>
   <customwidget>
    <class>ctkCheckBox</class>
    <extends>QWidget</extends>
    <header>ctkCheckBox.h</header>
   </customwidget>
  </customwidgets>
  <resources/>
  <connections/>
 </ui>
 
diff --git a/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorToolGUI.cpp b/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorToolGUI.cpp
index 7e4fcf7b78..47c31e4702 100644
--- a/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorToolGUI.cpp
+++ b/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorToolGUI.cpp
@@ -1,395 +1,391 @@
 #include "QmitkTotalSegmentatorToolGUI.h"
 
 #include "mitkProcessExecutor.h"
 #include "mitkTotalSegmentatorTool.h"
 #include <QApplication>
 #include <QDir>
 #include <QDirIterator>
 #include <QFileDialog>
 #include <QIcon>
 #include <QMessageBox>
 #include <QStandardPaths>
 #include <QUrl>
 #include <QtGlobal>
 
 MITK_TOOL_GUI_MACRO(MITKSEGMENTATIONUI_EXPORT, QmitkTotalSegmentatorToolGUI, "")
 
 QmitkTotalSegmentatorToolGUI::QmitkTotalSegmentatorToolGUI()
   : QmitkMultiLabelSegWithPreviewToolGUIBase(), m_SuperclassEnableConfirmSegBtnFnc(m_EnableConfirmSegBtnFnc)
 {
   // Nvidia-smi command returning zero doesn't always imply lack of GPUs.
   // Pytorch uses its own libraries to communicate to the GPUs. Hence, only a warning can be given.
   if (m_GpuLoader.GetGPUCount() == 0)
   {
     std::string warning = "WARNING: No GPUs were detected on your machine. The TotalSegmentator tool can be very slow.";
     this->ShowErrorMessage(warning);
   }
   m_EnableConfirmSegBtnFnc = [this](bool enabled)
   { return !m_FirstPreviewComputation ? m_SuperclassEnableConfirmSegBtnFnc(enabled) : false; };
 }
 
 void QmitkTotalSegmentatorToolGUI::ConnectNewTool(mitk::SegWithPreviewTool *newTool)
 {
   Superclass::ConnectNewTool(newTool);
   newTool->IsTimePointChangeAwareOff();
   m_FirstPreviewComputation = true;
 }
 
 void QmitkTotalSegmentatorToolGUI::InitializeUI(QBoxLayout *mainLayout)
 {
   m_Controls.setupUi(this);
 #ifndef _WIN32
   m_Controls.sysPythonComboBox->addItem("/usr/bin");
 #endif
   m_Controls.sysPythonComboBox->addItem("Select");
   this->AutoParsePythonPaths();
 
-  m_Controls.pythonEnvComboBox->addItem("Default");
   m_Controls.pythonEnvComboBox->addItem("Select");
   m_Controls.pythonEnvComboBox->setDuplicatesEnabled(false);
   m_Controls.pythonEnvComboBox->setDisabled(true);
   m_Controls.previewButton->setDisabled(true);
   m_Controls.statusLabel->setTextFormat(Qt::RichText);
   m_Controls.subtaskComboBox->addItems(m_VALID_TASKS);
   QString welcomeText;
   this->SetGPUInfo();
   if (m_GpuLoader.GetGPUCount() != 0)
   {
     welcomeText = "<b>STATUS: </b><i>Welcome to Total Segmentator tool. You're in luck: " +
                                QString::number(m_GpuLoader.GetGPUCount()) + " GPU(s) were detected.</i>";
   }
   else
   {
     welcomeText = "<b>STATUS: </b><i>Welcome to Total Segmentator tool. Sorry, " +
                               QString::number(m_GpuLoader.GetGPUCount()) + " GPUs were detected.</i>";
   }
   mainLayout->addLayout(m_Controls.verticalLayout);
 
   connect(m_Controls.previewButton, SIGNAL(clicked()), this, SLOT(OnPreviewBtnClicked()));
   connect(m_Controls.installButton, SIGNAL(clicked()), this, SLOT(OnInstallBtnClicked()));
   connect(m_Controls.overrideBox, SIGNAL(stateChanged(int)), this, SLOT(OnOverrideChecked(int)));
+  connect(m_Controls.pythonEnvComboBox,
+          QOverload<int>::of(&QComboBox::activated),
+          [=](int index) { OnPythonPathChanged(m_Controls.pythonEnvComboBox->itemText(index)); });
 
   Superclass::InitializeUI(mainLayout);
   //QString lastSelectedPyEnv = m_Settings.value("TotalSeg/LastPythonPath").toString();
   //m_Controls.pythonEnvComboBox->insertItem(0, lastSelectedPyEnv);
   const QString storageDir = QStandardPaths::writableLocation(QStandardPaths::GenericDataLocation) + QDir::separator() +
                                qApp->organizationName() + QDir::separator() + m_VENV_NAME;
   m_IsInstalled = this->IsTotalSegmentatorInstalled(storageDir);
   if (m_IsInstalled)
   {
     m_PythonPath = GetPythonPathFromUI(storageDir);
     m_Installer.SetVirtualEnvPath(m_PythonPath);
     this->EnableAll(m_IsInstalled);
     welcomeText += " Totalsegmentator is already found installed"; 
   }
   else
   {
     welcomeText += " Totalsegmentator not installed. Please click on \"Install Totalsegmentator\" above.";
   }
   this->WriteStatusMessage(welcomeText);
 }
 
 void QmitkTotalSegmentatorToolGUI::EnableWidgets(bool enabled)
 {
   Superclass::EnableWidgets(enabled);
 }
 
 void QmitkTotalSegmentatorToolGUI::SetGPUInfo()
 {
   std::vector<QmitkGPUSpec> specs = m_GpuLoader.GetAllGPUSpecs();
   for (const QmitkGPUSpec &gpuSpec : specs)
   {
     m_Controls.gpuComboBox->addItem(QString::number(gpuSpec.id) + ": " + gpuSpec.name + " (" + gpuSpec.memory + ")");
   }
   if (specs.empty())
   {
     m_Controls.gpuComboBox->setEditable(true);
     m_Controls.gpuComboBox->addItem(QString::number(0));
     m_Controls.gpuComboBox->setValidator(new QIntValidator(0, 999, this));
   }
 }
 
 unsigned int QmitkTotalSegmentatorToolGUI::FetchSelectedGPUFromUI()
 {
   QString gpuInfo = m_Controls.gpuComboBox->currentText();
   if (m_GpuLoader.GetGPUCount() == 0)
   {
     return static_cast<unsigned int>(gpuInfo.toInt());
   }
   else
   {
     QString gpuId = gpuInfo.split(":", QString::SplitBehavior::SkipEmptyParts).first();
     return static_cast<unsigned int>(gpuId.toInt());
   }
 }
 
 void QmitkTotalSegmentatorToolGUI::EnableAll(bool isEnable)
 {
   m_Controls.previewButton->setEnabled(isEnable);
   m_Controls.subtaskComboBox->setEnabled(isEnable);
   m_Controls.installButton->setEnabled((!isEnable));
 }
 
 void QmitkTotalSegmentatorToolGUI::OnInstallBtnClicked()
 {
   bool isInstalled = false;
   MITK_INFO << m_Controls.sysPythonComboBox->currentText().toStdString();
   QString systemPython = GetPythonPathFromUI(m_Controls.sysPythonComboBox->currentText());
   MITK_INFO << systemPython.toStdString();
   if (systemPython.isEmpty())
   {
     this->WriteErrorMessage("Couldn't find Python");
     return;
   }
   else
   {
     m_Installer.SetSystemPythonPath(systemPython);
   }
   
   isInstalled = m_Installer.SetupVirtualEnv();
   if (isInstalled)
   {
     const QString pythonPath = m_Installer.GetVirtualEnvPath();
     m_PythonPath = GetPythonPathFromUI(m_Installer.GetVirtualEnvPath());
     this->WriteStatusMessage("Successfully installed TotalSegmentator");
   }
   else
   {
     this->WriteErrorMessage("Couldn't find TotalSegmentator");
   }
   this->EnableAll(isInstalled);
 }
 
 void QmitkTotalSegmentatorToolGUI::OnPreviewBtnClicked()
 {
   auto tool = this->GetConnectedToolAs<mitk::TotalSegmentatorTool>();
   if (nullptr == tool)
   {
     return;
   }
   // QString pythonPathTextItem = "";
   try
   {
     m_Controls.previewButton->setEnabled(false);
     qApp->processEvents();
     if (!this->IsTotalSegmentatorInstalled(m_PythonPath))
     {
       throw std::runtime_error(m_WARNING_TOTALSEG_NOT_FOUND);
     }
     bool isFast = m_Controls.fastBox->isChecked();
     QString subTask = m_Controls.subtaskComboBox->currentText();
     if (subTask != m_VALID_TASKS[0])
     {
       isFast = true;
     }
     tool->SetPythonPath(m_PythonPath.toStdString());
     tool->SetGpuId(FetchSelectedGPUFromUI());
     tool->SetFast(isFast);
     tool->SetSubTask(subTask.toStdString());
     this->WriteStatusMessage(QString("<b>STATUS: </b><i>Starting Segmentation task... This might take a while.</i>"));
     tool->UpdatePreview();
     m_Controls.previewButton->setEnabled(true);
   }
   catch (const std::exception &e)
   {
     std::stringstream errorMsg;
     errorMsg << "<b>STATUS: </b>Error while processing parameters for TotalSegmentator segmentation. Reason: "
              << e.what();
     this->ShowErrorMessage(errorMsg.str());
     this->WriteErrorMessage(QString::fromStdString(errorMsg.str()));
     m_Controls.previewButton->setEnabled(true);
     return;
   }
   catch (...)
   {
     std::string errorMsg = "Unkown error occured while generation TotalSegmentator segmentation.";
     this->ShowErrorMessage(errorMsg);
     m_Controls.previewButton->setEnabled(true);
     return;
   }
   this->SetLabelSetPreview(tool->GetPreviewSegmentation());
   tool->IsTimePointChangeAwareOn();
   this->ActualizePreviewLabelVisibility();
   this->WriteStatusMessage("<b>STATUS: </b><i>Segmentation task finished successfully.</i>");
   /* if (!pythonPathTextItem.isEmpty()) // only cache if the prediction ended without errors.
   {
     QString lastSelectedPyEnv = m_Settings.value("TotalSeg/LastPythonPath").toString();
     if (lastSelectedPyEnv != pythonPathTextItem)
     {
       m_Settings.setValue("TotalSeg/LastPythonPath", pythonPathTextItem);
     }
   }*/
 }
 
 void QmitkTotalSegmentatorToolGUI::ShowErrorMessage(const std::string &message, QMessageBox::Icon icon)
 {
   this->setCursor(Qt::ArrowCursor);
   QMessageBox *messageBox = new QMessageBox(icon, nullptr, message.c_str());
   messageBox->exec();
   delete messageBox;
   MITK_WARN << message;
 }
 
 void QmitkTotalSegmentatorToolGUI::WriteStatusMessage(const QString &message)
 {
   m_Controls.statusLabel->setText(message);
   m_Controls.statusLabel->setStyleSheet("font-weight: bold; color: white");
 }
 
 void QmitkTotalSegmentatorToolGUI::WriteErrorMessage(const QString &message)
 {
   m_Controls.statusLabel->setText(message);
   m_Controls.statusLabel->setStyleSheet("font-weight: bold; color: red");
 }
 
 bool QmitkTotalSegmentatorToolGUI::IsTotalSegmentatorInstalled(const QString &pythonPath)
 {
   QString fullPath = pythonPath;
   fullPath = fullPath.mid(fullPath.indexOf(" ") + 1);
-  bool isPythonExists, isTotalSegExists = false;
+  bool isPythonExists = false;
 #ifdef _WIN32
   isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python.exe"));
   if (!(fullPath.endsWith("Scripts", Qt::CaseInsensitive) || fullPath.endsWith("Scripts/", Qt::CaseInsensitive)))
   {
     fullPath += QDir::separator() + QString("Scripts");
     isPythonExists =
       (!isPythonExists) ? QFile::exists(fullPath + QDir::separator() + QString("python.exe")) : isPythonExists;
   }
 #else
   isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python3"));
   if (!(fullPath.endsWith("bin", Qt::CaseInsensitive) || fullPath.endsWith("bin/", Qt::CaseInsensitive)))
   {
     fullPath += QDir::separator() + QString("bin");
     isPythonExists =
       (!isPythonExists) ? QFile::exists(fullPath + QDir::separator() + QString("python3")) : isPythonExists;
   }
 #endif
   bool isExists = QFile::exists(fullPath + QDir::separator() + QString("TotalSegmentator")) && isPythonExists;
   return isExists;
 }
 
 void QmitkTotalSegmentatorToolGUI::AutoParsePythonPaths()
 {
   QString homeDir = QDir::homePath();
   std::vector<QString> searchDirs;
 #ifdef _WIN32
   searchDirs.push_back(QString("C:") + QDir::separator() + QString("ProgramData") + QDir::separator() +
                        QString("anaconda3"));
 #else
   // Add search locations for possible standard python paths here
   searchDirs.push_back(homeDir + QDir::separator() + "environments");
   searchDirs.push_back(homeDir + QDir::separator() + "anaconda3");
   searchDirs.push_back(homeDir + QDir::separator() + "miniconda3");
   searchDirs.push_back(homeDir + QDir::separator() + "opt" + QDir::separator() + "miniconda3");
   searchDirs.push_back(homeDir + QDir::separator() + "opt" + QDir::separator() + "anaconda3");
 #endif
   for (QString searchDir : searchDirs)
   {
     if (searchDir.endsWith("anaconda3", Qt::CaseInsensitive))
     {
       if (QDir(searchDir).exists())
       {
         m_Controls.sysPythonComboBox->insertItem(0, "(base): " + searchDir);
         searchDir.append((QDir::separator() + QString("envs")));
       }
     }
     for (QDirIterator subIt(searchDir, QDir::AllDirs, QDirIterator::NoIteratorFlags); subIt.hasNext();)
     {
       subIt.next();
       QString envName = subIt.fileName();
       if (!envName.startsWith('.')) // Filter out irrelevent hidden folders, if any.
       {
         m_Controls.sysPythonComboBox->insertItem(0, "(" + envName + "): " + subIt.filePath());
       }
     }
   }
   m_Controls.sysPythonComboBox->setCurrentIndex(-1);
 }
 
 void QmitkTotalSegmentatorToolGUI::OnPythonPathChanged(const QString &pyEnv)
 {
   if (pyEnv == QString("Select"))
   {
+    m_Controls.previewButton->setDisabled(true);
     QString path =
       QFileDialog::getExistingDirectory(m_Controls.pythonEnvComboBox->parentWidget(), "Python Path", "dir");
     if (!path.isEmpty())
     {
       this->OnPythonPathChanged(path);                                  // recall same function for new path validation
       bool oldState = m_Controls.pythonEnvComboBox->blockSignals(true); // block signal firing while inserting item
       m_Controls.pythonEnvComboBox->insertItem(0, path);
       m_Controls.pythonEnvComboBox->setCurrentIndex(0);
       m_Controls.pythonEnvComboBox->blockSignals(
         oldState); // unblock signal firing after inserting item. Remove this after Qt6 migration
     }
   }
   else if (!this->IsTotalSegmentatorInstalled(pyEnv))
   {
     this->ShowErrorMessage(m_WARNING_TOTALSEG_NOT_FOUND);
     m_Controls.previewButton->setDisabled(true);
   }
   else
   {// Show positive status meeage
     m_Controls.previewButton->setDisabled(false);
     m_PythonPath = GetPythonPathFromUI(pyEnv);
   }
 }
 
 QString QmitkTotalSegmentatorToolGUI::GetPythonPathFromUI(const QString &pyEnv)
 {
   QString pythonPath;
   QString fullPath = pyEnv.mid(pyEnv.indexOf(" ") + 1);
   bool isPythonExists = false;
 #ifdef _WIN32
   isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python.exe"));
   if (isPythonExists)
   {
     pythonPath = fullPath;
   }
   else if (!(fullPath.endsWith("Scripts", Qt::CaseInsensitive) || fullPath.endsWith("Scripts/", Qt::CaseInsensitive)))
   {
     fullPath += QDir::separator() + QString("Scripts");
     pythonPath = fullPath;
   }
 #else
   isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python3"));
   if (isPythonExists)
   {
     pythonPath = fullPath;
   }
   else if (!(fullPath.endsWith("bin", Qt::CaseInsensitive) || fullPath.endsWith("bin/", Qt::CaseInsensitive)))
   {
     fullPath += QDir::separator() + QString("bin");
     pythonPath = fullPath;
   }
 #endif
   return pythonPath;
 }
 
 void QmitkTotalSegmentatorToolGUI::OnOverrideChecked(int state)
 {
   bool isEnabled = false;
   if (state == Qt::Checked)
   {
     isEnabled = true;
     m_Controls.previewButton->setDisabled(true);
     m_PythonPath.clear();
-    connect(m_Controls.pythonEnvComboBox,
-            SIGNAL(currentTextChanged(const QString &)),
-            this,
-            SLOT(OnPythonPathChanged(const QString &)));
   }
   else
   {
     m_PythonPath.clear();
-    disconnect(m_Controls.pythonEnvComboBox,
-            SIGNAL(currentTextChanged(const QString &)),
-            this,
-            SLOT(OnPythonPathChanged(const QString &)));
+    m_Controls.previewButton->setDisabled(true);
     if (m_IsInstalled)
     {
       m_PythonPath = m_Installer.GetVirtualEnvPath();
       this->EnableAll(m_IsInstalled);
     }
   }
   m_Controls.pythonEnvComboBox->setEnabled(isEnabled);
 }