diff --git a/Modules/Segmentation/Interactions/mitkTotalSegmentatorTool.cpp b/Modules/Segmentation/Interactions/mitkTotalSegmentatorTool.cpp
index 5d2d2cafd8..216dcde9e3 100644
--- a/Modules/Segmentation/Interactions/mitkTotalSegmentatorTool.cpp
+++ b/Modules/Segmentation/Interactions/mitkTotalSegmentatorTool.cpp
@@ -1,270 +1,274 @@
 /*============================================================================
 
 The Medical Imaging Interaction Toolkit (MITK)
 
 Copyright (c) German Cancer Research Center (DKFZ)
 All rights reserved.
 
 Use of this source code is governed by a 3-clause BSD license that can be
 found in the LICENSE file.
 
 ============================================================================*/
 
 // MITK
 #include "mitkTotalSegmentatorTool.h"
 
 #include "mitkIOUtil.h"
 #include <filesystem>
 #include <itksys/SystemTools.hxx>
 
 // us
 #include <usGetModuleContext.h>
 #include <usModule.h>
 #include <usModuleContext.h>
 #include <usModuleResource.h>
 #include <usServiceReference.h>
 
 namespace mitk
 {
   MITK_TOOL_MACRO(MITKSEGMENTATION_EXPORT, TotalSegmentatorTool, "Total Segmentator");
 }
 
 mitk::TotalSegmentatorTool::~TotalSegmentatorTool()
 {
   itksys::SystemTools::RemoveADirectory(this->GetMitkTempDir());
 }
 
 void mitk::TotalSegmentatorTool::Activated()
 {
   Superclass::Activated();
   this->SetLabelTransferMode(LabelTransferMode::AllLabels);
 }
 
 const char **mitk::TotalSegmentatorTool::GetXPM() const
 {
   return nullptr;
 }
 
 us::ModuleResource mitk::TotalSegmentatorTool::GetIconResource() const
 {
   us::Module *module = us::GetModuleContext()->GetModule();
   us::ModuleResource resource = module->GetResource("AI.svg");
   return resource;
 }
 
 const char *mitk::TotalSegmentatorTool::GetName() const
 {
   return "TotalSegmentator";
 }
 
 void mitk::TotalSegmentatorTool::onPythonProcessEvent(itk::Object * /*pCaller*/, const itk::EventObject &e, void *)
 {
   std::string testCOUT;
   std::string testCERR;
   const auto *pEvent = dynamic_cast<const mitk::ExternalProcessStdOutEvent *>(&e);
 
   if (pEvent)
   {
     testCOUT = testCOUT + pEvent->GetOutput();
     MITK_INFO << testCOUT;
   }
 
   const auto *pErrEvent = dynamic_cast<const mitk::ExternalProcessStdErrEvent *>(&e);
 
   if (pErrEvent)
   {
     testCERR = testCERR + pErrEvent->GetOutput();
     MITK_ERROR << testCERR;
   }
 }
 
 void mitk::TotalSegmentatorTool::DoUpdatePreview(const Image *inputAtTimeStep,
                                                  const Image * /*oldSegAtTimeStep*/,
                                                  LabelSetImage *previewImage,
                                                  TimeStepType timeStep)
 {
   if (!m_IsMitkTempDirAvailable) // create temp directory if not done already
   {
     this->SetMitkTempDir(IOUtil::CreateTemporaryDirectory("mitk-XXXXXX"));
     m_IsMitkTempDirAvailable = true;
   }
   this->ParseLabelNames(this->GetLabelMapPath());
 
   ProcessExecutor::Pointer spExec = ProcessExecutor::New();
   itk::CStyleCommand::Pointer spCommand = itk::CStyleCommand::New();
   spCommand->SetCallback(&onPythonProcessEvent);
   spExec->AddObserver(ExternalProcessOutputEvent(), spCommand);
 
   std::string inDir, outDir, inputImagePath, outputImagePath, scriptPath;
   inDir = IOUtil::CreateTemporaryDirectory("totalseg-in-XXXXXX", this->GetMitkTempDir());
   std::ofstream tmpStream;
   inputImagePath = IOUtil::CreateTemporaryFile(tmpStream, m_TEMPLATE_FILENAME, inDir + IOUtil::GetDirectorySeparator());
   tmpStream.close();
   std::size_t found = inputImagePath.find_last_of(IOUtil::GetDirectorySeparator());
   std::string fileName = inputImagePath.substr(found + 1);
   std::string token = fileName.substr(0, fileName.find("_"));
   outDir = IOUtil::CreateTemporaryDirectory("totalseg-out-XXXXXX", this->GetMitkTempDir());
   outputImagePath = outDir + IOUtil::GetDirectorySeparator() + token + "_000.nii.gz";
   ProcessExecutor::ArgumentListType args;
 
   IOUtil::Save(inputAtTimeStep, inputImagePath);
 
   std::string *outArg = &outputImagePath;
   bool isSubTask = false;
   if (this->GetSubTask() != m_DEFAULT_TOTAL_TASK)
   {
     isSubTask = true;
     outputImagePath = outDir + IOUtil::GetDirectorySeparator() + this->GetSubTask() + ".nii.gz";
     outArg = &outDir;
   }
 
   this->run_totalsegmentator(
     spExec, inputImagePath, *outArg, this->GetFast(), !isSubTask, this->GetGpuId(), m_DEFAULT_TOTAL_TASK);
 
   if (isSubTask)
   {
     this->run_totalsegmentator(
       spExec, inputImagePath, *outArg, !isSubTask, !isSubTask, this->GetGpuId(), this->GetSubTask());
   }
 
   Image::Pointer outputImage = IOUtil::Load<Image>(outputImagePath);
   auto outputBuffer = mitk::LabelSetImage::New();
   outputBuffer->InitializeByLabeledImage(outputImage);
   outputBuffer->SetGeometry(inputAtTimeStep->GetGeometry());
   this->MapLabelsToSegmentation(outputBuffer, m_LabelMapTotal);
   TransferLabelSetImageContent(outputBuffer, previewImage, timeStep);
 }
 
 void mitk::TotalSegmentatorTool::run_totalsegmentator(ProcessExecutor::Pointer spExec,
                                                       const std::string &inputImagePath,
                                                       const std::string &outputImagePath,
                                                       bool isFast,
                                                       bool isMultiLabel,
                                                       unsigned int gpuId,
                                                       const std::string &subTask)
 {
   ProcessExecutor::ArgumentListType args;
   std::string command = "TotalSegmentator";
-#ifdef _WIN32
+#if defined(__APPLE__) || defined(_WIN32)
   command = "python";
 #else
   command = "TotalSegmentator";
 #endif
 
   args.clear();
 
 #ifdef _WIN32
   std::string ending = "Scripts";
   if (0 == this->GetPythonPath().compare(this->GetPythonPath().length() - ending.length(), ending.length(), ending))
   {
     args.push_back("TotalSegmentator");
   }
   else
   {
     args.push_back("Scripts/TotalSegmentator");
   }
 #endif
 
+#if defined(__APPLE__)
+  args.push_back("TotalSegmentator");
+#endif
+
   args.push_back("-i");
   args.push_back(inputImagePath);
 
   args.push_back("-o");
   args.push_back(outputImagePath);
 
   if (subTask != m_DEFAULT_TOTAL_TASK)
   {
     args.push_back("-ta");
     args.push_back(subTask);
   }
 
   if (isMultiLabel)
   {
     args.push_back("--ml");
   }
 
   if (isFast)
   {
     args.push_back("--fast");
   }
 
   try
   {
     std::string cudaEnv = "CUDA_VISIBLE_DEVICES=" + std::to_string(gpuId);
     itksys::SystemTools::PutEnv(cudaEnv.c_str());
 
     for (auto &arg : args)
       MITK_INFO << arg;
     MITK_INFO << this->GetPythonPath();
 
     spExec->Execute(this->GetPythonPath(), command, args);
   }
   catch (const mitk::Exception &e)
   {
     MITK_ERROR << e.GetDescription();
     return;
   }
 }
 
 void mitk::TotalSegmentatorTool::ParseLabelNames(const std::string &fileName)
 {
   std::fstream newfile;
   newfile.open(fileName, ios::in);
   std::stringstream buffer;
   if (newfile.is_open())
   {
     int line = 0;
     std::string temp;
     while (std::getline(newfile, temp))
     {
       if (line > 1 && line < 106)
       {
         buffer << temp;
       }
       ++line;
     }
   }
   std::string key, val;
   while (std::getline(std::getline(buffer, key, ':'), val, ','))
   {
     m_LabelMapTotal[std::stoi(key)] = val;
   }
 }
 
 void mitk::TotalSegmentatorTool::MapLabelsToSegmentation(mitk::LabelSetImage::Pointer outputBuffer,
                                                          std::map<int, std::string> &labelMap)
 {
   for (auto const &[key, val] : labelMap)
   {
     mitk::Label *labelptr = outputBuffer->GetLabel(key, 0);
     if (nullptr != labelptr)
     {
       labelptr->SetName(val);
     }
   }
 }
 
 std::string mitk::TotalSegmentatorTool::GetLabelMapPath()
 {
   std::string pythonFileName;
   std::filesystem::path pathToLabelMap(this->GetPythonPath());
   pathToLabelMap = pathToLabelMap.parent_path();
 #ifdef _WIN32
   pythonFileName = pathToLabelMap.string() + "/Lib/site-packages/totalsegmentator/map_to_binary.py";
 #else
   pathToLabelMap.append("lib");
   for (auto const &dir_entry : std::filesystem::directory_iterator{pathToLabelMap})
   {
     if (dir_entry.is_directory())
     {
       auto dirName = dir_entry.path().filename().string();
       if (dirName.rfind("python", 0) == 0)
       {
         pathToLabelMap.append(dir_entry.path().filename().string());
         break;
       }
     }
   }
   pythonFileName = pathToLabelMap.string() + "/site-packages/totalsegmentator/map_to_binary.py";
 #endif
   return pythonFileName;
 }