diff --git a/CMakeExternals/Vigra.cmake b/CMakeExternals/Vigra.cmake
index 3fd5a82954..2b47454640 100644
--- a/CMakeExternals/Vigra.cmake
+++ b/CMakeExternals/Vigra.cmake
@@ -1,56 +1,64 @@
 #-----------------------------------------------------------------------------
 # VIGRA
 #-----------------------------------------------------------------------------
 
 if(MITK_USE_Vigra)
 
   # Sanity checks
   if(DEFINED Vigra_DIR AND NOT EXISTS ${Vigra_DIR})
     message(FATAL_ERROR "Vigra_DIR variable is defined but corresponds to non-existing directory")
   endif()
 
   if(NOT ${MITK_USE_HDF5})
     message(FATAL_ERROR "HDF5 is required for Vigra. Please enable it.")
   endif()
 
   set(proj Vigra)
   set(proj_DEPENDENCIES HDF5)
   set(Vigra_DEPENDS ${proj})
 
+  # If a mac ports installation is present some imaging-io-libraries may interfere with the vigra build.
+  # Hence, we exclude them here.
+  set(mac_additional_cmake_args)
+  if(APPLE)
+    set(mac_additional_cmake_args -DJPEG_INCLUDE_DIR= -DJPEG_LIBRARY= -DTIFF_INCLUDE_DIR= -DTIFF_LIBRARY= -DPNG_LIBRARY_RELEASE= -DPNG_PNG_INCLUDE_DIR= )
+  endif()
+
   if(NOT DEFINED Vigra_DIR)
 
     set(additional_cmake_args )
     if(CTEST_USE_LAUNCHERS)
       list(APPEND additional_cmake_args
         "-DCMAKE_PROJECT_${proj}_INCLUDE:FILEPATH=${CMAKE_ROOT}/Modules/CTestUseLaunchers.cmake"
       )
     endif()
 
     ExternalProject_Add(${proj}
        URL ${MITK_THIRDPARTY_DOWNLOAD_PREFIX_URL}/vigra-1.10.0-src.tar.gz
        URL_MD5 4f963f0be4fcb8b06271c2aa40baa9be
        PATCH_COMMAND ${PATCH_COMMAND} -N -p1 -i ${CMAKE_CURRENT_LIST_DIR}/Vigra.patch
        CMAKE_GENERATOR ${gen}
        CMAKE_ARGS
          ${ep_common_args}
          ${additional_cmake_args}
+         ${mac_additional_cmake_args}
          -DAUTOEXEC_TESTS:BOOL=OFF
          -DWITH_VIGRANUMPY:BOOL=OFF
          -DHDF5_DIR:PATH=${HDF5_DIR}
          -DCMAKE_INSTALL_RPATH_USE_LINK_PATH:BOOL=TRUE
          -DCMAKE_INSTALL_PREFIX:PATH=<INSTALL_DIR>
        CMAKE_CACHE_ARGS
          ${ep_common_cache_args}
        CMAKE_CACHE_DEFAULT_ARGS
          ${ep_common_cache_default_args}
        DEPENDS ${proj_DEPENDENCIES}
       )
 
     set(Vigra_DIR ${ep_prefix})
 
   else()
 
     mitkMacroEmptyExternalProject(${proj} "${proj_DEPENDENCIES}")
 
   endif()
 endif(MITK_USE_Vigra)