diff --git a/CMakeExternals/ITK-4.13.3.patch b/CMakeExternals/ITK-4.13.3.patch
deleted file mode 100644
index a21a50b384..0000000000
--- a/CMakeExternals/ITK-4.13.3.patch
+++ /dev/null
@@ -1,53 +0,0 @@
-diff --git a/Modules/Core/Common/include/itkBoundingBox.h b/Modules/Core/Common/include/itkBoundingBox.h
-index 36b03aaa7f..64205acfab 100644
---- a/Modules/Core/Common/include/itkBoundingBox.h
-+++ b/Modules/Core/Common/include/itkBoundingBox.h
-@@ -87,7 +87,7 @@ public:
-   itkTypeMacro(BoundingBox, Object);
- 
-   /** Method for creation through the object factory. */
--  itkNewMacro(Self);
-+  itkFactorylessNewMacro(Self);
- 
-   /** Hold on to the type information specified by the template parameters. */
-   typedef TPointIdentifier                       PointIdentifier;
-diff --git a/Modules/Core/Common/include/itkVectorContainer.h b/Modules/Core/Common/include/itkVectorContainer.h
-index 72293c4ce8..e6366c66b5 100644
---- a/Modules/Core/Common/include/itkVectorContainer.h
-+++ b/Modules/Core/Common/include/itkVectorContainer.h
-@@ -92,7 +92,7 @@ public:
-   typedef VectorType                     STLContainerType;
- 
-   /** Method for creation through the object factory. */
--  itkNewMacro(Self);
-+  itkFactorylessNewMacro(Self);
- 
-   /** Standard part of every itk Object. */
-   itkTypeMacro(VectorContainer, Object);
-diff --git a/Modules/Core/Transform/include/itkScalableAffineTransform.h b/Modules/Core/Transform/include/itkScalableAffineTransform.h
-index 4e830476a2..b5efeb95a4 100644
---- a/Modules/Core/Transform/include/itkScalableAffineTransform.h
-+++ b/Modules/Core/Transform/include/itkScalableAffineTransform.h
-@@ -47,7 +47,8 @@ public:
-   itkTypeMacro(ScalableAffineTransform, AffineTransform);
- 
-   /** New macro for creation of through a Smart Pointer   */
--  itkNewMacro(Self);
-+  itkFactorylessNewMacro(Self);
-+  itkCloneMacro(Self);
- 
-   /** Dimension of the domain space. */
-   itkStaticConstMacro(InputSpaceDimension, unsigned int, NDimensions);
-diff --git a/Modules/ThirdParty/OpenJPEG/src/openjpeg/opj_includes.h b/Modules/ThirdParty/OpenJPEG/src/openjpeg/opj_includes.h
-index e75a220d4d..90d5bf1218 100644
---- a/Modules/ThirdParty/OpenJPEG/src/openjpeg/opj_includes.h
-+++ b/Modules/ThirdParty/OpenJPEG/src/openjpeg/opj_includes.h
-@@ -88,7 +88,7 @@ Most compilers implement their own version of this keyword ...
- #endif
- 
- /* MSVC and Borland C do not have lrintf */
--#if defined(_MSC_VER) || defined(__BORLANDC__)
-+#if (defined(_MSC_VER) && _MSC_VER < 1928) || defined(__BORLANDC__)
- 
- /* MSVC 64bits doesn't support _asm */
- #if !defined(_WIN64)
diff --git a/CMakeExternals/ITK.cmake b/CMakeExternals/ITK.cmake
index 3869dd614a..4bb85c5d7d 100644
--- a/CMakeExternals/ITK.cmake
+++ b/CMakeExternals/ITK.cmake
@@ -1,87 +1,87 @@
 #-----------------------------------------------------------------------------
 # ITK
 #-----------------------------------------------------------------------------
 
 # Sanity checks
 if(DEFINED ITK_DIR AND NOT EXISTS ${ITK_DIR})
   message(FATAL_ERROR "ITK_DIR variable is defined but corresponds to non-existing directory")
 endif()
 
 set(proj ITK)
 set(proj_DEPENDENCIES GDCM)
 
 if(MITK_USE_OpenCV)
   list(APPEND proj_DEPENDENCIES OpenCV)
 endif()
 
 if(MITK_USE_HDF5)
   list(APPEND proj_DEPENDENCIES HDF5)
 endif()
 
 set(ITK_DEPENDS ${proj})
 
 if(NOT DEFINED ITK_DIR)
 
   set(additional_cmake_args -DUSE_WRAP_ITK:BOOL=OFF)
 
+  list(APPEND additional_cmake_args
+    -DITKV4_COMPATIBILITY:BOOL=OFF
+    -DITK_LEGACY_REMOVE:BOOL=ON
+  )
+
   if(MITK_USE_OpenCV)
     list(APPEND additional_cmake_args
          -DModule_ITKVideoBridgeOpenCV:BOOL=ON
          -DOpenCV_DIR:PATH=${OpenCV_DIR}
         )
   endif()
 
   # Keep the behaviour of ITK 4.3 which by default turned on ITK Review
   # see MITK bug #17338
   list(APPEND additional_cmake_args
     -DModule_ITKReview:BOOL=ON
     -DModule_ITKOpenJPEG:BOOL=ON # for 4.7, the OpenJPEG is needed by review but the variable must be set
     -DModule_IsotropicWavelets:BOOL=ON
   )
 
   if(CTEST_USE_LAUNCHERS)
     list(APPEND additional_cmake_args
       "-DCMAKE_PROJECT_${proj}_INCLUDE:FILEPATH=${CMAKE_ROOT}/Modules/CTestUseLaunchers.cmake"
     )
   endif()
 
   mitk_query_custom_ep_vars()
 
   ExternalProject_Add(${proj}
      LIST_SEPARATOR ${sep}
      UPDATE_COMMAND ""
-     URL ${MITK_THIRDPARTY_DOWNLOAD_PREFIX_URL}/InsightToolkit-4.13.3.tar.gz
-     URL_MD5 d1c10c8288b47577d718a71190444815
-     PATCH_COMMAND
-       # 2021/03/26: Only the patch file changed since the last snapshot.
-       # The only purpose of this comment is to change this .cmake file
-       # to make our build system aware of a change.
-       ${PATCH_COMMAND} -N -p1 -i ${CMAKE_CURRENT_LIST_DIR}/ITK-4.13.3.patch
+     URL ${MITK_THIRDPARTY_DOWNLOAD_PREFIX_URL}/InsightToolkit-5.1.2.tar.gz
+     URL_MD5 e939fc61e7354eba20f98fbd7b034ec2
      CMAKE_GENERATOR ${gen}
      CMAKE_GENERATOR_PLATFORM ${gen_platform}
      CMAKE_ARGS
        ${ep_common_args}
        ${additional_cmake_args}
        -DBUILD_EXAMPLES:BOOL=OFF
        -DITK_USE_SYSTEM_GDCM:BOOL=ON
        -DGDCM_DIR:PATH=${GDCM_DIR}
        -DITK_USE_SYSTEM_HDF5:BOOL=ON
        -DHDF5_DIR:PATH=${HDF5_DIR}
        ${${proj}_CUSTOM_CMAKE_ARGS}
      CMAKE_CACHE_ARGS
        ${ep_common_cache_args}
        ${${proj}_CUSTOM_CMAKE_CACHE_ARGS}
      CMAKE_CACHE_DEFAULT_ARGS
        ${ep_common_cache_default_args}
        ${${proj}_CUSTOM_CMAKE_CACHE_DEFAULT_ARGS}
      DEPENDS ${proj_DEPENDENCIES}
     )
 
   set(ITK_DIR ${ep_prefix})
   mitkFunctionInstallExternalCMakeProject(${proj})
 
 else()
 
   mitkMacroEmptyExternalProject(${proj} "${proj_DEPENDENCIES}")
 
 endif()