diff --git a/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkTensorReconstructionWithEigenvalueCorrectionFilter.h b/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkTensorReconstructionWithEigenvalueCorrectionFilter.h index 9fd7134aa7..0136a7bd16 100644 --- a/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkTensorReconstructionWithEigenvalueCorrectionFilter.h +++ b/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkTensorReconstructionWithEigenvalueCorrectionFilter.h @@ -1,253 +1,255 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ /*========================================================================= Program: Tensor ToolKit - TTK Module: $URL: svn://scm.gforge.inria.fr/svn/ttk/trunk/Algorithms/itkTensorImageToDiffusionImageFilter.h $ Language: C++ Date: $Date: 2010-06-07 13:39:13 +0200 (Mo, 07 Jun 2010) $ Version: $Revision: 68 $ Copyright (c) INRIA 2010. All rights reserved. See LICENSE.txt for details. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the above copyright notices for more information. =========================================================================*/ #ifndef _itk_TensorReconstructionWithEigenvalueCorrectionFilter_h_ #define _itk_TensorReconstructionWithEigenvalueCorrectionFilter_h_ #include "itkImageToImageFilter.h" #include #include #include #include #include typedef itk::VectorImage ImageType; namespace itk { template class TensorReconstructionWithEigenvalueCorrectionFilter : public ImageToImageFilter< itk::Image< TDiffusionPixelType, 3 >, itk::Image,3> > { public: typedef TensorReconstructionWithEigenvalueCorrectionFilter Self; typedef SmartPointer Pointer; typedef SmartPointer ConstPointer; typedef ImageToImageFilter< Image< TDiffusionPixelType, 3>, Image< DiffusionTensor3D< TTensorPixelType >, 3 > > Superclass; /** Method for creation through the object factory. */ itkNewMacro(Self); /** Runtime information support. */ itkTypeMacro(TensorReconstructionWithEigenvalueCorrectionFilter, ImageToImageFilter); typedef TDiffusionPixelType ReferencePixelType; typedef TDiffusionPixelType GradientPixelType; typedef DiffusionTensor3D< TTensorPixelType > TensorPixelType; /** Reference image data, This image is aquired in the absence * of a diffusion sensitizing field gradient */ typedef typename Superclass::InputImageType ReferenceImageType; typedef Image< TensorPixelType, 3 > TensorImageType; typedef TensorImageType OutputImageType; typedef typename Superclass::OutputImageRegionType OutputImageRegionType; /** Typedef defining one (of the many) gradient images. */ typedef Image< GradientPixelType, 3 > GradientImageType; /** An alternative typedef defining one (of the many) gradient images. * It will be assumed that the vectorImage has the same dimension as the * Reference image and a vector length parameter of \c n (number of * gradient directions) */ typedef VectorImage< GradientPixelType, 3 > GradientImagesType; typedef typename GradientImagesType::PixelType GradientVectorType; /* /** Holds the tensor basis coefficients G_k typedef vnl_matrix_fixed< double, 6, 6 > TensorBasisMatrixType; typedef vnl_matrix< double > CoefficientMatrixType; */ /** Holds each magnetic field gradient used to acquire one DWImage */ typedef vnl_vector_fixed< double, 3 > GradientDirectionType; /** Container to hold gradient directions of the 'n' DW measurements */ typedef VectorContainer< unsigned int, GradientDirectionType > GradientDirectionContainerType; /** Another set method to add a gradient directions and its corresponding * image. The image here is a VectorImage. The user is expected to pass the * gradient directions in a container. The ith element of the container * corresponds to the gradient direction of the ith component image the * VectorImage. For the baseline image, a vector of all zeros * should be set. */ void SetGradientImage( GradientDirectionContainerType *, const GradientImagesType *image); /** Set method to set the reference image. */ void SetReferenceImage( ReferenceImageType *referenceImage ) { if( m_GradientImageTypeEnumeration == GradientIsInASingleImage) { itkExceptionMacro( << "Cannot call both methods:" << "AddGradientImage and SetGradientImage. Please call only one of them."); } this->ProcessObject::SetNthInput( 0, referenceImage ); m_GradientImageTypeEnumeration = GradientIsInManyImages; } /** Get reference image */ virtual ReferenceImageType * GetReferenceImage() { return ( static_cast< ReferenceImageType *>(this->ProcessObject::GetInput(0)) ); } /** Return the gradient direction. idx is 0 based */ virtual GradientDirectionType GetGradientDirection( unsigned int idx) const { if( idx >= m_NumberOfGradientDirections ) { itkExceptionMacro( << "Gradient direction " << idx << "does not exist" ); } return m_GradientDirectionContainer->ElementAt( idx+1 ); } itkSetMacro( BValue, TTensorPixelType); itkSetMacro( B0Threshold, float); + itkSetMacro (Flagstatus, int); itkGetMacro(PseudoInverse, vnl_matrix); itkGetMacro(H, vnl_matrix); itkGetMacro(BVec, vnl_vector); itkGetMacro(B0Mask, vnl_vector); itkGetMacro(Voxdim, vnl_vector); mitk::DiffusionImage::Pointer GetOutputDiffusionImage() { return m_OutputDiffusionImage; } ImageType::Pointer GetVectorImage() { return m_VectorImage; } itk::Image::Pointer GetMask() { return m_MaskImage; } //itkGetMacro(OutputDiffusionImage, mitk::DiffusionImage) //itkGetMacro( GradientDirectionContainer, GradientDirectionContainerType::Pointer); protected: TensorReconstructionWithEigenvalueCorrectionFilter(); ~TensorReconstructionWithEigenvalueCorrectionFilter() {}; void GenerateData(); typedef enum { GradientIsInASingleImage = 1, GradientIsInManyImages, Else } GradientImageTypeEnumeration; private: short CheckNeighbours(int x, int y, int z,int f, itk::Size<3> size); void CalculateAttenuation(vnl_vector org_data, vnl_vector &atten,int nof,int numberb0); void CalculateTensor(vnl_matrix pseudoInverse,vnl_vector atten, vnl_vector &tensor,int nof,int numberb0); /** Gradient image was specified in a single image or in multiple images */ GradientImageTypeEnumeration m_GradientImageTypeEnumeration; /** Number of gradient measurements */ unsigned int m_NumberOfGradientDirections; /** container to hold gradient directions */ GradientDirectionContainerType::Pointer m_GradientDirectionContainer; /** b-value */ TTensorPixelType m_BValue; /** Number of baseline images */ unsigned int m_NumberOfBaselineImages; mitk::DiffusionImage::Pointer m_OutputDiffusionImage; ImageType::Pointer m_VectorImage; float m_B0Threshold; itk::Image::Pointer m_MaskImage; vnl_matrix m_PseudoInverse; vnl_matrix m_H; vnl_vector m_BVec; vnl_vector m_B0Mask; vnl_vector m_Voxdim; + int m_Flagstatus; typename GradientImagesType::Pointer m_GradientImagePointer; }; } // end of namespace #ifndef ITK_MANUAL_INSTANTIATION #include "itkTensorReconstructionWithEigenvalueCorrectionFilter.txx" #endif #endif diff --git a/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkTensorReconstructionWithEigenvalueCorrectionFilter.txx b/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkTensorReconstructionWithEigenvalueCorrectionFilter.txx index 88d1f7e0ad..7a48b554e8 100644 --- a/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkTensorReconstructionWithEigenvalueCorrectionFilter.txx +++ b/Modules/DiffusionImaging/DiffusionCore/Algorithms/itkTensorReconstructionWithEigenvalueCorrectionFilter.txx @@ -1,594 +1,605 @@ /*=================================================================== The Medical Imaging Interaction Toolkit (MITK) Copyright (c) German Cancer Research Center, Division of Medical and Biological Informatics. All rights reserved. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See LICENSE.txt or http://www.mitk.org for details. ===================================================================*/ /*========================================================================= Program: Tensor ToolKit - TTK Module: $URL: svn://scm.gforge.inria.fr/svn/ttk/trunk/Algorithms/itkTensorImageToDiffusionImageFilter.txx $ Language: C++ Date: $Date: 2010-06-07 13:39:13 +0200 (Mo, 07 Jun 2010) $ Version: $Revision: 68 $ Copyright (c) INRIA 2010. All rights reserved. See LICENSE.txt for details. This software is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the above copyright notices for more information. =========================================================================*/ #ifndef _itk_TensorReconstructionWithEigenvalueCorrectionFilter_txx_ #define _itk_TensorReconstructionWithEigenvalueCorrectioFiltern_txx_ #endif #include "itkImageRegionConstIterator.h" #include #include namespace itk { template TensorReconstructionWithEigenvalueCorrectionFilter ::TensorReconstructionWithEigenvalueCorrectionFilter() { m_B0Threshold = 50.0; + m_Flagstatus = 0; } template void TensorReconstructionWithEigenvalueCorrectionFilter - ::GenerateData ( ) + ::GenerateData () { + m_GradientImagePointer = static_cast< GradientImagesType * >( this->ProcessObject::GetInput(0) ); typename GradientImagesType::SizeType size = m_GradientImagePointer->GetLargestPossibleRegion().GetSize(); int nof = m_GradientDirectionContainer->Size(); int numberb0=0; int cnt=0; for(int i=0; i vec = m_GradientDirectionContainer->ElementAt(i); if(vec[0]<0.0001 && vec[1]<0.0001 && vec[2]<0.0001 && vec[0]>-0.0001&& vec[1]>-0.0001 && vec[2]>-0.0001) { numberb0++; } } itk::Vector spacing_term = m_GradientImagePointer->GetSpacing(); itk::Matrix direction_term = m_GradientImagePointer->GetDirection(); vnl_vector spacing_vnl(3); vnl_matrix dir_vnl (3,3); for (int i=0;i<3;i++) { spacing_vnl[i]=spacing_term[i]; for(int j=0;j<3;j++) { dir_vnl[i][j]=direction_term[i][j]; } } vnl_matrix vox_dim_step (3,3); for (int i=0;i<3;i++) { for(int j=0;j<3;j++) { vox_dim_step[i][j]=spacing_vnl[i]*dir_vnl[i][j]; } } vnl_symmetric_eigensystem eigen_spacing(vox_dim_step); vnl_vector vox_dim (3); vox_dim[0]=eigen_spacing.get_eigenvalue(0); vox_dim[1]=eigen_spacing.get_eigenvalue(1); vox_dim[2]=eigen_spacing.get_eigenvalue(2); vox_dim=vox_dim/(vox_dim.min_value()); vnl_matrix directions(nof-numberb0,3); m_B0Mask.set_size(nof); for(int i=0; i vec = m_GradientDirectionContainer->ElementAt(i); if(vec[0]<0.0001 && vec[1]<0.0001 && vec[2]<0.0001 && vec[0]>-0.001&& vec[1]>-0.001 && vec[2]>-0.001) { m_B0Mask[i]=1; } else { m_B0Mask[i]=0; directions[cnt][0] = vec[0]; directions[cnt][1] = vec[1]; directions[cnt][2] = vec[2]; cnt++; } } vnl_matrix dirsTimesDirsTrans = directions*directions.transpose(); vnl_vector< double> diagonal(nof-numberb0); vnl_vector< double> b_vec(nof-numberb0); vnl_vector< double> temporary(3); for (int i=0;i H(nof-numberb0, 6); vnl_matrix H_org(nof-numberb0, 6); vnl_vector pre_tensor(9); int etbt[6] = { 0, 4, 8, 1, 5, 2 }; for (int i = 0; i < nof-numberb0; i++) { for (int j = 0; j < 3; j++) { temporary[j] = -directions[i][j]; } for (int j = 0; j < 3; j++) { for (int k = 0; k < 3; k++) { pre_tensor[k + 3 * j] = temporary[k] * directions[i][j]; } } for (int j = 0; j < 6; j++) { H[i][j] = pre_tensor[etbt[j]]; } for (int j = 0; j < 3; j++) { H[i][3 + j] *= 2.0; } } H_org=H; vnl_matrix inputtopseudoinverse=H.transpose()*H; vnl_symmetric_eigensystem eig( inputtopseudoinverse); vnl_matrix pseudoInverse = eig.pinverse()*H.transpose(); itk::Index<3> ix; ImageType::Pointer corrected_diffusion = ImageType::New(); corrected_diffusion->SetRegions(size); corrected_diffusion->SetSpacing(m_GradientImagePointer->GetSpacing()); corrected_diffusion->SetOrigin(m_GradientImagePointer->GetOrigin()); corrected_diffusion->SetVectorLength(nof); corrected_diffusion->Allocate(); typedef itk::VariableLengthVector VariableVectorType; VariableVectorType variableLengthVector; variableLengthVector.SetSize(nof); // removing negative values for ( int x=0;xGetPixel(ix); for( int f=0;fSetPixel(ix, variableLengthVector); } } } vnl_vector org_data(nof); vnl_vector atten(nof-numberb0); double mean_b=0.0; double pixel=0.0; vnl_vector tensor (6); typedef itk::Image MaskImageType; MaskImageType::Pointer mask = MaskImageType::New(); mask->SetRegions(m_GradientImagePointer->GetLargestPossibleRegion().GetSize()); mask->SetSpacing(m_GradientImagePointer->GetSpacing()); mask->SetOrigin(m_GradientImagePointer->GetOrigin()); mask->Allocate(); int mask_cnt=0; for(int x=0;xGetPixel(ix); for (int i=0;im_B0Threshold) { mask->SetPixel(ix, 1); mask_cnt++; } else { mask->SetPixel(ix, 0); } } } } std::cout << "Number of voxels in mask: " << mask_cnt << std::endl; typedef itk::Image< itk::DiffusionTensor3D, 3 > TensorImageType; TensorImageType::Pointer tensorImg = TensorImageType::New(); tensorImg->SetRegions(m_GradientImagePointer->GetLargestPossibleRegion().GetSize()); tensorImg->SetSpacing(m_GradientImagePointer->GetSpacing()); tensorImg->SetOrigin(m_GradientImagePointer->GetOrigin()); tensorImg->Allocate(); vnl_matrix temp_tensor(3,3); vnl_vector eigen_vals(3); int number_of_bads=0; int old_number_of_bads=10000000000000000; int diff=1; vnl_vector< double> pixel_max(nof); vnl_vector< double> pixel_min(nof); for (int i=1;i0) { for (int x=0;xGetPixel(ix); itk::DiffusionTensor3D ten; if(mask->GetPixel(ix) == 1) { ix[0] = x; ix[1] = y; ix[2] = z; GradientVectorType pt = corrected_diffusion->GetPixel(ix); for (int i=0;i eigen_tensor(temp_tensor); eigen_vals[0]=eigen_tensor.get_eigenvalue(0); eigen_vals[1]=eigen_tensor.get_eigenvalue(1); eigen_vals[2]=eigen_tensor.get_eigenvalue(2); } else // the tensor is invalid, i.e. contains some NAN entries { // set the eigenvalues manually to -1 to force the idx to be marked as bad voxel eigen_vals[0] = eigen_vals[1] = eigen_vals[2] = -1; } if( eigen_vals[0]>0.0 && eigen_vals[1]>0.0 && eigen_vals[2]>0.0) { tensorImg->SetPixel(ix, ten); }//end of if eigenvalues else { number_of_bads++; ten.Fill(0.0); tensorImg->SetPixel(ix, ten); for (int f=0;fpixel_max[f] || pt[f]< pixel_min[f]) { variableLengthVector[f] = CheckNeighbours(x,y,z,f,size); } } corrected_diffusion->SetPixel(ix, variableLengthVector); } } else { ten.Fill(0.0); tensorImg->SetPixel(ix, ten); } } } } diff=old_number_of_bads-number_of_bads; old_number_of_bads=number_of_bads; std::cout << "bad voxels: " << number_of_bads << std::endl; number_of_bads=0; } this->SetNthOutput(0, tensorImg); m_VectorImage = corrected_diffusion; m_MaskImage = mask; m_PseudoInverse = pseudoInverse; m_H = H_org; m_BVec=b_vec; m_Voxdim = vox_dim; } template void TensorReconstructionWithEigenvalueCorrectionFilter ::SetGradientImage( GradientDirectionContainerType *gradientDirection, const GradientImagesType *gradientImage ) { // Make sure crazy users did not call both AddGradientImage and // SetGradientImage if( m_GradientImageTypeEnumeration == GradientIsInManyImages ) { itkExceptionMacro( << "Cannot call both methods:" << "AddGradientImage and SetGradientImage. Please call only one of them."); } this->m_GradientDirectionContainer = gradientDirection; unsigned int numImages = gradientDirection->Size(); this->m_NumberOfBaselineImages = 0; this->m_NumberOfGradientDirections = numImages - this->m_NumberOfBaselineImages; // ensure that the gradient image we received has as many components as // the number of gradient directions if( gradientImage->GetVectorLength() != this->m_NumberOfBaselineImages + this->m_NumberOfGradientDirections ) { itkExceptionMacro( << this->m_NumberOfGradientDirections << " gradients + " << this->m_NumberOfBaselineImages << "baselines = " << this->m_NumberOfGradientDirections + this->m_NumberOfBaselineImages << " directions specified but image has " << gradientImage->GetVectorLength() << " components."); } this->ProcessObject::SetNthInput( 0, const_cast< GradientImagesType* >(gradientImage) ); m_GradientImageTypeEnumeration = GradientIsInASingleImage; } template short TensorReconstructionWithEigenvalueCorrectionFilter ::CheckNeighbours(int x, int y, int z,int f, itk::Size<3> size) { int init_i, init_j, init_c, limit_i, limit_j, limit_c; double tempsum=0.0; double temp_number=0.0; init_i=x-1; limit_i=x+2; if(x==0) init_i=x; else if(x==size[0]-1) limit_i=x+1; init_j=y-1; limit_j=y+2; if(y==0) init_j=y; else if(y==size[1]-1) limit_j=y+1; init_c=z-1; limit_c=z+2; if(z==0) init_c=z; else if(z==size[2]-1) limit_c=z+1; for(int i=init_i; i ix; ix[0] = i; ix[1] = j; ix[2] = c; GradientVectorType p = m_GradientImagePointer->GetPixel(ix); if(p[f]>=0.0) { tempsum=tempsum+p[f]; temp_number++; } } } } if (temp_number==0.0) { tempsum=0.0; } else { tempsum=tempsum/temp_number; } short ret = (short)tempsum; return ret; } template void TensorReconstructionWithEigenvalueCorrectionFilter ::CalculateAttenuation(vnl_vector org_data,vnl_vector &atten,int nof, int numberb0) { double mean_b=0.0; for (int i=0;i void TensorReconstructionWithEigenvalueCorrectionFilter ::CalculateTensor(vnl_matrix pseudoInverse,vnl_vector atten,vnl_vector &tensor, int nof,int numberb0) { for (int i=0;i