diff --git a/Modules/DiffusionImaging/Connectomics/CMakeLists.txt b/Modules/DiffusionImaging/Connectomics/CMakeLists.txt
index 719324116a..e6c1373f33 100644
--- a/Modules/DiffusionImaging/Connectomics/CMakeLists.txt
+++ b/Modules/DiffusionImaging/Connectomics/CMakeLists.txt
@@ -1,24 +1,28 @@
-# Boost throws a lot of unused variable warnings on linux
+# With apple clang 5.0 the following waring leads to an build error if boost is enabled
+if(APPLE)
+  mitkFunctionCheckCAndCXXCompilerFlags("-Wno-error=tautological-constant-out-of-range-compare" CMAKE_C_FLAGS CMAKE_CXX_FLAGS)
+endif()
 
+# Boost throws a lot of unused variable warnings on linux
 if(UNIX)
   mitkFunctionCheckCAndCXXCompilerFlags("-Wno-error=unused-variable" CMAKE_C_FLAGS CMAKE_CXX_FLAGS)
   mitkFunctionCheckCAndCXXCompilerFlags("-Wno-error=unneeded-internal-declaration" CMAKE_C_FLAGS CMAKE_CXX_FLAGS)
 endif()
 
 # there are additional warnings in boost headers in Release mode with special gcc versions
 if(CMAKE_COMPILER_IS_GNUCXX)
   if (CMAKE_BUILD_TYPE STREQUAL "Release" AND (${GCC_VERSION} VERSION_EQUAL "4.8" OR ${GCC_VERSION} VERSION_GREATER "4.8"))
     mitkFunctionCheckCAndCXXCompilerFlags("-Wno-error=maybe-uninitialized" CMAKE_C_FLAGS CMAKE_CXX_FLAGS)
     mitkFunctionCheckCAndCXXCompilerFlags("-Wno-error=unused-parameter" CMAKE_C_FLAGS CMAKE_CXX_FLAGS)
   endif()
 endif()
 
 MITK_CREATE_MODULE(
   SUBPROJECTS MITK-DTI
   INCLUDE_DIRS Algorithms IODataStructures Rendering ${CMAKE_CURRENT_BINARY_DIR}
   DEPENDS MitkDiffusionCore MitkFiberTracking
   PACKAGE_DEPENDS VTK|vtkInfovisLayout
   WARNINGS_AS_ERRORS
 )
 
 add_subdirectory(Testing)