diff --git a/Modules/Segmentation/Interactions/mitknnUnetTool.cpp b/Modules/Segmentation/Interactions/mitknnUnetTool.cpp
index 9ca820f1e5..ea59828a46 100644
--- a/Modules/Segmentation/Interactions/mitknnUnetTool.cpp
+++ b/Modules/Segmentation/Interactions/mitknnUnetTool.cpp
@@ -1,313 +1,314 @@
 /*============================================================================
 
 The Medical Imaging Interaction Toolkit (MITK)
 
 Copyright (c) German Cancer Research Center (DKFZ)
 All rights reserved.
 
 Use of this source code is governed by a 3-clause BSD license that can be
 found in the LICENSE file.
 
 ============================================================================*/
 
 #include "mitknnUnetTool.h"
 
 #include "mitkIOUtil.h"
 #include "mitkProcessExecutor.h"
 #include <itksys/SystemTools.hxx>
 #include <usGetModuleContext.h>
 #include <usModule.h>
 #include <usModuleContext.h>
 #include <usModuleResource.h>
+#include <filesystem>
 
 namespace mitk
 {
   MITK_TOOL_MACRO(MITKSEGMENTATION_EXPORT, nnUNetTool, "nnUNet tool");
 }
 
 mitk::nnUNetTool::~nnUNetTool()
 {
-  itksys::SystemTools::RemoveADirectory(this->GetMitkTempDir());
+  std::filesystem::remove_all(this->GetMitkTempDir());
 }
 
 void mitk::nnUNetTool::Activated()
 {
   Superclass::Activated();
   this->SetLabelTransferMode(LabelTransferMode::AllLabels);
 }
 
 void mitk::nnUNetTool::RenderOutputBuffer()
 {
   if (m_OutputBuffer != nullptr)
   {
     try
     {
       if (nullptr != this->GetPreviewSegmentationNode())
       {
         auto previewImage = this->GetPreviewSegmentation();
         previewImage->InitializeByLabeledImage(m_OutputBuffer);
       }
     }
     catch (const mitk::Exception &e)
     {
       MITK_INFO << e.GetDescription();
     }
   }
 }
 
 void mitk::nnUNetTool::SetOutputBuffer(LabelSetImage::Pointer segmentation)
 {
   m_OutputBuffer = segmentation;
 }
 
 mitk::LabelSetImage::Pointer mitk::nnUNetTool::GetOutputBuffer()
 {
   return m_OutputBuffer;
 }
 
 void mitk::nnUNetTool::ClearOutputBuffer()
 {
   m_OutputBuffer = nullptr;
 }
 
 us::ModuleResource mitk::nnUNetTool::GetIconResource() const
 {
   us::Module *module = us::GetModuleContext()->GetModule();
   us::ModuleResource resource = module->GetResource("AI.svg");
   return resource;
 }
 
 const char **mitk::nnUNetTool::GetXPM() const
 {
   return nullptr;
 }
 
 const char *mitk::nnUNetTool::GetName() const
 {
   return "nnUNet";
 }
 
 mitk::DataStorage *mitk::nnUNetTool::GetDataStorage()
 {
   return this->GetToolManager()->GetDataStorage();
 }
 
 mitk::DataNode *mitk::nnUNetTool::GetRefNode()
 {
   return this->GetToolManager()->GetReferenceData(0);
 }
 
 namespace
 {
   void onPythonProcessEvent(itk::Object * /*pCaller*/, const itk::EventObject &e, void *)
   {
     std::string testCOUT;
     std::string testCERR;
     const auto *pEvent = dynamic_cast<const mitk::ExternalProcessStdOutEvent *>(&e);
 
     if (pEvent)
     {
       testCOUT = testCOUT + pEvent->GetOutput();
       MITK_INFO << testCOUT;
     }
 
     const auto *pErrEvent = dynamic_cast<const mitk::ExternalProcessStdErrEvent *>(&e);
 
     if (pErrEvent)
     {
       testCERR = testCERR + pErrEvent->GetOutput();
       MITK_ERROR << testCERR;
     }
   }
 } // namespace
 
 void mitk::nnUNetTool::DoUpdatePreview(const Image* inputAtTimeStep, const Image* /*oldSegAtTimeStep*/, LabelSetImage* previewImage, TimeStepType /*timeStep*/)
 {
   if (this->GetMitkTempDir().empty())
   {
-    this->SetMitkTempDir(IOUtil::CreateTemporaryDirectory("mitk-XXXXXX"));
+    this->SetMitkTempDir(IOUtil::CreateTemporaryDirectory("mitk-nnunet-XXXXXX"));
   }
   std::string inDir, outDir, inputImagePath, outputImagePath, scriptPath;
 
   ProcessExecutor::Pointer spExec = ProcessExecutor::New();
   itk::CStyleCommand::Pointer spCommand = itk::CStyleCommand::New();
   spCommand->SetCallback(&onPythonProcessEvent);
   spExec->AddObserver(ExternalProcessOutputEvent(), spCommand);
   ProcessExecutor::ArgumentListType args;
 
   inDir = IOUtil::CreateTemporaryDirectory("nnunet-in-XXXXXX", this->GetMitkTempDir());
   std::ofstream tmpStream;
   inputImagePath = IOUtil::CreateTemporaryFile(tmpStream, m_TEMPLATE_FILENAME, inDir + IOUtil::GetDirectorySeparator());
   tmpStream.close();
   std::size_t found = inputImagePath.find_last_of(IOUtil::GetDirectorySeparator());
   std::string fileName = inputImagePath.substr(found + 1);
   std::string token = fileName.substr(0, fileName.find("_"));
 
   if (this->GetNoPip())
   {
     scriptPath = this->GetnnUNetDirectory() + IOUtil::GetDirectorySeparator() + "nnunet" +
                  IOUtil::GetDirectorySeparator() + "inference" + IOUtil::GetDirectorySeparator() + "predict_simple.py";
   }
 
   try
   {
     if (this->GetMultiModal())
     {
       const std::string fileFormat(".nii.gz");
       const std::string fileNamePart("_000_000");
       std::string outModalFile;
       size_t len = inDir.length() + 1 + token.length() + fileNamePart.length() + 1 + fileFormat.length();
       outModalFile.reserve(len); // The 1(s) indicates a directory separator char and an underscore.
       for (size_t i = 0; i < m_OtherModalPaths.size(); ++i)
       {
         mitk::Image::ConstPointer modalImage = m_OtherModalPaths[i];
         outModalFile.append(inDir);
         outModalFile.push_back(IOUtil::GetDirectorySeparator());
         outModalFile.append(token);
         outModalFile.append(fileNamePart);
         outModalFile.append(std::to_string(i));
         outModalFile.append(fileFormat);
         IOUtil::Save(modalImage.GetPointer(), outModalFile);
         outModalFile.clear();
       }
     }
     else
     {
       IOUtil::Save(inputAtTimeStep, inputImagePath);
     }
   }
   catch (const mitk::Exception &e)
   {
     MITK_ERROR << e.GetDescription();
     return;
   }
   // Code calls external process
   std::string command = "nnUNet_predict";
   if (this->GetNoPip())
   {
 #ifdef _WIN32
     command = "python";
 #else
     command = "python3";
 #endif
   }
   for (ModelParams &modelparam : m_ParamQ)
   {
     outDir = IOUtil::CreateTemporaryDirectory("nnunet-out-XXXXXX", this->GetMitkTempDir());
     outputImagePath = outDir + IOUtil::GetDirectorySeparator() + token + "_000.nii.gz";
     modelparam.outputDir = outDir;
     args.clear();
     if (this->GetNoPip())
     {
       args.push_back(scriptPath);
     }
     args.push_back("-i");
     args.push_back(inDir);
 
     args.push_back("-o");
     args.push_back(outDir);
 
     args.push_back("-t");
     args.push_back(modelparam.task);
 
     if (modelparam.model.find("cascade") != std::string::npos)
     {
       args.push_back("-ctr");
     }
     else
     {
       args.push_back("-tr");
     }
     args.push_back(modelparam.trainer);
 
     args.push_back("-m");
     args.push_back(modelparam.model);
 
     args.push_back("-p");
     args.push_back(modelparam.planId);
 
     if (!modelparam.folds.empty())
     {
       args.push_back("-f");
       for (auto fold : modelparam.folds)
       {
         args.push_back(fold);
       }
     }
 
     args.push_back("--num_threads_nifti_save");
     args.push_back("1"); // fixing to 1
 
     if (!this->GetMirror())
     {
       args.push_back("--disable_tta");
     }
 
     if (!this->GetMixedPrecision())
     {
       args.push_back("--disable_mixed_precision");
     }
 
     if (this->GetEnsemble())
     {
       args.push_back("--save_npz");
     }
 
     try
     {
       std::string resultsFolderEnv = "RESULTS_FOLDER=" + this->GetModelDirectory();
       itksys::SystemTools::PutEnv(resultsFolderEnv.c_str());
       std::string cudaEnv = "CUDA_VISIBLE_DEVICES=" + std::to_string(this->GetGpuId());
       itksys::SystemTools::PutEnv(cudaEnv.c_str());
 
       spExec->Execute(this->GetPythonPath(), command, args);
     }
     catch (const mitk::Exception &e)
     {
       /*
       Can't throw mitk exception to the caller. Refer: T28691
       */
       MITK_ERROR << e.GetDescription();
       return;
     }
   }
   if (this->GetEnsemble() && !this->GetPostProcessingJsonDirectory().empty())
   {
     args.clear();
     command = "nnUNet_ensemble";
     outDir = IOUtil::CreateTemporaryDirectory("nnunet-ensemble-out-XXXXXX", this->GetMitkTempDir());
     outputImagePath = outDir + IOUtil::GetDirectorySeparator() + token + "_000.nii.gz";
 
     args.push_back("-f");
     for (ModelParams &modelparam : m_ParamQ)
     {
       args.push_back(modelparam.outputDir);
     }
 
     args.push_back("-o");
     args.push_back(outDir);
 
     if (!this->GetPostProcessingJsonDirectory().empty())
     {
       args.push_back("-pp");
       args.push_back(this->GetPostProcessingJsonDirectory());
     }
 
     spExec->Execute(this->GetPythonPath(), command, args);
   }
   try
   {
     Image::Pointer outputImage = IOUtil::Load<Image>(outputImagePath);
     previewImage->InitializeByLabeledImage(outputImage);
     previewImage->SetGeometry(inputAtTimeStep->GetGeometry());
     m_InputBuffer = inputAtTimeStep;
     m_OutputBuffer = mitk::LabelSetImage::New();
     m_OutputBuffer->InitializeByLabeledImage(outputImage);
     m_OutputBuffer->SetGeometry(inputAtTimeStep->GetGeometry());
   }
   catch (const mitk::Exception &e)
   {
     MITK_ERROR << e.GetDescription();
     return;
   }
 }