diff --git a/CMakeExternals/ITK.cmake b/CMakeExternals/ITK.cmake
index 2dde71437d..257933614f 100644
--- a/CMakeExternals/ITK.cmake
+++ b/CMakeExternals/ITK.cmake
@@ -1,98 +1,99 @@
 #-----------------------------------------------------------------------------
 # ITK
 #-----------------------------------------------------------------------------
 
 # Sanity checks
 if(DEFINED ITK_DIR AND NOT EXISTS ${ITK_DIR})
   message(FATAL_ERROR "ITK_DIR variable is defined but corresponds to non-existing directory")
 endif()
 
 set(proj ITK)
 set(proj_DEPENDENCIES GDCM)
 if(MITK_USE_Python)
   list(APPEND proj_DEPENDENCIES CableSwig)
 endif()
 if(MITK_USE_OpenCV)
   list(APPEND proj_DEPENDENCIES OpenCV)
 endif()
 
 set(ITK_DEPENDS ${proj})
 
 if(NOT DEFINED ITK_DIR)
 
   set(additional_cmake_args )
   if(MINGW)
     set(additional_cmake_args
         -DCMAKE_USE_WIN32_THREADS:BOOL=ON
         -DCMAKE_USE_PTHREADS:BOOL=OFF)
   endif()
 
   if(MITK_USE_Python)
 
     list(APPEND additional_cmake_args
          -DITK_WRAPPING:BOOL=ON
+         -ITK_WRAP_PYTHON=ON
          -DPYTHON_EXECUTABLE:FILEPATH=${PYTHON_EXECUTABLE}
          -DPYTHON_INCLUDE_DIR:PATH=${PYTHON_INCLUDE_DIR}
          -DPYTHON_INCLUDE_DIR2:PATH=${PYTHON_INCLUDE_DIR2}
          -DPYTHON_LIBRARY:FILEPATH=${PYTHON_LIBRARY}
          #-DPYTHON_LIBRARIES=${PYTHON_LIBRARY}
          #-DPYTHON_DEBUG_LIBRARIES=${PYTHON_DEBUG_LIBRARIES}
          -DCableSwig_DIR:PATH=${CableSwig_DIR}
          #-DITK_WRAP_JAVA:BOOL=OFF
          -DITK_WRAP_unsigned_char:BOOL=ON
          #-DITK_WRAP_double:BOOL=ON
          -DITK_WRAP_rgb_unsigned_char:BOOL=ON
          #-DITK_WRAP_rgba_unsigned_char:BOOL=ON
          -DITK_WRAP_signed_char:BOOL=ON
          #-DWRAP_signed_long:BOOL=ON
          -DITK_WRAP_signed_short:BOOL=ON
          -DITK_WRAP_short:BOOL=ON
          -DITK_WRAP_unsigned_long:BOOL=ON
         )
   else()
     list(APPEND additional_cmake_args
          -DUSE_WRAP_ITK:BOOL=OFF
         )
   endif()
 
   if(MITK_USE_OpenCV)
     list(APPEND additional_cmake_args
          -DModule_ITKVideoBridgeOpenCV:BOOL=ON
          -DOpenCV_DIR:PATH=${OpenCV_DIR}
         )
   endif()
 
   # Keep the behaviour of ITK 4.3 which by default turned on ITK Review
   # see MITK bug #17338
   list(APPEND additional_cmake_args
     -DModule_ITKReview:BOOL=ON
   )
 
   set(ITK_PATCH_COMMAND ${CMAKE_COMMAND} -DTEMPLATE_FILE:FILEPATH=${MITK_SOURCE_DIR}/CMakeExternals/EmptyFileForPatching.dummy -P ${MITK_SOURCE_DIR}/CMakeExternals/PatchITK-4.5.1.cmake)
 
   ExternalProject_Add(${proj}
      SOURCE_DIR ${CMAKE_BINARY_DIR}/${proj}-src
      BINARY_DIR ${proj}-build
      PREFIX ${proj}-cmake
      URL ${MITK_THIRDPARTY_DOWNLOAD_PREFIX_URL}/InsightToolkit-4.5.1-3e550bf8.tar.gz
      URL_MD5 80e433ffc0e81cdc19a03dd02a3c329b
      INSTALL_COMMAND ""
      PATCH_COMMAND ${ITK_PATCH_COMMAND}
      CMAKE_GENERATOR ${gen}
      CMAKE_ARGS
        ${ep_common_args}
        ${additional_cmake_args}
        -DBUILD_TESTING:BOOL=OFF
        -DBUILD_EXAMPLES:BOOL=OFF
        -DITK_USE_SYSTEM_GDCM:BOOL=ON
        -DGDCM_DIR:PATH=${GDCM_DIR}
      DEPENDS ${proj_DEPENDENCIES}
     )
 
   set(ITK_DIR ${CMAKE_CURRENT_BINARY_DIR}/${proj}-build)
 
 else()
 
   mitkMacroEmptyExternalProject(${proj} "${proj_DEPENDENCIES}")
 
 endif()
diff --git a/Modules/Python/CMakeLists.txt b/Modules/Python/CMakeLists.txt
index 475bb4d8bf..7881e47c26 100644
--- a/Modules/Python/CMakeLists.txt
+++ b/Modules/Python/CMakeLists.txt
@@ -1,12 +1,12 @@
 if( MITK_USE_Python )
 
   MITK_CREATE_MODULE(
     DEPENDS MitkCore
     EXPORT_DEFINE MITK_PYTHON_EXPORT
-    PACKAGE_DEPENDS Qt4|QtGui CTK PythonLibs
+    PACKAGE_DEPENDS Qt4|QtGui CTK PythonLibs VTK|vtkPython+vtkWrappingPythonCore
   )
   configure_file(PythonPath.h.in
     "${CMAKE_CURRENT_BINARY_DIR}/PythonPath.h" @ONLY)
 
   add_subdirectory(Testing)
 endif()
diff --git a/Modules/Python/PythonPath.h.in b/Modules/Python/PythonPath.h.in
index 6f5daf2961..dded9c0ec3 100644
--- a/Modules/Python/PythonPath.h.in
+++ b/Modules/Python/PythonPath.h.in
@@ -1,21 +1,22 @@
 #ifdef _DEBUG
 #define PYTHON_PATH_BUILD_TYPE "/Debug"
 #else
 #define PYTHON_PATH_BUILD_TYPE "/Release"
 #endif
 
 #define PYTHONPATH_COMMAND "import sys\n"\
 "sys.path.append('@ITK_LIBRARY_DIRS@')\n"\
 "sys.path.append('@ITK_DIR@/Wrapping/WrapITK/Python')\n"\
 "sys.path.append('@ITK_LIBRARY_DIRS@" PYTHON_PATH_BUILD_TYPE "')\n"\
 "sys.path.append('@ITK_DIR@/Wrapping/WrapITK/Python" PYTHON_PATH_BUILD_TYPE "')\n"\
 "sys.path.append('@ITK_DIR@/Wrapping/Generators/Python')\n"\
 "sys.path.append('@ITK_DIR@/lib')\n"\
 "sys.path.append('@VTK_LIBRARY_DIRS@')\n"\
 "sys.path.append('@VTK_DIR@/Wrapping/Python')\n"\
+"sys.path.append('@VTK_DIR@/Wrapping/PythonCore')\n"\
+"sys.path.append('@VTK_DIR@/lib')\n"\
 "sys.path.append('@VTK_DIR@/bin" PYTHON_PATH_BUILD_TYPE "')\n"\
-"sys.path.append('@VTK_DIR@/Wrapping/Python')\n"\
 "sys.path.append('@OpenCV_DIR@/lib" PYTHON_PATH_BUILD_TYPE "')\n"\
 "sys.path.append('@OpenCV_DIR@/lib')\n"\
 "sys.path.append('@OpenCV_DIR@/bin')\n"\
 "sys.path.append('@OpenCV_DIR@/bin" PYTHON_PATH_BUILD_TYPE "')"