diff --git a/Plugins/org.mitk.gui.qt.diffusionimaging.tractography/src/internal/QmitkStreamlineTrackingView.cpp b/Plugins/org.mitk.gui.qt.diffusionimaging.tractography/src/internal/QmitkStreamlineTrackingView.cpp
index ffb42eadcd..94b0c2aea0 100644
--- a/Plugins/org.mitk.gui.qt.diffusionimaging.tractography/src/internal/QmitkStreamlineTrackingView.cpp
+++ b/Plugins/org.mitk.gui.qt.diffusionimaging.tractography/src/internal/QmitkStreamlineTrackingView.cpp
@@ -1,1019 +1,1026 @@
 /*===================================================================
 
 The Medical Imaging Interaction Toolkit (MITK)
 
 Copyright (c) German Cancer Research Center,
 Division of Medical and Biological Informatics.
 All rights reserved.
 
 This software is distributed WITHOUT ANY WARRANTY; without
 even the implied warranty of MERCHANTABILITY or FITNESS FOR
 A PARTICULAR PURPOSE.
 
 See LICENSE.txt or http://www.mitk.org for details.
 
 ===================================================================*/
 
 
 // Blueberry
 #include <berryISelectionService.h>
 #include <berryIWorkbenchWindow.h>
 #include <berryIStructuredSelection.h>
 
 // Qmitk
 #include "QmitkStreamlineTrackingView.h"
 #include "QmitkStdMultiWidget.h"
 
 // Qt
 #include <QMessageBox>
 
 // MITK
 #include <mitkLookupTable.h>
 #include <mitkLookupTableProperty.h>
 #include <mitkImageToItk.h>
 #include <mitkFiberBundle.h>
 #include <mitkImageCast.h>
 #include <mitkImageToItk.h>
 #include <mitkNodePredicateDataType.h>
 #include <mitkNodePredicateNot.h>
 #include <mitkNodePredicateAnd.h>
 #include <mitkNodePredicateProperty.h>
 #include <mitkNodePredicateDimension.h>
 #include <mitkOdfImage.h>
 #include <mitkSliceNavigationController.h>
 
 // VTK
 #include <vtkRenderWindowInteractor.h>
 #include <vtkPolyData.h>
 #include <vtkPoints.h>
 #include <vtkCellArray.h>
 #include <vtkSmartPointer.h>
 #include <vtkPolyLine.h>
 #include <vtkCellData.h>
 
 #include <itkTensorImageToOdfImageFilter.h>
 #include <omp.h>
 #include <boost/lexical_cast.hpp>
 
 const std::string QmitkStreamlineTrackingView::VIEW_ID = "org.mitk.views.streamlinetracking";
 const std::string id_DataManager = "org.mitk.views.datamanager";
 using namespace berry;
 
 QmitkStreamlineTrackingWorker::QmitkStreamlineTrackingWorker(QmitkStreamlineTrackingView* view)
     : m_View(view)
 {
 }
 
 void QmitkStreamlineTrackingWorker::run()
 {
     m_View->m_Tracker->Update();
     m_View->m_TrackingThread.quit();
 }
 
 QmitkStreamlineTrackingView::QmitkStreamlineTrackingView()
   : m_TrackingWorker(this)
   , m_Controls(nullptr)
   , m_FirstTensorProbRun(true)
   , m_FirstInteractiveRun(true)
   , m_TrackingHandler(nullptr)
   , m_ThreadIsRunning(false)
   , m_DeleteTrackingHandler(false)
   , m_Visible(false)
   , m_LastPrior("")
   , m_TrackingPriorHandler(nullptr)
 {
   m_TrackingWorker.moveToThread(&m_TrackingThread);
   connect(&m_TrackingThread, SIGNAL(started()), this, SLOT(BeforeThread()));
   connect(&m_TrackingThread, SIGNAL(started()), &m_TrackingWorker, SLOT(run()));
   connect(&m_TrackingThread, SIGNAL(finished()), this, SLOT(AfterThread()));
   m_TrackingTimer = new QTimer(this);
 }
 
 // Destructor
 QmitkStreamlineTrackingView::~QmitkStreamlineTrackingView()
 {
   if (m_Tracker.IsNull())
     return;
 
   m_Tracker->SetStopTracking(true);
   m_TrackingThread.wait();
 }
 
 void QmitkStreamlineTrackingView::CreateQtPartControl( QWidget *parent )
 {
   if ( !m_Controls )
   {
     // create GUI widgets from the Qt Designer's .ui file
     m_Controls = new Ui::QmitkStreamlineTrackingViewControls;
     m_Controls->setupUi( parent );
     m_Controls->m_FaImageBox->SetDataStorage(this->GetDataStorage());
     m_Controls->m_SeedImageBox->SetDataStorage(this->GetDataStorage());
     m_Controls->m_MaskImageBox->SetDataStorage(this->GetDataStorage());
     m_Controls->m_TargetImageBox->SetDataStorage(this->GetDataStorage());
     m_Controls->m_PriorImageBox->SetDataStorage(this->GetDataStorage());
     m_Controls->m_StopImageBox->SetDataStorage(this->GetDataStorage());
     m_Controls->m_ForestBox->SetDataStorage(this->GetDataStorage());
     m_Controls->m_ExclusionImageBox->SetDataStorage(this->GetDataStorage());
 
     mitk::TNodePredicateDataType<mitk::PeakImage>::Pointer isPeakImagePredicate = mitk::TNodePredicateDataType<mitk::PeakImage>::New();
     mitk::TNodePredicateDataType<mitk::Image>::Pointer isImagePredicate = mitk::TNodePredicateDataType<mitk::Image>::New();
     mitk::TNodePredicateDataType<mitk::TractographyForest>::Pointer isTractographyForest = mitk::TNodePredicateDataType<mitk::TractographyForest>::New();
 
     mitk::NodePredicateProperty::Pointer isBinaryPredicate = mitk::NodePredicateProperty::New("binary", mitk::BoolProperty::New(true));
     mitk::NodePredicateNot::Pointer isNotBinaryPredicate = mitk::NodePredicateNot::New( isBinaryPredicate );
     mitk::NodePredicateAnd::Pointer isNotABinaryImagePredicate = mitk::NodePredicateAnd::New( isImagePredicate, isNotBinaryPredicate );
     mitk::NodePredicateDimension::Pointer dimensionPredicate = mitk::NodePredicateDimension::New(3);
 
     m_Controls->m_ForestBox->SetPredicate(isTractographyForest);
     m_Controls->m_FaImageBox->SetPredicate( mitk::NodePredicateAnd::New(isNotABinaryImagePredicate, dimensionPredicate) );
     m_Controls->m_FaImageBox->SetZeroEntryText("--");
     m_Controls->m_SeedImageBox->SetPredicate( mitk::NodePredicateAnd::New(isImagePredicate, dimensionPredicate) );
     m_Controls->m_SeedImageBox->SetZeroEntryText("--");
     m_Controls->m_MaskImageBox->SetPredicate( mitk::NodePredicateAnd::New(isImagePredicate, dimensionPredicate) );
     m_Controls->m_MaskImageBox->SetZeroEntryText("--");
     m_Controls->m_StopImageBox->SetPredicate( mitk::NodePredicateAnd::New(isImagePredicate, dimensionPredicate) );
     m_Controls->m_StopImageBox->SetZeroEntryText("--");
     m_Controls->m_TargetImageBox->SetPredicate( mitk::NodePredicateAnd::New(isImagePredicate, dimensionPredicate) );
     m_Controls->m_TargetImageBox->SetZeroEntryText("--");
     m_Controls->m_PriorImageBox->SetPredicate( isPeakImagePredicate );
     m_Controls->m_PriorImageBox->SetZeroEntryText("--");
     m_Controls->m_ExclusionImageBox->SetPredicate( mitk::NodePredicateAnd::New(isImagePredicate, dimensionPredicate) );
     m_Controls->m_ExclusionImageBox->SetZeroEntryText("--");
 
     connect( m_TrackingTimer, SIGNAL(timeout()), this, SLOT(TimerUpdate()) );
     connect( m_Controls->commandLinkButton_2, SIGNAL(clicked()), this, SLOT(StopTractography()) );
     connect( m_Controls->commandLinkButton, SIGNAL(clicked()), this, SLOT(DoFiberTracking()) );
     connect( m_Controls->m_InteractiveBox, SIGNAL(stateChanged(int)), this, SLOT(ToggleInteractive()) );
     connect( m_Controls->m_ModeBox, SIGNAL(currentIndexChanged(int)), this, SLOT(UpdateGui()) );
     connect( m_Controls->m_FaImageBox, SIGNAL(currentIndexChanged(int)), this, SLOT(DeleteTrackingHandler()) );
     connect( m_Controls->m_ModeBox, SIGNAL(currentIndexChanged(int)), this, SLOT(DeleteTrackingHandler()) );
     connect( m_Controls->m_OutputProbMap, SIGNAL(stateChanged(int)), this, SLOT(OutputStyleSwitched()) );
 
     connect( m_Controls->m_SeedImageBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_ModeBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_StopImageBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_TargetImageBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_PriorImageBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_ExclusionImageBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_MaskImageBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_FaImageBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_ForestBox, SIGNAL(currentIndexChanged(int)), this, SLOT(ForestSwitched()) );
     connect( m_Controls->m_ForestBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_SeedsPerVoxelBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_NumFibersBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_ScalarThresholdBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_OdfCutoffBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_StepSizeBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_SamplingDistanceBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_AngularThresholdBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_MinTractLengthBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_fBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_gBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_NumSamplesBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_SeedRadiusBox, SIGNAL(editingFinished()), this, SLOT(InteractiveSeedChanged()) );
     connect( m_Controls->m_NumSeedsBox, SIGNAL(editingFinished()), this, SLOT(InteractiveSeedChanged()) );
     connect( m_Controls->m_OutputProbMap, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_SharpenOdfsBox, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_InterpolationBox, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_MaskInterpolationBox, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_FlipXBox, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_FlipYBox, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_FlipZBox, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_FrontalSamplesBox, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_StopVotesBox, SIGNAL(stateChanged(int)), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_LoopCheckBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_TrialsPerSeedBox, SIGNAL(editingFinished()), this, SLOT(OnParameterChanged()) );
     connect( m_Controls->m_EpConstraintsBox, SIGNAL(currentIndexChanged(int)), this, SLOT(OnParameterChanged()) );
 
     m_Controls->m_SeedsPerVoxelBox->editingFinished();
     m_Controls->m_NumFibersBox->editingFinished();
     m_Controls->m_ScalarThresholdBox->editingFinished();
     m_Controls->m_OdfCutoffBox->editingFinished();
     m_Controls->m_StepSizeBox->editingFinished();
     m_Controls->m_SamplingDistanceBox->editingFinished();
     m_Controls->m_AngularThresholdBox->editingFinished();
     m_Controls->m_MinTractLengthBox->editingFinished();
     m_Controls->m_fBox->editingFinished();
     m_Controls->m_gBox->editingFinished();
     m_Controls->m_NumSamplesBox->editingFinished();
     m_Controls->m_SeedRadiusBox->editingFinished();
     m_Controls->m_NumSeedsBox->editingFinished();
     m_Controls->m_LoopCheckBox->editingFinished();
     m_Controls->m_TrialsPerSeedBox->editingFinished();
 
     StartStopTrackingGui(false);
   }
 
   UpdateGui();
 }
 
 void QmitkStreamlineTrackingView::StopTractography()
 {
   if (m_Tracker.IsNull())
     return;
 
   m_Tracker->SetStopTracking(true);
 }
 
 void QmitkStreamlineTrackingView::TimerUpdate()
 {
   if (m_Tracker.IsNull())
     return;
 
   QString status_text(m_Tracker->GetStatusText().c_str());
   m_Controls->m_StatusTextBox->setText(status_text);
 }
 
 void QmitkStreamlineTrackingView::BeforeThread()
 {
   m_TrackingTimer->start(1000);
 }
 
 void QmitkStreamlineTrackingView::AfterThread()
 {
   m_TrackingTimer->stop();
   if (!m_Tracker->GetUseOutputProbabilityMap())
   {
     vtkSmartPointer<vtkPolyData> fiberBundle = m_Tracker->GetFiberPolyData();
 
     if (!m_Controls->m_InteractiveBox->isChecked() && fiberBundle->GetNumberOfLines() == 0)
     {
       QMessageBox warnBox;
       warnBox.setWindowTitle("Warning");
       warnBox.setText("No fiberbundle was generated!");
       warnBox.setDetailedText("No fibers were generated using the chosen parameters. Typical reasons are:\n\n- Cutoff too high. Some images feature very low FA/GFA/peak size. Try to lower this parameter.\n- Angular threshold too strict. Try to increase this parameter.\n- A small step sizes also means many steps to go wrong. Especially in the case of probabilistic tractography. Try to adjust the angular threshold.");
       warnBox.setIcon(QMessageBox::Warning);
       warnBox.exec();
 
       if (m_InteractivePointSetNode.IsNotNull())
         m_InteractivePointSetNode->SetProperty("color", mitk::ColorProperty::New(1,1,1));
       StartStopTrackingGui(false);
       if (m_DeleteTrackingHandler)
         DeleteTrackingHandler();
       UpdateGui();
 
       return;
     }
 
     mitk::FiberBundle::Pointer fib = mitk::FiberBundle::New(fiberBundle);
     fib->SetReferenceGeometry(dynamic_cast<mitk::Image*>(m_ParentNode->GetData())->GetGeometry());
     if (m_Controls->m_ResampleFibersBox->isChecked() && fiberBundle->GetNumberOfLines()>0)
       fib->Compress(m_Controls->m_FiberErrorBox->value());
     fib->ColorFibersByOrientation();
     m_Tracker->SetDicomProperties(fib);
 
     if (m_Controls->m_InteractiveBox->isChecked())
     {
       if (m_InteractiveNode.IsNull())
       {
         m_InteractiveNode = mitk::DataNode::New();
         QString name("Interactive");
         m_InteractiveNode->SetName(name.toStdString());
         GetDataStorage()->Add(m_InteractiveNode);
       }
       m_InteractiveNode->SetData(fib);
       m_InteractiveNode->SetFloatProperty("Fiber2DSliceThickness", m_Tracker->GetMinVoxelSize()/2);
 
       if (auto renderWindowPart = this->GetRenderWindowPart())
           renderWindowPart->RequestUpdate();
     }
     else
     {
       mitk::DataNode::Pointer node = mitk::DataNode::New();
       node->SetData(fib);
       QString name("FiberBundle_");
       name += m_ParentNode->GetName().c_str();
       name += "_Streamline";
       node->SetName(name.toStdString());
       node->SetFloatProperty("Fiber2DSliceThickness", m_Tracker->GetMinVoxelSize()/2);
       GetDataStorage()->Add(node, m_ParentNode);
     }
   }
   else
   {
     TrackerType::ItkDoubleImgType::Pointer outImg = m_Tracker->GetOutputProbabilityMap();
     mitk::Image::Pointer img = mitk::Image::New();
     img->InitializeByItk(outImg.GetPointer());
     img->SetVolume(outImg->GetBufferPointer());
 
     if (m_Controls->m_InteractiveBox->isChecked())
     {
       if (m_InteractiveNode.IsNull())
       {
         m_InteractiveNode = mitk::DataNode::New();
         QString name("Interactive");
         m_InteractiveNode->SetName(name.toStdString());
         GetDataStorage()->Add(m_InteractiveNode);
       }
       m_InteractiveNode->SetData(img);
 
       mitk::LookupTable::Pointer lut = mitk::LookupTable::New();
       lut->SetType(mitk::LookupTable::JET_TRANSPARENT);
       mitk::LookupTableProperty::Pointer lut_prop = mitk::LookupTableProperty::New();
       lut_prop->SetLookupTable(lut);
       m_InteractiveNode->SetProperty("LookupTable", lut_prop);
       m_InteractiveNode->SetProperty("opacity", mitk::FloatProperty::New(0.5));
       m_InteractiveNode->SetFloatProperty("Fiber2DSliceThickness", m_Tracker->GetMinVoxelSize()/2);
 
       if (auto renderWindowPart = this->GetRenderWindowPart())
           renderWindowPart->RequestUpdate();
     }
     else
     {
       mitk::DataNode::Pointer node = mitk::DataNode::New();
       node->SetData(img);
       QString name("ProbabilityMap_");
       name += m_ParentNode->GetName().c_str();
       node->SetName(name.toStdString());
 
       mitk::LookupTable::Pointer lut = mitk::LookupTable::New();
       lut->SetType(mitk::LookupTable::JET_TRANSPARENT);
       mitk::LookupTableProperty::Pointer lut_prop = mitk::LookupTableProperty::New();
       lut_prop->SetLookupTable(lut);
       node->SetProperty("LookupTable", lut_prop);
       node->SetProperty("opacity", mitk::FloatProperty::New(0.5));
 
       GetDataStorage()->Add(node, m_ParentNode);
     }
   }
   if (m_InteractivePointSetNode.IsNotNull())
     m_InteractivePointSetNode->SetProperty("color", mitk::ColorProperty::New(1,1,1));
   StartStopTrackingGui(false);
   if (m_DeleteTrackingHandler)
     DeleteTrackingHandler();
   UpdateGui();
 }
 
 void QmitkStreamlineTrackingView::InteractiveSeedChanged(bool posChanged)
 {
+  if(!CheckAndStoreLastParams(sender()) && !posChanged)
+    return;
   if (m_ThreadIsRunning || !m_Visible)
     return;
+
   if (!posChanged && (!m_Controls->m_InteractiveBox->isChecked() || !m_Controls->m_ParamUpdateBox->isChecked()) )
     return;
-  if(!CheckAndStoreLastParams(sender()) && !posChanged)
-    return;
 
   std::srand(std::time(0));
   m_SeedPoints.clear();
 
   itk::Point<float> world_pos = this->GetRenderWindowPart()->GetSelectedPosition();
 
   m_SeedPoints.push_back(world_pos);
   float radius = m_Controls->m_SeedRadiusBox->value();
   int num = m_Controls->m_NumSeedsBox->value();
 
   mitk::PointSet::Pointer pointset = mitk::PointSet::New();
   pointset->InsertPoint(0, world_pos);
   m_InteractivePointSetNode->SetProperty("pointsize", mitk::FloatProperty::New(radius*2));
   m_InteractivePointSetNode->SetProperty("point 2D size", mitk::FloatProperty::New(radius*2));
   m_InteractivePointSetNode->SetData(pointset);
 
   for (int i=1; i<num; i++)
   {
     itk::Vector<float> p;
     p[0] = rand()%1000-500;
     p[1] = rand()%1000-500;
     p[2] = rand()%1000-500;
     p.Normalize();
     p *= radius;
     m_SeedPoints.push_back(world_pos+p);
   }
   m_InteractivePointSetNode->SetProperty("color", mitk::ColorProperty::New(1,0,0));
   DoFiberTracking();
 }
 
 bool QmitkStreamlineTrackingView::CheckAndStoreLastParams(QObject* obj)
 {
   if (obj!=nullptr)
   {
     std::string new_val = "";
     if(qobject_cast<QDoubleSpinBox*>(obj)!=nullptr)
       new_val = boost::lexical_cast<std::string>(qobject_cast<QDoubleSpinBox*>(obj)->value());
     else if (qobject_cast<QSpinBox*>(obj)!=nullptr)
       new_val = boost::lexical_cast<std::string>(qobject_cast<QSpinBox*>(obj)->value());
 
     if (m_LastTractoParams.find(obj->objectName())==m_LastTractoParams.end())
     {
       m_LastTractoParams[obj->objectName()] = new_val;
       return false;
     }
     else if (m_LastTractoParams.at(obj->objectName()) != new_val)
     {
       m_LastTractoParams[obj->objectName()] = new_val;
       return true;
     }
     else if (m_LastTractoParams.at(obj->objectName()) == new_val)
       return false;
   }
   return true;
 }
 
 void QmitkStreamlineTrackingView::OnParameterChanged()
 {
+  UpdateGui();
+
   if(!CheckAndStoreLastParams(sender()))
     return;
 
-  UpdateGui();
   if (m_Controls->m_InteractiveBox->isChecked() && m_Controls->m_ParamUpdateBox->isChecked())
     DoFiberTracking();
 }
 
 void QmitkStreamlineTrackingView::ToggleInteractive()
 {
   UpdateGui();
 
   m_Controls->m_SeedsPerVoxelBox->setEnabled(!m_Controls->m_InteractiveBox->isChecked());
   m_Controls->m_SeedsPerVoxelLabel->setEnabled(!m_Controls->m_InteractiveBox->isChecked());
   m_Controls->m_SeedImageBox->setEnabled(!m_Controls->m_InteractiveBox->isChecked());
   m_Controls->label_6->setEnabled(!m_Controls->m_InteractiveBox->isChecked());
 
   if ( m_Controls->m_InteractiveBox->isChecked() )
   {
     if (m_FirstInteractiveRun)
     {
       QMessageBox::information(nullptr, "Information", "Place and move a spherical seed region anywhere in the image by left-clicking and dragging. If the seed region is colored red, tracking is in progress. If the seed region is colored white, tracking is finished.\nPlacing the seed region for the first time in a newly selected dataset might cause a short delay, since the tracker needs to be initialized.");
       m_FirstInteractiveRun = false;
     }
 
     QApplication::setOverrideCursor(Qt::PointingHandCursor);
     QApplication::processEvents();
 
     m_InteractivePointSetNode = mitk::DataNode::New();
     m_InteractivePointSetNode->SetProperty("color", mitk::ColorProperty::New(1,1,1));
     m_InteractivePointSetNode->SetName("InteractiveSeedRegion");
     mitk::PointSetShapeProperty::Pointer shape_prop = mitk::PointSetShapeProperty::New();
     shape_prop->SetValue(mitk::PointSetShapeProperty::PointSetShape::CIRCLE);
     m_InteractivePointSetNode->SetProperty("Pointset.2D.shape", shape_prop);
     GetDataStorage()->Add(m_InteractivePointSetNode);
 
 
     m_SliceChangeListener.RenderWindowPartActivated(this->GetRenderWindowPart());
     connect(&m_SliceChangeListener, SIGNAL(SliceChanged()), this, SLOT(OnSliceChanged()));
   }
   else
   {
     QApplication::restoreOverrideCursor();
     QApplication::processEvents();
 
     m_InteractiveNode = nullptr;
     m_InteractivePointSetNode = nullptr;
 
     m_SliceChangeListener.RenderWindowPartActivated(this->GetRenderWindowPart());
     disconnect(&m_SliceChangeListener, SIGNAL(SliceChanged()), this, SLOT(OnSliceChanged()));
   }
 }
 
 void QmitkStreamlineTrackingView::Activated()
 {
 
 }
 
 void QmitkStreamlineTrackingView::Deactivated()
 {
 
 }
 
 void QmitkStreamlineTrackingView::Visible()
 {
   m_Visible = true;
 }
 
 void QmitkStreamlineTrackingView::Hidden()
 {
   m_Visible = false;
   m_Controls->m_InteractiveBox->setChecked(false);
   ToggleInteractive();
 }
 
 void QmitkStreamlineTrackingView::OnSliceChanged()
 {
   InteractiveSeedChanged(true);
 }
 
 void QmitkStreamlineTrackingView::SetFocus()
 {
 }
 
 void QmitkStreamlineTrackingView::DeleteTrackingHandler()
 {
   if (!m_ThreadIsRunning && m_TrackingHandler != nullptr)
   {
     delete m_TrackingHandler;
     m_TrackingHandler = nullptr;
     m_DeleteTrackingHandler = false;
     m_LastPrior = "";
     if (m_TrackingPriorHandler != nullptr)
       delete m_TrackingPriorHandler;
   }
   else if (m_ThreadIsRunning)
   {
     m_DeleteTrackingHandler = true;
   }
 }
 
 void QmitkStreamlineTrackingView::ForestSwitched()
 {
   DeleteTrackingHandler();
 }
 
 void QmitkStreamlineTrackingView::OutputStyleSwitched()
 {
   if (m_InteractiveNode.IsNotNull())
     GetDataStorage()->Remove(m_InteractiveNode);
   m_InteractiveNode = nullptr;
 }
 
 void QmitkStreamlineTrackingView::OnSelectionChanged( berry::IWorkbenchPart::Pointer , const QList<mitk::DataNode::Pointer>& nodes )
 {
   std::vector< mitk::DataNode::Pointer > last_nodes = m_InputImageNodes;
   m_InputImageNodes.clear();
   m_InputImages.clear();
   m_AdditionalInputImages.clear();
   bool retrack = false;
 
   for( auto node : nodes )
   {
 
     if( node.IsNotNull() && dynamic_cast<mitk::Image*>(node->GetData()) )
     {
       if( dynamic_cast<mitk::TensorImage*>(node->GetData()) )
       {
         m_InputImageNodes.push_back(node);
         m_InputImages.push_back(dynamic_cast<mitk::Image*>(node->GetData()));
         retrack = true;
       }
       else if ( dynamic_cast<mitk::OdfImage*>(node->GetData()) )
       {
         m_InputImageNodes.push_back(node);
         m_InputImages.push_back(dynamic_cast<mitk::Image*>(node->GetData()));
         retrack = true;
       }
       else if ( mitk::DiffusionPropertyHelper::IsDiffusionWeightedImage( dynamic_cast<mitk::Image *>(node->GetData())) )
       {
         m_InputImageNodes.push_back(node);
         m_InputImages.push_back(dynamic_cast<mitk::Image*>(node->GetData()));
         retrack = true;
       }
       else
       {
         mitk::Image* img = dynamic_cast<mitk::Image*>(node->GetData());
         if (img!=nullptr)
         {
           int dim = img->GetDimension();
           unsigned int* dimensions = img->GetDimensions();
           if (dim==4 && dimensions[3]%3==0)
           {
             m_InputImageNodes.push_back(node);
             m_InputImages.push_back(dynamic_cast<mitk::Image*>(node->GetData()));
             retrack = true;
           }
           else if (dim==3)
           {
             m_AdditionalInputImages.push_back(dynamic_cast<mitk::Image*>(node->GetData()));
           }
         }
       }
     }
   }
 
   // sometimes the OnSelectionChanged event is sent twice and actually no selection has changed for the first event. We need to catch that.
   if (last_nodes.size() == m_InputImageNodes.size())
   {
     bool same_nodes = true;
     for (unsigned int i=0; i<m_InputImageNodes.size(); i++)
       if (last_nodes.at(i)!=m_InputImageNodes.at(i))
       {
         same_nodes = false;
         break;
       }
     if (same_nodes)
       return;
   }
 
   DeleteTrackingHandler();
   UpdateGui();
   if (retrack)
     OnParameterChanged();
 }
 
 void QmitkStreamlineTrackingView::UpdateGui()
 {
   m_Controls->m_TensorImageLabel->setText("<font color='red'>select in data-manager</font>");
 
   m_Controls->m_fBox->setEnabled(false);
   m_Controls->m_fLabel->setEnabled(false);
   m_Controls->m_gBox->setEnabled(false);
   m_Controls->m_gLabel->setEnabled(false);
   m_Controls->m_FaImageBox->setEnabled(true);
   m_Controls->mFaImageLabel->setEnabled(true);
   m_Controls->m_OdfCutoffBox->setEnabled(false);
   m_Controls->m_OdfCutoffLabel->setEnabled(false);
   m_Controls->m_SharpenOdfsBox->setEnabled(false);
   m_Controls->m_ForestBox->setVisible(false);
   m_Controls->m_ForestLabel->setVisible(false);
   m_Controls->commandLinkButton->setEnabled(false);
   m_Controls->m_TrialsPerSeedBox->setEnabled(false);
   m_Controls->m_TrialsPerSeedLabel->setEnabled(false);
-  m_Controls->m_TargetImageBox->setVisible(false);
-  m_Controls->m_TargetImageLabel->setVisible(false);
+  m_Controls->m_TargetImageBox->setEnabled(false);
+  m_Controls->m_TargetImageLabel->setEnabled(false);
 
   if (m_Controls->m_InteractiveBox->isChecked())
   {
     m_Controls->m_InteractiveSeedingFrame->setVisible(true);
     m_Controls->m_StaticSeedingFrame->setVisible(false);
     m_Controls->commandLinkButton_2->setVisible(false);
     m_Controls->commandLinkButton->setVisible(false);
   }
   else
   {
     m_Controls->m_InteractiveSeedingFrame->setVisible(false);
     m_Controls->m_StaticSeedingFrame->setVisible(true);
     m_Controls->commandLinkButton_2->setVisible(m_ThreadIsRunning);
     m_Controls->commandLinkButton->setVisible(!m_ThreadIsRunning);
   }
 
   if (m_Controls->m_EpConstraintsBox->currentIndex()>0)
   {
-    m_Controls->m_TargetImageBox->setVisible(true);
-    m_Controls->m_TargetImageLabel->setVisible(true);
+    m_Controls->m_TargetImageBox->setEnabled(true);
+    m_Controls->m_TargetImageLabel->setEnabled(true);
   }
 
   // trials per seed are only important for probabilistic tractography
   if (m_Controls->m_ModeBox->currentIndex()==1)
   {
     m_Controls->m_TrialsPerSeedBox->setEnabled(true);
     m_Controls->m_TrialsPerSeedLabel->setEnabled(true);
   }
 
   if(!m_InputImageNodes.empty())
   {
     if (m_InputImageNodes.size()>1)
       m_Controls->m_TensorImageLabel->setText( ( std::to_string(m_InputImageNodes.size()) + " images selected").c_str() );
     else
       m_Controls->m_TensorImageLabel->setText(m_InputImageNodes.at(0)->GetName().c_str());
     m_Controls->commandLinkButton->setEnabled(!m_Controls->m_InteractiveBox->isChecked() && !m_ThreadIsRunning);
 
     m_Controls->m_ScalarThresholdBox->setEnabled(true);
     m_Controls->m_FaThresholdLabel->setEnabled(true);
 
     if ( dynamic_cast<mitk::TensorImage*>(m_InputImageNodes.at(0)->GetData()) )
     {
       m_Controls->m_fBox->setEnabled(true);
       m_Controls->m_fLabel->setEnabled(true);
       m_Controls->m_gBox->setEnabled(true);
       m_Controls->m_gLabel->setEnabled(true);
     }
     else if ( dynamic_cast<mitk::OdfImage*>(m_InputImageNodes.at(0)->GetData()) )
     {
       m_Controls->m_OdfCutoffBox->setEnabled(true);
       m_Controls->m_OdfCutoffLabel->setEnabled(true);
       m_Controls->m_SharpenOdfsBox->setEnabled(true);
     }
     else if (  mitk::DiffusionPropertyHelper::IsDiffusionWeightedImage( dynamic_cast<mitk::Image *>(m_InputImageNodes.at(0)->GetData())) )
     {
       m_Controls->m_ForestBox->setVisible(true);
       m_Controls->m_ForestLabel->setVisible(true);
       m_Controls->m_ScalarThresholdBox->setEnabled(false);
       m_Controls->m_FaThresholdLabel->setEnabled(false);
     }
   }
 }
 
 void QmitkStreamlineTrackingView::StartStopTrackingGui(bool start)
 {
   m_ThreadIsRunning = start;
 
   if (!m_Controls->m_InteractiveBox->isChecked())
   {
     m_Controls->commandLinkButton_2->setVisible(start);
     m_Controls->commandLinkButton->setVisible(!start);
     m_Controls->m_InteractiveBox->setEnabled(!start);
     m_Controls->m_StatusTextBox->setVisible(start);
   }
 }
 
 void QmitkStreamlineTrackingView::DoFiberTracking()
 {
-  if (m_ThreadIsRunning || m_InputImages.empty() || !m_Visible)
+  if (m_InputImages.empty())
+  {
+    QMessageBox::information(nullptr, "Information", "Please select an input image in the datamaneger (tensor, ODF, peak or dMRI image)!");
+    return;
+  }
+  if (m_ThreadIsRunning || !m_Visible)
     return;
   if (m_Controls->m_InteractiveBox->isChecked() && m_SeedPoints.empty())
     return;
   StartStopTrackingGui(true);
 
   m_Tracker = TrackerType::New();
 
   if( dynamic_cast<mitk::TensorImage*>(m_InputImageNodes.at(0)->GetData()) )
   {
     if (m_Controls->m_ModeBox->currentIndex()==1)
     {
       if (m_InputImages.size()>1)
       {
         QMessageBox::information(nullptr, "Information", "Probabilistic tensor tractography is only implemented for single-tensor mode!");
         StartStopTrackingGui(false);
         return;
       }
 
       if (m_TrackingHandler==nullptr)
       {
         m_TrackingHandler = new mitk::TrackingHandlerOdf();
         mitk::TensorImage::ItkTensorImageType::Pointer itkImg = mitk::TensorImage::ItkTensorImageType::New();
         mitk::CastToItkImage(m_InputImages.at(0), itkImg);
 
         typedef itk::TensorImageToOdfImageFilter< float, float > FilterType;
         FilterType::Pointer filter = FilterType::New();
         filter->SetInput( itkImg );
         filter->Update();
         dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetOdfImage(filter->GetOutput());
 
         if (m_Controls->m_FaImageBox->GetSelectedNode().IsNotNull())
         {
           ItkFloatImageType::Pointer itkImg = ItkFloatImageType::New();
           mitk::CastToItkImage(dynamic_cast<mitk::Image*>(m_Controls->m_FaImageBox->GetSelectedNode()->GetData()), itkImg);
 
           dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetGfaImage(itkImg);
         }
       }
 
       dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetGfaThreshold(m_Controls->m_ScalarThresholdBox->value());
       dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetOdfThreshold(0);
       dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetSharpenOdfs(true);
       dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetIsOdfFromTensor(true);
     }
     else
     {
       if (m_TrackingHandler==nullptr)
       {
         m_TrackingHandler = new mitk::TrackingHandlerTensor();
         for (int i=0; i<(int)m_InputImages.size(); i++)
         {
           typedef mitk::ImageToItk< mitk::TrackingHandlerTensor::ItkTensorImageType > CasterType;
           CasterType::Pointer caster = CasterType::New();
           caster->SetInput(m_InputImages.at(i));
           caster->Update();
           mitk::TrackingHandlerTensor::ItkTensorImageType::ConstPointer itkImg = caster->GetOutput();
 
           dynamic_cast<mitk::TrackingHandlerTensor*>(m_TrackingHandler)->AddTensorImage(itkImg);
         }
 
         if (m_Controls->m_FaImageBox->GetSelectedNode().IsNotNull())
         {
           ItkFloatImageType::Pointer itkImg = ItkFloatImageType::New();
           mitk::CastToItkImage(dynamic_cast<mitk::Image*>(m_Controls->m_FaImageBox->GetSelectedNode()->GetData()), itkImg);
 
           dynamic_cast<mitk::TrackingHandlerTensor*>(m_TrackingHandler)->SetFaImage(itkImg);
         }
       }
 
       dynamic_cast<mitk::TrackingHandlerTensor*>(m_TrackingHandler)->SetFaThreshold(m_Controls->m_ScalarThresholdBox->value());
       dynamic_cast<mitk::TrackingHandlerTensor*>(m_TrackingHandler)->SetF((float)m_Controls->m_fBox->value());
       dynamic_cast<mitk::TrackingHandlerTensor*>(m_TrackingHandler)->SetG((float)m_Controls->m_gBox->value());
     }
   }
   else if ( dynamic_cast<mitk::OdfImage*>(m_InputImageNodes.at(0)->GetData()) )
   {
     if (m_TrackingHandler==nullptr)
     {
       m_TrackingHandler = new mitk::TrackingHandlerOdf();
       mitk::TrackingHandlerOdf::ItkOdfImageType::Pointer itkImg = mitk::TrackingHandlerOdf::ItkOdfImageType::New();
       mitk::CastToItkImage(m_InputImages.at(0), itkImg);
       dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetOdfImage(itkImg);
 
       if (m_Controls->m_FaImageBox->GetSelectedNode().IsNotNull())
       {
         ItkFloatImageType::Pointer itkImg = ItkFloatImageType::New();
         mitk::CastToItkImage(dynamic_cast<mitk::Image*>(m_Controls->m_FaImageBox->GetSelectedNode()->GetData()), itkImg);
         dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetGfaImage(itkImg);
       }
     }
 
     dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetGfaThreshold(m_Controls->m_ScalarThresholdBox->value());
     dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetOdfThreshold(m_Controls->m_OdfCutoffBox->value());
     dynamic_cast<mitk::TrackingHandlerOdf*>(m_TrackingHandler)->SetSharpenOdfs(m_Controls->m_SharpenOdfsBox->isChecked());
   }
   else if ( mitk::DiffusionPropertyHelper::IsDiffusionWeightedImage( dynamic_cast<mitk::Image*>(m_InputImageNodes.at(0)->GetData())) )
   {
     if ( m_Controls->m_ForestBox->GetSelectedNode().IsNull() )
     {
       QMessageBox::information(nullptr, "Information", "Not random forest for machine learning based tractography (raw dMRI tractography) selected. Did you accidentally select the raw diffusion-weighted image in the datamanager?");
       StartStopTrackingGui(false);
       return;
     }
 
     if (m_TrackingHandler==nullptr)
     {
       mitk::TractographyForest::Pointer forest = dynamic_cast<mitk::TractographyForest*>(m_Controls->m_ForestBox->GetSelectedNode()->GetData());
       mitk::Image::Pointer dwi = dynamic_cast<mitk::Image*>(m_InputImageNodes.at(0)->GetData());
 
       std::vector< std::vector< ItkFloatImageType::Pointer > > additionalFeatureImages;
       additionalFeatureImages.push_back(std::vector< ItkFloatImageType::Pointer >());
       for (auto img : m_AdditionalInputImages)
       {
         ItkFloatImageType::Pointer itkimg = ItkFloatImageType::New();
         mitk::CastToItkImage(img, itkimg);
         additionalFeatureImages.at(0).push_back(itkimg);
       }
 
       bool forest_valid = false;
       if (forest->GetNumFeatures()>=100)
       {
         int num_previous_directions = (forest->GetNumFeatures() - (100 + additionalFeatureImages.at(0).size()))/3;
         m_TrackingHandler = new mitk::TrackingHandlerRandomForest<6, 100>();
         dynamic_cast<mitk::TrackingHandlerRandomForest<6, 100>*>(m_TrackingHandler)->AddDwi(dwi);
         dynamic_cast<mitk::TrackingHandlerRandomForest<6, 100>*>(m_TrackingHandler)->SetAdditionalFeatureImages(additionalFeatureImages);
         dynamic_cast<mitk::TrackingHandlerRandomForest<6, 100>*>(m_TrackingHandler)->SetForest(forest);
         dynamic_cast<mitk::TrackingHandlerRandomForest<6, 100>*>(m_TrackingHandler)->SetNumPreviousDirections(num_previous_directions);
         forest_valid = dynamic_cast<mitk::TrackingHandlerRandomForest<6, 100>*>(m_TrackingHandler)->IsForestValid();
       }
       else
       {
         int num_previous_directions = (forest->GetNumFeatures() - (28 + additionalFeatureImages.at(0).size()))/3;
         m_TrackingHandler = new mitk::TrackingHandlerRandomForest<6, 28>();
         dynamic_cast<mitk::TrackingHandlerRandomForest<6, 28>*>(m_TrackingHandler)->AddDwi(dwi);
         dynamic_cast<mitk::TrackingHandlerRandomForest<6, 28>*>(m_TrackingHandler)->SetAdditionalFeatureImages(additionalFeatureImages);
         dynamic_cast<mitk::TrackingHandlerRandomForest<6, 28>*>(m_TrackingHandler)->SetForest(forest);
         dynamic_cast<mitk::TrackingHandlerRandomForest<6, 28>*>(m_TrackingHandler)->SetNumPreviousDirections(num_previous_directions);
         forest_valid = dynamic_cast<mitk::TrackingHandlerRandomForest<6, 28>*>(m_TrackingHandler)->IsForestValid();
       }
 
       if (!forest_valid)
       {
         QMessageBox::information(nullptr, "Information", "Random forest is invalid. The forest signatue does not match the parameters of TrackingHandlerRandomForest.");
         StartStopTrackingGui(false);
         return;
       }
     }
   }
   else
   {
     if (m_Controls->m_ModeBox->currentIndex()==1)
     {
       QMessageBox::information(nullptr, "Information", "Probabilstic tractography is not implemented for peak images.");
       StartStopTrackingGui(false);
       return;
     }
     try {
 
       if (m_TrackingHandler==nullptr)
       {
         typedef mitk::ImageToItk< mitk::TrackingHandlerPeaks::PeakImgType > CasterType;
         CasterType::Pointer caster = CasterType::New();
         caster->SetInput(m_InputImages.at(0));
         caster->SetCopyMemFlag(true);
         caster->Update();
         mitk::TrackingHandlerPeaks::PeakImgType::Pointer itkImg = caster->GetOutput();
         m_TrackingHandler = new mitk::TrackingHandlerPeaks();
         dynamic_cast<mitk::TrackingHandlerPeaks*>(m_TrackingHandler)->SetPeakImage(itkImg);
       }
 
       dynamic_cast<mitk::TrackingHandlerPeaks*>(m_TrackingHandler)->SetPeakThreshold(m_Controls->m_ScalarThresholdBox->value());
     }
     catch(...)
     {
       QMessageBox::information(nullptr, "Error", "Peak tracker could not be initialized. Is your input image in the correct format (4D float image, peaks in the 4th dimension)?");
       StartStopTrackingGui(false);
       return;
     }
   }
 
   m_TrackingHandler->SetFlipX(m_Controls->m_FlipXBox->isChecked());
   m_TrackingHandler->SetFlipY(m_Controls->m_FlipYBox->isChecked());
   m_TrackingHandler->SetFlipZ(m_Controls->m_FlipZBox->isChecked());
   m_TrackingHandler->SetInterpolate(m_Controls->m_InterpolationBox->isChecked());
   switch (m_Controls->m_ModeBox->currentIndex())
   {
   case 0:
     m_TrackingHandler->SetMode(mitk::TrackingDataHandler::MODE::DETERMINISTIC);
     break;
   case 1:
     m_TrackingHandler->SetMode(mitk::TrackingDataHandler::MODE::PROBABILISTIC);
     break;
   default:
     m_TrackingHandler->SetMode(mitk::TrackingDataHandler::MODE::DETERMINISTIC);
   }
 
   if (m_Controls->m_InteractiveBox->isChecked())
   {
     m_Tracker->SetSeedPoints(m_SeedPoints);
   }
   else if (m_Controls->m_SeedImageBox->GetSelectedNode().IsNotNull())
   {
     ItkFloatImageType::Pointer mask = ItkFloatImageType::New();
     mitk::CastToItkImage(dynamic_cast<mitk::Image*>(m_Controls->m_SeedImageBox->GetSelectedNode()->GetData()), mask);
     m_Tracker->SetSeedImage(mask);
   }
 
   if (m_Controls->m_MaskImageBox->GetSelectedNode().IsNotNull())
   {
     ItkFloatImageType::Pointer mask = ItkFloatImageType::New();
     mitk::CastToItkImage(dynamic_cast<mitk::Image*>(m_Controls->m_MaskImageBox->GetSelectedNode()->GetData()), mask);
     m_Tracker->SetMaskImage(mask);
   }
 
   if (m_Controls->m_StopImageBox->GetSelectedNode().IsNotNull())
   {
     ItkFloatImageType::Pointer mask = ItkFloatImageType::New();
     mitk::CastToItkImage(dynamic_cast<mitk::Image*>(m_Controls->m_StopImageBox->GetSelectedNode()->GetData()), mask);
     m_Tracker->SetStoppingRegions(mask);
   }
 
   if (m_Controls->m_TargetImageBox->GetSelectedNode().IsNotNull())
   {
     ItkFloatImageType::Pointer mask = ItkFloatImageType::New();
     mitk::CastToItkImage(dynamic_cast<mitk::Image*>(m_Controls->m_TargetImageBox->GetSelectedNode()->GetData()), mask);
     m_Tracker->SetTargetRegions(mask);
   }
 
   if (m_Controls->m_PriorImageBox->GetSelectedNode().IsNotNull())
   {
     if (m_LastPrior!=m_Controls->m_PriorImageBox->GetSelectedNode()->GetUID() || m_TrackingPriorHandler==nullptr)
     {
       typedef mitk::ImageToItk< mitk::TrackingHandlerPeaks::PeakImgType > CasterType;
       CasterType::Pointer caster = CasterType::New();
       caster->SetInput(dynamic_cast<mitk::PeakImage*>(m_Controls->m_PriorImageBox->GetSelectedNode()->GetData()));
       caster->SetCopyMemFlag(true);
       caster->Update();
       mitk::TrackingHandlerPeaks::PeakImgType::Pointer itkImg = caster->GetOutput();
       m_TrackingPriorHandler = new mitk::TrackingHandlerPeaks();
       dynamic_cast<mitk::TrackingHandlerPeaks*>(m_TrackingPriorHandler)->SetPeakImage(itkImg);
       dynamic_cast<mitk::TrackingHandlerPeaks*>(m_TrackingPriorHandler)->SetPeakThreshold(0.0);
       m_LastPrior = m_Controls->m_PriorImageBox->GetSelectedNode()->GetUID();
     }
 
     m_TrackingPriorHandler->SetInterpolate(m_Controls->m_InterpolationBox->isChecked());
     m_TrackingPriorHandler->SetMode(mitk::TrackingDataHandler::MODE::DETERMINISTIC);
 
     m_Tracker->SetTrackingPriorHandler(m_TrackingPriorHandler);
     m_Tracker->SetTrackingPriorWeight(m_Controls->m_PriorWeightBox->value());
     m_Tracker->SetTrackingPriorAsMask(m_Controls->m_PriorAsMaskBox->isChecked());
     m_Tracker->SetIntroduceDirectionsFromPrior(m_Controls->m_NewDirectionsFromPriorBox->isChecked());
   }
   else if (m_Controls->m_PriorImageBox->GetSelectedNode().IsNull())
     m_Tracker->SetTrackingPriorHandler(nullptr);
 
   if (m_Controls->m_ExclusionImageBox->GetSelectedNode().IsNotNull())
   {
     ItkFloatImageType::Pointer mask = ItkFloatImageType::New();
     mitk::CastToItkImage(dynamic_cast<mitk::Image*>(m_Controls->m_ExclusionImageBox->GetSelectedNode()->GetData()), mask);
     m_Tracker->SetExclusionRegions(mask);
   }
 
   // Endpoint constraints
   switch (m_Controls->m_EpConstraintsBox->currentIndex())
   {
   case 0:
     m_Tracker->SetEndpointConstraint(itk::StreamlineTrackingFilter::EndpointConstraints::NONE);
     m_Tracker->SetTargetRegions(nullptr);
     break;
   case 1:
     m_Tracker->SetEndpointConstraint(itk::StreamlineTrackingFilter::EndpointConstraints::EPS_IN_TARGET);
     break;
   case 2:
     m_Tracker->SetEndpointConstraint(itk::StreamlineTrackingFilter::EndpointConstraints::EPS_IN_TARGET_LABELDIFF);
     break;
   case 3:
     m_Tracker->SetEndpointConstraint(itk::StreamlineTrackingFilter::EndpointConstraints::EPS_IN_SEED_AND_TARGET);
     break;
   case 4:
     m_Tracker->SetEndpointConstraint(itk::StreamlineTrackingFilter::EndpointConstraints::MIN_ONE_EP_IN_TARGET);
     break;
   case 5:
     m_Tracker->SetEndpointConstraint(itk::StreamlineTrackingFilter::EndpointConstraints::ONE_EP_IN_TARGET);
     break;
   case 6:
     m_Tracker->SetEndpointConstraint(itk::StreamlineTrackingFilter::EndpointConstraints::NO_EP_IN_TARGET);
     break;
   }
 
   if (m_Tracker->GetEndpointConstraint()!=itk::StreamlineTrackingFilter::EndpointConstraints::NONE && m_Controls->m_TargetImageBox->GetSelectedNode().IsNull())
   {
     QMessageBox::information(nullptr, "Error", "Endpoint constraints are used but no target image is set!");
     StartStopTrackingGui(false);
     return;
   }
   else if (m_Tracker->GetEndpointConstraint()==itk::StreamlineTrackingFilter::EndpointConstraints::EPS_IN_SEED_AND_TARGET
            && (m_Controls->m_SeedImageBox->GetSelectedNode().IsNull()|| m_Controls->m_TargetImageBox->GetSelectedNode().IsNull()) )
   {
     QMessageBox::information(nullptr, "Error", "Endpoint constraint EPS_IN_SEED_AND_TARGET is used but no target or no seed image is set!");
     StartStopTrackingGui(false);
     return;
   }
 
   m_Tracker->SetInterpolateMasks(m_Controls->m_MaskInterpolationBox->isChecked());
   m_Tracker->SetVerbose(!m_Controls->m_InteractiveBox->isChecked());
   m_Tracker->SetSeedsPerVoxel(m_Controls->m_SeedsPerVoxelBox->value());
   m_Tracker->SetStepSize(m_Controls->m_StepSizeBox->value());
   m_Tracker->SetSamplingDistance(m_Controls->m_SamplingDistanceBox->value());
   m_Tracker->SetUseStopVotes(m_Controls->m_StopVotesBox->isChecked());
   m_Tracker->SetOnlyForwardSamples(m_Controls->m_FrontalSamplesBox->isChecked());
   m_Tracker->SetTrialsPerSeed(m_Controls->m_TrialsPerSeedBox->value());
   m_Tracker->SetMaxNumTracts(m_Controls->m_NumFibersBox->value());
   m_Tracker->SetNumberOfSamples(m_Controls->m_NumSamplesBox->value());
   m_Tracker->SetTrackingHandler(m_TrackingHandler);
   m_Tracker->SetLoopCheck(m_Controls->m_LoopCheckBox->value());
   m_Tracker->SetAngularThreshold(m_Controls->m_AngularThresholdBox->value());
   m_Tracker->SetMinTractLength(m_Controls->m_MinTractLengthBox->value());
   m_Tracker->SetUseOutputProbabilityMap(m_Controls->m_OutputProbMap->isChecked());
 
   m_ParentNode = m_InputImageNodes.at(0);
   m_TrackingThread.start(QThread::LowestPriority);
 }