diff --git a/Modules/Segmentation/Interactions/mitkTotalSegmentatorTool.cpp b/Modules/Segmentation/Interactions/mitkTotalSegmentatorTool.cpp
index e7d7e8143e..d84d95067e 100644
--- a/Modules/Segmentation/Interactions/mitkTotalSegmentatorTool.cpp
+++ b/Modules/Segmentation/Interactions/mitkTotalSegmentatorTool.cpp
@@ -1,339 +1,339 @@
 /*============================================================================
 
 The Medical Imaging Interaction Toolkit (MITK)
 
 Copyright (c) German Cancer Research Center (DKFZ)
 All rights reserved.
 
 Use of this source code is governed by a 3-clause BSD license that can be
 found in the LICENSE file.
 
 ============================================================================*/
 
 // MITK
 #include "mitkTotalSegmentatorTool.h"
 
 #include "mitkIOUtil.h"
 #include <algorithm>
 #include <filesystem>
 #include <itksys/SystemTools.hxx>
 
 // us
 #include <usGetModuleContext.h>
 #include <usModule.h>
 #include <usModuleContext.h>
 #include <usModuleResource.h>
 #include <usServiceReference.h>
 
 namespace mitk
 {
   MITK_TOOL_MACRO(MITKSEGMENTATION_EXPORT, TotalSegmentatorTool, "Total Segmentator");
 }
 
 mitk::TotalSegmentatorTool::~TotalSegmentatorTool()
 {
-  itksys::SystemTools::RemoveADirectory(this->GetMitkTempDir());
+  std::filesystem::remove_all(this->GetMitkTempDir());
 }
 
 mitk::TotalSegmentatorTool::TotalSegmentatorTool()
 {
   this->IsTimePointChangeAwareOff();
 }
 
 void mitk::TotalSegmentatorTool::Activated()
 {
   Superclass::Activated();
   this->SetLabelTransferMode(LabelTransferMode::AllLabels);
 }
 
 const char **mitk::TotalSegmentatorTool::GetXPM() const
 {
   return nullptr;
 }
 
 us::ModuleResource mitk::TotalSegmentatorTool::GetIconResource() const
 {
   us::Module *module = us::GetModuleContext()->GetModule();
   us::ModuleResource resource = module->GetResource("AI.svg");
   return resource;
 }
 
 const char *mitk::TotalSegmentatorTool::GetName() const
 {
   return "TotalSegmentator";
 }
 
 void mitk::TotalSegmentatorTool::onPythonProcessEvent(itk::Object * /*pCaller*/, const itk::EventObject &e, void *)
 {
   std::string testCOUT;
   std::string testCERR;
   const auto *pEvent = dynamic_cast<const mitk::ExternalProcessStdOutEvent *>(&e);
 
   if (pEvent)
   {
     testCOUT = testCOUT + pEvent->GetOutput();
     MITK_INFO << testCOUT;
   }
 
   const auto *pErrEvent = dynamic_cast<const mitk::ExternalProcessStdErrEvent *>(&e);
 
   if (pErrEvent)
   {
     testCERR = testCERR + pErrEvent->GetOutput();
     MITK_ERROR << testCERR;
   }
 }
 
 void mitk::TotalSegmentatorTool::DoUpdatePreview(const Image *inputAtTimeStep,
                                                  const Image * /*oldSegAtTimeStep*/,
                                                  LabelSetImage *previewImage,
                                                  TimeStepType timeStep)
 {
   if (this->m_MitkTempDir.empty())
   {
     this->SetMitkTempDir(IOUtil::CreateTemporaryDirectory("mitk-XXXXXX"));
   }
   if (m_LabelMapTotal.empty())
   {
     this->ParseLabelNames(this->GetLabelMapPath());
   }
   ProcessExecutor::Pointer spExec = ProcessExecutor::New();
   itk::CStyleCommand::Pointer spCommand = itk::CStyleCommand::New();
   spCommand->SetCallback(&onPythonProcessEvent);
   spExec->AddObserver(ExternalProcessOutputEvent(), spCommand);
 
   std::string inDir, outDir, inputImagePath, outputImagePath, scriptPath;
   inDir = IOUtil::CreateTemporaryDirectory("totalseg-in-XXXXXX", this->GetMitkTempDir());
   std::ofstream tmpStream;
   inputImagePath = IOUtil::CreateTemporaryFile(tmpStream, TEMPLATE_FILENAME, inDir + IOUtil::GetDirectorySeparator());
   tmpStream.close();
   std::size_t found = inputImagePath.find_last_of(IOUtil::GetDirectorySeparator());
   std::string fileName = inputImagePath.substr(found + 1);
   std::string token = fileName.substr(0, fileName.find("_"));
   outDir = IOUtil::CreateTemporaryDirectory("totalseg-out-XXXXXX", this->GetMitkTempDir());
   mitk::LabelSetImage::Pointer outputBuffer;
 
   IOUtil::Save(inputAtTimeStep, inputImagePath);
 
   outputImagePath = outDir + IOUtil::GetDirectorySeparator() + token + "_000.nii.gz";
   bool isSubTask = false;
   if (this->GetSubTask() != DEFAULT_TOTAL_TASK)
   {
     isSubTask = true;
     outputImagePath = outDir;
   }
 
   this->run_totalsegmentator(
     spExec, inputImagePath, outputImagePath, this->GetFast(), !isSubTask, this->GetGpuId(), DEFAULT_TOTAL_TASK);
 
   if (isSubTask)
   { // Run total segmentator again
     this->run_totalsegmentator(
       spExec, inputImagePath, outputImagePath, !isSubTask, !isSubTask, this->GetGpuId(), this->GetSubTask());
     // Construct Label Id map
     std::vector<std::string> files = SUBTASKS_MAP.at(this->GetSubTask());
     std::map<int, std::string> labelMapSubtask;
     int labelId = 1;
     for (auto const& file : files)
     {
       std::string labelName = file.substr(0, file.find('.'));
       labelMapSubtask[labelId] = labelName;
       labelId++;
     }
     // Agglomerate individual mask files into one multi-label image.
     std::for_each(files.begin(),
                   files.end(),
                   [&](std::string &fileName) { fileName = (outDir + IOUtil::GetDirectorySeparator() + fileName); });
     outputBuffer = AgglomerateLabelFiles(files, inputAtTimeStep->GetDimensions(), inputAtTimeStep->GetGeometry());
     // Assign label names to the agglomerated LabelSetImage
     this->MapLabelsToSegmentation(outputBuffer, labelMapSubtask);
   }
   else
   {
     Image::Pointer outputImage = IOUtil::Load<Image>(outputImagePath);
     outputBuffer = mitk::LabelSetImage::New();
     outputBuffer->InitializeByLabeledImage(outputImage);
     outputBuffer->SetGeometry(inputAtTimeStep->GetGeometry());
     this->MapLabelsToSegmentation(outputBuffer, m_LabelMapTotal);
   }
   this->TransferLabelSetImageContent(outputBuffer, previewImage, timeStep);
 }
 
 mitk::LabelSetImage::Pointer mitk::TotalSegmentatorTool::AgglomerateLabelFiles(std::vector<std::string> &filePaths,
                                                                                unsigned int *dimensions,
                                                                                mitk::BaseGeometry *geometry)
 {
   int labelId = 1;
   auto aggloLabelImage = mitk::LabelSetImage::New();
   auto initImage = mitk::Image::New();
   initImage->Initialize(mitk::MakeScalarPixelType<int>(), 3, dimensions);
   aggloLabelImage->Initialize(initImage);
   aggloLabelImage->SetGeometry(geometry);
   mitk::LabelSet::Pointer newlayer = mitk::LabelSet::New();
   newlayer->SetLayer(0);
   aggloLabelImage->AddLayer(newlayer);
 
   for (auto const &outputImagePath : filePaths)
   {
     double rgba[4];
     aggloLabelImage->GetActiveLabelSet()->GetLookupTable()->GetTableValue(labelId, rgba);
     mitk::Color color;
     color.SetRed(rgba[0]);
     color.SetGreen(rgba[1]);
     color.SetBlue(rgba[2]);
 
     auto label = mitk::Label::New();
     label->SetName("object-" + std::to_string(labelId));
     label->SetValue(labelId);
     label->SetColor(color);
     label->SetOpacity(rgba[3]);
 
     aggloLabelImage->GetActiveLabelSet()->AddLabel(label);
 
     Image::Pointer outputImage = IOUtil::Load<Image>(outputImagePath);
     auto source = mitk::LabelSetImage::New();
     source->InitializeByLabeledImage(outputImage);
     source->SetGeometry(geometry);
 
     auto labelSet = aggloLabelImage->GetActiveLabelSet();
     mitk::TransferLabelContent(source, aggloLabelImage, labelSet, 0, 0, false, {{1, labelId}});
     labelId++;
   }
   return aggloLabelImage;
 }
 
 void mitk::TotalSegmentatorTool::run_totalsegmentator(ProcessExecutor::Pointer spExec,
                                                       const std::string &inputImagePath,
                                                       const std::string &outputImagePath,
                                                       bool isFast,
                                                       bool isMultiLabel,
                                                       unsigned int gpuId,
                                                       const std::string &subTask)
 {
   ProcessExecutor::ArgumentListType args;
   std::string command = "TotalSegmentator";
 #if defined(__APPLE__) || defined(_WIN32)
   command = "python";
 #endif
 
   args.clear();
 
 #ifdef _WIN32
   std::string ending = "Scripts";
   if (0 == this->GetPythonPath().compare(this->GetPythonPath().length() - ending.length(), ending.length(), ending))
   {
     args.push_back("TotalSegmentator");
   }
   else
   {
     args.push_back("Scripts/TotalSegmentator");
   }
 #endif
 
 #if defined(__APPLE__)
   args.push_back("TotalSegmentator");
 #endif
 
   args.push_back("-i");
   args.push_back(inputImagePath);
 
   args.push_back("-o");
   args.push_back(outputImagePath);
 
   if (subTask != DEFAULT_TOTAL_TASK)
   {
     args.push_back("-ta");
     args.push_back(subTask);
   }
 
   if (isMultiLabel)
   {
     args.push_back("--ml");
   }
 
   if (isFast)
   {
     args.push_back("--fast");
   }
 
   try
   {
     std::string cudaEnv = "CUDA_VISIBLE_DEVICES=" + std::to_string(gpuId);
     itksys::SystemTools::PutEnv(cudaEnv.c_str());
 
     for (auto &arg : args)
       MITK_INFO << arg;
     MITK_INFO << this->GetPythonPath();
 
     spExec->Execute(this->GetPythonPath(), command, args);
   }
   catch (const mitk::Exception &e)
   {
     MITK_ERROR << e.GetDescription();
     return;
   }
 }
 
 void mitk::TotalSegmentatorTool::ParseLabelNames(const std::string &fileName)
 {
   std::fstream newfile;
   newfile.open(fileName, ios::in);
   std::stringstream buffer;
   if (newfile.is_open())
   {
     int line = 0;
     std::string temp;
     while (std::getline(newfile, temp))
     {
       if (line > 1 && line < 106)
       {
         buffer << temp;
       }
       ++line;
     }
   }
   std::string key, val;
   while (std::getline(std::getline(buffer, key, ':'), val, ','))
   {
     m_LabelMapTotal[std::stoi(key)] = val;
   }
 }
 
 void mitk::TotalSegmentatorTool::MapLabelsToSegmentation(mitk::LabelSetImage::Pointer outputBuffer,
                                                          std::map<int, std::string> &labelMap)
 {
   for (auto const &[key, val] : labelMap)
   {
     mitk::Label *labelptr = outputBuffer->GetActiveLabelSet()->GetLabel(key);
     if (nullptr != labelptr)
     {
       labelptr->SetName(val);
     }
   }
 }
 
 std::string mitk::TotalSegmentatorTool::GetLabelMapPath()
 {
   std::string pythonFileName;
   std::filesystem::path pathToLabelMap(this->GetPythonPath());
   pathToLabelMap = pathToLabelMap.parent_path();
 #ifdef _WIN32
   pythonFileName = pathToLabelMap.string() + "/Lib/site-packages/totalsegmentator/map_to_binary.py";
 #else
   pathToLabelMap.append("lib");
   for (auto const &dir_entry : std::filesystem::directory_iterator{pathToLabelMap})
   {
     if (dir_entry.is_directory())
     {
       auto dirName = dir_entry.path().filename().string();
       if (dirName.rfind("python", 0) == 0)
       {
         pathToLabelMap.append(dir_entry.path().filename().string());
         break;
       }
     }
   }
   pythonFileName = pathToLabelMap.string() + "/site-packages/totalsegmentator/map_to_binary.py";
 #endif
   return pythonFileName;
 }
diff --git a/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorToolGUI.cpp b/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorToolGUI.cpp
index 43449b73a1..2fabc542b1 100644
--- a/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorToolGUI.cpp
+++ b/Modules/SegmentationUI/Qmitk/QmitkTotalSegmentatorToolGUI.cpp
@@ -1,499 +1,500 @@
 #include "QmitkTotalSegmentatorToolGUI.h"
 
 #include "mitkProcessExecutor.h"
 #include "mitkTotalSegmentatorTool.h"
 #include <QApplication>
 #include <QDir>
 #include <QDirIterator>
 #include <QFileDialog>
 #include <QIcon>
 #include <QmitkStyleManager.h>
 #include <QMessageBox>
 
 MITK_TOOL_GUI_MACRO(MITKSEGMENTATIONUI_EXPORT, QmitkTotalSegmentatorToolGUI, "")
 
 QmitkTotalSegmentatorToolGUI::QmitkTotalSegmentatorToolGUI()
   : QmitkMultiLabelSegWithPreviewToolGUIBase(), m_SuperclassEnableConfirmSegBtnFnc(m_EnableConfirmSegBtnFnc)
 {
   // Nvidia-smi command returning zero doesn't always imply lack of GPUs.
   // Pytorch uses its own libraries to communicate to the GPUs. Hence, only a warning can be given.
   if (m_GpuLoader.GetGPUCount() == 0)
   {
     std::string warning = "WARNING: No GPUs were detected on your machine. The TotalSegmentator tool can be very slow.";
     this->ShowErrorMessage(warning);
   }
   m_EnableConfirmSegBtnFnc = [this](bool enabled)
   { return !m_FirstPreviewComputation ? m_SuperclassEnableConfirmSegBtnFnc(enabled) : false; };
 }
 
 void QmitkTotalSegmentatorToolGUI::ConnectNewTool(mitk::SegWithPreviewTool *newTool)
 {
   Superclass::ConnectNewTool(newTool);
   m_FirstPreviewComputation = true;
 }
 
 void QmitkTotalSegmentatorToolGUI::InitializeUI(QBoxLayout *mainLayout)
 {
   m_Controls.setupUi(this);
 #ifndef _WIN32
   m_Controls.sysPythonComboBox->addItem("/usr/bin");
 #endif
   this->AutoParsePythonPaths();
   m_Controls.sysPythonComboBox->addItem("Select");
   m_Controls.sysPythonComboBox->setCurrentIndex(0);
   m_Controls.pythonEnvComboBox->addItem("Select");
   m_Controls.pythonEnvComboBox->setDuplicatesEnabled(false);
   m_Controls.pythonEnvComboBox->setDisabled(true);
   m_Controls.previewButton->setDisabled(true);
   m_Controls.statusLabel->setTextFormat(Qt::RichText);
   m_Controls.subtaskComboBox->addItems(VALID_TASKS);
   QString welcomeText;
   this->SetGPUInfo();
   if (m_GpuLoader.GetGPUCount() != 0)
   {
     welcomeText = "<b>STATUS: </b><i>Welcome to TotalSegmentator tool. You're in luck: " +
                                QString::number(m_GpuLoader.GetGPUCount()) + " GPU(s) were detected.</i>";
   }
   else
   {
     welcomeText = "<b>STATUS: </b><i>Welcome to TotalSegmentator tool. Sorry, " +
                               QString::number(m_GpuLoader.GetGPUCount()) + " GPUs were detected.</i>";
   }
 
   connect(m_Controls.previewButton, SIGNAL(clicked()), this, SLOT(OnPreviewBtnClicked()));
   connect(m_Controls.clearButton, SIGNAL(clicked()), this, SLOT(OnClearInstall()));
   connect(m_Controls.installButton, SIGNAL(clicked()), this, SLOT(OnInstallBtnClicked()));
   connect(m_Controls.overrideBox, SIGNAL(stateChanged(int)), this, SLOT(OnOverrideChecked(int)));
   connect(m_Controls.pythonEnvComboBox,
           QOverload<int>::of(&QComboBox::activated),
           [=](int index) { OnPythonPathChanged(m_Controls.pythonEnvComboBox->itemText(index)); });
   connect(m_Controls.sysPythonComboBox,
           QOverload<int>::of(&QComboBox::activated),
           [=](int index) { OnSystemPythonChanged(m_Controls.sysPythonComboBox->itemText(index)); });
 
   QString lastSelectedPyEnv = m_Settings.value("TotalSeg/LastCustomPythonPath").toString();
   if (!lastSelectedPyEnv.isEmpty() && lastSelectedPyEnv!= "Select")
   {
     m_Controls.pythonEnvComboBox->insertItem(0, lastSelectedPyEnv);
   }
   const QString storageDir = m_Installer.GetVirtualEnvPath();
   m_IsInstalled = this->IsTotalSegmentatorInstalled(storageDir);
   if (m_IsInstalled)
   {
     m_PythonPath = GetExactPythonPath(storageDir);
     m_Installer.SetVirtualEnvPath(m_PythonPath);
     this->EnableAll(m_IsInstalled);
     welcomeText += " TotalSegmentator is already found installed."; 
   }
   else
   {
     welcomeText += " TotalSegmentator is not installed. Please click on \"Install TotalSegmentator\" above.";
   }
   this->WriteStatusMessage(welcomeText);
 
   QIcon deleteIcon =
     QmitkStyleManager::ThemeIcon(QStringLiteral(":/org_mitk_icons/icons/awesome/scalable/actions/edit-delete.svg"));
   QIcon arrowIcon =
     QmitkStyleManager::ThemeIcon(QStringLiteral(":/org_mitk_icons/icons/awesome/scalable/actions/go-next.svg"));
   m_Controls.clearButton->setIcon(deleteIcon);
   m_Controls.previewButton->setIcon(arrowIcon);
 
   mainLayout->addLayout(m_Controls.verticalLayout);
   Superclass::InitializeUI(mainLayout);
 }
 
 void QmitkTotalSegmentatorToolGUI::SetGPUInfo()
 {
   std::vector<QmitkGPUSpec> specs = m_GpuLoader.GetAllGPUSpecs();
   for (const QmitkGPUSpec &gpuSpec : specs)
   {
     m_Controls.gpuComboBox->addItem(QString::number(gpuSpec.id) + ": " + gpuSpec.name + " (" + gpuSpec.memory + ")");
   }
   if (specs.empty())
   {
     m_Controls.gpuComboBox->setEditable(true);
     m_Controls.gpuComboBox->addItem(QString::number(0));
     m_Controls.gpuComboBox->setValidator(new QIntValidator(0, 999, this));
   }
 }
 
 unsigned int QmitkTotalSegmentatorToolGUI::FetchSelectedGPUFromUI() const
 {
   QString gpuInfo = m_Controls.gpuComboBox->currentText();
   if (m_GpuLoader.GetGPUCount() == 0)
   {
     return static_cast<unsigned int>(gpuInfo.toInt());
   }
   else
   {
     QString gpuId = gpuInfo.split(":", QString::SplitBehavior::SkipEmptyParts).first();
     return static_cast<unsigned int>(gpuId.toInt());
   }
 }
 
 void QmitkTotalSegmentatorToolGUI::EnableAll(bool isEnable)
 {
   m_Controls.previewButton->setEnabled(isEnable);
   m_Controls.subtaskComboBox->setEnabled(isEnable);
   m_Controls.installButton->setEnabled((!isEnable));
 }
 
 void QmitkTotalSegmentatorToolGUI::OnInstallBtnClicked()
 {
   bool isInstalled = false;
   QString systemPython = OnSystemPythonChanged(m_Controls.sysPythonComboBox->currentText());
   if (systemPython.isEmpty())
   {
     this->WriteErrorMessage("<b>ERROR: </b>Couldn't find Python.");
   }
   else
   {
     this->WriteStatusMessage("<b>STATUS: </b>Installing TotalSegmentator...");
     m_Installer.SetSystemPythonPath(systemPython);
     isInstalled = m_Installer.SetupVirtualEnv(m_Installer.VENV_NAME);
     if (isInstalled)
     {
       const QString pythonPath = m_Installer.GetVirtualEnvPath();
       m_PythonPath = GetExactPythonPath(pythonPath);
       this->WriteStatusMessage("<b>STATUS: </b>Successfully installed TotalSegmentator.");
     }
     else
     {
       this->WriteErrorMessage("<b>ERROR: </b>Couldn't install TotalSegmentator.");
     }
   }
   this->EnableAll(isInstalled);
 }
 
 void QmitkTotalSegmentatorToolGUI::OnPreviewBtnClicked()
 {
   auto tool = this->GetConnectedToolAs<mitk::TotalSegmentatorTool>();
   if (nullptr == tool)
   {
     return;
   }
   try
   {
     m_Controls.previewButton->setEnabled(false);
     qApp->processEvents();
     if (!this->IsTotalSegmentatorInstalled(m_PythonPath))
     {
       throw std::runtime_error(WARNING_TOTALSEG_NOT_FOUND);
     }
     bool isFast = m_Controls.fastBox->isChecked();
     QString subTask = m_Controls.subtaskComboBox->currentText();
     if (subTask != VALID_TASKS[0])
     {
       isFast = true;
     }
     tool->SetPythonPath(m_PythonPath.toStdString());
     tool->SetGpuId(FetchSelectedGPUFromUI());
     tool->SetFast(isFast);
     tool->SetSubTask(subTask.toStdString());
     this->WriteStatusMessage(QString("<b>STATUS: </b><i>Starting Segmentation task... This might take a while.</i>"));
     tool->UpdatePreview();
     m_Controls.previewButton->setEnabled(true);
     m_FirstPreviewComputation = false;
   }
   catch (const std::exception &e)
   {
     std::stringstream errorMsg;
     errorMsg << "<b>STATUS: </b>Error while processing parameters for TotalSegmentator segmentation. Reason: "
              << e.what();
     this->ShowErrorMessage(errorMsg.str());
     this->WriteErrorMessage(QString::fromStdString(errorMsg.str()));
     m_Controls.previewButton->setEnabled(true);
     return;
   }
   catch (...)
   {
     std::string errorMsg = "Unkown error occured while generation TotalSegmentator segmentation.";
     this->ShowErrorMessage(errorMsg);
     m_Controls.previewButton->setEnabled(true);
     return;
   }
   this->SetLabelSetPreview(tool->GetPreviewSegmentation());
   this->ActualizePreviewLabelVisibility();
   this->WriteStatusMessage("<b>STATUS: </b><i>Segmentation task finished successfully.</i>");
   QString pythonPathTextItem = m_Controls.pythonEnvComboBox->currentText();
   if (!pythonPathTextItem.isEmpty() && pythonPathTextItem != "Select") // only cache if the prediction ended without errors.
   {
     QString lastSelectedPyEnv = m_Settings.value("TotalSeg/LastCustomPythonPath").toString();
     if (lastSelectedPyEnv != pythonPathTextItem)
     {
       m_Settings.setValue("TotalSeg/LastCustomPythonPath", pythonPathTextItem);
     }
   }
 }
 
 void QmitkTotalSegmentatorToolGUI::ShowErrorMessage(const std::string &message, QMessageBox::Icon icon)
 {
   this->setCursor(Qt::ArrowCursor);
   QMessageBox *messageBox = new QMessageBox(icon, nullptr, message.c_str());
   messageBox->exec();
   delete messageBox;
   MITK_WARN << message;
 }
 
 void QmitkTotalSegmentatorToolGUI::WriteStatusMessage(const QString &message)
 {
   m_Controls.statusLabel->setText(message);
   m_Controls.statusLabel->setStyleSheet("font-weight: bold; color: white");
   qApp->processEvents();
 }
 
 void QmitkTotalSegmentatorToolGUI::WriteErrorMessage(const QString &message)
 {
   m_Controls.statusLabel->setText(message);
   m_Controls.statusLabel->setStyleSheet("font-weight: bold; color: red");
   qApp->processEvents();
 }
 
 bool QmitkTotalSegmentatorToolGUI::IsTotalSegmentatorInstalled(const QString &pythonPath)
 {
   QString fullPath = pythonPath;
   bool isPythonExists = false;
 #ifdef _WIN32
   isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python.exe"));
   if (!(fullPath.endsWith("Scripts", Qt::CaseInsensitive) || fullPath.endsWith("Scripts/", Qt::CaseInsensitive)))
   {
     fullPath += QDir::separator() + QString("Scripts");
     isPythonExists =
       (!isPythonExists) ? QFile::exists(fullPath + QDir::separator() + QString("python.exe")) : isPythonExists;
   }
 #else
   isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python3"));
   if (!(fullPath.endsWith("bin", Qt::CaseInsensitive) || fullPath.endsWith("bin/", Qt::CaseInsensitive)))
   {
     fullPath += QDir::separator() + QString("bin");
     isPythonExists =
       (!isPythonExists) ? QFile::exists(fullPath + QDir::separator() + QString("python3")) : isPythonExists;
   }
 #endif
   bool isExists = QFile::exists(fullPath + QDir::separator() + QString("TotalSegmentator")) && isPythonExists;
   return isExists;
 }
 
 void QmitkTotalSegmentatorToolGUI::AutoParsePythonPaths()
 {
   QString homeDir = QDir::homePath();
   std::vector<QString> searchDirs;
 #ifdef _WIN32
   searchDirs.push_back(QString("C:") + QDir::separator() + QString("ProgramData") + QDir::separator() +
                        QString("anaconda3"));
 #else
   // Add search locations for possible standard python paths here
   searchDirs.push_back(homeDir + QDir::separator() + "environments");
   searchDirs.push_back(homeDir + QDir::separator() + "anaconda3");
   searchDirs.push_back(homeDir + QDir::separator() + "miniconda3");
   searchDirs.push_back(homeDir + QDir::separator() + "opt" + QDir::separator() + "miniconda3");
   searchDirs.push_back(homeDir + QDir::separator() + "opt" + QDir::separator() + "anaconda3");
 #endif
   for (QString searchDir : searchDirs)
   {
     if (searchDir.endsWith("anaconda3", Qt::CaseInsensitive))
     {
       if (QDir(searchDir).exists())
       {
         m_Controls.sysPythonComboBox->addItem("(base): " + searchDir);
         searchDir.append((QDir::separator() + QString("envs")));
       }
     }
     for (QDirIterator subIt(searchDir, QDir::AllDirs, QDirIterator::NoIteratorFlags); subIt.hasNext();)
     {
       subIt.next();
       QString envName = subIt.fileName();
       if (!envName.startsWith('.')) // Filter out irrelevent hidden folders, if any.
       {
         m_Controls.sysPythonComboBox->addItem("(" + envName + "): " + subIt.filePath());
       }
     }
   }
 }
 
 QString QmitkTotalSegmentatorToolGUI::OnSystemPythonChanged(const QString &pyEnv)
 {
   QString pyPath;
   if (pyEnv == QString("Select"))
   {
     m_Controls.previewButton->setDisabled(true);
     QString path =
       QFileDialog::getExistingDirectory(m_Controls.sysPythonComboBox->parentWidget(), "Python Path", "dir");
     if (!path.isEmpty())
     {
       this->OnSystemPythonChanged(path);                                // recall same function for new path validation
       bool oldState = m_Controls.sysPythonComboBox->blockSignals(true); // block signal firing while inserting item
       m_Controls.sysPythonComboBox->insertItem(0, path);
       m_Controls.sysPythonComboBox->setCurrentIndex(0);
       m_Controls.sysPythonComboBox->blockSignals(
         oldState); // unblock signal firing after inserting item. Remove this after Qt6 migration
     }
   }
   else
   { 
     QString uiPyPath = this->GetPythonPathFromUI(pyEnv);
     pyPath = this->GetExactPythonPath(uiPyPath);
   }
   return pyPath;
 }
 
 void QmitkTotalSegmentatorToolGUI::OnPythonPathChanged(const QString &pyEnv)
 {
   if (pyEnv == QString("Select"))
   {
     m_Controls.previewButton->setDisabled(true);
     QString path =
       QFileDialog::getExistingDirectory(m_Controls.pythonEnvComboBox->parentWidget(), "Python Path", "dir");
     if (!path.isEmpty())
     {
       this->OnPythonPathChanged(path);                                  // recall same function for new path validation
       bool oldState = m_Controls.pythonEnvComboBox->blockSignals(true); // block signal firing while inserting item
       m_Controls.pythonEnvComboBox->insertItem(0, path);
       m_Controls.pythonEnvComboBox->setCurrentIndex(0);
       m_Controls.pythonEnvComboBox->blockSignals(
         oldState); // unblock signal firing after inserting item. Remove this after Qt6 migration
     }
   }
   else if (!this->IsTotalSegmentatorInstalled(pyEnv))
   {
     this->ShowErrorMessage(WARNING_TOTALSEG_NOT_FOUND);
     m_Controls.previewButton->setDisabled(true);
   }
   else
   {// Show positive status meeage
     m_Controls.previewButton->setDisabled(false);
     QString uiPyPath = this->GetPythonPathFromUI(pyEnv);
     m_PythonPath = this->GetExactPythonPath(uiPyPath);
   }
 }
 
 QString QmitkTotalSegmentatorToolGUI::GetPythonPathFromUI(const QString &pyUI) const
 {
   QString fullPath = pyUI;
   if (-1 != fullPath.indexOf(")"))
   {
     fullPath = fullPath.mid(fullPath.indexOf(")") + 2);
   }
   return fullPath.simplified();
 }
 
 QString QmitkTotalSegmentatorToolGUI::GetExactPythonPath(const QString &pyEnv) const
 {
   QString fullPath = pyEnv;
   bool isPythonExists = false;
 #ifdef _WIN32
   isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python.exe"));
   if (!isPythonExists &&
       !(fullPath.endsWith("Scripts", Qt::CaseInsensitive) || fullPath.endsWith("Scripts/", Qt::CaseInsensitive)))
   {
     fullPath += QDir::separator() + QString("Scripts");
     isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python.exe"));
   }
 #else
   isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python3"));
   if (!isPythonExists && !(fullPath.endsWith("bin", Qt::CaseInsensitive) ||
                             fullPath.endsWith("bin/", Qt::CaseInsensitive)))
   {
     fullPath += QDir::separator() + QString("bin");
     isPythonExists = QFile::exists(fullPath + QDir::separator() + QString("python3"));
   }
 #endif
   if (!isPythonExists)
   {
     fullPath.clear();
   }
   return fullPath;
 }
 
 void QmitkTotalSegmentatorToolGUI::OnOverrideChecked(int state)
 {
   bool isEnabled = false;
   if (state == Qt::Checked)
   {
     isEnabled = true;
     m_Controls.previewButton->setDisabled(true);
     m_PythonPath.clear();
   }
   else
   {
     m_PythonPath.clear();
     m_Controls.previewButton->setDisabled(true);
     if (m_IsInstalled)
     {
-      m_PythonPath = m_Installer.GetVirtualEnvPath();
+      const QString pythonPath = m_Installer.GetVirtualEnvPath();
+      m_PythonPath = this->GetExactPythonPath(pythonPath);
       this->EnableAll(m_IsInstalled);
     }
   }
   m_Controls.pythonEnvComboBox->setEnabled(isEnabled);
 }
 
 void QmitkTotalSegmentatorToolGUI::OnClearInstall()
 {
   QDir folderPath(m_Installer.GetVirtualEnvPath());
   if (folderPath.removeRecursively())
   {
     m_Controls.installButton->setEnabled(true);
     if (!m_Controls.overrideBox->isChecked())
     {
       m_Controls.previewButton->setEnabled(false);
     }
   }
   else
   {
     MITK_ERROR
       << "The virtual environment couldn't be removed. Please check if you have the required access privileges or, some other process is accessing the folders.";
   }
 }
 
 bool QmitkTotalSegmentatorToolInstaller::SetupVirtualEnv(const QString& venvName)
 {
   if (GetSystemPythonPath().isEmpty())
   {
     return false;
   }
   QDir folderPath(GetBaseDir());
   folderPath.mkdir(venvName);
   if (!folderPath.cd(venvName))
   {
     return false; // Check if directory creation was successful.
   }
   mitk::ProcessExecutor::ArgumentListType args;
   auto spExec = mitk::ProcessExecutor::New();
   auto spCommand = itk::CStyleCommand::New();
   spCommand->SetCallback(&PrintProcessEvent);
   spExec->AddObserver(mitk::ExternalProcessOutputEvent(), spCommand);
 
   args.push_back("-m");
   args.push_back("venv");
   args.push_back(venvName.toStdString());
 #ifdef _WIN32
   QString pythonFile = GetSystemPythonPath() + QDir::separator() + "python.exe";
   QString pythonExeFolder = "Scripts";
 #else
   QString pythonFile = GetSystemPythonPath() + QDir::separator() + "python3";
   QString pythonExeFolder = "bin";
 #endif
   spExec->Execute(GetBaseDir().toStdString(), pythonFile.toStdString(), args); // Setup local virtual environment
   if (folderPath.cd(pythonExeFolder))
   {
     this->SetPythonPath(folderPath.absolutePath());
     this->SetPipPath(folderPath.absolutePath());
     this->InstallPytorch();
     for (auto &package : PACKAGES)
     {
       this->PipInstall(package.toStdString(), &PrintProcessEvent);
     }
     std::string pythonCode; // python syntax to check if torch is installed with CUDA.
     pythonCode.append("import torch;");
     pythonCode.append("print('Pytorch was installed with CUDA') if torch.cuda.is_available() else print('PyTorch was "
                       "installed WITHOUT CUDA');");
     this->ExecutePython(pythonCode, &PrintProcessEvent);
     return true;
   }
   return false;
 }
 
 QString QmitkTotalSegmentatorToolInstaller::GetVirtualEnvPath() 
 {
   return STORAGE_DIR + VENV_NAME;
 }