diff --git a/.gitignore b/.gitignore
index 0096abe..fc1fdd0 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1,15 +1,16 @@
 *.pyc
 *.pickle
 *.ipynb_checkpoints*
 *.pkl
 *.log
 *.png
 *.jpg
 *.pdf
 *.egg-info
+*.so
 sandbox/*
 .idea/*
 __pycache__/
 
 
 !/assets/*
diff --git a/custom_extensions/roi_align/src/RoIAlign_cuda.cu b/custom_extensions/roi_align/src/RoIAlign_cuda.cu
index 47c870a..39426bf 100644
--- a/custom_extensions/roi_align/src/RoIAlign_cuda.cu
+++ b/custom_extensions/roi_align/src/RoIAlign_cuda.cu
@@ -1,422 +1,422 @@
 /*
 ROIAlign implementation in CUDA from pytorch framework
 (https://github.com/pytorch/vision/tree/master/torchvision/csrc/cuda on Nov 14 2019)
 
 */
 
 #include <ATen/ATen.h>
 #include <ATen/TensorUtils.h>
 #include <ATen/cuda/CUDAContext.h>
 #include <c10/cuda/CUDAGuard.h>
 #include <ATen/cuda/CUDAApplyUtils.cuh>
 #include <typeinfo>
 #include "cuda_helpers.h"
 
 template <typename T>
 __device__ T bilinear_interpolate(
     const T* input,
     const int height,
     const int width,
     T y,
     T x,
     const int index /* index for debug only*/) {
   // deal with cases that inverse elements are out of feature map boundary
   if (y < -1.0 || y > height || x < -1.0 || x > width) {
     // empty
     return 0;
   }
 
   if (y <= 0)
     y = 0;
   if (x <= 0)
     x = 0;
 
   int y_low = (int)y;
   int x_low = (int)x;
   int y_high;
   int x_high;
 
   if (y_low >= height - 1) {
     y_high = y_low = height - 1;
     y = (T)y_low;
   } else {
     y_high = y_low + 1;
   }
 
   if (x_low >= width - 1) {
     x_high = x_low = width - 1;
     x = (T)x_low;
   } else {
     x_high = x_low + 1;
   }
 
   T ly = y - y_low;
   T lx = x - x_low;
   T hy = 1. - ly, hx = 1. - lx;
 
   // do bilinear interpolation
   T v1 = input[y_low * width + x_low];
   T v2 = input[y_low * width + x_high];
   T v3 = input[y_high * width + x_low];
   T v4 = input[y_high * width + x_high];
   T w1 = hy * hx, w2 = hy * lx, w3 = ly * hx, w4 = ly * lx;
 
   T val = (w1 * v1 + w2 * v2 + w3 * v3 + w4 * v4);
 
   return val;
 }
 
 template <typename T>
 __global__ void RoIAlignForward(
     const int nthreads,
     const T* input,
     const T spatial_scale,
     const int channels,
     const int height,
     const int width,
     const int pooled_height,
     const int pooled_width,
     const int sampling_ratio,
     const T* rois,
     T* output) {
   CUDA_1D_KERNEL_LOOP(index, nthreads) {
     // (n, c, ph, pw) is an element in the pooled output
     const int pw = index % pooled_width;
     const int ph = (index / pooled_width) % pooled_height;
     const int c = (index / pooled_width / pooled_height) % channels;
     const int n = index / pooled_width / pooled_height / channels;
 
     const T* offset_rois = rois + n * 5;
     int roi_batch_ind = offset_rois[0];
 
     // Do not using rounding; this implementation detail is critical
     T roi_start_h = offset_rois[1] * spatial_scale;
     T roi_start_w = offset_rois[2] * spatial_scale;
     T roi_end_h = offset_rois[3] * spatial_scale;
     T roi_end_w = offset_rois[4] * spatial_scale;
 
     // Force malformed ROIs to be 1x1
     T roi_width = max(roi_end_w - roi_start_w, (T)1.);
     T roi_height = max(roi_end_h - roi_start_h, (T)1.);
 
     T bin_size_h = static_cast<T>(roi_height) / static_cast<T>(pooled_height);
     T bin_size_w = static_cast<T>(roi_width) / static_cast<T>(pooled_width);
 
     const T* offset_input =
         input + (roi_batch_ind * channels + c) * height * width;
 
     // We use roi_bin_grid to sample the grid and mimic integral
     int roi_bin_grid_h = (sampling_ratio > 0)
         ? sampling_ratio
         : ceil(roi_height / pooled_height); // e.g., = 2
     int roi_bin_grid_w =
         (sampling_ratio > 0) ? sampling_ratio : ceil(roi_width / pooled_width);
 
     // We do average (integral) pooling inside a bin
     const T count = roi_bin_grid_h * roi_bin_grid_w; // e.g. = 4
     T output_val = 0.;
     for (int iy = 0; iy < roi_bin_grid_h; iy++) // e.g., iy = 0, 1
     {
       const T y = roi_start_h + ph * bin_size_h +
-          static_cast<T>(iy + .5f) * (bin_size_h - 1.f) / static_cast<T>(roi_bin_grid_h); // e.g., 0.5, 1.5
+          static_cast<T>(iy + .5f) * bin_size_h / static_cast<T>(roi_bin_grid_h); // e.g., 0.5, 1.5
       for (int ix = 0; ix < roi_bin_grid_w; ix++) {
         const T x = roi_start_w + pw * bin_size_w +
-            static_cast<T>(ix + .5f) * (bin_size_w - 1.f) / static_cast<T>(roi_bin_grid_w);
+            static_cast<T>(ix + .5f) * bin_size_w / static_cast<T>(roi_bin_grid_w);
         T val = bilinear_interpolate(offset_input, height, width, y, x, index);
         output_val += val;
       }
     }
     output_val /= count;
 
     output[index] = output_val;
   }
 }
 
 template <typename T>
 __device__ void bilinear_interpolate_gradient(
     const int height,
     const int width,
     T y,
     T x,
     T& w1,
     T& w2,
     T& w3,
     T& w4,
     int& x_low,
     int& x_high,
     int& y_low,
     int& y_high,
     const int index /* index for debug only*/) {
   // deal with cases that inverse elements are out of feature map boundary
   if (y < -1.0 || y > height || x < -1.0 || x > width) {
     // empty
     w1 = w2 = w3 = w4 = 0.;
     x_low = x_high = y_low = y_high = -1;
     return;
   }
 
   if (y <= 0)
     y = 0;
   if (x <= 0)
     x = 0;
 
   y_low = (int)y;
   x_low = (int)x;
 
   if (y_low >= height - 1) {
     y_high = y_low = height - 1;
     y = (T)y_low;
   } else {
     y_high = y_low + 1;
   }
 
   if (x_low >= width - 1) {
     x_high = x_low = width - 1;
     x = (T)x_low;
   } else {
     x_high = x_low + 1;
   }
 
   T ly = y - y_low;
   T lx = x - x_low;
   T hy = 1. - ly, hx = 1. - lx;
 
   // reference in forward
   // T v1 = input[y_low * width + x_low];
   // T v2 = input[y_low * width + x_high];
   // T v3 = input[y_high * width + x_low];
   // T v4 = input[y_high * width + x_high];
   // T val = (w1 * v1 + w2 * v2 + w3 * v3 + w4 * v4);
 
   w1 = hy * hx, w2 = hy * lx, w3 = ly * hx, w4 = ly * lx;
 
   return;
 }
 
 template <typename T>
 __global__ void RoIAlignBackward(
     const int nthreads,
     const T* grad_output,
     const T spatial_scale,
     const int channels,
     const int height,
     const int width,
     const int pooled_height,
     const int pooled_width,
     const int sampling_ratio,
     T* grad_input,
     const T* rois,
     const int n_stride,
     const int c_stride,
     const int h_stride,
     const int w_stride)
 {
   CUDA_1D_KERNEL_LOOP(index, nthreads) {
     // (n, c, ph, pw) is an element in the pooled output
     int pw = index % pooled_width;
     int ph = (index / pooled_width) % pooled_height;
     int c = (index / pooled_width / pooled_height) % channels;
     int n = index / pooled_width / pooled_height / channels;
 
     const T* offset_rois = rois + n * 5;
     int roi_batch_ind = offset_rois[0];
 
     // Do not using rounding; this implementation detail is critical
     T roi_start_h = offset_rois[1] * spatial_scale;
     T roi_start_w = offset_rois[2] * spatial_scale;
     T roi_end_h = offset_rois[3] * spatial_scale;
     T roi_end_w = offset_rois[4] * spatial_scale;
 
     // Force malformed ROIs to be 1x1
     T roi_width = max(roi_end_w - roi_start_w, (T)1.);
     T roi_height = max(roi_end_h - roi_start_h, (T)1.);
     T bin_size_h = static_cast<T>(roi_height) / static_cast<T>(pooled_height);
     T bin_size_w = static_cast<T>(roi_width) / static_cast<T>(pooled_width);
 
     T* offset_grad_input =
         grad_input + ((roi_batch_ind * channels + c) * height * width);
 
     // We need to index the gradient using the tensor strides to access the
     // correct values.
     int output_offset = n * n_stride + c * c_stride;
     const T* offset_grad_output = grad_output + output_offset;
     const T grad_output_this_bin =
         offset_grad_output[ph * h_stride + pw * w_stride];
 
     // We use roi_bin_grid to sample the grid and mimic integral
     int roi_bin_grid_h = (sampling_ratio > 0)
         ? sampling_ratio
         : ceil(roi_height / pooled_height); // e.g., = 2
     int roi_bin_grid_w =
         (sampling_ratio > 0) ? sampling_ratio : ceil(roi_width / pooled_width);
 
     // We do average (integral) pooling inside a bin
     const T count = roi_bin_grid_h * roi_bin_grid_w; // e.g. = 4
 
     for (int iy = 0; iy < roi_bin_grid_h; iy++) // e.g., iy = 0, 1
     {
       const T y = roi_start_h + ph * bin_size_h +
-          static_cast<T>(iy + .5f) * (bin_size_h - 1.f) / static_cast<T>(roi_bin_grid_h); // e.g., 0.5, 1.5
+          static_cast<T>(iy + .5f) * bin_size_h / static_cast<T>(roi_bin_grid_h); // e.g., 0.5, 1.5
       for (int ix = 0; ix < roi_bin_grid_w; ix++) {
         const T x = roi_start_w + pw * bin_size_w  +
-            static_cast<T>(ix + .5f) * (bin_size_w - 1.f) / static_cast<T>(roi_bin_grid_w);
+            static_cast<T>(ix + .5f) * bin_size_w / static_cast<T>(roi_bin_grid_w);
 
         T w1, w2, w3, w4;
         int x_low, x_high, y_low, y_high;
 
         bilinear_interpolate_gradient(
             height,
             width,
             y,
             x,
             w1,
             w2,
             w3,
             w4,
             x_low,
             x_high,
             y_low,
             y_high,
             index);
 
         T g1 = grad_output_this_bin * w1 / count;
         T g2 = grad_output_this_bin * w2 / count;
         T g3 = grad_output_this_bin * w3 / count;
         T g4 = grad_output_this_bin * w4 / count;
 
         if (x_low >= 0 && x_high >= 0 && y_low >= 0 && y_high >= 0) {
           atomicAdd(
               offset_grad_input + y_low * width + x_low, static_cast<T>(g1));
           atomicAdd(
               offset_grad_input + y_low * width + x_high, static_cast<T>(g2));
           atomicAdd(
               offset_grad_input + y_high * width + x_low, static_cast<T>(g3));
           atomicAdd(
               offset_grad_input + y_high * width + x_high, static_cast<T>(g4));
         } // if
       } // ix
     } // iy
   } // CUDA_1D_KERNEL_LOOP
 } // RoIAlignBackward
 
 at::Tensor ROIAlign_forward_cuda(const at::Tensor& input, const at::Tensor& rois, const float spatial_scale,
                                 const int pooled_height, const int pooled_width, const int sampling_ratio) {
   /*
    input: feature-map tensor, shape (batch, n_channels, y, x(, z))
    */
   AT_ASSERTM(input.device().is_cuda(), "input must be a CUDA tensor");
   AT_ASSERTM(rois.device().is_cuda(), "rois must be a CUDA tensor");
 
   at::TensorArg input_t{input, "input", 1}, rois_t{rois, "rois", 2};
 
   at::CheckedFrom c = "ROIAlign_forward_cuda";
   at::checkAllSameGPU(c, {input_t, rois_t});
   at::checkAllSameType(c, {input_t, rois_t});
 
   at::cuda::CUDAGuard device_guard(input.device());
 
   int num_rois = rois.size(0);
   int channels = input.size(1);
   int height = input.size(2);
   int width = input.size(3);
 
   at::Tensor output = at::zeros(
       {num_rois, channels, pooled_height, pooled_width}, input.options());
 
   auto output_size = num_rois * pooled_height * pooled_width * channels;
   cudaStream_t stream = at::cuda::getCurrentCUDAStream();
 
   dim3 grid(std::min(
       at::cuda::ATenCeilDiv(
           static_cast<int64_t>(output_size), static_cast<int64_t>(512)),
       static_cast<int64_t>(4096)));
   dim3 block(512);
 
   if (output.numel() == 0) {
     AT_CUDA_CHECK(cudaGetLastError());
     return output;
   }
 
   AT_DISPATCH_FLOATING_TYPES_AND_HALF(input.type(), "ROIAlign_forward", [&] {
     RoIAlignForward<scalar_t><<<grid, block, 0, stream>>>(
         output_size,
         input.contiguous().data_ptr<scalar_t>(),
         spatial_scale,
         channels,
         height,
         width,
         pooled_height,
         pooled_width,
         sampling_ratio,
         rois.contiguous().data_ptr<scalar_t>(),
         output.data_ptr<scalar_t>());
   });
   AT_CUDA_CHECK(cudaGetLastError());
   return output;
 }
 
 at::Tensor ROIAlign_backward_cuda(
     const at::Tensor& grad,
     const at::Tensor& rois,
     const float spatial_scale,
     const int pooled_height,
     const int pooled_width,
     const int batch_size,
     const int channels,
     const int height,
     const int width,
     const int sampling_ratio) {
   AT_ASSERTM(grad.device().is_cuda(), "grad must be a CUDA tensor");
   AT_ASSERTM(rois.device().is_cuda(), "rois must be a CUDA tensor");
 
   at::TensorArg grad_t{grad, "grad", 1}, rois_t{rois, "rois", 2};
 
   at::CheckedFrom c = "ROIAlign_backward_cuda";
   at::checkAllSameGPU(c, {grad_t, rois_t});
   at::checkAllSameType(c, {grad_t, rois_t});
 
   at::cuda::CUDAGuard device_guard(grad.device());
 
   at::Tensor grad_input =
       at::zeros({batch_size, channels, height, width}, grad.options());
 
   cudaStream_t stream = at::cuda::getCurrentCUDAStream();
 
   dim3 grid(std::min(
       at::cuda::ATenCeilDiv(
           static_cast<int64_t>(grad.numel()), static_cast<int64_t>(512)),
       static_cast<int64_t>(4096)));
   dim3 block(512);
 
   // handle possibly empty gradients
   if (grad.numel() == 0) {
     AT_CUDA_CHECK(cudaGetLastError());
     return grad_input;
   }
 
   int n_stride = grad.stride(0);
   int c_stride = grad.stride(1);
   int h_stride = grad.stride(2);
   int w_stride = grad.stride(3);
 
   AT_DISPATCH_FLOATING_TYPES_AND_HALF(grad.type(), "ROIAlign_backward", [&] {
     RoIAlignBackward<scalar_t><<<grid, block, 0, stream>>>(
         grad.numel(),
         grad.data_ptr<scalar_t>(),
         spatial_scale,
         channels,
         height,
         width,
         pooled_height,
         pooled_width,
         sampling_ratio,
         grad_input.data_ptr<scalar_t>(),
         rois.contiguous().data_ptr<scalar_t>(),
         n_stride,
         c_stride,
         h_stride,
         w_stride);
   });
   AT_CUDA_CHECK(cudaGetLastError());
   return grad_input;
 }
\ No newline at end of file
diff --git a/custom_extensions/roi_align/src/RoIAlign_cuda_3d.cu b/custom_extensions/roi_align/src/RoIAlign_cuda_3d.cu
index 0c75a34..182274f 100644
--- a/custom_extensions/roi_align/src/RoIAlign_cuda_3d.cu
+++ b/custom_extensions/roi_align/src/RoIAlign_cuda_3d.cu
@@ -1,487 +1,487 @@
 /*
 ROIAlign implementation in CUDA from pytorch framework
 (https://github.com/pytorch/vision/tree/master/torchvision/csrc/cuda on Nov 14 2019)
 
 Adapted for additional 3D capability by G. Ramien, DKFZ Heidelberg
 */
 
 #include <ATen/ATen.h>
 #include <ATen/TensorUtils.h>
 #include <ATen/cuda/CUDAContext.h>
 #include <c10/cuda/CUDAGuard.h>
 #include <ATen/cuda/CUDAApplyUtils.cuh>
 #include <cstdio>
 #include "cuda_helpers.h"
 
 /*-------------- gpu kernels -----------------*/
 
 template <typename T>
 __device__ T linear_interpolate(const T xl, const T val_low, const T val_high){
 
   T val = (val_high - val_low) * xl + val_low;
   return val;
 }
 
 template <typename T>
 __device__ T trilinear_interpolate(const T* input, const int height, const int width, const int depth,
                 T y, T x, T z, const int index /* index for debug only*/) {
   // deal with cases that inverse elements are out of feature map boundary
   if (y < -1.0 || y > height || x < -1.0 || x > width || z < -1.0 || z > depth) {
     // empty
     return 0;
   }
   if (y <= 0)
     y = 0;
   if (x <= 0)
     x = 0;
   if (z <= 0)
     z = 0;
 
   int y0 = (int)y;
   int x0 = (int)x;
   int z0 = (int)z;
   int y1;
   int x1;
   int z1;
 
   if (y0 >= height - 1) {
   /*if nearest gridpoint to y on the lower end is on border or border-1, set low, high, mid(=actual point) to border-1*/
     y1 = y0 = height - 1;
     y = (T)y0;
   } else {
     /* y1 is one pixel from y0, y is the actual point somewhere in between  */
     y1 = y0 + 1;
   }
   if (x0 >= width - 1) {
     x1 = x0 = width - 1;
     x = (T)x0;
   } else {
     x1 = x0 + 1;
   }
   if (z0 >= depth - 1) {
     z1 = z0 = depth - 1;
     z = (T)z0;
   } else {
     z1 = z0 + 1;
   }
 
 
   // do linear interpolation of x values
   // distance of actual point to lower boundary point, already normalized since x_high - x0 = 1
   T dis = x - x0;
   /*  accessing element b,c,y,x,z in 1D-rolled-out array of a tensor with dimensions (B, C, Y, X, Z):
       tensor[b,c,y,x,z] = arr[ (((b*C+c)*Y+y)*X + x)*Z + z ] = arr[ alpha + (y*X + x)*Z + z ]
       with alpha = batch&channel locator = (b*C+c)*YXZ.
-      hence, as current input pointer is already offset by alpha: y,x,z at input[( y*X + x)*Z + z], where
+      hence, as current input pointer is already offset by alpha: y,x,z is at input[( y*X + x)*Z + z], where
       X = width, Z = depth.
   */
   T x00 = linear_interpolate(dis, input[(y0*width+ x0)*depth+z0], input[(y0*width+ x1)*depth+z0]);
   T x10 = linear_interpolate(dis, input[(y1*width+ x0)*depth+z0], input[(y1*width+ x1)*depth+z0]);
   T x01 = linear_interpolate(dis, input[(y0*width+ x0)*depth+z1], input[(y0*width+ x1)*depth+z1]);
   T x11 = linear_interpolate(dis, input[(y1*width+ x0)*depth+z1], input[(y1*width+ x1)*depth+z1]);
 
   // linear interpol of y values = bilinear interpol of f(x,y)
   dis = y - y0;
   T xy0 = linear_interpolate(dis, x00, x10);
   T xy1 = linear_interpolate(dis, x01, x11);
 
   // linear interpol of z value = trilinear interpol of f(x,y,z)
   dis = z - z0;
   T xyz = linear_interpolate(dis, xy0, xy1);
 
   return xyz;
 }
 
 template <typename T>
 __device__ void trilinear_interpolate_gradient(const int height, const int width, const int depth, T y, T x, T z,
     T& g000, T& g001, T& g010, T& g100, T& g011, T& g101, T& g110, T& g111,
     int& x0, int& x1, int& y0, int& y1, int& z0, int&z1, const int index /* index for debug only*/)
 {
   // deal with cases that inverse elements are out of feature map boundary
   if (y < -1.0 || y > height || x < -1.0 || x > width || z < -1.0 || z > depth) {
     // empty
     g000 = g001 = g010 = g100 = g011 = g101 = g110 = g111 = 0.;
     x0 = x1 = y0 = y1 = z0 = z1 = -1;
     return;
   }
 
   if (y <= 0)
     y = 0;
   if (x <= 0)
     x = 0;
   if (z <= 0)
     z = 0;
 
   y0 = (int)y;
   x0 = (int)x;
   z0 = (int)z;
 
   if (y0 >= height - 1) {
     y1 = y0 = height - 1;
     y = (T)y0;
   } else {
     y1 = y0 + 1;
   }
 
   if (x0 >= width - 1) {
     x1 = x0 = width - 1;
     x = (T)x0;
   } else {
     x1 = x0 + 1;
   }
 
   if (z0 >= depth - 1) {
     z1 = z0 = depth - 1;
     z = (T)z0;
   } else {
     z1 = z0 + 1;
   }
 
   // forward calculations are added as hints
   T dis_x = x - x0;
   //T x00 = linear_interpolate(dis, input[(y0*width+ x0)*depth+z0], input[(y0*width+ x1)*depth+z0]); // v000, v100
   //T x10 = linear_interpolate(dis, input[(y1*width+ x0)*depth+z0], input[(y1*width+ x1)*depth+z0]); // v010, v110
   //T x01 = linear_interpolate(dis, input[(y0*width+ x0)*depth+z1], input[(y0*width+ x1)*depth+z1]); // v001, v101
   //T x11 = linear_interpolate(dis, input[(y1*width+ x0)*depth+z1], input[(y1*width+ x1)*depth+z1]); // v011, v111
 
   // linear interpol of y values = bilinear interpol of f(x,y)
   T dis_y = y - y0;
   //T xy0 = linear_interpolate(dis, x00, x10);
   //T xy1 = linear_interpolate(dis, x01, x11);
 
   // linear interpol of z value = trilinear interpol of f(x,y,z)
   T dis_z = z - z0;
   //T xyz = linear_interpolate(dis, xy0, xy1);
 
   /* need: grad_i := d(xyz)/d(v_i) with v_i = input_value_i  for all i = 0,..,7 (eight input values --> eight-entry gradient)
      d(lin_interp(dis,x,y))/dx = (-dis +1) and d(lin_interp(dis,x,y))/dy = dis --> derivatives are indep of x,y.
      notation: gxyz = gradient for d(trilin_interp)/d(input_value_at_xyz)
      below grads were calculated by hand
      save time by reusing (1-dis_x) = 1-x+x0 = x1-x =: dis_x1 */
   T dis_x1 = (1-dis_x), dis_y1 = (1-dis_y), dis_z1 = (1-dis_z);
 
   g000 = dis_z1 * dis_y1  * dis_x1;
   g001 = dis_z  * dis_y1  * dis_x1;
   g010 = dis_z1 * dis_y   * dis_x1;
   g100 = dis_z1 * dis_y1  * dis_x;
   g011 = dis_z  * dis_y   * dis_x1;
   g101 = dis_z  * dis_y1  * dis_x;
   g110 = dis_z1 * dis_y   * dis_x;
   g111 = dis_z  * dis_y   * dis_x;
 
   return;
 }
 
 template <typename T>
 __global__ void RoIAlignForward(const int nthreads, const T* input, const T spatial_scale, const int channels,
     const int height, const int width, const int depth, const int pooled_height, const int pooled_width,
     const int pooled_depth, const int sampling_ratio, const T* rois, T* output)
 {
 
   CUDA_1D_KERNEL_LOOP(index, nthreads) {
     // (n, c, ph, pw, pd) is an element in the pooled output
     int pd =  index % pooled_depth;
     int pw = (index / pooled_depth) % pooled_width;
     int ph = (index / pooled_depth / pooled_width) % pooled_height;
     int c  = (index / pooled_depth / pooled_width / pooled_height) % channels;
     int n  =  index / pooled_depth / pooled_width / pooled_height / channels;
 
 
     // rois are (y1,x1,y2,x2,z1,z2) --> tensor of shape (n_rois, 6)
     const T* offset_rois = rois + n * 7;
     int roi_batch_ind = offset_rois[0];
     // Do not use rounding; this implementation detail is critical
     T roi_start_h = offset_rois[1] * spatial_scale;
     T roi_start_w = offset_rois[2] * spatial_scale;
     T roi_end_h = offset_rois[3] * spatial_scale;
     T roi_end_w = offset_rois[4] * spatial_scale;
     T roi_start_d = offset_rois[5] * spatial_scale;
     T roi_end_d = offset_rois[6] * spatial_scale;
 
     // Force malformed ROIs to be 1x1
     T roi_height = max(roi_end_h - roi_start_h, (T)1.);
     T roi_width = max(roi_end_w - roi_start_w, (T)1.);
     T roi_depth = max(roi_end_d - roi_start_d, (T)1.);
 
     T bin_size_h = static_cast<T>(roi_height) / static_cast<T>(pooled_height);
     T bin_size_w = static_cast<T>(roi_width) / static_cast<T>(pooled_width);
     T bin_size_d = static_cast<T>(roi_depth) / static_cast<T>(pooled_depth);
 
     const T* offset_input =
         input + (roi_batch_ind * channels + c) * height * width * depth;
 
     // We use roi_bin_grid to sample the grid and mimic integral
     // roi_bin_grid == nr of sampling points per bin >= 1
     int roi_bin_grid_h =
         (sampling_ratio > 0) ? sampling_ratio : ceil(roi_height / pooled_height); // e.g., = 2
     int roi_bin_grid_w =
         (sampling_ratio > 0) ? sampling_ratio : ceil(roi_width / pooled_width);
     int roi_bin_grid_d =
         (sampling_ratio > 0) ? sampling_ratio : ceil(roi_depth / pooled_depth);
 
     // We do average (integral) pooling inside a bin
     const T n_voxels = roi_bin_grid_h * roi_bin_grid_w * roi_bin_grid_d; // e.g. = 4
 
     T output_val = 0.;
     for (int iy = 0; iy < roi_bin_grid_h; iy++) // e.g., iy = 0, 1
     {
       const T y = roi_start_h + ph * bin_size_h +
-          static_cast<T>(iy + .5f) * (bin_size_h - 1.f) / static_cast<T>(roi_bin_grid_h); // e.g., 0.5, 1.5, always in the middle of two grid pointsk
+          static_cast<T>(iy + .5f) * bin_size_h / static_cast<T>(roi_bin_grid_h); // e.g., 0.5, 1.5, always in the middle of two grid pointsk
 
       for (int ix = 0; ix < roi_bin_grid_w; ix++)
       {
         const T x = roi_start_w + pw * bin_size_w +
-            static_cast<T>(ix + .5f) * (bin_size_w - 1.f) / static_cast<T>(roi_bin_grid_w);
+            static_cast<T>(ix + .5f) * bin_size_w / static_cast<T>(roi_bin_grid_w);
 
         for (int iz = 0; iz < roi_bin_grid_d; iz++)
         {
           const T z = roi_start_d + pd * bin_size_d +
-              static_cast<T>(iz + .5f) * (bin_size_d - 1.f) / static_cast<T>(roi_bin_grid_d);
+              static_cast<T>(iz + .5f) * bin_size_d / static_cast<T>(roi_bin_grid_d);
           // TODO verify trilinear interpolation
           T val = trilinear_interpolate(offset_input, height, width, depth, y, x, z, index);
           output_val += val;
         } // z iterator and calc+add value
       } // x iterator
     } // y iterator
     output_val /= n_voxels;
 
     output[index] = output_val;
   }
 }
 
 template <typename T>
 __global__ void RoIAlignBackward(const int nthreads, const T* grad_output, const T spatial_scale, const int channels,
     const int height, const int width, const int depth, const int pooled_height, const int pooled_width,
     const int pooled_depth, const int sampling_ratio, T* grad_input, const T* rois,
     const int n_stride, const int c_stride, const int h_stride, const int w_stride, const int d_stride)
 {
 
   CUDA_1D_KERNEL_LOOP(index, nthreads) {
     // (n, c, ph, pw, pd) is an element in the pooled output
     int pd =  index % pooled_depth;
     int pw = (index / pooled_depth) % pooled_width;
     int ph = (index / pooled_depth / pooled_width) % pooled_height;
     int c  = (index / pooled_depth / pooled_width / pooled_height) % channels;
     int n  =  index / pooled_depth / pooled_width / pooled_height / channels;
 
 
     const T* offset_rois = rois + n * 7;
     int roi_batch_ind = offset_rois[0];
 
     // Do not using rounding; this implementation detail is critical
     T roi_start_h = offset_rois[1] * spatial_scale;
     T roi_start_w = offset_rois[2] * spatial_scale;
     T roi_end_h = offset_rois[3] * spatial_scale;
     T roi_end_w = offset_rois[4] * spatial_scale;
     T roi_start_d = offset_rois[5] * spatial_scale;
     T roi_end_d = offset_rois[6] * spatial_scale;
 
 
     // Force malformed ROIs to be 1x1
     T roi_width = max(roi_end_w - roi_start_w, (T)1.);
     T roi_height = max(roi_end_h - roi_start_h, (T)1.);
     T roi_depth = max(roi_end_d - roi_start_d, (T)1.);
     T bin_size_h = static_cast<T>(roi_height) / static_cast<T>(pooled_height);
     T bin_size_w = static_cast<T>(roi_width) / static_cast<T>(pooled_width);
     T bin_size_d = static_cast<T>(roi_depth) / static_cast<T>(pooled_depth);
 
     // offset: index b,c,y,x,z of tensor of shape (B,C,Y,X,Z) is
     // b*C*Y*X*Z + c * Y*X*Z + y * X*Z + x *Z + z = (b*C+c)Y*X*Z + ...
     T* offset_grad_input =
         grad_input + ((roi_batch_ind * channels + c) * height * width * depth);
 
     // We need to index the gradient using the tensor strides to access the correct values.
     int output_offset = n * n_stride + c * c_stride;
     const T* offset_grad_output = grad_output + output_offset;
     const T grad_output_this_bin = offset_grad_output[ph * h_stride + pw * w_stride + pd * d_stride];
 
     // We use roi_bin_grid to sample the grid and mimic integral
     int roi_bin_grid_h = (sampling_ratio > 0) ? sampling_ratio : ceil(roi_height / pooled_height); // e.g., = 2
     int roi_bin_grid_w = (sampling_ratio > 0) ? sampling_ratio : ceil(roi_width / pooled_width);
     int roi_bin_grid_d = (sampling_ratio > 0) ? sampling_ratio : ceil(roi_depth / pooled_depth);
 
     // We do average (integral) pooling inside a bin
     const T n_voxels = roi_bin_grid_h * roi_bin_grid_w * roi_bin_grid_d; // e.g. = 6
 
     for (int iy = 0; iy < roi_bin_grid_h; iy++) // e.g., iy = 0, 1
     {
       const T y = roi_start_h + ph * bin_size_h +
-          static_cast<T>(iy + .5f) * (bin_size_h - 1.f) / static_cast<T>(roi_bin_grid_h); // e.g., 0.5, 1.5
+          static_cast<T>(iy + .5f) * bin_size_h / static_cast<T>(roi_bin_grid_h); // e.g., 0.5, 1.5
 
       for (int ix = 0; ix < roi_bin_grid_w; ix++)
       {
         const T x = roi_start_w + pw * bin_size_w +
-          static_cast<T>(ix + .5f) * (bin_size_w - 1.f) / static_cast<T>(roi_bin_grid_w);
+          static_cast<T>(ix + .5f) * bin_size_w / static_cast<T>(roi_bin_grid_w);
 
         for (int iz = 0; iz < roi_bin_grid_d; iz++)
         {
           const T z = roi_start_d + pd * bin_size_d +
-              static_cast<T>(iz + .5f) * (bin_size_d - 1.f) / static_cast<T>(roi_bin_grid_d);
+              static_cast<T>(iz + .5f) * bin_size_d / static_cast<T>(roi_bin_grid_d);
 
           T g000, g001, g010, g100, g011, g101, g110, g111; // will hold the current partial derivatives
           int x0, x1, y0, y1, z0, z1;
           /* notation: gxyz = gradient at xyz, where x,y,z need to lie on feature-map grid (i.e., =x0,x1 etc.) */
           trilinear_interpolate_gradient(height, width, depth, y, x, z,
                                          g000, g001, g010, g100, g011, g101, g110, g111,
                                          x0, x1, y0, y1, z0, z1, index);
           /* chain rule: derivatives (i.e., the gradient) of trilin_interpolate(v1,v2,v3,v4,...) (div by n_voxels
              as we actually need gradient of whole roi_align) are multiplied with gradient so far*/
           g000 *= grad_output_this_bin / n_voxels;
           g001 *= grad_output_this_bin / n_voxels;
           g010 *= grad_output_this_bin / n_voxels;
           g100 *= grad_output_this_bin / n_voxels;
           g011 *= grad_output_this_bin / n_voxels;
           g101 *= grad_output_this_bin / n_voxels;
           g110 *= grad_output_this_bin / n_voxels;
           g111 *= grad_output_this_bin / n_voxels;
 
           if (x0 >= 0 && x1 >= 0 && y0 >= 0 && y1 >= 0 && z0 >= 0 && z1 >= 0)
           { // atomicAdd(address, content) reads content under address, adds content to it, while: no other thread
             // can interfere with the memory at address during this operation (thread lock, therefore "atomic").
             atomicAdd(offset_grad_input + (y0 * width + x0) * depth + z0, static_cast<T>(g000));
             atomicAdd(offset_grad_input + (y0 * width + x0) * depth + z1, static_cast<T>(g001));
             atomicAdd(offset_grad_input + (y1 * width + x0) * depth + z0, static_cast<T>(g010));
             atomicAdd(offset_grad_input + (y0 * width + x1) * depth + z0, static_cast<T>(g100));
             atomicAdd(offset_grad_input + (y1 * width + x0) * depth + z1, static_cast<T>(g011));
             atomicAdd(offset_grad_input + (y0 * width + x1) * depth + z1, static_cast<T>(g101));
             atomicAdd(offset_grad_input + (y1 * width + x1) * depth + z0, static_cast<T>(g110));
             atomicAdd(offset_grad_input + (y1 * width + x1) * depth + z1, static_cast<T>(g111));
           } // if
         } // iz
       } // ix
     } // iy
   } // CUDA_1D_KERNEL_LOOP
 } // RoIAlignBackward
 
 
 /*----------- wrapper functions ----------------*/
 
 at::Tensor ROIAlign_forward_cuda(const at::Tensor& input, const at::Tensor& rois, const float spatial_scale,
                                 const int pooled_height, const int pooled_width, const int pooled_depth, const int sampling_ratio) {
   /*
    input: feature-map tensor, shape (batch, n_channels, y, x(, z))
    */
   AT_ASSERTM(input.device().is_cuda(), "input must be a CUDA tensor");
   AT_ASSERTM(rois.device().is_cuda(), "rois must be a CUDA tensor");
 
   at::TensorArg input_t{input, "input", 1}, rois_t{rois, "rois", 2};
 
   at::CheckedFrom c = "ROIAlign_forward_cuda";
   at::checkAllSameGPU(c, {input_t, rois_t});
   at::checkAllSameType(c, {input_t, rois_t});
 
   at::cuda::CUDAGuard device_guard(input.device());
 
   auto num_rois = rois.size(0);
   auto channels = input.size(1);
   auto height = input.size(2);
   auto width = input.size(3);
   auto depth = input.size(4);
 
   at::Tensor output = at::zeros(
       {num_rois, channels, pooled_height, pooled_width, pooled_depth}, input.options());
 
   auto output_size = num_rois * channels * pooled_height * pooled_width * pooled_depth;
   cudaStream_t stream = at::cuda::getCurrentCUDAStream();
 
   dim3 grid(std::min(
       at::cuda::ATenCeilDiv(static_cast<int64_t>(output_size), static_cast<int64_t>(512)), static_cast<int64_t>(4096)));
   dim3 block(512);
 
   if (output.numel() == 0) {
     AT_CUDA_CHECK(cudaGetLastError());
     return output;
   }
 
   AT_DISPATCH_FLOATING_TYPES_AND_HALF(input.type(), "ROIAlign forward in 3d", [&] {
     RoIAlignForward<scalar_t><<<grid, block, 0, stream>>>(
         output_size,
         input.contiguous().data_ptr<scalar_t>(),
         spatial_scale,
         channels,
         height,
         width,
         depth,
         pooled_height,
         pooled_width,
         pooled_depth,
         sampling_ratio,
         rois.contiguous().data_ptr<scalar_t>(),
         output.data_ptr<scalar_t>());
   });
   AT_CUDA_CHECK(cudaGetLastError());
   return output;
 }
 
 at::Tensor ROIAlign_backward_cuda(
     const at::Tensor& grad,
     const at::Tensor& rois,
     const float spatial_scale,
     const int pooled_height,
     const int pooled_width,
     const int pooled_depth,
     const int batch_size,
     const int channels,
     const int height,
     const int width,
     const int depth,
     const int sampling_ratio)
 {
   AT_ASSERTM(grad.device().is_cuda(), "grad must be a CUDA tensor");
   AT_ASSERTM(rois.device().is_cuda(), "rois must be a CUDA tensor");
 
   at::TensorArg grad_t{grad, "grad", 1}, rois_t{rois, "rois", 2};
 
   at::CheckedFrom c = "ROIAlign_backward_cuda";
   at::checkAllSameGPU(c, {grad_t, rois_t});
   at::checkAllSameType(c, {grad_t, rois_t});
 
   at::cuda::CUDAGuard device_guard(grad.device());
 
   at::Tensor grad_input =
       at::zeros({batch_size, channels, height, width, depth}, grad.options());
 
   cudaStream_t stream = at::cuda::getCurrentCUDAStream();
 
   dim3 grid(std::min(
       at::cuda::ATenCeilDiv(
           static_cast<int64_t>(grad.numel()), static_cast<int64_t>(512)),
       static_cast<int64_t>(4096)));
   dim3 block(512);
 
   // handle possibly empty gradients
   if (grad.numel() == 0) {
     AT_CUDA_CHECK(cudaGetLastError());
     return grad_input;
   }
 
   int n_stride = grad.stride(0);
   int c_stride = grad.stride(1);
   int h_stride = grad.stride(2);
   int w_stride = grad.stride(3);
   int d_stride = grad.stride(4);
 
   AT_DISPATCH_FLOATING_TYPES_AND_HALF(grad.type(), "ROIAlign backward 3D", [&] {
     RoIAlignBackward<scalar_t><<<grid, block, 0, stream>>>(
         grad.numel(),
         grad.data_ptr<scalar_t>(),
         spatial_scale,
         channels,
         height,
         width,
         depth,
         pooled_height,
         pooled_width,
         pooled_depth,
         sampling_ratio,
         grad_input.data_ptr<scalar_t>(),
         rois.contiguous().data_ptr<scalar_t>(),
         n_stride,
         c_stride,
         h_stride,
         w_stride,
         d_stride);
   });
   AT_CUDA_CHECK(cudaGetLastError());
   return grad_input;
 }
\ No newline at end of file
diff --git a/datasets/toy/configs.py b/datasets/toy/configs.py
index df1997b..8210f14 100644
--- a/datasets/toy/configs.py
+++ b/datasets/toy/configs.py
@@ -1,490 +1,490 @@
 #!/usr/bin/env python
 # Copyright 2019 Division of Medical Image Computing, German Cancer Research Center (DKFZ).
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
 # You may obtain a copy of the License at
 #
 #     http://www.apache.org/licenses/LICENSE-2.0
 #
 # Unless required by applicable law or agreed to in writing, software
 # distributed under the License is distributed on an "AS IS" BASIS,
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
 # ==============================================================================
 
 import sys
 import os
 sys.path.append(os.path.dirname(os.path.realpath(__file__)))
 import numpy as np
 from default_configs import DefaultConfigs
 from collections import namedtuple
 
 boxLabel = namedtuple('boxLabel', ["name", "color"])
 Label = namedtuple("Label", ['id', 'name', 'shape', 'radius', 'color', 'regression', 'ambiguities', 'gt_distortion'])
 binLabel = namedtuple("binLabel", ['id', 'name', 'color', 'bin_vals'])
 
 class Configs(DefaultConfigs):
 
     def __init__(self, server_env=None):
         super(Configs, self).__init__(server_env)
 
         #########################
         #         Prepro        #
         #########################
 
         self.pp_rootdir = os.path.join('/home/gregor/datasets/toy', "cyl1ps_dev")
         self.pp_npz_dir = self.pp_rootdir+"_npz"
 
         self.pre_crop_size = [320,320,8] #y,x,z; determines pp data shape (2D easily implementable, but only 3D for now)
         self.min_2d_radius = 6 #in pixels
         self.n_train_samples, self.n_test_samples = 1200, 1000
 
         # not actually real one-hot encoding (ohe) but contains more info: roi-overlap only within classes.
         self.pp_create_ohe_seg = False
         self.pp_empty_samples_ratio = 0.1
 
         self.pp_place_radii_mid_bin = True
         self.pp_only_distort_2d = True
         # outer-most intensity of blurred radii, relative to inner-object intensity. <1 for decreasing, > 1 for increasing.
         # e.g.: setting 0.1 means blurred edge has min intensity 10% as large as inner-object intensity.
         self.pp_blur_min_intensity = 0.2
 
         self.max_instances_per_sample = 1 #how many max instances over all classes per sample (img if 2d, vol if 3d)
         self.max_instances_per_class = self.max_instances_per_sample  # how many max instances per image per class
         self.noise_scale = 0.  # std-dev of gaussian noise
 
         self.ambigs_sampling = "gaussian" #"gaussian" or "uniform"
         """ radius_calib: gt distort for calibrating uncertainty. Range of gt distortion is inferable from
             image by distinguishing it from the rest of the object.
             blurring width around edge will be shifted so that symmetric rel to orig radius.
             blurring scale: if self.ambigs_sampling is uniform, distribution's non-zero range (b-a) will be sqrt(12)*scale
             since uniform dist has variance (b-a)²/12. b,a will be placed symmetrically around unperturbed radius.
             if sampling is gaussian, then scale parameter sets one std dev, i.e., blurring width will be orig_radius * std_dev * 2.
         """
         self.ambiguities = {
              #set which classes to apply which ambs to below in class labels
              #choose out of: 'outer_radius', 'inner_radius', 'radii_relations'.
              #kind              #probability   #scale (gaussian std, relative to unperturbed value)
             #"outer_radius":     (1.,            0.5),
             #"outer_radius_xy":  (1.,            0.5),
             #"inner_radius":     (0.5,            0.1),
             #"radii_relations":  (0.5,            0.1),
             "radius_calib":     (1.,            1./6)
         }
 
         # shape choices: 'cylinder', 'block'
         #                        id,    name,       shape,      radius,                 color,              regression,     ambiguities,    gt_distortion
         self.pp_classes = [Label(1,     'cylinder', 'cylinder', ((6,6,1),(40,40,8)),    (*self.blue, 1.),   "radius_2d",    (),             ()),
                            #Label(2,      'block',      'block',        ((6,6,1),(40,40,8)),  (*self.aubergine,1.),  "radii_2d", (), ('radius_calib',))
             ]
 
 
         #########################
         #         I/O           #
         #########################
 
         self.data_sourcedir = '/home/gregor/datasets/toy/cyl1ps_dev'
 
         if server_env:
             self.data_sourcedir = '/datasets/data_ramien/toy/cyl1ps_dev_npz'
 
 
         self.test_data_sourcedir = os.path.join(self.data_sourcedir, 'test')
         self.data_sourcedir = os.path.join(self.data_sourcedir, "train")
 
         self.info_df_name = 'info_df.pickle'
 
         # one out of ['mrcnn', 'retina_net', 'retina_unet', 'detection_unet', 'ufrcnn', 'detection_fpn'].
         self.model = 'mrcnn'
         self.model_path = 'models/{}.py'.format(self.model if not 'retina' in self.model else 'retina_net')
         self.model_path = os.path.join(self.source_dir, self.model_path)
 
 
         #########################
         #      Architecture     #
         #########################
 
         # one out of [2, 3]. dimension the model operates in.
-        self.dim = 2
+        self.dim = 3
 
         # 'class', 'regression', 'regression_bin', 'regression_ken_gal'
         # currently only tested mode is a single-task at a time (i.e., only one task in below list)
         # but, in principle, tasks could be combined (e.g., object classes and regression per class)
         self.prediction_tasks = ['class', ]
 
         self.start_filts = 48 if self.dim == 2 else 18
         self.end_filts = self.start_filts * 4 if self.dim == 2 else self.start_filts * 2
         self.res_architecture = 'resnet50' # 'resnet101' , 'resnet50'
         self.norm = 'instance_norm' # one of None, 'instance_norm', 'batch_norm'
         self.relu = 'relu'
         # one of 'xavier_uniform', 'xavier_normal', or 'kaiming_normal', None (=default = 'kaiming_uniform')
         self.weight_init = None
 
         self.regression_n_features = 1  # length of regressor target vector
 
 
         #########################
         #      Data Loader      #
         #########################
 
         self.num_epochs = 32
         self.num_train_batches = 120 if self.dim == 2 else 80
         self.batch_size = 8 if self.dim == 2 else 4
 
         self.n_cv_splits = 4
         # select modalities from preprocessed data
         self.channels = [0]
         self.n_channels = len(self.channels)
 
         # which channel (mod) to show as bg in plotting, will be extra added to batch if not in self.channels
         self.plot_bg_chan = 0
         self.crop_margin = [20, 20, 1]  # has to be smaller than respective patch_size//2
         self.patch_size_2D = self.pre_crop_size[:2]
         self.patch_size_3D = self.pre_crop_size[:2]+[8]
 
         # patch_size to be used for training. pre_crop_size is the patch_size before data augmentation.
         self.patch_size = self.patch_size_2D if self.dim == 2 else self.patch_size_3D
 
         # ratio of free sampled batch elements before class balancing is triggered
         # (>0 to include "empty"/background patches.)
         self.batch_random_ratio = 0.2
         self.balance_target = "class_targets" if 'class' in self.prediction_tasks else "rg_bin_targets"
 
         self.observables_patient = []
         self.observables_rois = []
 
         self.seed = 3 #for generating folds
 
         #############################
         # Colors, Classes, Legends  #
         #############################
         self.plot_frequency = 1
 
         binary_bin_labels = [binLabel(1,  'r<=25',      (*self.green, 1.),      (1,25)),
                              binLabel(2,  'r>25',       (*self.red, 1.),        (25,))]
         quintuple_bin_labels = [binLabel(1,  'r2-10',   (*self.green, 1.),      (2,10)),
                                 binLabel(2,  'r10-20',  (*self.yellow, 1.),     (10,20)),
                                 binLabel(3,  'r20-30',  (*self.orange, 1.),     (20,30)),
                                 binLabel(4,  'r30-40',  (*self.bright_red, 1.), (30,40)),
                                 binLabel(5,  'r>40',    (*self.red, 1.), (40,))]
 
         # choose here if to do 2-way or 5-way regression-bin classification
         task_spec_bin_labels = quintuple_bin_labels
 
         self.class_labels = [
             # regression: regression-task label, either value or "(x,y,z)_radius" or "radii".
             # ambiguities: name of above defined ambig to apply to image data (not gt); need to be iterables!
             # gt_distortion: name of ambig to apply to gt only; needs to be iterable!
             #      #id  #name   #shape  #radius     #color              #regression #ambiguities    #gt_distortion
             Label(  0,  'bg',   None,   (0, 0, 0),  (*self.white, 0.),  (0, 0, 0),  (),             ())]
         if "class" in self.prediction_tasks:
             self.class_labels += self.pp_classes
         else:
             self.class_labels += [Label(1, 'object', 'object', ('various',), (*self.orange, 1.), ('radius_2d',), ("various",), ('various',))]
 
 
         if any(['regression' in task for task in self.prediction_tasks]):
             self.bin_labels = [binLabel(0,  'bg',       (*self.white, 1.),      (0,))]
             self.bin_labels += task_spec_bin_labels
             self.bin_id2label = {label.id: label for label in self.bin_labels}
             bins = [(min(label.bin_vals), max(label.bin_vals)) for label in self.bin_labels]
             self.bin_id2rg_val = {ix: [np.mean(bin)] for ix, bin in enumerate(bins)}
             self.bin_edges = [(bins[i][1] + bins[i + 1][0]) / 2 for i in range(len(bins) - 1)]
             self.bin_dict = {label.id: label.name for label in self.bin_labels if label.id != 0}
 
         if self.class_specific_seg:
           self.seg_labels = self.class_labels
 
         self.box_type2label = {label.name: label for label in self.box_labels}
         self.class_id2label = {label.id: label for label in self.class_labels}
         self.class_dict = {label.id: label.name for label in self.class_labels if label.id != 0}
 
         self.seg_id2label = {label.id: label for label in self.seg_labels}
         self.cmap = {label.id: label.color for label in self.seg_labels}
 
         self.plot_prediction_histograms = True
         self.plot_stat_curves = False
         self.has_colorchannels = False
         self.plot_class_ids = True
 
         self.num_classes = len(self.class_dict)
         self.num_seg_classes = len(self.seg_labels)
 
         #########################
         #   Data Augmentation   #
         #########################
         self.do_aug = True
         self.da_kwargs = {
             'mirror': True,
             'mirror_axes': tuple(np.arange(0, self.dim, 1)),
             'do_elastic_deform': False,
             'alpha': (500., 1500.),
             'sigma': (40., 45.),
             'do_rotation': False,
             'angle_x': (0., 2 * np.pi),
             'angle_y': (0., 0),
             'angle_z': (0., 0),
             'do_scale': False,
             'scale': (0.8, 1.1),
             'random_crop': False,
             'rand_crop_dist': (self.patch_size[0] / 2. - 3, self.patch_size[1] / 2. - 3),
             'border_mode_data': 'constant',
             'border_cval_data': 0,
             'order_data': 1
         }
 
         if self.dim == 3:
             self.da_kwargs['do_elastic_deform'] = False
             self.da_kwargs['angle_x'] = (0, 0.0)
             self.da_kwargs['angle_y'] = (0, 0.0)  # must be 0!!
             self.da_kwargs['angle_z'] = (0., 2 * np.pi)
 
         #########################
         #  Schedule / Selection #
         #########################
 
         # decide whether to validate on entire patient volumes (like testing) or sampled patches (like training)
         # the former is morge accurate, while the latter is faster (depending on volume size)
         self.val_mode = 'val_sampling' # one of 'val_sampling' , 'val_patient'
         if self.val_mode == 'val_patient':
             self.max_val_patients = 220  # if 'all' iterates over entire val_set once.
         if self.val_mode == 'val_sampling':
             self.num_val_batches = 35 if self.dim==2 else 25
 
         self.save_n_models = 2
         self.min_save_thresh = 1 if self.dim == 2 else 1  # =wait time in epochs
         if "class" in self.prediction_tasks:
             self.model_selection_criteria = {name + "_ap": 1. for name in self.class_dict.values()}
         elif any("regression" in task for task in self.prediction_tasks):
             self.model_selection_criteria = {name + "_ap": 0.2 for name in self.class_dict.values()}
             self.model_selection_criteria.update({name + "_avp": 0.8 for name in self.class_dict.values()})
 
         self.lr_decay_factor = 0.5
         self.scheduling_patience = int(self.num_epochs / 5)
         self.weight_decay = 1e-5
         self.clip_norm = None  # number or None
 
         #########################
         #   Testing / Plotting  #
         #########################
 
         self.test_aug_axes = (0,1,(0,1)) # None or list: choices are 0,1,(0,1)
         self.held_out_test_set = True
         self.max_test_patients = "all"  # number or "all" for all
 
         self.test_against_exact_gt = True # only True implemented
         self.val_against_exact_gt = False # True is an unrealistic --> irrelevant scenario.
         self.report_score_level = ['rois']  # 'patient' or 'rois' (incl)
         self.patient_class_of_interest = 1
         self.patient_bin_of_interest = 2
 
         self.eval_bins_separately = False#"additionally" if not 'class' in self.prediction_tasks else False
         self.metrics = ['ap', 'auc', 'dice']
         if any(['regression' in task for task in self.prediction_tasks]):
             self.metrics += ['avp', 'rg_MAE_weighted', 'rg_MAE_weighted_tp',
                              'rg_bin_accuracy_weighted', 'rg_bin_accuracy_weighted_tp']
         if 'aleatoric' in self.model:
             self.metrics += ['rg_uncertainty', 'rg_uncertainty_tp', 'rg_uncertainty_tp_weighted']
         self.evaluate_fold_means = True
 
         self.ap_match_ious = [0.5]  # threshold(s) for considering a prediction as true positive
         self.min_det_thresh = 0.3
 
         self.model_max_iou_resolution = 0.2
 
         # aggregation method for test and val_patient predictions.
         # wbc = weighted box clustering as in https://arxiv.org/pdf/1811.08661.pdf,
         # nms = standard non-maximum suppression, or None = no clustering
         self.clustering = 'wbc'
         # iou thresh (exclusive!) for regarding two preds as concerning the same ROI
         self.clustering_iou = self.model_max_iou_resolution  # has to be larger than desired possible overlap iou of model predictions
 
         self.merge_2D_to_3D_preds = False
         self.merge_3D_iou = self.model_max_iou_resolution
         self.n_test_plots = 1  # per fold and rank
 
         self.test_n_epochs = self.save_n_models  # should be called n_test_ens, since is number of models to ensemble over during testing
         # is multiplied by (1 + nr of test augs)
 
         #########################
         #   Assertions          #
         #########################
         if not 'class' in self.prediction_tasks:
             assert self.num_classes == 1
 
         #########################
         #   Add model specifics #
         #########################
 
         {'mrcnn': self.add_mrcnn_configs, 'mrcnn_aleatoric': self.add_mrcnn_configs,
          'retina_net': self.add_mrcnn_configs, 'retina_unet': self.add_mrcnn_configs,
          'detection_unet': self.add_det_unet_configs, 'detection_fpn': self.add_det_fpn_configs
          }[self.model]()
 
     def rg_val_to_bin_id(self, rg_val):
         #only meant for isotropic radii!!
         # only 2D radii (x and y dims) or 1D (x or y) are expected
         return np.round(np.digitize(rg_val, self.bin_edges).mean())
 
 
     def add_det_fpn_configs(self):
 
       self.learning_rate = [1 * 1e-4] * self.num_epochs
       self.dynamic_lr_scheduling = True
       self.scheduling_criterion = 'torch_loss'
       self.scheduling_mode = 'min' if "loss" in self.scheduling_criterion else 'max'
 
       self.n_roi_candidates = 4 if self.dim == 2 else 6
       # max number of roi candidates to identify per image (slice in 2D, volume in 3D)
 
       # loss mode: either weighted cross entropy ('wce'), batch-wise dice loss ('dice), or the sum of both ('dice_wce')
       self.seg_loss_mode = 'wce'
       self.wce_weights = [1] * self.num_seg_classes if 'dice' in self.seg_loss_mode else [0.1, 1]
 
       self.fp_dice_weight = 1 if self.dim == 2 else 1
       # if <1, false positive predictions in foreground are penalized less.
 
       self.detection_min_confidence = 0.05
       # how to determine score of roi: 'max' or 'median'
       self.score_det = 'max'
 
     def add_det_unet_configs(self):
 
       self.learning_rate = [1 * 1e-4] * self.num_epochs
       self.dynamic_lr_scheduling = True
       self.scheduling_criterion = "torch_loss"
       self.scheduling_mode = 'min' if "loss" in self.scheduling_criterion else 'max'
 
       # max number of roi candidates to identify per image (slice in 2D, volume in 3D)
       self.n_roi_candidates = 4 if self.dim == 2 else 6
 
       # loss mode: either weighted cross entropy ('wce'), batch-wise dice loss ('dice), or the sum of both ('dice_wce')
       self.seg_loss_mode = 'wce'
       self.wce_weights = [1] * self.num_seg_classes if 'dice' in self.seg_loss_mode else [0.1, 1]
       # if <1, false positive predictions in foreground are penalized less.
       self.fp_dice_weight = 1 if self.dim == 2 else 1
 
       self.detection_min_confidence = 0.05
       # how to determine score of roi: 'max' or 'median'
       self.score_det = 'max'
 
       self.init_filts = 32
       self.kernel_size = 3  # ks for horizontal, normal convs
       self.kernel_size_m = 2  # ks for max pool
       self.pad = "same"  # "same" or integer, padding of horizontal convs
 
     def add_mrcnn_configs(self):
 
       self.learning_rate = [1e-4] * self.num_epochs
       self.dynamic_lr_scheduling = True  # with scheduler set in exec
       self.scheduling_criterion = max(self.model_selection_criteria, key=self.model_selection_criteria.get)
       self.scheduling_mode = 'min' if "loss" in self.scheduling_criterion else 'max'
 
       # number of classes for network heads: n_foreground_classes + 1 (background)
       self.head_classes = self.num_classes + 1 if 'class' in self.prediction_tasks else 2
 
       # feed +/- n neighbouring slices into channel dimension. set to None for no context.
       self.n_3D_context = None
       if self.n_3D_context is not None and self.dim == 2:
         self.n_channels *= (self.n_3D_context * 2 + 1)
 
       self.detect_while_training = True
       # disable the re-sampling of mask proposals to original size for speed-up.
       # since evaluation is detection-driven (box-matching) and not instance segmentation-driven (iou-matching),
       # mask outputs are optional.
       self.return_masks_in_train = True
       self.return_masks_in_val = True
       self.return_masks_in_test = True
 
       # feature map strides per pyramid level are inferred from architecture. anchor scales are set accordingly.
       self.backbone_strides = {'xy': [4, 8, 16, 32], 'z': [1, 2, 4, 8]}
       # anchor scales are chosen according to expected object sizes in data set. Default uses only one anchor scale
       # per pyramid level. (outer list are pyramid levels (corresponding to BACKBONE_STRIDES), inner list are scales per level.)
       self.rpn_anchor_scales = {'xy': [[4], [8], [16], [32]], 'z': [[1], [2], [4], [8]]}
       # choose which pyramid levels to extract features from: P2: 0, P3: 1, P4: 2, P5: 3.
       self.pyramid_levels = [0, 1, 2, 3]
       # number of feature maps in rpn. typically lowered in 3D to save gpu-memory.
       self.n_rpn_features = 512 if self.dim == 2 else 64
 
       # anchor ratios and strides per position in feature maps.
       self.rpn_anchor_ratios = [0.5, 1., 2.]
       self.rpn_anchor_stride = 1
       # Threshold for first stage (RPN) non-maximum suppression (NMS):  LOWER == HARDER SELECTION
       self.rpn_nms_threshold = max(0.8, self.model_max_iou_resolution)
 
       # loss sampling settings.
       self.rpn_train_anchors_per_image = 4
       self.train_rois_per_image = 6 # per batch_instance
       self.roi_positive_ratio = 0.5
       self.anchor_matching_iou = 0.8
 
       # k negative example candidates are drawn from a pool of size k*shem_poolsize (stochastic hard-example mining),
       # where k<=#positive examples.
       self.shem_poolsize = 2
 
       self.pool_size = (7, 7) if self.dim == 2 else (7, 7, 3)
       self.mask_pool_size = (14, 14) if self.dim == 2 else (14, 14, 5)
       self.mask_shape = (28, 28) if self.dim == 2 else (28, 28, 10)
 
       self.rpn_bbox_std_dev = np.array([0.1, 0.1, 0.1, 0.2, 0.2, 0.2])
       self.bbox_std_dev = np.array([0.1, 0.1, 0.1, 0.2, 0.2, 0.2])
       self.window = np.array([0, 0, self.patch_size[0], self.patch_size[1], 0, self.patch_size_3D[2]])
       self.scale = np.array([self.patch_size[0], self.patch_size[1], self.patch_size[0], self.patch_size[1],
                              self.patch_size_3D[2], self.patch_size_3D[2]])  # y1,x1,y2,x2,z1,z2
 
       if self.dim == 2:
         self.rpn_bbox_std_dev = self.rpn_bbox_std_dev[:4]
         self.bbox_std_dev = self.bbox_std_dev[:4]
         self.window = self.window[:4]
         self.scale = self.scale[:4]
 
       self.plot_y_max = 1.5
       self.n_plot_rpn_props = 5 if self.dim == 2 else 30  # per batch_instance (slice in 2D / patient in 3D)
 
       # pre-selection in proposal-layer (stage 1) for NMS-speedup. applied per batch element.
       self.pre_nms_limit = 2000 if self.dim == 2 else 4000
 
       # n_proposals to be selected after NMS per batch element. too high numbers blow up memory if "detect_while_training" is True,
       # since proposals of the entire batch are forwarded through second stage as one "batch".
       self.roi_chunk_size = 1300 if self.dim == 2 else 500
       self.post_nms_rois_training = 200 * (self.head_classes-1) if self.dim == 2 else 400
       self.post_nms_rois_inference = 200 * (self.head_classes-1)
 
       # Final selection of detections (refine_detections)
       self.model_max_instances_per_batch_element = 9 if self.dim == 2 else 18 # per batch element and class.
       self.detection_nms_threshold = self.model_max_iou_resolution  # needs to be > 0, otherwise all predictions are one cluster.
       self.model_min_confidence = 0.2  # iou for nms in box refining (directly after heads), should be >0 since ths>=x in mrcnn.py
 
       if self.dim == 2:
         self.backbone_shapes = np.array(
           [[int(np.ceil(self.patch_size[0] / stride)),
             int(np.ceil(self.patch_size[1] / stride))]
            for stride in self.backbone_strides['xy']])
       else:
         self.backbone_shapes = np.array(
           [[int(np.ceil(self.patch_size[0] / stride)),
             int(np.ceil(self.patch_size[1] / stride)),
             int(np.ceil(self.patch_size[2] / stride_z))]
            for stride, stride_z in zip(self.backbone_strides['xy'], self.backbone_strides['z']
                                        )])
 
       if self.model == 'retina_net' or self.model == 'retina_unet':
         # whether to use focal loss or SHEM for loss-sample selection
         self.focal_loss = False
         # implement extra anchor-scales according to https://arxiv.org/abs/1708.02002
         self.rpn_anchor_scales['xy'] = [[ii[0], ii[0] * (2 ** (1 / 3)), ii[0] * (2 ** (2 / 3))] for ii in
                                         self.rpn_anchor_scales['xy']]
         self.rpn_anchor_scales['z'] = [[ii[0], ii[0] * (2 ** (1 / 3)), ii[0] * (2 ** (2 / 3))] for ii in
                                        self.rpn_anchor_scales['z']]
         self.n_anchors_per_pos = len(self.rpn_anchor_ratios) * 3
 
         # pre-selection of detections for NMS-speedup. per entire batch.
         self.pre_nms_limit = (500 if self.dim == 2 else 6250) * self.batch_size
 
         # anchor matching iou is lower than in Mask R-CNN according to https://arxiv.org/abs/1708.02002
         self.anchor_matching_iou = 0.7
 
         if self.model == 'retina_unet':
           self.operate_stride1 = True
diff --git a/exec.py b/exec.py
index 59476e0..dc570eb 100644
--- a/exec.py
+++ b/exec.py
@@ -1,340 +1,341 @@
 #!/usr/bin/env python
 # Copyright 2019 Division of Medical Image Computing, German Cancer Research Center (DKFZ).
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
 # You may obtain a copy of the License at
 #
 #     http://www.apache.org/licenses/LICENSE-2.0
 #
 # Unless required by applicable law or agreed to in writing, software
 # distributed under the License is distributed on an "AS IS" BASIS,
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
 # ==============================================================================
 
 """ execution script. this where all routines come together and the only script you need to call.
     refer to parse args below to see options for execution.
 """
 
 import plotting as plg
 
 import os
 import warnings
 import argparse
 import time
 
 import torch
 
 import utils.exp_utils as utils
 from evaluator import Evaluator
 from predictor import Predictor
 
 
 for msg in ["Attempting to set identical bottom==top results",
             "This figure includes Axes that are not compatible with tight_layout",
             "Data has no positive values, and therefore cannot be log-scaled.",
             ".*invalid value encountered in true_divide.*"]:
     warnings.filterwarnings("ignore", msg)
 
 
 def train(cf, logger):
     """
     performs the training routine for a given fold. saves plots and selected parameters to the experiment dir
     specified in the configs. logs to file and tensorboard.
     """
     logger.info('performing training in {}D over fold {} on experiment {} with model {}'.format(
         cf.dim, cf.fold, cf.exp_dir, cf.model))
     logger.time("train_val")
 
     # -------------- inits and settings -----------------
     net = model.net(cf, logger).cuda()
     if cf.optimizer == "ADAM":
         optimizer = torch.optim.Adam(net.parameters(), lr=cf.learning_rate[0], weight_decay=cf.weight_decay)
     elif cf.optimizer == "SGD":
         optimizer = torch.optim.SGD(net.parameters(), lr=cf.learning_rate[0], weight_decay=cf.weight_decay, momentum=0.3)
     if cf.dynamic_lr_scheduling:
         scheduler = torch.optim.lr_scheduler.ReduceLROnPlateau(optimizer, mode=cf.scheduling_mode, factor=cf.lr_decay_factor,
                                                                     patience=cf.scheduling_patience)
     model_selector = utils.ModelSelector(cf, logger)
 
     starting_epoch = 1
-    if cf.resume_from_checkpoint:
+    if cf.resume:
+        checkpoint_path = os.path.join(cf.fold_dir, "last_state.pth")
         starting_epoch, net, optimizer, model_selector = \
-            utils.load_checkpoint(cf.resume_from_checkpoint, net, optimizer, model_selector)
-        logger.info('resumed from checkpoint {} at epoch {}'.format(cf.resume_from_checkpoint, starting_epoch))
+            utils.load_checkpoint(checkpoint_path, net, optimizer, model_selector)
+        logger.info('resumed from checkpoint {} to epoch {}'.format(checkpoint_path, starting_epoch))
 
     # prepare monitoring
     monitor_metrics = utils.prepare_monitoring(cf)
 
     logger.info('loading dataset and initializing batch generators...')
     batch_gen = data_loader.get_train_generators(cf, logger)
 
     # -------------- training -----------------
     for epoch in range(starting_epoch, cf.num_epochs + 1):
 
         logger.info('starting training epoch {}/{}'.format(epoch, cf.num_epochs))
         logger.time("train_epoch")
 
         net.train()
 
         train_results_list = []
         train_evaluator = Evaluator(cf, logger, mode='train')
 
         for i in range(cf.num_train_batches):
             logger.time("train_batch_loadfw")
             batch = next(batch_gen['train'])
             batch_gen['train'].generator.stats['roi_counts'] += batch['roi_counts']
             batch_gen['train'].generator.stats['empty_counts'] += batch['empty_counts']
 
             logger.time("train_batch_loadfw")
             logger.time("train_batch_netfw")
             results_dict = net.train_forward(batch)
             logger.time("train_batch_netfw")
             logger.time("train_batch_bw")
             optimizer.zero_grad()
             results_dict['torch_loss'].backward()
             if cf.clip_norm:
                 torch.nn.utils.clip_grad_norm_(net.parameters(), cf.clip_norm, norm_type=2) # gradient clipping
             optimizer.step()
             train_results_list.append(({k:v for k,v in results_dict.items() if k != "seg_preds"}, batch["pid"])) # slim res dict
             if not cf.server_env:
                 print("\rFinished training batch " +
                       "{}/{} in {:.1f}s ({:.2f}/{:.2f} forw load/net, {:.2f} backw).".format(i+1, cf.num_train_batches,
                                                                                              logger.get_time("train_batch_loadfw")+
                                                                                              logger.get_time("train_batch_netfw")
                                                                                              +logger.time("train_batch_bw"),
                                                                                              logger.get_time("train_batch_loadfw",reset=True),
                                                                                              logger.get_time("train_batch_netfw", reset=True),
                                                                                              logger.get_time("train_batch_bw", reset=True)), end="", flush=True)
         print()
 
         #--------------- train eval ----------------
         if (epoch-1)%cf.plot_frequency==0:
             # view an example batch
             utils.split_off_process(plg.view_batch, cf, batch, results_dict, has_colorchannels=cf.has_colorchannels,
                                     show_gt_labels=True, get_time="train-example plot",
                                     out_file=os.path.join(cf.plot_dir, 'batch_example_train_{}.png'.format(cf.fold)))
 
 
         logger.time("evals")
         _, monitor_metrics['train'] = train_evaluator.evaluate_predictions(train_results_list, monitor_metrics['train'])
         logger.time("evals")
         logger.time("train_epoch", toggle=False)
         del train_results_list
 
         #----------- validation ------------
         logger.info('starting validation in mode {}.'.format(cf.val_mode))
         logger.time("val_epoch")
         with torch.no_grad():
             net.eval()
             val_results_list = []
             val_evaluator = Evaluator(cf, logger, mode=cf.val_mode)
             val_predictor = Predictor(cf, net, logger, mode='val')
 
             for i in range(batch_gen['n_val']):
                 logger.time("val_batch")
                 batch = next(batch_gen[cf.val_mode])
                 if cf.val_mode == 'val_patient':
                     results_dict = val_predictor.predict_patient(batch)
                 elif cf.val_mode == 'val_sampling':
                     results_dict = net.train_forward(batch, is_validation=True)
                 val_results_list.append([results_dict, batch["pid"]])
                 if not cf.server_env:
                     print("\rFinished validation {} {}/{} in {:.1f}s.".format('patient' if cf.val_mode=='val_patient' else 'batch',
                                                                               i + 1, batch_gen['n_val'],
                                                                               logger.time("val_batch")), end="", flush=True)
             print()
 
             #------------ val eval -------------
             if (epoch - 1) % cf.plot_frequency == 0:
                 utils.split_off_process(plg.view_batch, cf, batch, results_dict, has_colorchannels=cf.has_colorchannels,
                                         show_gt_labels=True, get_time="val-example plot",
                                         out_file=os.path.join(cf.plot_dir, 'batch_example_val_{}.png'.format(cf.fold)))
 
             logger.time("evals")
             _, monitor_metrics['val'] = val_evaluator.evaluate_predictions(val_results_list, monitor_metrics['val'])
 
             model_selector.run_model_selection(net, optimizer, monitor_metrics, epoch)
             del val_results_list
             #----------- monitoring -------------
             monitor_metrics.update({"lr": 
                 {str(g) : group['lr'] for (g, group) in enumerate(optimizer.param_groups)}})
             logger.metrics2tboard(monitor_metrics, global_step=epoch)
             logger.time("evals")
 
             logger.info('finished epoch {}/{}, took {:.2f}s. train total: {:.2f}s, average: {:.2f}s. val total: {:.2f}s, average: {:.2f}s.'.format(
                 epoch, cf.num_epochs, logger.get_time("train_epoch")+logger.time("val_epoch"), logger.get_time("train_epoch"),
                 logger.get_time("train_epoch", reset=True)/cf.num_train_batches, logger.get_time("val_epoch"),
                 logger.get_time("val_epoch", reset=True)/batch_gen["n_val"]))
             logger.info("time for evals: {:.2f}s".format(logger.get_time("evals", reset=True)))
 
         #-------------- scheduling -----------------
         if not cf.dynamic_lr_scheduling:
             for param_group in optimizer.param_groups:
                 param_group['lr'] = cf.learning_rate[epoch-1]
         else:
             scheduler.step(monitor_metrics["val"][cf.scheduling_criterion][-1])
 
     logger.time("train_val")
     logger.info("Training and validating over {} epochs took {}".format(cf.num_epochs, logger.get_time("train_val", format="hms", reset=True)))
     batch_gen['train'].generator.print_stats(logger, plot=True)
 
 def test(cf, logger, max_fold=None):
     """performs testing for a given fold (or held out set). saves stats in evaluator.
     """
     logger.time("test_fold")
     logger.info('starting testing model of fold {} in exp {}'.format(cf.fold, cf.exp_dir))
     net = model.net(cf, logger).cuda()
     batch_gen = data_loader.get_test_generator(cf, logger)
 
     test_predictor = Predictor(cf, net, logger, mode='test')
     test_results_list = test_predictor.predict_test_set(batch_gen, return_results = not hasattr(
         cf, "eval_test_separately") or not cf.eval_test_separately)
 
     if test_results_list is not None:
         test_evaluator = Evaluator(cf, logger, mode='test')
         test_evaluator.evaluate_predictions(test_results_list)
         test_evaluator.score_test_df(max_fold=max_fold)
 
     logger.info('Testing of fold {} took {}.\n'.format(cf.fold, logger.get_time("test_fold", reset=True, format="hms")))
 
 if __name__ == '__main__':
     stime = time.time()
 
     parser = argparse.ArgumentParser()
     parser.add_argument('--dataset_name', type=str, default='toy',
                         help="path to the dataset-specific code in source_dir/datasets")
     parser.add_argument('--exp_dir', type=str, default='/home/gregor/Documents/regrcnn/datasets/toy/experiments/dev',
                         help='path to experiment dir. will be created if non existent.')
     parser.add_argument('-m', '--mode', type=str,  default='train_test', help='one out of: create_exp, analysis, train, train_test, or test')
     parser.add_argument('-f', '--folds', nargs='+', type=int, default=None, help='None runs over all folds in CV. otherwise specify list of folds.')
     parser.add_argument('--server_env', default=False, action='store_true', help='change IO settings to deploy models on a cluster.')
     parser.add_argument('--data_dest', type=str, default=None, help="path to final data folder if different from config")
     parser.add_argument('--use_stored_settings', default=False, action='store_true',
                         help='load configs from existing exp_dir instead of source dir. always done for testing, '
                              'but can be set to true to do the same for training. useful in job scheduler environment, '
                              'where source code might change before the job actually runs.')
-    parser.add_argument('--resume_from_checkpoint', type=str, default=None,
-                        help='path to checkpoint. if resuming from checkpoint, the desired fold still needs to be parsed via --folds.')
+    parser.add_argument('--resume', action="store_true", default=False,
+                        help='if given, resume from checkpoint(s) of the specified folds.')
     parser.add_argument('-d', '--dev', default=False, action='store_true', help="development mode: shorten everything")
 
     args = parser.parse_args()
     args.dataset_name = os.path.join("datasets", args.dataset_name) if not "datasets" in args.dataset_name else args.dataset_name
     folds = args.folds
-    resume_from_checkpoint = None if args.resume_from_checkpoint in ['None', 'none'] else args.resume_from_checkpoint
+    resume = None if args.resume in ['None', 'none'] else args.resume
 
     if args.mode == 'create_exp':
         cf = utils.prep_exp(args.dataset_name, args.exp_dir, args.server_env, use_stored_settings=False)
         logger = utils.get_logger(cf.exp_dir, cf.server_env, -1)
         logger.info('created experiment directory at {}'.format(args.exp_dir))
 
     elif args.mode == 'train' or args.mode == 'train_test':
         cf = utils.prep_exp(args.dataset_name, args.exp_dir, args.server_env, args.use_stored_settings)
         if args.dev:
             folds = [0,1]
             cf.batch_size, cf.num_epochs, cf.min_save_thresh, cf.save_n_models = 3 if cf.dim==2 else 1, 2, 0, 1
             cf.num_train_batches, cf.num_val_batches, cf.max_val_patients = 5, 1, 1
             cf.test_n_epochs =  cf.save_n_models
             cf.max_test_patients = 1
             torch.backends.cudnn.benchmark = cf.dim==3
         else:
             torch.backends.cudnn.benchmark = cf.cuda_benchmark
         if args.data_dest is not None:
             cf.data_dest = args.data_dest
             
         logger = utils.get_logger(cf.exp_dir, cf.server_env, cf.sysmetrics_interval)
         data_loader = utils.import_module('data_loader', os.path.join(args.dataset_name, 'data_loader.py'))
         model = utils.import_module('model', cf.model_path)
         logger.info("loaded model from {}".format(cf.model_path))
         if folds is None:
             folds = range(cf.n_cv_splits)
 
         for fold in folds:
             """k-fold cross-validation: the dataset is split into k equally-sized folds, one used for validation,
             one for testing, the rest for training. This loop iterates k-times over the dataset, cyclically moving the
             splits. k==folds, fold in [0,folds) says which split is used for testing.
             """
             cf.fold_dir = os.path.join(cf.exp_dir, 'fold_{}'.format(fold)); cf.fold = fold
             logger.set_logfile(fold=fold)
-            cf.resume_from_checkpoint = resume_from_checkpoint
+            cf.resume = resume
             if not os.path.exists(cf.fold_dir):
                 os.mkdir(cf.fold_dir)
             train(cf, logger)
-            cf.resume_from_checkpoint = None
+            cf.resume = None
             if args.mode == 'train_test':
                 test(cf, logger)
 
     elif args.mode == 'test':
         cf = utils.prep_exp(args.dataset_name, args.exp_dir, args.server_env, use_stored_settings=True, is_training=False)
         if args.data_dest is not None:
             cf.data_dest = args.data_dest
         logger = utils.get_logger(cf.exp_dir, cf.server_env, cf.sysmetrics_interval)
         data_loader = utils.import_module('data_loader', os.path.join(args.dataset_name, 'data_loader.py'))
         model = utils.import_module('model', cf.model_path)
         logger.info("loaded model from {}".format(cf.model_path))
 
         fold_dirs = sorted([os.path.join(cf.exp_dir, f) for f in os.listdir(cf.exp_dir) if
                      os.path.isdir(os.path.join(cf.exp_dir, f)) and f.startswith("fold")])
         if folds is None:
             folds = range(cf.n_cv_splits)
         if args.dev:
             folds = folds[:2]
             cf.batch_size, cf.max_test_patients, cf.test_n_epochs = 1 if cf.dim==2 else 1, 2, 2
         else:
             torch.backends.cudnn.benchmark = cf.cuda_benchmark
         for fold in folds:
             cf.fold_dir = os.path.join(cf.exp_dir, 'fold_{}'.format(fold)); cf.fold = fold
             logger.set_logfile(fold=fold)
             if cf.fold_dir in fold_dirs:
                 test(cf, logger, max_fold=max([int(f[-1]) for f in fold_dirs]))
             else:
                 logger.info("Skipping fold {} since no model parameters found.".format(fold))
     # load raw predictions saved by predictor during testing, run aggregation algorithms and evaluation.
     elif args.mode == 'analysis':
         """ analyse already saved predictions.
         """
         cf = utils.prep_exp(args.dataset_name, args.exp_dir, args.server_env, use_stored_settings=True, is_training=False)
         logger = utils.get_logger(cf.exp_dir, cf.server_env, cf.sysmetrics_interval)
 
         if cf.held_out_test_set and not cf.eval_test_fold_wise:
             predictor = Predictor(cf, net=None, logger=logger, mode='analysis')
             results_list = predictor.load_saved_predictions()
             logger.info('starting evaluation...')
             cf.fold = 0
             evaluator = Evaluator(cf, logger, mode='test')
             evaluator.evaluate_predictions(results_list)
             evaluator.score_test_df(max_fold=0)
         else:
             fold_dirs = sorted([os.path.join(cf.exp_dir, f) for f in os.listdir(cf.exp_dir) if
                          os.path.isdir(os.path.join(cf.exp_dir, f)) and f.startswith("fold")])
             if args.dev:
                 fold_dirs = fold_dirs[:1]
             if folds is None:
                 folds = range(cf.n_cv_splits)
             for fold in folds:
                 cf.fold = fold; cf.fold_dir = os.path.join(cf.exp_dir, 'fold_{}'.format(cf.fold))
                 logger.set_logfile(fold=fold)
                 if cf.fold_dir in fold_dirs:
                     predictor = Predictor(cf, net=None, logger=logger, mode='analysis')
                     results_list = predictor.load_saved_predictions()
                     # results_list[x][1] is pid, results_list[x][0] is list of len samples-per-patient, each entry hlds
                     # list of boxes per that sample, i.e., len(results_list[x][y][0]) would be nr of boxes in sample y of patient x
                     logger.info('starting evaluation...')
                     evaluator = Evaluator(cf, logger, mode='test')
                     evaluator.evaluate_predictions(results_list)
                     max_fold = max([int(f[-1]) for f in fold_dirs])
                     evaluator.score_test_df(max_fold=max_fold)
                 else:
                     logger.info("Skipping fold {} since no model parameters found.".format(fold))
     else:
         raise ValueError('mode "{}" specified in args is not implemented.'.format(args.mode))
         
     mins, secs = divmod((time.time() - stime), 60)
     h, mins = divmod(mins, 60)
     t = "{:d}h:{:02d}m:{:02d}s".format(int(h), int(mins), int(secs))
     logger.info("{} total runtime: {}".format(os.path.split(__file__)[1], t))
     del logger
     torch.cuda.empty_cache()
 
diff --git a/predictor.py b/predictor.py
index 2e2e3ef..99035bd 100644
--- a/predictor.py
+++ b/predictor.py
@@ -1,1007 +1,1005 @@
 #!/usr/bin/env python
 # Copyright 2019 Division of Medical Image Computing, German Cancer Research Center (DKFZ).
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
 # You may obtain a copy of the License at
 #
 #     http://www.apache.org/licenses/LICENSE-2.0
 #
 # Unless required by applicable law or agreed to in writing, software
 # distributed under the License is distributed on an "AS IS" BASIS,
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
 # ==============================================================================
 
 import os
 from multiprocessing import Pool
 import pickle
 import time
 
 import numpy as np
 import torch
 from scipy.stats import norm
 from collections import OrderedDict
 
 import plotting as plg
 import utils.model_utils as mutils
 import utils.exp_utils as utils
 
 
 def get_mirrored_patch_crops(patch_crops, org_img_shape):
     mirrored_patch_crops = []
     mirrored_patch_crops.append([[org_img_shape[2] - ii[1], org_img_shape[2] - ii[0], ii[2], ii[3]]
                                  if len(ii) == 4 else [org_img_shape[2] - ii[1], org_img_shape[2] - ii[0], ii[2],
                                                        ii[3], ii[4], ii[5]]
                                  for ii in patch_crops])
 
     mirrored_patch_crops.append([[ii[0], ii[1], org_img_shape[3] - ii[3], org_img_shape[3] - ii[2]]
                                  if len(ii) == 4 else [ii[0], ii[1], org_img_shape[3] - ii[3],
                                                        org_img_shape[3] - ii[2], ii[4], ii[5]]
                                  for ii in patch_crops])
 
     mirrored_patch_crops.append([[org_img_shape[2] - ii[1],
                                   org_img_shape[2] - ii[0],
                                   org_img_shape[3] - ii[3],
                                   org_img_shape[3] - ii[2]]
                                  if len(ii) == 4 else
                                  [org_img_shape[2] - ii[1],
                                   org_img_shape[2] - ii[0],
                                   org_img_shape[3] - ii[3],
                                   org_img_shape[3] - ii[2], ii[4], ii[5]]
                                  for ii in patch_crops])
 
     return mirrored_patch_crops
 
 def get_mirrored_patch_crops_ax_dep(patch_crops, org_img_shape, mirror_axes):
     mirrored_patch_crops = []
     for ax_ix, axes in enumerate(mirror_axes):
         if isinstance(axes, (int, float)) and int(axes) == 0:
             mirrored_patch_crops.append([[org_img_shape[2] - ii[1], org_img_shape[2] - ii[0], ii[2], ii[3]]
                                          if len(ii) == 4 else [org_img_shape[2] - ii[1], org_img_shape[2] - ii[0],
                                                                ii[2], ii[3], ii[4], ii[5]]
                                          for ii in patch_crops])
         elif isinstance(axes, (int, float)) and int(axes) == 1:
             mirrored_patch_crops.append([[ii[0], ii[1], org_img_shape[3] - ii[3], org_img_shape[3] - ii[2]]
                                          if len(ii) == 4 else [ii[0], ii[1], org_img_shape[3] - ii[3],
                                                                org_img_shape[3] - ii[2], ii[4], ii[5]]
                                          for ii in patch_crops])
         elif hasattr(axes, "__iter__") and (tuple(axes) == (0, 1) or tuple(axes) == (1, 0)):
             mirrored_patch_crops.append([[org_img_shape[2] - ii[1],
                                           org_img_shape[2] - ii[0],
                                           org_img_shape[3] - ii[3],
                                           org_img_shape[3] - ii[2]]
                                          if len(ii) == 4 else
                                          [org_img_shape[2] - ii[1],
                                           org_img_shape[2] - ii[0],
                                           org_img_shape[3] - ii[3],
                                           org_img_shape[3] - ii[2], ii[4], ii[5]]
                                          for ii in patch_crops])
         else:
             raise Exception("invalid mirror axes {} in get mirrored patch crops".format(axes))
 
     return mirrored_patch_crops
 
 def apply_wbc_to_patient(inputs):
     """
     wrapper around prediction box consolidation: weighted box clustering (wbc). processes a single patient.
     loops over batch elements in patient results (1 in 3D, slices in 2D) and foreground classes,
     aggregates and stores results in new list.
     :return. patient_results_list: list over batch elements. each element is a list over boxes, where each box is
                                  one dictionary: [[box_0, ...], [box_n,...]]. batch elements are slices for 2D
                                  predictions, and a dummy batch dimension of 1 for 3D predictions.
     :return. pid: string. patient id.
     """
     regress_flag, in_patient_results_list, pid, class_dict, clustering_iou, n_ens = inputs
     out_patient_results_list = [[] for _ in range(len(in_patient_results_list))]
 
     for bix, b in enumerate(in_patient_results_list):
 
         for cl in list(class_dict.keys()):
 
             boxes = [(ix, box) for ix, box in enumerate(b) if
                      (box['box_type'] == 'det' and box['box_pred_class_id'] == cl)]
             box_coords = np.array([b[1]['box_coords'] for b in boxes])
             box_scores = np.array([b[1]['box_score'] for b in boxes])
             box_center_factor = np.array([b[1]['box_patch_center_factor'] for b in boxes])
             box_n_overlaps = np.array([b[1]['box_n_overlaps'] for b in boxes])
             try:
                 box_patch_id = np.array([b[1]['patch_id'] for b in boxes])
             except KeyError: #backward compatibility for already saved pred results ... omg
                 box_patch_id = np.array([b[1]['ens_ix'] for b in boxes])
             box_regressions = np.array([b[1]['regression'] for b in boxes]) if regress_flag else None
             box_rg_bins = np.array([b[1]['rg_bin'] if 'rg_bin' in b[1].keys() else float('NaN') for b in boxes])
             box_rg_uncs = np.array([b[1]['rg_uncertainty'] if 'rg_uncertainty' in b[1].keys() else float('NaN') for b in boxes])
 
             if 0 not in box_scores.shape:
                 keep_scores, keep_coords, keep_n_missing, keep_regressions, keep_rg_bins, keep_rg_uncs = \
                     weighted_box_clustering(box_coords, box_scores, box_center_factor, box_n_overlaps, box_rg_bins, box_rg_uncs,
                                              box_regressions, box_patch_id, clustering_iou, n_ens)
 
 
                 for boxix in range(len(keep_scores)):
                     clustered_box = {'box_type': 'det', 'box_coords': keep_coords[boxix],
                                      'box_score': keep_scores[boxix], 'cluster_n_missing': keep_n_missing[boxix],
                                      'box_pred_class_id': cl}
                     if regress_flag:
                         clustered_box.update({'regression': keep_regressions[boxix],
                                               'rg_uncertainty': keep_rg_uncs[boxix],
                                               'rg_bin': keep_rg_bins[boxix]})
 
                     out_patient_results_list[bix].append(clustered_box)
 
         # add gt boxes back to new output list.
         out_patient_results_list[bix].extend([box for box in b if box['box_type'] == 'gt'])
 
     return [out_patient_results_list, pid]
 
 
 def weighted_box_clustering(box_coords, scores, box_pc_facts, box_n_ovs, box_rg_bins, box_rg_uncs,
                              box_regress, box_patch_id, thresh, n_ens):
     """Consolidates overlapping predictions resulting from patch overlaps, test data augmentations and temporal ensembling.
     clusters predictions together with iou > thresh (like in NMS). Output score and coordinate for one cluster are the
     average weighted by individual patch center factors (how trustworthy is this candidate measured by how centered
     its position within the patch is) and the size of the corresponding box.
     The number of expected predictions at a position is n_data_aug * n_temp_ens * n_overlaps_at_position
     (1 prediction per unique patch). Missing predictions at a cluster position are defined as the number of unique
     patches in the cluster, which did not contribute any predict any boxes.
     :param dets: (n_dets, (y1, x1, y2, x2, (z1), (z2), scores, box_pc_facts, box_n_ovs).
     :param box_coords: y1, x1, y2, x2, (z1), (z2).
     :param scores: confidence scores.
     :param box_pc_facts: patch-center factors from position on patch tiles.
     :param box_n_ovs: number of patch overlaps at box position.
     :param box_rg_bins: regression bin predictions.
     :param box_rg_uncs: (n_dets,) regression uncertainties (from model mrcnn_aleatoric).
     :param box_regress: (n_dets, n_regression_features).
     :param box_patch_id: ensemble index.
     :param thresh: threshold for iou_matching.
     :param n_ens: number of models, that are ensembled. (-> number of expected predictions per position).
     :return: keep_scores: (n_keep)  new scores of boxes to be kept.
     :return: keep_coords: (n_keep, (y1, x1, y2, x2, (z1), (z2)) new coordinates of boxes to be kept.
     """
 
     dim = 2 if box_coords.shape[1] == 4 else 3
     y1 = box_coords[:,0]
     x1 = box_coords[:,1]
     y2 = box_coords[:,2]
     x2 = box_coords[:,3]
 
     areas = (y2 - y1 + 1) * (x2 - x1 + 1)
     if dim == 3:
         z1 = box_coords[:, 4]
         z2 = box_coords[:, 5]
         areas *= (z2 - z1 + 1)
 
     # order is the sorted index.  maps order to index o[1] = 24 (rank1, ix 24)
     order = scores.argsort()[::-1]
 
     keep_scores = []
     keep_coords = []
     keep_n_missing = []
     keep_regress = []
     keep_rg_bins = []
     keep_rg_uncs = []
 
     while order.size > 0:
         i = order[0]  # highest scoring element
         yy1 = np.maximum(y1[i], y1[order])
         xx1 = np.maximum(x1[i], x1[order])
         yy2 = np.minimum(y2[i], y2[order])
         xx2 = np.minimum(x2[i], x2[order])
 
         w = np.maximum(0, xx2 - xx1 + 1)
         h = np.maximum(0, yy2 - yy1 + 1)
         inter = w * h
 
         if dim == 3:
             zz1 = np.maximum(z1[i], z1[order])
             zz2 = np.minimum(z2[i], z2[order])
             d = np.maximum(0, zz2 - zz1 + 1)
             inter *= d
 
         # overlap between currently highest scoring box and all boxes.
         ovr = inter / (areas[i] + areas[order] - inter)
         ovr_fl = inter.astype('float64') / (areas[i] + areas[order] - inter.astype('float64'))
         assert np.all(ovr==ovr_fl), "ovr {}\n ovr_float {}".format(ovr, ovr_fl)
         # get all the predictions that match the current box to build one cluster.
         matches = np.nonzero(ovr > thresh)[0]
 
         match_n_ovs = box_n_ovs[order[matches]]
         match_pc_facts = box_pc_facts[order[matches]]
         match_patch_id = box_patch_id[order[matches]]
         match_ov_facts = ovr[matches]
         match_areas = areas[order[matches]]
         match_scores = scores[order[matches]]
 
         # weight all scores in cluster by patch factors, and size.
         match_score_weights = match_ov_facts * match_areas * match_pc_facts
         match_scores *= match_score_weights
 
         # for the weighted average, scores have to be divided by the number of total expected preds at the position
         # of the current cluster. 1 Prediction per patch is expected. therefore, the number of ensembled models is
         # multiplied by the mean overlaps of  patches at this position (boxes of the cluster might partly be
         # in areas of different overlaps).
         n_expected_preds = n_ens * np.mean(match_n_ovs)
         # the number of missing predictions is obtained as the number of patches,
         # which did not contribute any prediction to the current cluster.
         n_missing_preds = np.max((0, n_expected_preds - np.unique(match_patch_id).shape[0]))
 
         # missing preds are given the mean weighting
         # (expected prediction is the mean over all predictions in cluster).
         denom = np.sum(match_score_weights) + n_missing_preds * np.mean(match_score_weights)
 
         # compute weighted average score for the cluster
         avg_score = np.sum(match_scores) / denom
 
         # compute weighted average of coordinates for the cluster. now only take existing
         # predictions into account.
         avg_coords = [np.sum(y1[order[matches]] * match_scores) / np.sum(match_scores),
                       np.sum(x1[order[matches]] * match_scores) / np.sum(match_scores),
                       np.sum(y2[order[matches]] * match_scores) / np.sum(match_scores),
                       np.sum(x2[order[matches]] * match_scores) / np.sum(match_scores)]
 
         if dim == 3:
             avg_coords.append(np.sum(z1[order[matches]] * match_scores) / np.sum(match_scores))
             avg_coords.append(np.sum(z2[order[matches]] * match_scores) / np.sum(match_scores))
 
         if box_regress is not None:
             # compute wt. avg. of regression vectors (component-wise average)
             avg_regress = np.sum(box_regress[order[matches]] * match_scores[:, np.newaxis], axis=0) / np.sum(
                 match_scores)
             avg_rg_bins = np.round(np.sum(box_rg_bins[order[matches]] * match_scores) / np.sum(match_scores))
             avg_rg_uncs = np.sum(box_rg_uncs[order[matches]] * match_scores) / np.sum(match_scores)
         else:
             avg_regress = np.array(float('NaN'))
             avg_rg_bins = np.array(float('NaN'))
             avg_rg_uncs = np.array(float('NaN'))
 
         # some clusters might have very low scores due to high amounts of missing predictions.
         # filter out the with a conservative threshold, to speed up evaluation.
         if avg_score > 0.01:
             keep_scores.append(avg_score)
             keep_coords.append(avg_coords)
             keep_n_missing.append((n_missing_preds / n_expected_preds * 100))  # relative
             keep_regress.append(avg_regress)
             keep_rg_uncs.append(avg_rg_uncs)
             keep_rg_bins.append(avg_rg_bins)
 
         # get index of all elements that were not matched and discard all others.
         inds = np.nonzero(ovr <= thresh)[0]
         inds_where = np.where(ovr<=thresh)[0]
         assert np.all(inds == inds_where), "inds_nonzero {} \ninds_where {}".format(inds, inds_where)
         order = order[inds]
 
     return keep_scores, keep_coords, keep_n_missing, keep_regress, keep_rg_bins, keep_rg_uncs
 
 
 def apply_nms_to_patient(inputs):
 
     in_patient_results_list, pid, class_dict, iou_thresh = inputs
     out_patient_results_list = []
 
 
     # collect box predictions over batch dimension (slices) and store slice info as slice_ids.
     for batch in in_patient_results_list:
         batch_el_boxes = []
         for cl in list(class_dict.keys()):
             det_boxes = [box for box in batch if (box['box_type'] == 'det' and box['box_pred_class_id'] == cl)]
 
             box_coords = np.array([box['box_coords'] for box in det_boxes])
             box_scores = np.array([box['box_score'] for box in det_boxes])
             if 0 not in box_scores.shape:
                 keep_ix = mutils.nms_numpy(box_coords, box_scores, iou_thresh)
             else:
                 keep_ix = []
 
             batch_el_boxes += [det_boxes[ix] for ix in keep_ix]
 
         batch_el_boxes += [box for box in batch if box['box_type'] == 'gt']
         out_patient_results_list.append(batch_el_boxes)
 
     assert len(in_patient_results_list) == len(out_patient_results_list), "batch dim needs to be maintained, in: {}, out {}".format(len(in_patient_results_list), len(out_patient_results_list))
 
     return [out_patient_results_list, pid]
 
 def nms_2to3D(dets, thresh):
     """
     Merges 2D boxes to 3D cubes. For this purpose, boxes of all slices are regarded as lying in one slice.
     An adaptation of Non-maximum suppression is applied where clusters are found (like in NMS) with the extra constraint
     that suppressed boxes have to have 'connected' z coordinates w.r.t the core slice (cluster center, highest
     scoring box, the prevailing box). 'connected' z-coordinates are determined
     as the z-coordinates with predictions until the first coordinate for which no prediction is found.
 
     example: a cluster of predictions was found overlap > iou thresh in xy (like NMS). The z-coordinate of the highest
     scoring box is 50. Other predictions have 23, 46, 48, 49, 51, 52, 53, 56, 57.
     Only the coordinates connected with 50 are clustered to one cube: 48, 49, 51, 52, 53. (46 not because nothing was
     found in 47, so 47 is a 'hole', which interrupts the connection). Only the boxes corresponding to these coordinates
     are suppressed. All others are kept for building of further clusters.
 
     This algorithm works better with a certain min_confidence of predictions, because low confidence (e.g. noisy/cluttery)
     predictions can break the relatively strong assumption of defining cubes' z-boundaries at the first 'hole' in the cluster.
 
     :param dets: (n_detections, (y1, x1, y2, x2, scores, slice_id)
     :param thresh: iou matchin threshold (like in NMS).
     :return: keep: (n_keep,) 1D tensor of indices to be kept.
     :return: keep_z: (n_keep, [z1, z2]) z-coordinates to be added to boxes, which are kept in order to form cubes.
     """
 
     y1 = dets[:, 0]
     x1 = dets[:, 1]
     y2 = dets[:, 2]
     x2 = dets[:, 3]
     assert np.all(y1 <= y2) and np.all(x1 <= x2), """"the definition of the coordinates is crucially important here: 
         where maximum is taken needs to be the lower coordinate"""
     scores = dets[:, -2]
     slice_id = dets[:, -1]
 
     areas = (x2 - x1 + 1) * (y2 - y1 + 1)
     order = scores.argsort()[::-1]
 
     keep = []
     keep_z = []
 
     while order.size > 0:  # order is the sorted index.  maps order to index: order[1] = 24 means (rank1, ix 24)
         i = order[0]  # highest scoring element
         yy1 = np.maximum(y1[i], y1[order])  # highest scoring element still in >order<, is compared to itself: okay?
         xx1 = np.maximum(x1[i], x1[order])
         yy2 = np.minimum(y2[i], y2[order])
         xx2 = np.minimum(x2[i], x2[order])
 
         h = np.maximum(0.0, yy2 - yy1 + 1)
         w = np.maximum(0.0, xx2 - xx1 + 1)
         inter = h * w
 
         iou = inter / (areas[i] + areas[order] - inter)
         matches = np.argwhere(
             iou > thresh)  # get all the elements that match the current box and have a lower score
 
         slice_ids = slice_id[order[matches]]
         core_slice = slice_id[int(i)]
         upper_holes = [ii for ii in np.arange(core_slice, np.max(slice_ids)) if ii not in slice_ids]
         lower_holes = [ii for ii in np.arange(np.min(slice_ids), core_slice) if ii not in slice_ids]
         max_valid_slice_id = np.min(upper_holes) if len(upper_holes) > 0 else np.max(slice_ids)
         min_valid_slice_id = np.max(lower_holes) if len(lower_holes) > 0 else np.min(slice_ids)
         z_matches = matches[(slice_ids <= max_valid_slice_id) & (slice_ids >= min_valid_slice_id)]
 
         # expand by one z voxel since box content is surrounded w/o overlap, i.e., z-content computed as z2-z1
         z1 = np.min(slice_id[order[z_matches]]) - 1
         z2 = np.max(slice_id[order[z_matches]]) + 1
 
         keep.append(i)
         keep_z.append([z1, z2])
         order = np.delete(order, z_matches, axis=0)
 
     return keep, keep_z
 
 def apply_2d_3d_merging_to_patient(inputs):
     """
     wrapper around 2Dto3D merging operation. Processes a single patient. Takes 2D patient results (slices in batch dimension)
     and returns 3D patient results (dummy batch dimension of 1). Applies an adaption of Non-Maximum Surpression
     (Detailed methodology is described in nms_2to3D).
     :return. results_dict_boxes: list over batch elements (1 in 3D). each element is a list over boxes, where each box is
                                  one dictionary: [[box_0, ...], [box_n,...]].
     :return. pid: string. patient id.
     """
 
     in_patient_results_list, pid, class_dict, merge_3D_iou = inputs
     out_patient_results_list = []
 
     for cl in list(class_dict.keys()):
         det_boxes, slice_ids = [], []
         # collect box predictions over batch dimension (slices) and store slice info as slice_ids.
         for batch_ix, batch in enumerate(in_patient_results_list):
             batch_element_det_boxes = [(ix, box) for ix, box in enumerate(batch) if
                                        (box['box_type'] == 'det' and box['box_pred_class_id'] == cl)]
             det_boxes += batch_element_det_boxes
             slice_ids += [batch_ix] * len(batch_element_det_boxes)
 
         box_coords = np.array([batch[1]['box_coords'] for batch in det_boxes])
         box_scores = np.array([batch[1]['box_score'] for batch in det_boxes])
         slice_ids = np.array(slice_ids)
 
         if 0 not in box_scores.shape:
             keep_ix, keep_z = nms_2to3D(
                 np.concatenate((box_coords, box_scores[:, None], slice_ids[:, None]), axis=1), merge_3D_iou)
         else:
             keep_ix, keep_z = [], []
 
         # store kept predictions in new results list and add corresponding z-dimension info to coordinates.
         for kix, kz in zip(keep_ix, keep_z):
             keep_box = det_boxes[kix][1]
             keep_box['box_coords'] = list(keep_box['box_coords']) + kz
             out_patient_results_list.append(keep_box)
 
     gt_boxes = [box for b in in_patient_results_list for box in b if box['box_type'] == 'gt']
     if len(gt_boxes) > 0:
         assert np.all([len(box["box_coords"]) == 6 for box in gt_boxes]), "expanded preds to 3D but GT is 2D."
     out_patient_results_list += gt_boxes
 
     return [[out_patient_results_list], pid]  # additional list wrapping is extra batch dim.
 
 
 class Predictor:
     """
 	    Prediction pipeline:
 	    - receives a patched patient image (n_patches, c, y, x, (z)) from patient data loader.
 	    - forwards patches through model in chunks of batch_size. (method: batch_tiling_forward)
 	    - unmolds predictions (boxes and segmentations) to original patient coordinates. (method: spatial_tiling_forward)
 
 	    Ensembling (mode == 'test'):
 	    - for inference, forwards 4 mirrored versions of image to through model and unmolds predictions afterwards
 	      accordingly (method: data_aug_forward)
 	    - for inference, loads multiple parameter-sets of the trained model corresponding to different epochs. for each
 	      parameter-set loops over entire test set, runs prediction pipeline for each patient. (method: predict_test_set)
 
 	    Consolidation of predictions:
 	    - consolidates a patient's predictions (boxes, segmentations) collected over patches, data_aug- and temporal ensembling,
 	      performs clustering and weighted averaging (external function: apply_wbc_to_patient) to obtain consistent outptus.
 	    - for 2D networks, consolidates box predictions to 3D cubes via clustering (adaption of non-maximum surpression).
 	      (external function: apply_2d_3d_merging_to_patient)
 
 	    Ground truth handling:
 	    - dissmisses any ground truth boxes returned by the model (happens in validation mode, patch-based groundtruth)
 	    - if provided by data loader, adds patient-wise ground truth to the final predictions to be passed to the evaluator.
     """
     def __init__(self, cf, net, logger, mode):
 
         self.cf = cf
         self.batch_size = cf.batch_size
         self.logger = logger
         self.mode = mode
         self.net = net
         self.n_ens = 1
         self.rank_ix = '0'
         self.regress_flag = any(['regression' in task for task in self.cf.prediction_tasks])
 
         if self.cf.merge_2D_to_3D_preds:
             assert self.cf.dim == 2, "Merge 2Dto3D only valid for 2D preds, but current dim is {}.".format(self.cf.dim)
 
         if self.mode == 'test':
             last_state_path = os.path.join(self.cf.fold_dir, 'last_state.pth')
             try:
                 self.model_index = torch.load(last_state_path)["model_index"]
                 self.model_index = self.model_index[self.model_index["rank"] <= self.cf.test_n_epochs]
             except FileNotFoundError:
                 raise FileNotFoundError('no last_state/model_index file in fold directory. '
                                    'seems like you are trying to run testing without prior training...')
             self.n_ens = cf.test_n_epochs
             if self.cf.test_aug_axes is not None:
                 self.n_ens *= (len(self.cf.test_aug_axes)+1)
             self.example_plot_dir = os.path.join(cf.test_dir, "example_plots")
             os.makedirs(self.example_plot_dir, exist_ok=True)
 
     def batch_tiling_forward(self, batch):
         """
         calls the actual network forward method. in patch-based prediction, the batch dimension might be overladed
         with n_patches >> batch_size, which would exceed gpu memory. In this case, batches are processed in chunks of
         batch_size. validation mode calls the train method to monitor losses (returned ground truth objects are discarded).
         test mode calls the test forward method, no ground truth required / involved.
         :return. results_dict: stores the results for one patient. dictionary with keys:
                  - 'boxes': list over batch elements. each element is a list over boxes, where each box is
                             one dictionary: [[box_0, ...], [box_n,...]]. batch elements are slices for 2D predictions,
                             and a dummy batch dimension of 1 for 3D predictions.
                  - 'seg_preds': pixel-wise predictions. (b, 1, y, x, (z))
                  - loss / class_loss (only in validation mode)
         """
 
         img = batch['data']
 
         if img.shape[0] <= self.batch_size:
 
             if self.mode == 'val':
                 # call training method to monitor losses
                 results_dict = self.net.train_forward(batch, is_validation=True)
                 # discard returned ground-truth boxes (also training info boxes).
                 results_dict['boxes'] = [[box for box in b if box['box_type'] == 'det'] for b in results_dict['boxes']]
             elif self.mode == 'test':
                 results_dict = self.net.test_forward(batch, return_masks=self.cf.return_masks_in_test)
 
         else: # needs batch tiling
             split_ixs = np.split(np.arange(img.shape[0]), np.arange(img.shape[0])[::self.batch_size])
             chunk_dicts = []
             for chunk_ixs in split_ixs[1:]:  # first split is elements before 0, so empty
                 b = {k: batch[k][chunk_ixs] for k in batch.keys()
                      if (isinstance(batch[k], np.ndarray) and batch[k].shape[0] == img.shape[0])}
                 if self.mode == 'val':
                     chunk_dicts += [self.net.train_forward(b, is_validation=True)]
                 else:
                     chunk_dicts += [self.net.test_forward(b, return_masks=self.cf.return_masks_in_test)]
 
             results_dict = {}
             # flatten out batch elements from chunks ([chunk, chunk] -> [b, b, b, b, ...])
             results_dict['boxes'] = [item for d in chunk_dicts for item in d['boxes']]
             results_dict['seg_preds'] = np.array([item for d in chunk_dicts for item in d['seg_preds']])
 
             if self.mode == 'val':
                 # if hasattr(self.cf, "losses_to_monitor"):
                 #     loss_names = self.cf.losses_to_monitor
                 # else:
                 #     loss_names = {name for dic in chunk_dicts for name in dic if 'loss' in name}
                 # estimate patient loss by mean over batch_chunks. Most similar to training loss.
                 results_dict['torch_loss'] = torch.mean(torch.cat([d['torch_loss'] for d in chunk_dicts]))
                 results_dict['class_loss'] = np.mean([d['class_loss'] for d in chunk_dicts])
                 # discard returned ground-truth boxes (also training info boxes).
                 results_dict['boxes'] = [[box for box in b if box['box_type'] == 'det'] for b in results_dict['boxes']]
 
         return results_dict
 
     def spatial_tiling_forward(self, batch, patch_crops = None, n_aug='0'):
         """
         forwards batch to batch_tiling_forward method and receives and returns a dictionary with results.
         if patch-based prediction, the results received from batch_tiling_forward will be on a per-patch-basis.
         this method uses the provided patch_crops to re-transform all predictions to whole-image coordinates.
         Patch-origin information of all box-predictions will be needed for consolidation, hence it is stored as
         'patch_id', which is a unique string for each patch (also takes current data aug and temporal epoch instances
         into account). all box predictions get additional information about the amount overlapping patches at the
         respective position (used for consolidation).
         :return. results_dict: stores the results for one patient. dictionary with keys:
                  - 'boxes': list over batch elements. each element is a list over boxes, where each box is
                             one dictionary: [[box_0, ...], [box_n,...]]. batch elements are slices for 2D predictions,
                             and a dummy batch dimension of 1 for 3D predictions.
                  - 'seg_preds': pixel-wise predictions. (b, 1, y, x, (z))
                  - monitor_values (only in validation mode)
         returned dict is a flattened version with 1 batch instance (3D) or slices (2D)
         """
 
         if patch_crops is not None:
             #print("patch_crops not None, applying patch center factor")
 
             patches_dict = self.batch_tiling_forward(batch)
             results_dict = {'boxes': [[] for _ in range(batch['original_img_shape'][0])]}
             #bc of ohe--> channel dim of seg has size num_classes
             out_seg_shape = list(batch['original_img_shape'])
             out_seg_shape[1] = patches_dict["seg_preds"].shape[1]
             out_seg_preds = np.zeros(out_seg_shape, dtype=np.float16)
             patch_overlap_map = np.zeros_like(out_seg_preds, dtype='uint8')
             for pix, pc in enumerate(patch_crops):
                 if self.cf.dim == 3:
                     out_seg_preds[:, :, pc[0]:pc[1], pc[2]:pc[3], pc[4]:pc[5]] += patches_dict['seg_preds'][pix]
                     patch_overlap_map[:, :, pc[0]:pc[1], pc[2]:pc[3], pc[4]:pc[5]] += 1
                 elif self.cf.dim == 2:
                     out_seg_preds[pc[4]:pc[5], :, pc[0]:pc[1], pc[2]:pc[3], ] += patches_dict['seg_preds'][pix]
                     patch_overlap_map[pc[4]:pc[5], :, pc[0]:pc[1], pc[2]:pc[3], ] += 1
 
             out_seg_preds[patch_overlap_map > 0] /= patch_overlap_map[patch_overlap_map > 0]
             results_dict['seg_preds'] = out_seg_preds
 
             for pix, pc in enumerate(patch_crops):
                 patch_boxes = patches_dict['boxes'][pix]
                 for box in patch_boxes:
 
                     # add unique patch id for consolidation of predictions.
                     box['patch_id'] = self.rank_ix + '_' + n_aug + '_' + str(pix)
                     # boxes from the edges of a patch have a lower prediction quality, than the ones at patch-centers.
                     # hence they will be down-weighted for consolidation, using the 'box_patch_center_factor', which is
                     # obtained by a gaussian distribution over positions in the patch and average over spatial dimensions.
                     # Also the info 'box_n_overlaps' is stored for consolidation, which represents the amount of
                     # overlapping patches at the box's position.
 
                     c = box['box_coords']
                     #box_centers = np.array([(c[ii] + c[ii+2])/2 for ii in range(len(c)//2)])
                     box_centers = [(c[ii] + c[ii + 2]) / 2 for ii in range(2)]
                     if self.cf.dim == 3:
                         box_centers.append((c[4] + c[5]) / 2)
                     box['box_patch_center_factor'] = np.mean(
                         [norm.pdf(bc, loc=pc, scale=pc * 0.8) * np.sqrt(2 * np.pi) * pc * 0.8 for bc, pc in
                          zip(box_centers, np.array(self.cf.patch_size) / 2)])
                     if self.cf.dim == 3:
                         c += np.array([pc[0], pc[2], pc[0], pc[2], pc[4], pc[4]])
                         int_c = [int(np.floor(ii)) if ix%2 == 0 else int(np.ceil(ii))  for ix, ii in enumerate(c)]
                         box['box_n_overlaps'] = np.mean(patch_overlap_map[:, :, int_c[1]:int_c[3], int_c[0]:int_c[2], int_c[4]:int_c[5]])
                         results_dict['boxes'][0].append(box)
                     else:
                         c += np.array([pc[0], pc[2], pc[0], pc[2]])
                         int_c = [int(np.floor(ii)) if ix % 2 == 0 else int(np.ceil(ii)) for ix, ii in enumerate(c)]
                         box['box_n_overlaps'] = np.mean(
                             patch_overlap_map[pc[4], :, int_c[1]:int_c[3], int_c[0]:int_c[2]])
                         results_dict['boxes'][pc[4]].append(box)
 
             if self.mode == 'val':
                 results_dict['torch_loss'] = patches_dict['torch_loss']
                 results_dict['class_loss'] = patches_dict['class_loss']
 
         else:
             results_dict = self.batch_tiling_forward(batch)
             for b in results_dict['boxes']:
                 for box in b:
                     box['box_patch_center_factor'] = 1
                     box['box_n_overlaps'] = 1
                     box['patch_id'] = self.rank_ix + '_' + n_aug
 
         return results_dict
 
     def data_aug_forward(self, batch):
         """
         in val_mode: passes batch through to spatial_tiling method without data_aug.
         in test_mode: if cf.test_aug is set in configs, createst 4 mirrored versions of the input image,
         passes all of them to the next processing step (spatial_tiling method) and re-transforms returned predictions
         to original image version.
         :return. results_dict: stores the results for one patient. dictionary with keys:
                  - 'boxes': list over batch elements. each element is a list over boxes, where each box is
                             one dictionary: [[box_0, ...], [box_n,...]]. batch elements are slices for 2D predictions,
                             and a dummy batch dimension of 1 for 3D predictions.
                  - 'seg_preds': pixel-wise predictions. (b, 1, y, x, (z))
                  - loss / class_loss (only in validation mode)
         """
         patch_crops = batch['patch_crop_coords'] if self.patched_patient else None
         results_list = [self.spatial_tiling_forward(batch, patch_crops)]
         org_img_shape = batch['original_img_shape']
 
         if self.mode == 'test' and self.cf.test_aug_axes is not None:
             if isinstance(self.cf.test_aug_axes, (int, float)):
                 self.cf.test_aug_axes = (self.cf.test_aug_axes,)
             #assert np.all(np.array(self.cf.test_aug_axes)<self.cf.dim), "test axes {} need to be spatial axes".format(self.cf.test_aug_axes)
 
             if self.patched_patient:
                 # apply mirror transformations to patch-crop coordinates, for correct tiling in spatial_tiling method.
                 mirrored_patch_crops = get_mirrored_patch_crops_ax_dep(patch_crops, batch['original_img_shape'],
                                                                        self.cf.test_aug_axes)
                 self.logger.info("mirrored patch crop coords for patched patient in test augs!")
             else:
                 mirrored_patch_crops = [None] * 3
 
             img = np.copy(batch['data'])
 
             for n_aug, sp_axis in enumerate(self.cf.test_aug_axes):
                 #sp_axis = np.array(axis) #-2 #spatial axis index
                 axis = np.array(sp_axis)+2
                 if isinstance(sp_axis, (int, float)):
                     # mirroring along one axis at a time
                     batch['data'] = np.flip(img, axis=axis).copy()
                     chunk_dict = self.spatial_tiling_forward(batch, mirrored_patch_crops[n_aug], n_aug=str(n_aug))
                     # re-transform coordinates.
                     for ix in range(len(chunk_dict['boxes'])):
                         for boxix in range(len(chunk_dict['boxes'][ix])):
                             coords = chunk_dict['boxes'][ix][boxix]['box_coords'].copy()
                             coords[sp_axis] = org_img_shape[axis] - chunk_dict['boxes'][ix][boxix]['box_coords'][sp_axis+2]
                             coords[sp_axis+2] = org_img_shape[axis] - chunk_dict['boxes'][ix][boxix]['box_coords'][sp_axis]
                             assert coords[2] >= coords[0], [coords, chunk_dict['boxes'][ix][boxix]['box_coords']]
                             assert coords[3] >= coords[1], [coords, chunk_dict['boxes'][ix][boxix]['box_coords']]
                             chunk_dict['boxes'][ix][boxix]['box_coords'] = coords
                     # re-transform segmentation predictions.
                     chunk_dict['seg_preds'] = np.flip(chunk_dict['seg_preds'], axis=axis)
 
                 elif hasattr(sp_axis, "__iter__") and tuple(sp_axis)==(0,1) or tuple(sp_axis)==(1,0):
                     #NEED: mirrored patch crops are given as [(y-axis), (x-axis), (y-,x-axis)], obey this order!
                     # mirroring along two axes at same time
                     batch['data'] = np.flip(np.flip(img, axis=axis[0]), axis=axis[1]).copy()
                     chunk_dict = self.spatial_tiling_forward(batch, mirrored_patch_crops[n_aug], n_aug=str(n_aug))
                     # re-transform coordinates.
                     for ix in range(len(chunk_dict['boxes'])):
                         for boxix in range(len(chunk_dict['boxes'][ix])):
                             coords = chunk_dict['boxes'][ix][boxix]['box_coords'].copy()
                             coords[sp_axis[0]] = org_img_shape[axis[0]] - chunk_dict['boxes'][ix][boxix]['box_coords'][sp_axis[0]+2]
                             coords[sp_axis[0]+2] = org_img_shape[axis[0]] - chunk_dict['boxes'][ix][boxix]['box_coords'][sp_axis[0]]
                             coords[sp_axis[1]] = org_img_shape[axis[1]] - chunk_dict['boxes'][ix][boxix]['box_coords'][sp_axis[1]+2]
                             coords[sp_axis[1]+2] = org_img_shape[axis[1]] - chunk_dict['boxes'][ix][boxix]['box_coords'][sp_axis[1]]
                             assert coords[2] >= coords[0], [coords, chunk_dict['boxes'][ix][boxix]['box_coords']]
                             assert coords[3] >= coords[1], [coords, chunk_dict['boxes'][ix][boxix]['box_coords']]
                             chunk_dict['boxes'][ix][boxix]['box_coords'] = coords
                     # re-transform segmentation predictions.
                     chunk_dict['seg_preds'] = np.flip(np.flip(chunk_dict['seg_preds'], axis=axis[0]), axis=axis[1]).copy()
 
                 else:
                     raise Exception("Invalid axis type {} in test augs".format(type(axis)))
                 results_list.append(chunk_dict)
 
             batch['data'] = img
 
         # aggregate all boxes/seg_preds per batch element from data_aug predictions.
         results_dict = {}
         results_dict['boxes'] = [[item for d in results_list for item in d['boxes'][batch_instance]]
                                  for batch_instance in range(org_img_shape[0])]
         # results_dict['seg_preds'] = np.array([[item for d in results_list for item in d['seg_preds'][batch_instance]]
         #                                       for batch_instance in range(org_img_shape[0])])
         results_dict['seg_preds'] = np.stack([dic['seg_preds'] for dic in results_list], axis=1)
         # needs segs probs in seg_preds entry:
         results_dict['seg_preds'] = np.sum(results_dict['seg_preds'], axis=1) #add up seg probs from different augs per class
 
         if self.mode == 'val':
             results_dict['torch_loss'] = results_list[0]['torch_loss']
             results_dict['class_loss'] = results_list[0]['class_loss']
 
         return results_dict
 
     def load_saved_predictions(self):
         """loads raw predictions saved by self.predict_test_set. aggregates and/or merges 2D boxes to 3D cubes for
             evaluation (if model predicts 2D but evaluation is run in 3D), according to settings config.
         :return: list_of_results_per_patient: list over patient results. each entry is a dict with keys:
             - 'boxes': list over batch elements. each element is a list over boxes, where each box is
                        one dictionary: [[box_0, ...], [box_n,...]]. batch elements are slices for 2D predictions
                        (if not merged to 3D), and a dummy batch dimension of 1 for 3D predictions.
             - 'batch_dices': dice scores as recorded in raw prediction results.
             - 'seg_preds': not implemented yet. could replace dices by seg preds to have raw seg info available, however
                 would consume critically large memory amount. todo evaluation of instance/semantic segmentation.
         """
 
         results_file = 'pred_results.pkl' if not self.cf.held_out_test_set else 'pred_results_held_out.pkl'
         if not self.cf.held_out_test_set or self.cf.eval_test_fold_wise:
             self.logger.info("loading saved predictions of fold {}".format(self.cf.fold))
             with open(os.path.join(self.cf.fold_dir, results_file), 'rb') as handle:
                 results_list = pickle.load(handle)
             box_results_list = [(res_dict["boxes"], pid) for res_dict, pid in results_list]
 
             da_factor = len(self.cf.test_aug_axes)+1 if self.cf.test_aug_axes is not None else 1
             self.n_ens = self.cf.test_n_epochs * da_factor
             self.logger.info('loaded raw test set predictions with n_patients = {} and n_ens = {}'.format(
                 len(results_list), self.n_ens))
         else:
             self.logger.info("loading saved predictions of hold-out test set")
             fold_dirs = sorted([os.path.join(self.cf.exp_dir, f) for f in os.listdir(self.cf.exp_dir) if
                                 os.path.isdir(os.path.join(self.cf.exp_dir, f)) and f.startswith("fold")])
 
             results_list = []
             folds_loaded = 0
             for fold in range(self.cf.n_cv_splits):
                 fold_dir = os.path.join(self.cf.exp_dir, 'fold_{}'.format(fold))
                 if fold_dir in fold_dirs:
                     with open(os.path.join(fold_dir, results_file), 'rb') as handle:
                         fold_list = pickle.load(handle)
                         results_list += fold_list
                         folds_loaded += 1
                 else:
                     self.logger.info("Skipping fold {} since no saved predictions found.".format(fold))
             box_results_list = []
             for res_dict, pid in results_list: #without filtering gt out:
                 box_results_list.append((res_dict['boxes'], pid))
                 #it's usually not right to filter out gts here, is it?
 
             da_factor = len(self.cf.test_aug_axes)+1 if self.cf.test_aug_axes is not None else 1
             self.n_ens = self.cf.test_n_epochs * da_factor * folds_loaded
 
         # -------------- aggregation of boxes via clustering -----------------
 
         if self.cf.clustering == "wbc":
             self.logger.info('applying WBC to test-set predictions with iou {} and n_ens {} over {} patients'.format(
                 self.cf.clustering_iou, self.n_ens, len(box_results_list)))
 
             mp_inputs = [[self.regress_flag, ii[0], ii[1], self.cf.class_dict, self.cf.clustering_iou, self.n_ens] for ii
                          in box_results_list]
             del box_results_list
             pool = Pool(processes=self.cf.n_workers)
             box_results_list = pool.map(apply_wbc_to_patient, mp_inputs, chunksize=1)
             pool.close()
             pool.join()
             del mp_inputs
         elif self.cf.clustering == "nms":
             self.logger.info('applying standard NMS to test-set predictions with iou {} over {} patients.'.format(
                 self.cf.clustering_iou, len(box_results_list)))
             pool = Pool(processes=self.cf.n_workers)
             mp_inputs = [[ii[0], ii[1], self.cf.class_dict, self.cf.clustering_iou] for ii in box_results_list]
             del box_results_list
             box_results_list = pool.map(apply_nms_to_patient, mp_inputs, chunksize=1)
             pool.close()
             pool.join()
             del mp_inputs
 
         if self.cf.merge_2D_to_3D_preds:
             self.logger.info('applying 2Dto3D merging to test-set predictions with iou = {}.'.format(self.cf.merge_3D_iou))
             pool = Pool(processes=self.cf.n_workers)
             mp_inputs = [[ii[0], ii[1], self.cf.class_dict, self.cf.merge_3D_iou] for ii in box_results_list]
             box_results_list = pool.map(apply_2d_3d_merging_to_patient, mp_inputs, chunksize=1)
             pool.close()
             pool.join()
             del mp_inputs
 
         for ix in range(len(results_list)):
             assert np.all(results_list[ix][1] == box_results_list[ix][1]), "pid mismatch between loaded and aggregated results"
             results_list[ix][0]["boxes"] = box_results_list[ix][0]
 
         return results_list # holds (results_dict, pid)
 
     def predict_patient(self, batch):
         """
         predicts one patient.
         called either directly via loop over validation set in exec.py (mode=='val')
         or from self.predict_test_set (mode=='test).
         in val mode:  adds 3D ground truth info to predictions and runs consolidation and 2Dto3D merging of predictions.
         in test mode: returns raw predictions (ground truth addition, consolidation, 2D to 3D merging are
                       done in self.predict_test_set, because patient predictions across several epochs might be needed
                       to be collected first, in case of temporal ensembling).
         :return. results_dict: stores the results for one patient. dictionary with keys:
                  - 'boxes': list over batch elements. each element is a list over boxes, where each box is
                             one dictionary: [[box_0, ...], [box_n,...]]. batch elements are slices for 2D predictions
                             (if not merged to 3D), and a dummy batch dimension of 1 for 3D predictions.
                  - 'seg_preds': pixel-wise predictions. (b, 1, y, x, (z))
                  - loss / class_loss (only in validation mode)
         """
-        if self.mode=="test":
-            self.logger.info('predicting patient {} for fold {} '.format(np.unique(batch['pid']), self.cf.fold))
+        #if self.mode=="test":
+        #    self.logger.info('predicting patient {} for fold {} '.format(np.unique(batch['pid']), self.cf.fold))
 
         # True if patient is provided in patches and predictions need to be tiled.
         self.patched_patient = 'patch_crop_coords' in list(batch.keys())
 
         # forward batch through prediction pipeline.
         results_dict = self.data_aug_forward(batch)
         #has seg probs in entry 'seg_preds'
 
         if self.mode == 'val':
             for b in range(batch['patient_bb_target'].shape[0]):
                 for t in range(len(batch['patient_bb_target'][b])):
                     gt_box = {'box_type': 'gt', 'box_coords': batch['patient_bb_target'][b][t],
                               'class_targets': batch['patient_class_targets'][b][t]}
                     for name in self.cf.roi_items:
                         gt_box.update({name : batch['patient_'+name][b][t]})
                     results_dict['boxes'][b].append(gt_box)
 
             if 'dice' in self.cf.metrics:
                 if self.patched_patient:
                     assert 'patient_seg' in batch.keys(), "Results_dict preds are in original patient shape."
                 results_dict['batch_dices'] = mutils.dice_per_batch_and_class(
                     results_dict['seg_preds'], batch["patient_seg"] if self.patched_patient else batch['seg'],
                     self.cf.num_seg_classes, convert_to_ohe=True)
             if self.patched_patient and self.cf.clustering == "wbc":
                 wbc_input = [self.regress_flag, results_dict['boxes'], 'dummy_pid', self.cf.class_dict, self.cf.clustering_iou, self.n_ens]
                 results_dict['boxes'] = apply_wbc_to_patient(wbc_input)[0]
             elif self.patched_patient:
                 nms_inputs = [results_dict['boxes'], 'dummy_pid', self.cf.class_dict, self.cf.clustering_iou]
                 results_dict['boxes'] = apply_nms_to_patient(nms_inputs)[0]
 
             if self.cf.merge_2D_to_3D_preds:
                 results_dict['2D_boxes'] = results_dict['boxes']
                 merge_dims_inputs = [results_dict['boxes'], 'dummy_pid', self.cf.class_dict, self.cf.merge_3D_iou]
                 results_dict['boxes'] = apply_2d_3d_merging_to_patient(merge_dims_inputs)[0]
 
         return results_dict
 
     def predict_test_set(self, batch_gen, return_results=True):
         """
         wrapper around test method, which loads multiple (or one) epoch parameters (temporal ensembling), loops through
         the test set and collects predictions per patient. Also flattens the results per patient and epoch
         and adds optional ground truth boxes for evaluation. Saves out the raw result list for later analysis and
         optionally consolidates and returns predictions immediately.
         :return: (optionally) list_of_results_per_patient: list over patient results. each entry is a dict with keys:
                  - 'boxes': list over batch elements. each element is a list over boxes, where each box is
                             one dictionary: [[box_0, ...], [box_n,...]]. batch elements are slices for 2D predictions
                             (if not merged to 3D), and a dummy batch dimension of 1 for 3D predictions.
                  - 'seg_preds': not implemented yet. todo evaluation of instance/semantic segmentation.
         """
 
         # -------------- raw predicting -----------------
         dict_of_patients_results = OrderedDict()
         set_of_result_types = set()
 
         self.model_index = self.model_index.sort_values(by="rank")
         # get paths of all parameter sets to be loaded for temporal ensembling. (or just one for no temp. ensembling).
         weight_paths = [os.path.join(self.cf.fold_dir, file_name) for file_name in self.model_index["file_name"]]
 
 
         for rank_ix, weight_path in enumerate(weight_paths):
             self.logger.info(('tmp ensembling over rank_ix:{} epoch:{}'.format(rank_ix, weight_path)))
             self.net.load_state_dict(torch.load(weight_path))
             self.net.eval()
             self.rank_ix = str(rank_ix)
             with torch.no_grad():
                 plot_batches = np.random.choice(np.arange(batch_gen['n_test']), size=self.cf.n_test_plots, replace=False)
                 for i in range(batch_gen['n_test']):
                     batch = next(batch_gen['test'])
                     pid = np.unique(batch['pid'])
                     assert len(pid)==1
                     pid = pid[0]
 
                     if not pid in dict_of_patients_results.keys():  # store batch info in patient entry of results dict.
                         dict_of_patients_results[pid] = {}
                         dict_of_patients_results[pid]['results_dicts'] = []
                         dict_of_patients_results[pid]['patient_bb_target'] = batch['patient_bb_target']
 
                         for name in self.cf.roi_items:
                             dict_of_patients_results[pid]["patient_"+name] = batch["patient_"+name]
                     stime = time.time()
                     results_dict = self.predict_patient(batch) #only holds "boxes", "seg_preds"
                     # needs ohe seg probs in seg_preds entry:
                     results_dict['seg_preds'] = np.argmax(results_dict['seg_preds'], axis=1)[:,np.newaxis]
                     self.logger.info("predicting patient {} with weight rank {} (progress: {}/{}) took {:.2f}s".format(
                         str(pid), rank_ix, (rank_ix)*batch_gen['n_test']+(i+1), len(weight_paths)*batch_gen['n_test'], time.time()-stime))
 
                     if i in plot_batches and (not self.patched_patient or 'patient_data' in batch.keys()):
                         try:
                             # view qualitative results of random test case
                             self.logger.time("test_plot")
                             out_file = os.path.join(self.example_plot_dir,
                                                     'batch_example_test_{}_rank_{}.png'.format(self.cf.fold, rank_ix))
                             utils.split_off_process(plg.view_batch, self.cf, batch, results_dict,
                                                     has_colorchannels=self.cf.has_colorchannels,
                                                     show_gt_labels=True, show_seg_ids='dice' in self.cf.metrics,
                                                     get_time="test-example plot", out_file=out_file)
-                            self.logger.info("split-off example test plot {} in {:.2f}s".format(
-                                os.path.basename(out_file), self.logger.time("test_plot")))
                         except Exception as e:
                             self.logger.info("WARNING: error in view_batch: {}".format(e))
 
                     if 'dice' in self.cf.metrics:
                         if self.patched_patient:
                             assert 'patient_seg' in batch.keys(), "Results_dict preds are in original patient shape."
                         results_dict['batch_dices'] = mutils.dice_per_batch_and_class( results_dict['seg_preds'],
                                 batch["patient_seg"] if self.patched_patient else batch['seg'],
                                 self.cf.num_seg_classes, convert_to_ohe=True)
 
                     dict_of_patients_results[pid]['results_dicts'].append({k:v for k,v in results_dict.items()
                                                                            if k in ["boxes", "batch_dices"]})
                     # collect result types to know which ones to look for when saving
                     set_of_result_types.update(dict_of_patients_results[pid]['results_dicts'][-1].keys())
 
 
 
         # -------------- re-order, save raw results -----------------
         self.logger.info('finished predicting test set. starting aggregation of predictions.')
         results_per_patient = []
         for pid, p_dict in dict_of_patients_results.items():
         # dict_of_patients_results[pid]['results_list'] has length batch['n_test']
 
             results_dict = {}
             # collect all boxes/seg_preds of same batch_instance over temporal instances.
             b_size = len(p_dict['results_dicts'][0]["boxes"])
             for res_type in [rtype for rtype in set_of_result_types if rtype in ["boxes", "batch_dices"]]:#, "seg_preds"]]:
                 if not 'batch' in res_type: #assume it's results on batch-element basis
                     results_dict[res_type] = [[item for rank_dict in p_dict['results_dicts'] for item in rank_dict[res_type][batch_instance]]
                                              for batch_instance in range(b_size)]
                 else:
                     results_dict[res_type] = []
                     for dict in p_dict['results_dicts']:
                         if 'dice' in res_type:
                             item = dict[res_type] #dict['batch_dices'] has shape (num_seg_classes,)
                             assert len(item) == self.cf.num_seg_classes, \
                                 "{}, {}".format(len(item), self.cf.num_seg_classes)
                         else:
                             raise NotImplementedError
                         results_dict[res_type].append(item)
                     # rdict[dice] shape (n_rank_epochs (n_saved_ranks), nsegclasses)
                     # calc mean over test epochs so inline with shape from sampling
                     results_dict[res_type] = np.mean(results_dict[res_type], axis=0) #maybe error type with other than dice
 
             if not hasattr(self.cf, "eval_test_separately") or not self.cf.eval_test_separately:
                 # add unpatched 2D or 3D (if dim==3 or merge_2D_to_3D) ground truth boxes for evaluation.
                 for b in range(p_dict['patient_bb_target'].shape[0]):
                     for targ in range(len(p_dict['patient_bb_target'][b])):
                         gt_box = {'box_type': 'gt', 'box_coords':p_dict['patient_bb_target'][b][targ],
                                   'class_targets': p_dict['patient_class_targets'][b][targ]}
                         for name in self.cf.roi_items:
                             gt_box.update({name: p_dict["patient_"+name][b][targ]})
                         results_dict['boxes'][b].append(gt_box)
 
             results_per_patient.append([results_dict, pid])
 
         out_string = 'pred_results_held_out' if self.cf.held_out_test_set else 'pred_results'
         with open(os.path.join(self.cf.fold_dir, '{}.pkl'.format(out_string)), 'wb') as handle:
             pickle.dump(results_per_patient, handle)
 
         if return_results:
             # -------------- results processing, clustering, etc. -----------------
             final_patient_box_results = [ (res_dict["boxes"], pid) for res_dict,pid in results_per_patient ]
             if self.cf.clustering == "wbc":
                 self.logger.info('applying WBC to test-set predictions with iou = {} and n_ens = {}.'.format(
                     self.cf.clustering_iou, self.n_ens))
                 mp_inputs = [[self.regress_flag, ii[0], ii[1], self.cf.class_dict, self.cf.clustering_iou, self.n_ens] for ii in final_patient_box_results]
                 del final_patient_box_results
                 pool = Pool(processes=self.cf.n_workers)
                 final_patient_box_results = pool.map(apply_wbc_to_patient, mp_inputs, chunksize=1)
                 pool.close()
                 pool.join()
                 del mp_inputs
             elif self.cf.clustering == "nms":
                 self.logger.info('applying standard NMS to test-set predictions with iou = {}.'.format(self.cf.clustering_iou))
                 pool = Pool(processes=self.cf.n_workers)
                 mp_inputs = [[ii[0], ii[1], self.cf.class_dict, self.cf.clustering_iou] for ii in final_patient_box_results]
                 del final_patient_box_results
                 final_patient_box_results = pool.map(apply_nms_to_patient, mp_inputs, chunksize=1)
                 pool.close()
                 pool.join()
                 del mp_inputs
 
             if self.cf.merge_2D_to_3D_preds:
                 self.logger.info('applying 2D-to-3D merging to test-set predictions with iou = {}.'.format(self.cf.merge_3D_iou))
                 mp_inputs = [[ii[0], ii[1], self.cf.class_dict, self.cf.merge_3D_iou] for ii in final_patient_box_results]
                 del final_patient_box_results
                 pool = Pool(processes=self.cf.n_workers)
                 final_patient_box_results = pool.map(apply_2d_3d_merging_to_patient, mp_inputs, chunksize=1)
                 pool.close()
                 pool.join()
                 del mp_inputs
             # final_patient_box_results holds [avg_boxes, pid] if wbc
             for ix in range(len(results_per_patient)):
                 assert results_per_patient[ix][1] == final_patient_box_results[ix][1], "should be same pid"
                 results_per_patient[ix][0]["boxes"] = final_patient_box_results[ix][0]
             # results_per_patient = [(res_dict["boxes"] = boxes, pid) for (boxes,pid) in final_patient_box_results]
 
             return results_per_patient # holds list of (results_dict, pid)
diff --git a/shell_scripts/cluster_runner_meddec.sh b/shell_scripts/cluster_runner_meddec.sh
index d884226..0cee463 100644
--- a/shell_scripts/cluster_runner_meddec.sh
+++ b/shell_scripts/cluster_runner_meddec.sh
@@ -1,65 +1,64 @@
 #!/bin/bash
 
 #Usage:
 # -->not true?: this script has to be started from the same directory the python files called below lie in (e.g. exec.py lies in meddetectiontkit).
 # part of the slurm-job name you pass to sbatch will be the experiment folder's name.
 # you need to pass 3 positional arguments to this script (cluster_runner_..sh #1 #2 #3):
 # -#1 source directory in which main source code (framework) is located (e.g. medicaldetectiontoolkit/)
 # -#2 the exp_dir where job-specific code was copied before by create_exp and exp results are safed by exec.py
 # -#3 absolute path to dataset-specific code in source dir
 # -#4 mode to run
 # -#5 folds to run on
 
 source_dir=${1}
 exp_dir=${2}
 dataset_abs_path=${3}
 mode=${4}
 folds=${5}
 resume=$6
 
 #known problem: trap somehow does not execute the rm -r tmp_dir command when using scancel on job
 #trap clean_up EXIT KILL TERM ABRT QUIT
 
 job_dir=/ssd/ramien/${LSB_JOBID}
 
 tmp_dir_data=${job_dir}/data
 mkdir $tmp_dir_data
 
 tmp_dir_cache=${job_dir}/cache
 mkdir $tmp_dir_cache
 CUDA_CACHE_PATH=$tmp_dir_cache
 export CUDA_CACHE_PATH
 
 
 #data must not lie permantly on nodes' ssd, only during training time
 #needs to be named with the SLURM_JOB_ID to not be automatically removed
 #can permanently lie on /datasets drive --> copy from there before every experiment
 #files on datasets are saved as npz (compressed) --> use data_manager.py to copy and unpack into .npy; is done implicitly in exec.py
 
 #(tensorboard --logdir ${exp_dir}/.. --port 1337 || echo "tboard startup failed")& # || tensorboard --logdir ${exp_dir}/.. --port 1338)&
 #tboard_pid=$!
 
 #clean_up() {
 #	rm -rf ${job_dir};
 #}
 
 export OMP_NUM_THREADS=1 # this is a work-around fix for batchgenerators to deal with numpy-inherent multi-threading.
 
+launch_opts=${source_dir}/exec.py --use_stored_settings --server_env --dataset_name ${dataset_abs_path} --data_dest ${tmp_dir_data} --exp_dir ${exp_dir} --mode ${mode}
+
+if [ ! -z "${resume}" ]; then
+  launch_opts=${launch_opts} --resume
+  echo "Resuming from checkpoint(s)."
+fi
+
 if [ ! -z "${folds}" ]; then
-	if [ -z "${resume}" ]; then
-		resume='None'
-	else
-		resume=${exp_dir}"/fold_${folds}/last_state.pth"
-		echo "Resuming from checkpoint at ${resume}."
-	fi
-	python ${source_dir}/exec.py --use_stored_settings --server_env --dataset_name ${dataset_abs_path} --data_dest ${tmp_dir_data} --exp_dir ${exp_dir} --mode ${mode} --folds ${folds} --resume_from_checkpoint ${resume}
-	
-else
-	python ${source_dir}/exec.py --use_stored_settings --server_env --dataset_name ${dataset_abs_path} --data_dest ${tmp_dir_data} --exp_dir ${exp_dir} --mode ${mode}
-	
+  launch_opts=${launch_opts} --folds ${folds}
 fi
 
+python ${launch_opts}
+
 
 
 
 
diff --git a/unittests.py b/unittests.py
index 2811c00..80726a8 100644
--- a/unittests.py
+++ b/unittests.py
@@ -1,623 +1,625 @@
 #!/usr/bin/env python
 # Copyright 2019 Division of Medical Image Computing, German Cancer Research Center (DKFZ).
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
 # You may obtain a copy of the License at
 #
 #     http://www.apache.org/licenses/LICENSE-2.0
 #
 # Unless required by applicable law or agreed to in writing, software
 # distributed under the License is distributed on an "AS IS" BASIS,
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
 # ==============================================================================
 
 import unittest
 
 import os
 import pickle
 import time
 from multiprocessing import  Pool
 import subprocess
 from pathlib import Path
 
 import numpy as np
 import pandas as pd
 import torch
 import torchvision as tv
 
 import tqdm
 
 import plotting as plg
 import utils.exp_utils as utils
 import utils.model_utils as mutils
 
 """ Note on unittests: run this file either in the way intended for unittests by starting the script with
     python -m unittest unittests.py or start it as a normal python file as python unittests.py.
     You can selective run single tests by calling python -m unittest unittests.TestClassOfYourChoice, where 
     TestClassOfYourChoice is the name of the test defined below, e.g., CompareFoldSplits.
 """
 
 
 
 def inspect_info_df(pp_dir):
     """ use your debugger to look into the info df of a pp dir.
     :param pp_dir: preprocessed-data directory
     """
 
     info_df = pd.read_pickle(os.path.join(pp_dir, "info_df.pickle"))
 
     return
 
 
 def generate_boxes(count, dim=2, h=100, w=100, d=20, normalize=False, on_grid=False, seed=0):
     """ generate boxes of format [y1, x1, y2, x2, (z1, z2)].
     :param count: nr of boxes
     :param dim: dimension of boxes (2 or 3)
     :return: boxes in format (n_boxes, 4 or 6), scores
     """
     np.random.seed(seed)
     if on_grid:
         lower_y = np.random.randint(0, h // 2, (count,))
         lower_x = np.random.randint(0, w // 2, (count,))
         upper_y = np.random.randint(h // 2, h, (count,))
         upper_x = np.random.randint(w // 2, w, (count,))
         if dim == 3:
             lower_z = np.random.randint(0, d // 2, (count,))
             upper_z = np.random.randint(d // 2, d, (count,))
     else:
         lower_y = np.random.rand(count) * h / 2.
         lower_x = np.random.rand(count) * w / 2.
         upper_y = (np.random.rand(count) + 1.) * h / 2.
         upper_x = (np.random.rand(count) + 1.) * w / 2.
         if dim == 3:
             lower_z = np.random.rand(count) * d / 2.
             upper_z = (np.random.rand(count) + 1.) * d / 2.
 
     if dim == 3:
         boxes = np.array(list(zip(lower_y, lower_x, upper_y, upper_x, lower_z, upper_z)))
         # add an extreme box that tests the boundaries
         boxes = np.concatenate((boxes, np.array([[0., 0., h, w, 0, d]])))
     else:
         boxes = np.array(list(zip(lower_y, lower_x, upper_y, upper_x)))
         boxes = np.concatenate((boxes, np.array([[0., 0., h, w]])))
 
     scores = np.random.rand(count + 1)
     if normalize:
         divisor = np.array([h, w, h, w, d, d]) if dim == 3 else np.array([h, w, h, w])
         boxes = boxes / divisor
     return boxes, scores
 
 #------- perform integrity checks on data set(s) -----------
 class VerifyLIDCSAIntegrity(unittest.TestCase):
     """ Perform integrity checks on preprocessed single-annotator GTs of LIDC data set.
     """
     @staticmethod
     def check_patient_sa_gt(pid, pp_dir, check_meta_files, check_info_df):
 
         faulty_cases = pd.DataFrame(columns=['pid', 'rater', 'cl_targets', 'roi_ids'])
 
         all_segs = np.load(os.path.join(pp_dir, pid + "_rois.npz"), mmap_mode='r')
         all_segs = all_segs[list(all_segs.keys())[0]]
         all_roi_ids = np.unique(all_segs[all_segs > 0])
         assert len(all_roi_ids) == np.max(all_segs), "roi ids not consecutive"
         if check_meta_files:
             meta_file = os.path.join(pp_dir, pid + "_meta_info.pickle")
             with open(meta_file, "rb") as handle:
                 info = pickle.load(handle)
             assert info["pid"] == pid, "wrong pid in meta_file"
             all_cl_targets = info["class_target"]
         if check_info_df:
             info_df = pd.read_pickle(os.path.join(pp_dir, "info_df.pickle"))
             pid_info = info_df[info_df.pid == pid]
             assert len(pid_info) == 1, "found {} entries for pid {} in info df, expected exactly 1".format(len(pid_info),
                                                                                                            pid)
             if check_meta_files:
                 assert pid_info[
                            "class_target"] == all_cl_targets, "meta_info and info_df class targets mismatch:\n{}\n{}".format(
                     pid_info["class_target"], all_cl_targets)
             all_cl_targets = pid_info["class_target"].iloc[0]
         assert len(all_roi_ids) == len(all_cl_targets)
         for rater in range(4):
             seg = all_segs[rater]
             roi_ids = np.unique(seg[seg > 0])
             cl_targs = np.array([roi[rater] for roi in all_cl_targets])
             assert np.count_nonzero(cl_targs) == len(roi_ids), "rater {} has targs {} but roi ids {}".format(rater, cl_targs, roi_ids)
             assert len(cl_targs) >= len(roi_ids), "not all marked rois have a label"
             for zeroix_roi_id, rating in enumerate(cl_targs):
                 if not ((rating > 0) == (np.any(seg == zeroix_roi_id + 1))):
                     print("\n\nFAULTY CASE:", end=" ", )
                     print("pid {}, rater {}, cl_targs {}, ids {}\n".format(pid, rater, cl_targs, roi_ids))
                     faulty_cases = faulty_cases.append(
                         {'pid': pid, 'rater': rater, 'cl_targets': cl_targs, 'roi_ids': roi_ids}, ignore_index=True)
         print("finished checking pid {}, {} faulty cases".format(pid, len(faulty_cases)))
         return faulty_cases
 
     def check_sa_gts(cf, pp_dir, pid_subset=None, check_meta_files=False, check_info_df=True, processes=os.cpu_count()):
         report_name = "verify_seg_label_pairings.csv"
         pids = {file_name.split("_")[0] for file_name in os.listdir(pp_dir) if file_name not in [report_name, "info_df.pickle"]}
         if pid_subset is not None:
             pids = [pid for pid in pids if pid in pid_subset]
 
 
         faulty_cases = pd.DataFrame(columns=['pid', 'rater', 'cl_targets', 'roi_ids'])
 
         p = Pool(processes=processes)
         mp_args = zip(pids, [pp_dir]*len(pids), [check_meta_files]*len(pids), [check_info_df]*len(pids))
         patient_cases = p.starmap(self.check_patient_sa_gt, mp_args)
         p.close(); p.join()
         faulty_cases = faulty_cases.append(patient_cases, sort=False)
 
 
         print("\n\nfaulty case count {}".format(len(faulty_cases)))
         print(faulty_cases)
         findings_file = os.path.join(pp_dir, "verify_seg_label_pairings.csv")
         faulty_cases.to_csv(findings_file)
 
         assert len(faulty_cases)==0, "there was a faulty case in data set {}.\ncheck {}".format(pp_dir, findings_file)
 
     def test(self):
         pp_root = "/mnt/HDD2TB/Documents/data/"
         pp_dir = "lidc/pp_20190805"
         gt_dir = os.path.join(pp_root, pp_dir, "patient_gts_sa")
         self.check_sa_gts(gt_dir, check_meta_files=True, check_info_df=False, pid_subset=None)  # ["0811a", "0812a"])
 
 #------ compare segmentation gts of preprocessed data sets ------
 class CompareSegGTs(unittest.TestCase):
     """ load and compare pre-processed gts by dice scores of segmentations.
 
     """
     @staticmethod
     def group_seg_paths(ref_path, comp_paths):
         # not working recursively
         ref_files = [fn for fn in os.listdir(ref_path) if
                      os.path.isfile(os.path.join(ref_path, fn)) and 'seg' in fn and fn.endswith('.npy')]
 
         comp_files = [[os.path.join(c_path, fn) for c_path in comp_paths] for fn in ref_files]
 
         ref_files = [os.path.join(ref_path, fn) for fn in ref_files]
 
         return zip(ref_files, comp_files)
 
     @staticmethod
     def load_calc_dice(paths):
         dices = []
         ref_seg = np.load(paths[0])[np.newaxis, np.newaxis]
         n_classes = len(np.unique(ref_seg))
         ref_seg = mutils.get_one_hot_encoding(ref_seg, n_classes)
 
         for c_file in paths[1]:
             c_seg = np.load(c_file)[np.newaxis, np.newaxis]
             assert n_classes == len(np.unique(c_seg)), "unequal nr of objects/classes betw segs {} {}".format(paths[0],
                                                                                                               c_file)
             c_seg = mutils.get_one_hot_encoding(c_seg, n_classes)
 
             dice = mutils.dice_per_batch_inst_and_class(c_seg, ref_seg, n_classes, convert_to_ohe=False)
             dices.append(dice)
         print("processed ref_path {}".format(paths[0]))
         return np.mean(dices), np.std(dices)
 
     def iterate_files(self, grouped_paths, processes=os.cpu_count()):
         p = Pool(processes)
 
         means_stds = np.array(p.map(self.load_calc_dice, grouped_paths))
 
         p.close(); p.join()
         min_dice = np.min(means_stds[:, 0])
         print("min mean dice {:.2f}, max std {:.4f}".format(min_dice, np.max(means_stds[:, 1])))
         assert min_dice > 1-1e5, "compared seg gts have insufficient minimum mean dice overlap of {}".format(min_dice)
 
     def test(self):
         ref_path = '/mnt/HDD2TB/Documents/data/prostate/data_t2_250519_ps384_gs6071'
         comp_paths = ['/mnt/HDD2TB/Documents/data/prostate/data_t2_190419_ps384_gs6071', ]
         paths = self.group_seg_paths(ref_path, comp_paths)
         self.iterate_files(paths)
 
 #------- check if cross-validation fold splits of different experiments are identical ----------
 class CompareFoldSplits(unittest.TestCase):
     """ Find evtl. differences in cross-val file splits across different experiments.
     """
     @staticmethod
     def group_id_paths(ref_exp_dir, comp_exp_dirs):
 
         f_name = 'fold_ids.pickle'
 
         ref_paths = os.path.join(ref_exp_dir, f_name)
         assert os.path.isfile(ref_paths), "ref file {} does not exist.".format(ref_paths)
 
 
         ref_paths = [ref_paths for comp_ed in comp_exp_dirs]
         comp_paths = [os.path.join(comp_ed, f_name) for comp_ed in comp_exp_dirs]
 
         return zip(ref_paths, comp_paths)
 
     @staticmethod
     def comp_fold_ids(mp_input):
         fold_ids1, fold_ids2 = mp_input
         with open(fold_ids1, 'rb') as f:
             fold_ids1 = pickle.load(f)
         try:
             with open(fold_ids2, 'rb') as f:
                 fold_ids2 = pickle.load(f)
         except FileNotFoundError:
             print("comp file {} does not exist.".format(fold_ids2))
             return
 
         n_splits = len(fold_ids1)
         assert n_splits == len(fold_ids2), "mismatch n splits: ref has {}, comp {}".format(n_splits, len(fold_ids2))
         split_diffs = [np.setdiff1d(fold_ids1[s], fold_ids2[s]) for s in range(n_splits)]
         all_equal = np.any(split_diffs)
         return (split_diffs, all_equal)
 
     def iterate_exp_dirs(self, ref_exp, comp_exps, processes=os.cpu_count()):
 
         grouped_paths = list(self.group_id_paths(ref_exp, comp_exps))
         print("performing {} comparisons of cross-val file splits".format(len(grouped_paths)))
         p = Pool(processes)
         split_diffs = p.map(self.comp_fold_ids, grouped_paths)
         p.close(); p.join()
 
         df = pd.DataFrame(index=range(0,len(grouped_paths)), columns=["ref", "comp", "all_equal"])#, "diffs"])
         for ix, (ref, comp) in enumerate(grouped_paths):
             df.iloc[ix] = [ref, comp, split_diffs[ix][1]]#, split_diffs[ix][0]]
 
         print("Any splits not equal?", df.all_equal.any())
         assert not df.all_equal.any(), "a split set is different from reference split set, {}".format(df[~df.all_equal])
 
     def test(self):
         exp_parent_dir = '/home/gregor/networkdrives/E132-Cluster-Projects/prostate/experiments/'
         ref_exp = '/home/gregor/networkdrives/E132-Cluster-Projects/prostate/experiments/gs6071_detfpn2d_cl_bs10'
         comp_exps = [os.path.join(exp_parent_dir, p) for p in os.listdir(exp_parent_dir)]
         comp_exps = [p for p in comp_exps if os.path.isdir(p) and p != ref_exp]
         self.iterate_exp_dirs(ref_exp, comp_exps)
 
 
 #------- check if cross-validation fold splits of a single experiment are actually incongruent (as required) ----------
 class VerifyFoldSplits(unittest.TestCase):
     """ Check, for a single fold_ids file, i.e., for a single experiment, if the assigned folds (assignment of data
         identifiers) is actually incongruent. No overlaps between folds are required for a correct cross validation.
     """
     @staticmethod
     def verify_fold_ids(splits):
         for i, split1 in enumerate(splits):
             for j, split2 in enumerate(splits):
                 if j > i:
                     inter = np.intersect1d(split1, split2)
                     if len(inter) > 0:
                         raise Exception("Split {} and {} intersect by pids {}".format(i, j, inter))
     def test(self):
         exp_dir = "/home/gregor/Documents/medicaldetectiontoolkit/datasets/lidc/experiments/dev"
         check_file = os.path.join(exp_dir, 'fold_ids.pickle')
         with open(check_file, 'rb') as handle:
             splits = pickle.load(handle)
         self.verify_fold_ids(splits)
 
 # -------- check own nms CUDA implement against own numpy implement ------
 class CheckNMSImplementation(unittest.TestCase):
 
     @staticmethod
     def assert_res_equality(keep_ics1, keep_ics2, boxes, scores, tolerance=0, names=("res1", "res2")):
         """
         :param keep_ics1: keep indices (results), torch.Tensor of shape (n_ics,)
         :param keep_ics2:
         :return:
         """
         keep_ics1, keep_ics2 = keep_ics1.cpu().numpy(), keep_ics2.cpu().numpy()
         discrepancies = np.setdiff1d(keep_ics1, keep_ics2)
         try:
             checks = np.array([
                 len(discrepancies) <= tolerance
             ])
         except:
             checks = np.zeros((1,)).astype("bool")
         msgs = np.array([
             """{}: {} \n{}: {} \nboxes: {}\n {}\n""".format(names[0], keep_ics1, names[1], keep_ics2, boxes,
                                                             scores)
         ])
 
         assert np.all(checks), "NMS: results mismatch: " + "\n".join(msgs[~checks])
 
     def single_case(self, count=20, dim=3, threshold=0.2, seed=0):
         boxes, scores = generate_boxes(count, dim, seed=seed, h=320, w=280, d=30)
 
         keep_numpy = torch.tensor(mutils.nms_numpy(boxes, scores, threshold))
 
         # for some reason torchvision nms requires box coords as floats.
         boxes = torch.from_numpy(boxes).type(torch.float32)
         scores = torch.from_numpy(scores).type(torch.float32)
         if dim == 2:
             """need to wait until next pytorch release where they fixed nms on cpu (currently they have >= where it
             needs to be >.
             """
             keep_ops = tv.ops.nms(boxes, scores, threshold)
             # self.assert_res_equality(keep_numpy, keep_ops, boxes, scores, tolerance=0, names=["np", "ops"])
             pass
 
         boxes = boxes.cuda()
         scores = scores.cuda()
         keep = self.nms_ext.nms(boxes, scores, threshold)
         self.assert_res_equality(keep_numpy, keep, boxes, scores, tolerance=0, names=["np", "cuda"])
 
     def test(self, n_cases=200, box_count=30, threshold=0.5):
         # dynamically import module so that it doesn't affect other tests if import fails
         self.nms_ext = utils.import_module("nms_ext", 'custom_extensions/nms/nms.py')
         # change seed to something fix if you want exactly reproducible test
         seed0 = np.random.randint(50)
         print("NMS test progress (done/total box configurations) 2D:", end="\n")
         for i in tqdm.tqdm(range(n_cases)):
             self.single_case(count=box_count, dim=2, threshold=threshold, seed=seed0+i)
         print("NMS test progress (done/total box configurations) 3D:", end="\n")
         for i in tqdm.tqdm(range(n_cases)):
             self.single_case(count=box_count, dim=3, threshold=threshold, seed=seed0+i)
 
         return
 
 class CheckRoIAlignImplementation(unittest.TestCase):
 
     def prepare(self, dim=2):
 
         b, c, h, w = 1, 3, 50, 50
         # feature map, (b, c, h, w(, z))
         if dim == 2:
             fmap = torch.rand(b, c, h, w).cuda()
             # rois = torch.tensor([[
             #     [0.1, 0.1, 0.3, 0.3],
             #     [0.2, 0.2, 0.4, 0.7],
             #     [0.5, 0.7, 0.7, 0.9],
             # ]]).cuda()
             pool_size = (7, 7)
             rois = generate_boxes(5, dim=dim, h=h, w=w, on_grid=True, seed=np.random.randint(50))[0]
         elif dim == 3:
             d = 20
             fmap = torch.rand(b, c, h, w, d).cuda()
             # rois = torch.tensor([[
             #     [0.1, 0.1, 0.3, 0.3, 0.1, 0.1],
             #     [0.2, 0.2, 0.4, 0.7, 0.2, 0.4],
             #     [0.5, 0.0, 0.7, 1.0, 0.4, 0.5],
             #     [0.0, 0.0, 0.9, 1.0, 0.0, 1.0],
             # ]]).cuda()
             pool_size = (7, 7, 3)
             rois = generate_boxes(5, dim=dim, h=h, w=w, d=d, on_grid=True, seed=np.random.randint(50),
                                   normalize=False)[0]
         else:
             raise ValueError("dim needs to be 2 or 3")
 
         rois = [torch.from_numpy(rois).type(dtype=torch.float32).cuda(), ]
         fmap.requires_grad_(True)
         return fmap, rois, pool_size
 
     def check_2d(self):
         """ check vs torchvision ops not possible as on purpose different approach.
         :return:
         """
         raise NotImplementedError
         # fmap, rois, pool_size = self.prepare(dim=2)
         # ra_object = self.ra_ext.RoIAlign(output_size=pool_size, spatial_scale=1., sampling_ratio=-1)
         # align_ext = ra_object(fmap, rois)
         # loss_ext = align_ext.sum()
         # loss_ext.backward()
         #
         # rois_swapped = [rois[0][:, [1,3,0,2]]]
         # align_ops = tv.ops.roi_align(fmap, rois_swapped, pool_size)
         # loss_ops = align_ops.sum()
         # loss_ops.backward()
         #
         # assert (loss_ops == loss_ext), "sum of roialign ops and extension 2D diverges"
         # assert (align_ops == align_ext).all(), "ROIAlign failed 2D test"
 
     def check_3d(self):
         fmap, rois, pool_size = self.prepare(dim=3)
         ra_object = self.ra_ext.RoIAlign(output_size=pool_size, spatial_scale=1., sampling_ratio=-1)
         align_ext = ra_object(fmap, rois)
         loss_ext = align_ext.sum()
         loss_ext.backward()
 
         align_np = mutils.roi_align_3d_numpy(fmap.cpu().detach().numpy(), [roi.cpu().numpy() for roi in rois],
                                              pool_size)
         align_np = np.squeeze(align_np)  # remove singleton batch dim
 
         align_ext = align_ext.cpu().detach().numpy()
         assert np.allclose(align_np, align_ext, rtol=1e-5,
                            atol=1e-8), "RoIAlign differences in numpy and CUDA implement"
 
     def specific_example_check(self):
         # dummy input
         self.ra_ext = utils.import_module("ra_ext", 'custom_extensions/roi_align/roi_align.py')
         exp = 6
         pool_size = (2,2)
         fmap = torch.arange(exp**2).view(exp,exp).unsqueeze(0).unsqueeze(0).cuda().type(dtype=torch.float32)
 
         boxes = torch.tensor([[1., 1., 5., 5.]]).cuda()/exp
         ind = torch.tensor([0.]*len(boxes)).cuda().type(torch.float32)
         y_exp, x_exp = fmap.shape[2:]  # exp = expansion
         boxes.mul_(torch.tensor([y_exp, x_exp, y_exp, x_exp], dtype=torch.float32).cuda())
         boxes = torch.cat((ind.unsqueeze(1), boxes), dim=1)
         aligned_tv = tv.ops.roi_align(fmap, boxes, output_size=pool_size, sampling_ratio=-1)
         aligned = self.ra_ext.roi_align_2d(fmap, boxes, output_size=pool_size, sampling_ratio=-1)
 
         boxes_3d = torch.cat((boxes, torch.tensor([[-1.,1.]]*len(boxes)).cuda()), dim=1)
         fmap_3d = fmap.unsqueeze(dim=-1)
         pool_size = (*pool_size,1)
         ra_object = self.ra_ext.RoIAlign(output_size=pool_size, spatial_scale=1.,)
         aligned_3d = ra_object(fmap_3d, boxes_3d)
 
-        expected_res = torch.tensor([[[[10.5000, 12.5000],
-                                       [22.5000, 24.5000]]]]).cuda()
-        expected_res_3d = torch.tensor([[[[[10.5000],[12.5000]],
-                                          [[22.5000],[24.5000]]]]]).cuda()
+        # expected_res = torch.tensor([[[[10.5000, 12.5000], # this would be with an alternative grid-point setting
+        #                                [22.5000, 24.5000]]]]).cuda()
+        expected_res = torch.tensor([[[[14., 16.],
+                                       [26., 28.]]]]).cuda()
+        expected_res_3d = torch.tensor([[[[[14.],[16.]],
+                                          [[26.],[28.]]]]]).cuda()
         assert torch.all(aligned==expected_res), "2D RoIAlign check vs. specific example failed. res: {}\n expected: {}\n".format(aligned, expected_res)
         assert torch.all(aligned_3d==expected_res_3d), "3D RoIAlign check vs. specific example failed. res: {}\n expected: {}\n".format(aligned_3d, expected_res_3d)
 
     def manual_check(self):
         """ print examples from a toy batch to file.
         :return:
         """
         self.ra_ext = utils.import_module("ra_ext", 'custom_extensions/roi_align/roi_align.py')
         # actual mrcnn mask input
         from datasets.toy import configs
         cf = configs.Configs()
         cf.exp_dir = "datasets/toy/experiments/dev/"
         cf.plot_dir = cf.exp_dir + "plots"
         os.makedirs(cf.exp_dir, exist_ok=True)
         cf.fold = 0
         cf.n_workers = 1
         logger = utils.get_logger(cf.exp_dir)
         data_loader = utils.import_module('data_loader', os.path.join("datasets", "toy", 'data_loader.py'))
         batch_gen = data_loader.get_train_generators(cf, logger=logger)
         batch = next(batch_gen['train'])
         roi_mask = np.zeros((1, 320, 200))
         bb_target = (np.array([50, 40, 90, 120])).astype("int")
         roi_mask[:, bb_target[0]+1:bb_target[2]+1, bb_target[1]+1:bb_target[3]+1] = 1.
         #batch = {"roi_masks": np.array([np.array([roi_mask, roi_mask]), np.array([roi_mask])]), "bb_target": [[bb_target, bb_target + 25], [bb_target-20]]}
         #batch_boxes_cor = [torch.tensor(batch_el_boxes).cuda().float() for batch_el_boxes in batch_cor["bb_target"]]
         batch_boxes = [torch.tensor(batch_el_boxes).cuda().float() for batch_el_boxes in batch["bb_target"]]
         #import IPython; IPython.embed()
         for b in range(len(batch_boxes)):
             roi_masks = batch["roi_masks"][b]
             #roi_masks_cor = batch_cor["roi_masks"][b]
             if roi_masks.sum()>0:
                 boxes = batch_boxes[b]
                 roi_masks = torch.tensor(roi_masks).cuda().type(dtype=torch.float32)
                 box_ids = torch.arange(roi_masks.shape[0]).cuda().unsqueeze(1).type(dtype=torch.float32)
                 masks = tv.ops.roi_align(roi_masks, [boxes], cf.mask_shape)
                 masks = masks.squeeze(1)
                 masks = torch.round(masks)
                 masks_own = self.ra_ext.roi_align_2d(roi_masks, torch.cat((box_ids, boxes), dim=1), cf.mask_shape)
                 boxes = boxes.type(torch.int)
                 #print("check roi mask", roi_masks[0, 0, boxes[0][0]:boxes[0][2], boxes[0][1]:boxes[0][3]].sum(), (boxes[0][2]-boxes[0][0]) * (boxes[0][3]-boxes[0][1]))
                 #print("batch masks", batch["roi_masks"])
                 masks_own = masks_own.squeeze(1)
                 masks_own = torch.round(masks_own)
                 #import IPython; IPython.embed()
                 for mix, mask in enumerate(masks):
                     fig = plg.plt.figure()
                     ax = fig.add_subplot()
                     ax.imshow(roi_masks[mix][0].cpu().numpy(), cmap="gray", vmin=0.)
                     ax.axis("off")
                     y1, x1, y2, x2 = boxes[mix]
                     bbox = plg.mpatches.Rectangle((x1, y1), x2-x1, y2-y1, linewidth=0.9, edgecolor="c", facecolor='none')
                     ax.add_patch(bbox)
                     x1, y1, x2, y2 = boxes[mix]
                     bbox = plg.mpatches.Rectangle((x1, y1), x2 - x1, y2 - y1, linewidth=0.9, edgecolor="r",
                                                   facecolor='none')
                     ax.add_patch(bbox)
                     debug_dir = Path("/home/gregor/Documents/regrcnn/datasets/toy/experiments/debugroial")
                     os.makedirs(debug_dir, exist_ok=True)
                     plg.plt.savefig(debug_dir/"mask_b{}_{}.png".format(b, mix))
                     plg.plt.imsave(debug_dir/"mask_b{}_{}_pooled_tv.png".format(b, mix), mask.cpu().numpy(), cmap="gray", vmin=0.)
                     plg.plt.imsave(debug_dir/"mask_b{}_{}_pooled_own.png".format(b, mix), masks_own[mix].cpu().numpy(), cmap="gray", vmin=0.)
         return
 
     def test(self):
         # dynamically import module so that it doesn't affect other tests if import fails
         self.ra_ext = utils.import_module("ra_ext", 'custom_extensions/roi_align/roi_align.py')
 
         self.specific_example_check()
 
         # 2d test
         #self.check_2d()
 
         # 3d test
         self.check_3d()
 
         return
 
 
 class CheckRuntimeErrors(unittest.TestCase):
     """ Check if minimal examples of the exec.py module finish without runtime errors.
         This check requires a working path to data in the toy-dataset configs.
     """
 
     def test(self):
         cf = utils.import_module("toy_cf", 'datasets/toy/configs.py').Configs()
         exp_dir = "./unittesting/"
         #checks = {"retina_net": False, "mrcnn": False}
         #print("Testing for runtime errors with models {}".format(list(checks.keys())))
         #for model in tqdm.tqdm(list(checks.keys())):
             # cf.model = model
             # cf.model_path = 'models/{}.py'.format(cf.model if not 'retina' in cf.model else 'retina_net')
             # cf.model_path = os.path.join(cf.source_dir, cf.model_path)
             # {'mrcnn': cf.add_mrcnn_configs,
             #  'retina_net': cf.add_mrcnn_configs, 'retina_unet': cf.add_mrcnn_configs,
             #  'detection_unet': cf.add_det_unet_configs, 'detection_fpn': cf.add_det_fpn_configs
             #  }[model]()
         # todo change structure of configs-handling with exec.py so that its dynamically parseable instead of needing to
         # todo be changed in the file all the time.
         checks = {cf.model:False}
         completed_process = subprocess.run("python exec.py --dev --dataset_name toy -m train_test --exp_dir {}".format(exp_dir),
                                            shell=True, capture_output=True, text=True)
         if completed_process.returncode!=0:
             print("Runtime test of model {} failed due to\n{}".format(cf.model, completed_process.stderr))
         else:
             checks[cf.model] = True
         subprocess.call("rm -rf {}".format(exp_dir), shell=True)
         assert all(checks.values()), "A runtime test crashed."
 
 class MulithreadedDataiterator(unittest.TestCase):
 
     def test(self):
         print("Testing multithreaded iterator.")
 
 
         dataset = "toy"
         exp_dir = Path("datasets/{}/experiments/dev".format(dataset))
         cf_file = utils.import_module("cf_file", exp_dir/"configs.py")
         cf = cf_file.Configs()
         dloader = utils.import_module('data_loader', 'datasets/{}/data_loader.py'.format(dataset))
         cf.exp_dir = Path(exp_dir)
         cf.n_workers = 5
 
         cf.batch_size = 3
         cf.fold = 0
         cf.plot_dir = cf.exp_dir / "plots"
         logger = utils.get_logger(cf.exp_dir, cf.server_env, cf.sysmetrics_interval)
         cf.num_val_batches = "all"
         cf.val_mode = "val_sampling"
         cf.n_workers = 8
         batch_gens = dloader.get_train_generators(cf, logger, data_statistics=False)
         val_loader = batch_gens["val_sampling"]
 
         for epoch in range(4):
             produced_ids = []
             for i in range(batch_gens['n_val']):
                 batch = next(val_loader)
                 produced_ids.append(batch["pid"])
             uni, cts = np.unique(np.concatenate(produced_ids), return_counts=True)
             assert np.all(cts < 3), "with batch size one: every item should occur exactly once.\n uni {}, cts {}".format(
                 uni[cts>2], cts[cts>2])
             #assert len(np.setdiff1d(val_loader.generator.dataset_pids, uni))==0, "not all val pids were shown."
             assert len(np.setdiff1d(uni, val_loader.generator.dataset_pids))==0, "pids shown that are not val set. impossible?"
 
         cf.n_workers = os.cpu_count()
         cf.batch_size = int(val_loader.generator.dataset_length / cf.n_workers) + 2
         val_loader = dloader.create_data_gen_pipeline(cf, val_loader.generator._data, do_aug=False, sample_pids_w_replace=False,
                                                              max_batches=None, raise_stop_iteration=True)
         for epoch in range(2):
             produced_ids = []
             for b, batch in enumerate(val_loader):
                 produced_ids.append(batch["pid"])
             uni, cts = np.unique(np.concatenate(produced_ids), return_counts=True)
             assert np.all(cts == 1), "with batch size one: every item should occur exactly once.\n uni {}, cts {}".format(
                 uni[cts>1], cts[cts>1])
             assert len(np.setdiff1d(val_loader.generator.dataset_pids, uni))==0, "not all val pids were shown."
             assert len(np.setdiff1d(uni, val_loader.generator.dataset_pids))==0, "pids shown that are not val set. impossible?"
 
 
 
 
         pass
 
 
 if __name__=="__main__":
     stime = time.time()
 
     t = CheckRoIAlignImplementation()
     t.manual_check()
     #unittest.main()
 
     mins, secs = divmod((time.time() - stime), 60)
     h, mins = divmod(mins, 60)
     t = "{:d}h:{:02d}m:{:02d}s".format(int(h), int(mins), int(secs))
     print("{} total runtime: {}".format(os.path.split(__file__)[1], t))
\ No newline at end of file
diff --git a/utils/exp_utils.py b/utils/exp_utils.py
index 73c1b43..fb50471 100644
--- a/utils/exp_utils.py
+++ b/utils/exp_utils.py
@@ -1,692 +1,692 @@
 #!/usr/bin/env python
 # Copyright 2019 Division of Medical Image Computing, German Cancer Research Center (DKFZ).
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
 # You may obtain a copy of the License at
 #
 #     http://www.apache.org/licenses/LICENSE-2.0
 #
 # Unless required by applicable law or agreed to in writing, software
 # distributed under the License is distributed on an "AS IS" BASIS,
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
 # ==============================================================================
 # import plotting as plg
 
 import sys
 import os
 import subprocess
 from multiprocessing import Process
 import threading
 import pickle
 import importlib.util
 import psutil
 import time
 import nvidia_smi
 
 import logging
 from torch.utils.tensorboard import SummaryWriter
 
 from collections import OrderedDict
 import numpy as np
 import pandas as pd
 import torch
 
 
 def import_module(name, path):
     """
     correct way of importing a module dynamically in python 3.
     :param name: name given to module instance.
     :param path: path to module.
     :return: module: returned module instance.
     """
     spec = importlib.util.spec_from_file_location(name, path)
     module = importlib.util.module_from_spec(spec)
     spec.loader.exec_module(module)
     return module
 
 
 def save_obj(obj, name):
     """Pickle a python object."""
     with open(name + '.pkl', 'wb') as f:
         pickle.dump(obj, f, pickle.HIGHEST_PROTOCOL)
 
 
 def load_obj(file_path):
     with open(file_path, 'rb') as handle:
         return pickle.load(handle)
 
 
 def IO_safe(func, *args, _tries=5, _raise=True, **kwargs):
     """ Wrapper calling function func with arguments args and keyword arguments kwargs to catch input/output errors
         on cluster.
     :param func: function to execute (intended to be read/write operation to a problematic cluster drive, but can be
         any function).
     :param args: positional args of func.
     :param kwargs: kw args of func.
     :param _tries: how many attempts to make executing func.
     """
     for _try in range(_tries):
         try:
             return func(*args, **kwargs)
         except OSError as e:  # to catch cluster issues with network drives
             if _raise:
                 raise e
             else:
                 print("After attempting execution {} time{}, following error occurred:\n{}".format(_try + 1,
                                                                                                    "" if _try == 0 else "s",
                                                                                                    e))
                 continue
 
 def split_off_process(target, *args, daemon=False, **kwargs):
     """Start a process that won't block parent script.
     No join(), no return value. If daemon=False: before parent exits, it waits for this to finish.
     """
     p = Process(target=target, args=tuple(args), kwargs=kwargs, daemon=daemon)
     p.start()
     return p
 
 
 def query_nvidia_gpu(device_id, d_keyword=None, no_units=False):
     """
     :param device_id:
     :param d_keyword: -d, --display argument (keyword(s) for selective display), all are selected if None
     :return: dict of gpu-info items
     """
     cmd = ['nvidia-smi', '-i', str(device_id), '-q']
     if d_keyword is not None:
         cmd += ['-d', d_keyword]
     outp = subprocess.check_output(cmd).strip().decode('utf-8').split("\n")
     outp = [x for x in outp if len(x) > 0]
     headers = [ix for ix, item in enumerate(outp) if len(item.split(":")) == 1] + [len(outp)]
 
     out_dict = {}
     for lix, hix in enumerate(headers[:-1]):
         head = outp[hix].strip().replace(" ", "_").lower()
         out_dict[head] = {}
         for lix2 in range(hix, headers[lix + 1]):
             try:
                 key, val = [x.strip().lower() for x in outp[lix2].split(":")]
                 if no_units:
                     val = val.split()[0]
                 out_dict[head][key] = val
             except:
                 pass
 
     return out_dict
 
 
 class CombinedPrinter(object):
     """combined print function.
     prints to logger and/or file if given, to normal print if non given.
 
     """
 
     def __init__(self, logger=None, file=None):
 
         if logger is None and file is None:
             self.out = [print]
         elif logger is None:
             self.out = [file.write]
         elif file is None:
             self.out = [logger.info]
         else:
             self.out = [logger.info, file.write]
 
     def __call__(self, string):
         for fct in self.out:
             fct(string)
 
 
 class Nvidia_GPU_Logger(object):
     def __init__(self):
         self.count = None
 
     def get_vals(self):
 
         # cmd = ['nvidia-settings', '-t', '-q', 'GPUUtilization']
         # gpu_util = subprocess.check_output(cmd).strip().decode('utf-8').split(",")
         # gpu_util = dict([f.strip().split("=") for f in gpu_util])
         # cmd[-1] = 'UsedDedicatedGPUMemory'
         # gpu_used_mem = subprocess.check_output(cmd).strip().decode('utf-8')
 
 
         nvidia_smi.nvmlInit()
         # card id 0 hardcoded here, there is also a call to get all available card ids, so we could iterate
         self.gpu_handle = nvidia_smi.nvmlDeviceGetHandleByIndex(0)
         util_res = nvidia_smi.nvmlDeviceGetUtilizationRates(self.gpu_handle)
         #mem_res = nvidia_smi.nvmlDeviceGetMemoryInfo(self.gpu_handle)
         # current_vals = {"gpu_mem_alloc": mem_res.used / (1024**2), "gpu_graphics_util": int(gpu_util['graphics']),
         #                 "gpu_mem_util": gpu_util['memory'], "time": time.time()}
         current_vals = {"gpu_graphics_util": float(util_res.gpu),
                         "time": time.time()}
         return current_vals
 
     def loop(self, interval):
         i = 0
         while True:
             current_vals = self.get_vals()
             self.log["time"].append(time.time())
             self.log["gpu_util"].append(current_vals["gpu_graphics_util"])
             if self.count is not None:
                 i += 1
                 if i == self.count:
                     exit(0)
             time.sleep(self.interval)
 
     def start(self, interval=1.):
         self.interval = interval
         self.start_time = time.time()
         self.log = {"time": [], "gpu_util": []}
         if self.interval is not None:
             thread = threading.Thread(target=self.loop)
             thread.daemon = True
             thread.start()
 
 class CombinedLogger(object):
     """Combine console and tensorboard logger and record system metrics.
     """
 
     def __init__(self, name, log_dir, server_env=True, fold="all", sysmetrics_interval=2):
         self.pylogger = logging.getLogger(name)
         self.tboard = SummaryWriter(log_dir=os.path.join(log_dir, "tboard"))
         self.times = {}
         self.log_dir = log_dir
         self.fold = str(fold)
         self.server_env = server_env
 
         self.pylogger.setLevel(logging.DEBUG)
         self.log_file = os.path.join(log_dir, "fold_"+self.fold, 'exec.log')
         os.makedirs(os.path.dirname(self.log_file), exist_ok=True)
         self.pylogger.addHandler(logging.FileHandler(self.log_file))
         if not server_env:
             self.pylogger.addHandler(ColorHandler())
         else:
             self.pylogger.addHandler(logging.StreamHandler())
         self.pylogger.propagate = False
 
         # monitor system metrics (cpu, mem, ...)
         if not server_env and sysmetrics_interval > 0:
             self.sysmetrics = pd.DataFrame(
                 columns=["global_step", "rel_time", r"CPU (%)", "mem_used (GB)", r"mem_used (%)",
                          r"swap_used (GB)", r"gpu_utilization (%)"], dtype="float16")
             for device in range(torch.cuda.device_count()):
                 self.sysmetrics[
                     "mem_allocd (GB) by torch on {:10s}".format(torch.cuda.get_device_name(device))] = np.nan
                 self.sysmetrics[
                     "mem_cached (GB) by torch on {:10s}".format(torch.cuda.get_device_name(device))] = np.nan
             self.sysmetrics_start(sysmetrics_interval)
             pass
         else:
             print("NOT logging sysmetrics")
 
     def __getattr__(self, attr):
         """delegate all undefined method requests to objects of
         this class in order pylogger, tboard (first find first serve).
         E.g., combinedlogger.add_scalars(...) should trigger self.tboard.add_scalars(...)
         """
         for obj in [self.pylogger, self.tboard]:
             if attr in dir(obj):
                 return getattr(obj, attr)
         print("logger attr not found")
         #raise AttributeError("CombinedLogger has no attribute {}".format(attr))
 
     def set_logfile(self, fold=None, log_file=None):
         if fold is not None:
             self.fold = str(fold)
         if log_file is None:
             self.log_file = os.path.join(self.log_dir, "fold_"+self.fold, 'exec.log')
         else:
             self.log_file = log_file
         os.makedirs(os.path.dirname(self.log_file), exist_ok=True)
         for hdlr in self.pylogger.handlers:
             hdlr.close()
         self.pylogger.handlers = []
         self.pylogger.addHandler(logging.FileHandler(self.log_file))
         if not self.server_env:
             self.pylogger.addHandler(ColorHandler())
         else:
             self.pylogger.addHandler(logging.StreamHandler())
 
     def time(self, name, toggle=None):
         """record time-spans as with a stopwatch.
         :param name:
         :param toggle: True^=On: start time recording, False^=Off: halt rec. if None determine from current status.
         :return: either start-time or last recorded interval
         """
         if toggle is None:
             if name in self.times.keys():
                 toggle = not self.times[name]["toggle"]
             else:
                 toggle = True
 
         if toggle:
             if not name in self.times.keys():
                 self.times[name] = {"total": 0, "last": 0}
             elif self.times[name]["toggle"] == toggle:
                 self.info("restarting running stopwatch")
             self.times[name]["last"] = time.time()
             self.times[name]["toggle"] = toggle
             return time.time()
         else:
             if toggle == self.times[name]["toggle"]:
                 self.info("WARNING: tried to stop stopped stop watch: {}.".format(name))
             self.times[name]["last"] = time.time() - self.times[name]["last"]
             self.times[name]["total"] += self.times[name]["last"]
             self.times[name]["toggle"] = toggle
             return self.times[name]["last"]
 
     def get_time(self, name=None, kind="total", format=None, reset=False):
         """
         :param name:
         :param kind: 'total' or 'last'
         :param format: None for float, "hms"/"ms" for (hours), mins, secs as string
         :param reset: reset time after retrieving
         :return:
         """
         if name is None:
             times = self.times
             if reset:
                 self.reset_time()
             return times
 
         else:
             if self.times[name]["toggle"]:
                 self.time(name, toggle=False)
             time = self.times[name][kind]
             if format == "hms":
                 m, s = divmod(time, 60)
                 h, m = divmod(m, 60)
                 time = "{:d}h:{:02d}m:{:02d}s".format(int(h), int(m), int(s))
             elif format == "ms":
                 m, s = divmod(time, 60)
                 time = "{:02d}m:{:02d}s".format(int(m), int(s))
             if reset:
                 self.reset_time(name)
             return time
 
     def reset_time(self, name=None):
         if name is None:
             self.times = {}
         else:
             del self.times[name]
 
     def sysmetrics_update(self, global_step=None):
         if global_step is None:
             global_step = time.strftime("%x_%X")
         mem = psutil.virtual_memory()
         mem_used = (mem.total - mem.available)
         gpu_vals = self.gpu_logger.get_vals()
         rel_time = time.time() - self.sysmetrics_start_time
         self.sysmetrics.loc[len(self.sysmetrics)] = [global_step, rel_time,
                                                      psutil.cpu_percent(), mem_used / 1024 ** 3,
                                                      mem_used / mem.total * 100,
                                                      psutil.swap_memory().used / 1024 ** 3,
                                                      int(gpu_vals['gpu_graphics_util']),
                                                      *[torch.cuda.memory_allocated(d) / 1024 ** 3 for d in
                                                        range(torch.cuda.device_count())],
                                                      *[torch.cuda.memory_cached(d) / 1024 ** 3 for d in
                                                        range(torch.cuda.device_count())]
                                                      ]
         return self.sysmetrics.loc[len(self.sysmetrics) - 1].to_dict()
 
     def sysmetrics2tboard(self, metrics=None, global_step=None, suptitle=None):
         tag = "per_time"
         if metrics is None:
             metrics = self.sysmetrics_update(global_step=global_step)
             tag = "per_epoch"
 
         if suptitle is not None:
             suptitle = str(suptitle)
         elif self.fold != "":
             suptitle = "Fold_" + str(self.fold)
         if suptitle is not None:
             self.tboard.add_scalars(suptitle + "/System_Metrics/" + tag,
                                     {k: v for (k, v) in metrics.items() if (k != "global_step"
                                                                             and k != "rel_time")}, global_step)
 
     def sysmetrics_loop(self):
         try:
             os.nice(-19)
             self.info("Logging system metrics with superior process priority.")
         except:
             self.info("Logging system metrics without superior process priority.")
         while True:
             metrics = self.sysmetrics_update()
             self.sysmetrics2tboard(metrics, global_step=metrics["rel_time"])
             # print("thread alive", self.thread.is_alive())
             time.sleep(self.sysmetrics_interval)
 
     def sysmetrics_start(self, interval):
         if interval is not None and interval > 0:
             self.sysmetrics_interval = interval
             self.gpu_logger = Nvidia_GPU_Logger()
             self.sysmetrics_start_time = time.time()
             self.sys_metrics_process = split_off_process(target=self.sysmetrics_loop, daemon=True)
             # self.thread = threading.Thread(target=self.sysmetrics_loop)
             # self.thread.daemon = True
             # self.thread.start()
 
     def sysmetrics_save(self, out_file):
         self.sysmetrics.to_pickle(out_file)
 
     def metrics2tboard(self, metrics, global_step=None, suptitle=None):
         """
         :param metrics: {'train': dataframe, 'val':df}, df as produced in
             evaluator.py.evaluate_predictions
         """
         # print("metrics", metrics)
         if global_step is None:
             global_step = len(metrics['train'][list(metrics['train'].keys())[0]]) - 1
         if suptitle is not None:
             suptitle = str(suptitle)
         else:
             suptitle = "Fold_" + str(self.fold)
 
         for key in ['train', 'val']:
             # series = {k:np.array(v[-1]) for (k,v) in metrics[key].items() if not np.isnan(v[-1]) and not 'Bin_Stats' in k}
             loss_series = {}
             unc_series = {}
             bin_stat_series = {}
             mon_met_series = {}
             for tag, val in metrics[key].items():
                 val = val[-1]  # maybe remove list wrapping, recording in evaluator?
                 if 'bin_stats' in tag.lower() and not np.isnan(val):
                     bin_stat_series["{}".format(tag.split("/")[-1])] = val
                 elif 'uncertainty' in tag.lower() and not np.isnan(val):
                     unc_series["{}".format(tag)] = val
                 elif 'loss' in tag.lower() and not np.isnan(val):
                     loss_series["{}".format(tag)] = val
                 elif not np.isnan(val):
                     mon_met_series["{}".format(tag)] = val
 
             self.tboard.add_scalars(suptitle + "/Binary_Statistics/{}".format(key), bin_stat_series, global_step)
             self.tboard.add_scalars(suptitle + "/Uncertainties/{}".format(key), unc_series, global_step)
             self.tboard.add_scalars(suptitle + "/Losses/{}".format(key), loss_series, global_step)
             self.tboard.add_scalars(suptitle + "/Monitor_Metrics/{}".format(key), mon_met_series, global_step)
         self.tboard.add_scalars(suptitle + "/Learning_Rate", metrics["lr"], global_step)
         return
 
     def batchImgs2tboard(self, batch, results_dict, cmap, boxtype2color, img_bg=False, global_step=None):
         raise NotImplementedError("not up-to-date, problem with importing plotting-file, torchvision dependency.")
         if len(batch["seg"].shape) == 5:  # 3D imgs
             slice_ix = np.random.randint(batch["seg"].shape[-1])
             seg_gt = plg.to_rgb(batch['seg'][:, 0, :, :, slice_ix], cmap)
             seg_pred = plg.to_rgb(results_dict['seg_preds'][:, 0, :, :, slice_ix], cmap)
 
             mod_img = plg.mod_to_rgb(batch["data"][:, 0, :, :, slice_ix]) if img_bg else None
 
         elif len(batch["seg"].shape) == 4:
             seg_gt = plg.to_rgb(batch['seg'][:, 0, :, :], cmap)
             seg_pred = plg.to_rgb(results_dict['seg_preds'][:, 0, :, :], cmap)
             mod_img = plg.mod_to_rgb(batch["data"][:, 0]) if img_bg else None
         else:
             raise Exception("batch content has wrong format: {}".format(batch["seg"].shape))
 
         # from here on only works in 2D
         seg_gt = np.transpose(seg_gt, axes=(0, 3, 1, 2))  # previous shp: b,x,y,c
         seg_pred = np.transpose(seg_pred, axes=(0, 3, 1, 2))
 
         seg = np.concatenate((seg_gt, seg_pred), axis=0)
         # todo replace torchvision (tv) dependency
         seg = tv.utils.make_grid(torch.from_numpy(seg), nrow=2)
         self.tboard.add_image("Batch seg, 1st col: gt, 2nd: pred.", seg, global_step=global_step)
 
         if img_bg:
             bg_img = np.transpose(mod_img, axes=(0, 3, 1, 2))
         else:
             bg_img = seg_gt
         box_imgs = plg.draw_boxes_into_batch(bg_img, results_dict["boxes"], boxtype2color)
         box_imgs = tv.utils.make_grid(torch.from_numpy(box_imgs), nrow=4)
         self.tboard.add_image("Batch bboxes", box_imgs, global_step=global_step)
 
         return
 
     def __del__(self):  # otherwise might produce multiple prints e.g. in ipython console
         self.sys_metrics_process.terminate()
         for hdlr in self.pylogger.handlers:
             hdlr.close()
         self.pylogger.handlers = []
         del self.pylogger
         self.tboard.close()
 
 
 def get_logger(exp_dir, server_env=False, sysmetrics_interval=2):
     log_dir = os.path.join(exp_dir, "logs")
     logger = CombinedLogger('Reg R-CNN', log_dir, server_env=server_env,
                             sysmetrics_interval=sysmetrics_interval)
     print("logging to {}".format(logger.log_file))
     return logger
 
 
 def prep_exp(dataset_path, exp_path, server_env, use_stored_settings=True, is_training=True):
     """
     I/O handling, creating of experiment folder structure. Also creates a snapshot of configs/model scripts and copies them to the exp_dir.
     This way the exp_dir contains all info needed to conduct an experiment, independent to changes in actual source code. Thus, training/inference of this experiment can be started at anytime.
     Therefore, the model script is copied back to the source code dir as tmp_model (tmp_backbone).
     Provides robust structure for cloud deployment.
     :param dataset_path: path to source code for specific data set. (e.g. medicaldetectiontoolkit/lidc_exp)
     :param exp_path: path to experiment directory.
     :param server_env: boolean flag. pass to configs script for cloud deployment.
     :param use_stored_settings: boolean flag. When starting training: If True, starts training from snapshot in existing
         experiment directory, else creates experiment directory on the fly using configs/model scripts from source code.
     :param is_training: boolean flag. distinguishes train vs. inference mode.
     :return: configs object.
     """
 
     if is_training:
 
         if use_stored_settings:
             cf_file = import_module('cf', os.path.join(exp_path, 'configs.py'))
             cf = cf_file.Configs(server_env)
             # in this mode, previously saved model and backbone need to be found in exp dir.
             if not os.path.isfile(os.path.join(exp_path, 'model.py')) or \
                     not os.path.isfile(os.path.join(exp_path, 'backbone.py')):
                 raise Exception(
                     "Selected use_stored_settings option but no model and/or backbone source files exist in exp dir.")
             cf.model_path = os.path.join(exp_path, 'model.py')
             cf.backbone_path = os.path.join(exp_path, 'backbone.py')
         else:  # this case overwrites settings files in exp dir, i.e., default_configs, configs, backbone, model
             os.makedirs(exp_path, exist_ok=True)
             # run training with source code info and copy snapshot of model to exp_dir for later testing (overwrite scripts if exp_dir already exists.)
             subprocess.call('cp {} {}'.format('default_configs.py', os.path.join(exp_path, 'default_configs.py')),
                             shell=True)
             subprocess.call(
                 'cp {} {}'.format(os.path.join(dataset_path, 'configs.py'), os.path.join(exp_path, 'configs.py')),
                 shell=True)
             cf_file = import_module('cf_file', os.path.join(dataset_path, 'configs.py'))
             cf = cf_file.Configs(server_env)
             subprocess.call('cp {} {}'.format(cf.model_path, os.path.join(exp_path, 'model.py')), shell=True)
             subprocess.call('cp {} {}'.format(cf.backbone_path, os.path.join(exp_path, 'backbone.py')), shell=True)
             if os.path.isfile(os.path.join(exp_path, "fold_ids.pickle")):
                 subprocess.call('rm {}'.format(os.path.join(exp_path, "fold_ids.pickle")), shell=True)
 
     else:  # testing, use model and backbone stored in exp dir.
         cf_file = import_module('cf', os.path.join(exp_path, 'configs.py'))
         cf = cf_file.Configs(server_env)
         cf.model_path = os.path.join(exp_path, 'model.py')
         cf.backbone_path = os.path.join(exp_path, 'backbone.py')
 
     cf.exp_dir = exp_path
     cf.test_dir = os.path.join(cf.exp_dir, 'test')
     cf.plot_dir = os.path.join(cf.exp_dir, 'plots')
     if not os.path.exists(cf.test_dir):
         os.mkdir(cf.test_dir)
     if not os.path.exists(cf.plot_dir):
         os.mkdir(cf.plot_dir)
     cf.experiment_name = exp_path.split("/")[-1]
     cf.dataset_name = dataset_path
     cf.server_env = server_env
     cf.created_fold_id_pickle = False
 
     return cf
 
 
 class ModelSelector:
     '''
     saves a checkpoint after each epoch as 'last_state' (can be loaded to continue interrupted training).
     saves the top-k (k=cf.save_n_models) ranked epochs. In inference, predictions of multiple epochs can be ensembled
     to improve performance.
     '''
 
     def __init__(self, cf, logger):
 
         self.cf = cf
         self.logger = logger
 
         self.model_index = pd.DataFrame(columns=["rank", "score", "criteria_values", "file_name"],
                                         index=pd.RangeIndex(self.cf.min_save_thresh, self.cf.num_epochs, name="epoch"))
 
     def run_model_selection(self, net, optimizer, monitor_metrics, epoch):
         """rank epoch via weighted mean from self.cf.model_selection_criteria: {criterion : weight}
         :param net:
         :param optimizer:
         :param monitor_metrics:
         :param epoch:
         :return:
         """
         crita = self.cf.model_selection_criteria  # shorter alias
         metrics =  monitor_metrics['val']
 
         epoch_score = np.sum([metrics[criterion][-1] * weight for criterion, weight in crita.items() if
                               not np.isnan(metrics[criterion][-1])])
-        if not self.cf.resume_from_checkpoint:
+        if not self.cf.resume:
             epoch_score_check = np.sum([metrics[criterion][epoch] * weight for criterion, weight in crita.items() if
                                   not np.isnan(metrics[criterion][epoch])])
             assert np.all(epoch_score == epoch_score_check)
 
         self.model_index.loc[epoch, ["score", "criteria_values"]] = epoch_score, {cr: metrics[cr][-1] for cr in crita.keys()}
 
         nonna_ics = self.model_index["score"].dropna(axis=0).index
         order = np.argsort(self.model_index.loc[nonna_ics, "score"].to_numpy(), kind="stable")[::-1]
         self.model_index.loc[nonna_ics, "rank"] = np.argsort(order) + 1 # no zero-indexing for ranks (best rank is 1).
 
         rank = int(self.model_index.loc[epoch, "rank"])
         if rank <= self.cf.save_n_models:
             name = '{}_best_params.pth'.format(epoch)
             if self.cf.server_env:
                 IO_safe(torch.save, net.state_dict(), os.path.join(self.cf.fold_dir, name))
             else:
                 torch.save(net.state_dict(), os.path.join(self.cf.fold_dir, name))
             self.model_index.loc[epoch, "file_name"] = name
             self.logger.info("saved current epoch {} at rank {}".format(epoch, rank))
 
             clean_up = self.model_index.dropna(axis=0, subset=["file_name"])
             clean_up = clean_up[clean_up["rank"] > self.cf.save_n_models]
             if clean_up.size > 0:
                 file_name = clean_up["file_name"].to_numpy().item()
                 subprocess.call("rm {}".format(os.path.join(self.cf.fold_dir, file_name)), shell=True)
                 self.logger.info("removed outranked epoch {} at {}".format(clean_up.index.values.item(),
                                                                        os.path.join(self.cf.fold_dir, file_name)))
                 self.model_index.loc[clean_up.index, "file_name"] = np.nan
 
         state = {
             'epoch': epoch,
             'state_dict': net.state_dict(),
             'optimizer': optimizer.state_dict(),
             'model_index': self.model_index,
         }
 
         if self.cf.server_env:
             IO_safe(torch.save, state, os.path.join(self.cf.fold_dir, 'last_state.pth'))
         else:
             torch.save(state, os.path.join(self.cf.fold_dir, 'last_state.pth'))
 
 def load_checkpoint(checkpoint_path, net, optimizer, model_selector):
     checkpoint = torch.load(checkpoint_path)
     net.load_state_dict(checkpoint['state_dict'])
     optimizer.load_state_dict(checkpoint['optimizer'])
     model_selector.model_index = checkpoint["model_index"]
     return checkpoint['epoch'] + 1, net, optimizer, model_selector
 
 
 def prepare_monitoring(cf):
     """
     creates dictionaries, where train/val metrics are stored.
     """
     metrics = {}
     # first entry for loss dict accounts for epoch starting at 1.
     metrics['train'] = OrderedDict()  # [(l_name, [np.nan]) for l_name in cf.losses_to_monitor] )
     metrics['val'] = OrderedDict()  # [(l_name, [np.nan]) for l_name in cf.losses_to_monitor] )
     metric_classes = []
     if 'rois' in cf.report_score_level:
         metric_classes.extend([v for k, v in cf.class_dict.items()])
         if hasattr(cf, "eval_bins_separately") and cf.eval_bins_separately:
             metric_classes.extend([v for k, v in cf.bin_dict.items()])
     if 'patient' in cf.report_score_level:
         metric_classes.extend(['patient_' + cf.class_dict[cf.patient_class_of_interest]])
         if hasattr(cf, "eval_bins_separately") and cf.eval_bins_separately:
             metric_classes.extend(['patient_' + cf.bin_dict[cf.patient_bin_of_interest]])
     for cl in metric_classes:
         for m in cf.metrics:
             metrics['train'][cl + '_' + m] = [np.nan]
             metrics['val'][cl + '_' + m] = [np.nan]
 
     return metrics
 
 
 class _AnsiColorizer(object):
     """
     A colorizer is an object that loosely wraps around a stream, allowing
     callers to write text to the stream in a particular color.
 
     Colorizer classes must implement C{supported()} and C{write(text, color)}.
     """
     _colors = dict(black=30, red=31, green=32, yellow=33,
                    blue=34, magenta=35, cyan=36, white=37, default=39)
 
     def __init__(self, stream):
         self.stream = stream
 
     @classmethod
     def supported(cls, stream=sys.stdout):
         """
         A class method that returns True if the current platform supports
         coloring terminal output using this method. Returns False otherwise.
         """
         if not stream.isatty():
             return False  # auto color only on TTYs
         try:
             import curses
         except ImportError:
             return False
         else:
             try:
                 try:
                     return curses.tigetnum("colors") > 2
                 except curses.error:
                     curses.setupterm()
                     return curses.tigetnum("colors") > 2
             except:
                 raise
                 # guess false in case of error
                 return False
 
     def write(self, text, color):
         """
         Write the given text to the stream in the given color.
 
         @param text: Text to be written to the stream.
 
         @param color: A string label for a color. e.g. 'red', 'white'.
         """
         color = self._colors[color]
         self.stream.write('\x1b[%sm%s\x1b[0m' % (color, text))
 
 
 class ColorHandler(logging.StreamHandler):
 
     def __init__(self, stream=sys.stdout):
         super(ColorHandler, self).__init__(_AnsiColorizer(stream))
 
     def emit(self, record):
         msg_colors = {
             logging.DEBUG: "green",
             logging.INFO: "default",
             logging.WARNING: "red",
             logging.ERROR: "red"
         }
         color = msg_colors.get(record.levelno, "blue")
         self.stream.write(record.msg + "\n", color)
diff --git a/utils/model_utils.py b/utils/model_utils.py
index da1f34a..e951ec7 100644
--- a/utils/model_utils.py
+++ b/utils/model_utils.py
@@ -1,1527 +1,1527 @@
 #!/usr/bin/env python
 # Copyright 2019 Division of Medical Image Computing, German Cancer Research Center (DKFZ).
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
 # You may obtain a copy of the License at
 #
 #     http://www.apache.org/licenses/LICENSE-2.0
 #
 # Unless required by applicable law or agreed to in writing, software
 # distributed under the License is distributed on an "AS IS" BASIS,
 # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 # See the License for the specific language governing permissions and
 # limitations under the License.
 # ==============================================================================
 
 """
 Parts are based on https://github.com/multimodallearning/pytorch-mask-rcnn
 published under MIT license.
 """
 import warnings
 warnings.filterwarnings('ignore', '.*From scipy 0.13.0, the output shape of zoom()*')
 
 import numpy as np
 import scipy.misc
 import scipy.ndimage
 import scipy.interpolate
 from scipy.ndimage.measurements import label as lb
 import torch
 
 import tqdm
 
 from custom_extensions.nms import nms
 from custom_extensions.roi_align import roi_align
 
 ############################################################
 #  Segmentation Processing
 ############################################################
 
 def sum_tensor(input, axes, keepdim=False):
     axes = np.unique(axes)
     if keepdim:
         for ax in axes:
             input = input.sum(ax, keepdim=True)
     else:
         for ax in sorted(axes, reverse=True):
             input = input.sum(int(ax))
     return input
 
 def get_one_hot_encoding(y, n_classes):
     """
     transform a numpy label array to a one-hot array of the same shape.
     :param y: array of shape (b, 1, y, x, (z)).
     :param n_classes: int, number of classes to unfold in one-hot encoding.
     :return y_ohe: array of shape (b, n_classes, y, x, (z))
     """
 
     dim = len(y.shape) - 2
     if dim == 2:
         y_ohe = np.zeros((y.shape[0], n_classes, y.shape[2], y.shape[3])).astype('int32')
     elif dim == 3:
         y_ohe = np.zeros((y.shape[0], n_classes, y.shape[2], y.shape[3], y.shape[4])).astype('int32')
     else:
         raise Exception("invalid dimensions {} encountered".format(y.shape))
     for cl in np.arange(n_classes):
         y_ohe[:, cl][y[:, 0] == cl] = 1
     return y_ohe
 
 def dice_per_batch_inst_and_class(pred, y, n_classes, convert_to_ohe=True, smooth=1e-8):
     '''
     computes dice scores per batch instance and class.
     :param pred: prediction array of shape (b, 1, y, x, (z)) (e.g. softmax prediction with argmax over dim 1)
     :param y: ground truth array of shape (b, 1, y, x, (z)) (contains int [0, ..., n_classes]
     :param n_classes: int
     :return: dice scores of shape (b, c)
     '''
     if convert_to_ohe:
         pred = get_one_hot_encoding(pred, n_classes)
         y = get_one_hot_encoding(y, n_classes)
     axes = tuple(range(2, len(pred.shape)))
     intersect = np.sum(pred*y, axis=axes)
     denominator = np.sum(pred, axis=axes)+np.sum(y, axis=axes)
     dice = (2.0*intersect + smooth) / (denominator + smooth)
     return dice
 
 def dice_per_batch_and_class(pred, targ, n_classes, convert_to_ohe=True, smooth=1e-8):
     '''
     computes dice scores per batch and class.
     :param pred: prediction array of shape (b, 1, y, x, (z)) (e.g. softmax prediction with argmax over dim 1)
     :param targ: ground truth array of shape (b, 1, y, x, (z)) (contains int [0, ..., n_classes])
     :param n_classes: int
     :param smooth: Laplacian smooth, https://en.wikipedia.org/wiki/Additive_smoothing
     :return: dice scores of shape (b, c)
     '''
     if convert_to_ohe:
         pred = get_one_hot_encoding(pred, n_classes)
         targ = get_one_hot_encoding(targ, n_classes)
     axes = (0, *list(range(2, len(pred.shape)))) #(0,2,3(,4))
 
     intersect = np.sum(pred * targ, axis=axes)
 
     denominator = np.sum(pred, axis=axes) + np.sum(targ, axis=axes)
     dice = (2.0 * intersect + smooth) / (denominator + smooth)
 
     assert dice.shape==(n_classes,), "dice shp {}".format(dice.shape)
     return dice
 
 
 def batch_dice(pred, y, false_positive_weight=1.0, smooth=1e-6):
     '''
     compute soft dice over batch. this is a differentiable score and can be used as a loss function.
     only dice scores of foreground classes are returned, since training typically
     does not benefit from explicit background optimization. Pixels of the entire batch are considered a pseudo-volume to compute dice scores of.
     This way, single patches with missing foreground classes can not produce faulty gradients.
     :param pred: (b, c, y, x, (z)), softmax probabilities (network output).
     :param y: (b, c, y, x, (z)), one hote encoded segmentation mask.
     :param false_positive_weight: float [0,1]. For weighting of imbalanced classes,
     reduces the penalty for false-positive pixels. Can be beneficial sometimes in data with heavy fg/bg imbalances.
     :return: soft dice score (float).This function discards the background score and returns the mena of foreground scores.
     '''
 
     if len(pred.size()) == 4:
         axes = (0, 2, 3)
         intersect = sum_tensor(pred * y, axes, keepdim=False)
         denom = sum_tensor(false_positive_weight*pred + y, axes, keepdim=False)
         return torch.mean(( (2*intersect + smooth) / (denom + smooth))[1:]) #only fg dice here.
 
     elif len(pred.size()) == 5:
         axes = (0, 2, 3, 4)
         intersect = sum_tensor(pred * y, axes, keepdim=False)
         denom = sum_tensor(false_positive_weight*pred + y, axes, keepdim=False)
         return torch.mean(( (2*intersect + smooth) / (denom + smooth))[1:]) #only fg dice here.
     else:
         raise ValueError('wrong input dimension in dice loss')
 
 
 ############################################################
 #  Bounding Boxes
 ############################################################
 
 def compute_iou_2D(box, boxes, box_area, boxes_area):
     """Calculates IoU of the given box with the array of the given boxes.
     box: 1D vector [y1, x1, y2, x2] THIS IS THE GT BOX
     boxes: [boxes_count, (y1, x1, y2, x2)]
     box_area: float. the area of 'box'
     boxes_area: array of length boxes_count.
 
     Note: the areas are passed in rather than calculated here for
           efficency. Calculate once in the caller to avoid duplicate work.
     """
     # Calculate intersection areas
     y1 = np.maximum(box[0], boxes[:, 0])
     y2 = np.minimum(box[2], boxes[:, 2])
     x1 = np.maximum(box[1], boxes[:, 1])
     x2 = np.minimum(box[3], boxes[:, 3])
     intersection = np.maximum(x2 - x1, 0) * np.maximum(y2 - y1, 0)
     union = box_area + boxes_area[:] - intersection[:]
     iou = intersection / union
 
     return iou
 
 
 def compute_iou_3D(box, boxes, box_volume, boxes_volume):
     """Calculates IoU of the given box with the array of the given boxes.
     box: 1D vector [y1, x1, y2, x2, z1, z2] (typically gt box)
     boxes: [boxes_count, (y1, x1, y2, x2, z1, z2)]
     box_area: float. the area of 'box'
     boxes_area: array of length boxes_count.
 
     Note: the areas are passed in rather than calculated here for
           efficency. Calculate once in the caller to avoid duplicate work.
     """
     # Calculate intersection areas
     y1 = np.maximum(box[0], boxes[:, 0])
     y2 = np.minimum(box[2], boxes[:, 2])
     x1 = np.maximum(box[1], boxes[:, 1])
     x2 = np.minimum(box[3], boxes[:, 3])
     z1 = np.maximum(box[4], boxes[:, 4])
     z2 = np.minimum(box[5], boxes[:, 5])
     intersection = np.maximum(x2 - x1, 0) * np.maximum(y2 - y1, 0) * np.maximum(z2 - z1, 0)
     union = box_volume + boxes_volume[:] - intersection[:]
     iou = intersection / union
 
     return iou
 
 
 
 def compute_overlaps(boxes1, boxes2):
     """Computes IoU overlaps between two sets of boxes.
     boxes1, boxes2: [N, (y1, x1, y2, x2)]. / 3D: (z1, z2))
     For better performance, pass the largest set first and the smaller second.
     :return: (#boxes1, #boxes2), ious of each box of 1 machted with each of 2
     """
     # Areas of anchors and GT boxes
     if boxes1.shape[1] == 4:
         area1 = (boxes1[:, 2] - boxes1[:, 0]) * (boxes1[:, 3] - boxes1[:, 1])
         area2 = (boxes2[:, 2] - boxes2[:, 0]) * (boxes2[:, 3] - boxes2[:, 1])
         # Compute overlaps to generate matrix [boxes1 count, boxes2 count]
         # Each cell contains the IoU value.
         overlaps = np.zeros((boxes1.shape[0], boxes2.shape[0]))
         for i in range(overlaps.shape[1]):
             box2 = boxes2[i] #this is the gt box
             overlaps[:, i] = compute_iou_2D(box2, boxes1, area2[i], area1)
         return overlaps
 
     else:
         # Areas of anchors and GT boxes
         volume1 = (boxes1[:, 2] - boxes1[:, 0]) * (boxes1[:, 3] - boxes1[:, 1]) * (boxes1[:, 5] - boxes1[:, 4])
         volume2 = (boxes2[:, 2] - boxes2[:, 0]) * (boxes2[:, 3] - boxes2[:, 1]) * (boxes2[:, 5] - boxes2[:, 4])
         # Compute overlaps to generate matrix [boxes1 count, boxes2 count]
         # Each cell contains the IoU value.
         overlaps = np.zeros((boxes1.shape[0], boxes2.shape[0]))
         for i in range(boxes2.shape[0]):
             box2 = boxes2[i]  # this is the gt box
             overlaps[:, i] = compute_iou_3D(box2, boxes1, volume2[i], volume1)
         return overlaps
 
 
 
 def box_refinement(box, gt_box):
     """Compute refinement needed to transform box to gt_box.
     box and gt_box are [N, (y1, x1, y2, x2)] / 3D: (z1, z2))
     """
     height = box[:, 2] - box[:, 0]
     width = box[:, 3] - box[:, 1]
     center_y = box[:, 0] + 0.5 * height
     center_x = box[:, 1] + 0.5 * width
 
     gt_height = gt_box[:, 2] - gt_box[:, 0]
     gt_width = gt_box[:, 3] - gt_box[:, 1]
     gt_center_y = gt_box[:, 0] + 0.5 * gt_height
     gt_center_x = gt_box[:, 1] + 0.5 * gt_width
 
     dy = (gt_center_y - center_y) / height
     dx = (gt_center_x - center_x) / width
     dh = torch.log(gt_height / height)
     dw = torch.log(gt_width / width)
     result = torch.stack([dy, dx, dh, dw], dim=1)
 
     if box.shape[1] > 4:
         depth = box[:, 5] - box[:, 4]
         center_z = box[:, 4] + 0.5 * depth
         gt_depth = gt_box[:, 5] - gt_box[:, 4]
         gt_center_z = gt_box[:, 4] + 0.5 * gt_depth
         dz = (gt_center_z - center_z) / depth
         dd = torch.log(gt_depth / depth)
         result = torch.stack([dy, dx, dz, dh, dw, dd], dim=1)
 
     return result
 
 
 
 def unmold_mask_2D(mask, bbox, image_shape):
     """Converts a mask generated by the neural network into a format similar
     to it's original shape.
     mask: [height, width] of type float. A small, typically 28x28 mask.
     bbox: [y1, x1, y2, x2]. The box to fit the mask in.
 
     Returns a binary mask with the same size as the original image.
     """
     y1, x1, y2, x2 = bbox
     out_zoom = [y2 - y1, x2 - x1]
     zoom_factor = [i / j for i, j in zip(out_zoom, mask.shape)]
 
     mask = scipy.ndimage.zoom(mask, zoom_factor, order=1).astype(np.float32)
 
     # Put the mask in the right location.
     full_mask = np.zeros(image_shape[:2]) #only y,x
     full_mask[y1:y2, x1:x2] = mask
     return full_mask
 
 
 def unmold_mask_2D_torch(mask, bbox, image_shape):
     """Converts a mask generated by the neural network into a format similar
     to it's original shape.
     mask: [height, width] of type float. A small, typically 28x28 mask.
     bbox: [y1, x1, y2, x2]. The box to fit the mask in.
 
     Returns a binary mask with the same size as the original image.
     """
     y1, x1, y2, x2 = bbox
     out_zoom = [(y2 - y1).float(), (x2 - x1).float()]
     zoom_factor = [i / j for i, j in zip(out_zoom, mask.shape)]
 
     mask = mask.unsqueeze(0).unsqueeze(0)
     mask = torch.nn.functional.interpolate(mask, scale_factor=zoom_factor)
     mask = mask[0][0]
     #mask = scipy.ndimage.zoom(mask.cpu().numpy(), zoom_factor, order=1).astype(np.float32)
     #mask = torch.from_numpy(mask).cuda()
     # Put the mask in the right location.
     full_mask = torch.zeros(image_shape[:2])  # only y,x
     full_mask[y1:y2, x1:x2] = mask
     return full_mask
 
 
 
 def unmold_mask_3D(mask, bbox, image_shape):
     """Converts a mask generated by the neural network into a format similar
     to it's original shape.
     mask: [height, width] of type float. A small, typically 28x28 mask.
     bbox: [y1, x1, y2, x2, z1, z2]. The box to fit the mask in.
 
     Returns a binary mask with the same size as the original image.
     """
     y1, x1, y2, x2, z1, z2 = bbox
     out_zoom = [y2 - y1, x2 - x1, z2 - z1]
     zoom_factor = [i/j for i,j in zip(out_zoom, mask.shape)]
     mask = scipy.ndimage.zoom(mask, zoom_factor, order=1).astype(np.float32)
 
     # Put the mask in the right location.
     full_mask = np.zeros(image_shape[:3])
     full_mask[y1:y2, x1:x2, z1:z2] = mask
     return full_mask
 
 def nms_numpy(box_coords, scores, thresh):
     """ non-maximum suppression on 2D or 3D boxes in numpy.
     :param box_coords: [y1,x1,y2,x2 (,z1,z2)] with y1<=y2, x1<=x2, z1<=z2.
     :param scores: ranking scores (higher score == higher rank) of boxes.
     :param thresh: IoU threshold for clustering.
     :return:
     """
     y1 = box_coords[:, 0]
     x1 = box_coords[:, 1]
     y2 = box_coords[:, 2]
     x2 = box_coords[:, 3]
     assert np.all(y1 <= y2) and np.all(x1 <= x2), """"the definition of the coordinates is crucially important here: 
             coordinates of which maxima are taken need to be the lower coordinates"""
     areas = (x2 - x1) * (y2 - y1)
 
     is_3d = box_coords.shape[1] == 6
     if is_3d: # 3-dim case
         z1 = box_coords[:, 4]
         z2 = box_coords[:, 5]
         assert np.all(z1<=z2), """"the definition of the coordinates is crucially important here: 
            coordinates of which maxima are taken need to be the lower coordinates"""
         areas *= (z2 - z1)
 
     order = scores.argsort()[::-1]
 
     keep = []
     while order.size > 0:  # order is the sorted index.  maps order to index: order[1] = 24 means (rank1, ix 24)
         i = order[0] # highest scoring element
         yy1 = np.maximum(y1[i], y1[order])  # highest scoring element still in >order<, is compared to itself, that is okay.
         xx1 = np.maximum(x1[i], x1[order])
         yy2 = np.minimum(y2[i], y2[order])
         xx2 = np.minimum(x2[i], x2[order])
 
         h = np.maximum(0.0, yy2 - yy1)
         w = np.maximum(0.0, xx2 - xx1)
         inter = h * w
 
         if is_3d:
             zz1 = np.maximum(z1[i], z1[order])
             zz2 = np.minimum(z2[i], z2[order])
             d = np.maximum(0.0, zz2 - zz1)
             inter *= d
 
         iou = inter / (areas[i] + areas[order] - inter)
 
         non_matches = np.nonzero(iou <= thresh)[0]  # get all elements that were not matched and discard all others.
         order = order[non_matches]
         keep.append(i)
 
     return keep
 
 
 
 ############################################################
 #  M-RCNN
 ############################################################
 
 def refine_proposals(rpn_pred_probs, rpn_pred_deltas, proposal_count, batch_anchors, cf):
     """
     Receives anchor scores and selects a subset to pass as proposals
     to the second stage. Filtering is done based on anchor scores and
     non-max suppression to remove overlaps. It also applies bounding
     box refinment details to anchors.
     :param rpn_pred_probs: (b, n_anchors, 2)
     :param rpn_pred_deltas: (b, n_anchors, (y, x, (z), log(h), log(w), (log(d))))
     :return: batch_normalized_props: Proposals in normalized coordinates (b, proposal_count, (y1, x1, y2, x2, (z1), (z2), score))
     :return: batch_out_proposals: Box coords + RPN foreground scores
     for monitoring/plotting (b, proposal_count, (y1, x1, y2, x2, (z1), (z2), score))
     """
     std_dev = torch.from_numpy(cf.rpn_bbox_std_dev[None]).float().cuda()
     norm = torch.from_numpy(cf.scale).float().cuda()
     anchors = batch_anchors.clone()
 
 
 
     batch_scores = rpn_pred_probs[:, :, 1]
     # norm deltas
     batch_deltas = rpn_pred_deltas * std_dev
     batch_normalized_props = []
     batch_out_proposals = []
 
     # loop over batch dimension.
     for ix in range(batch_scores.shape[0]):
 
         scores = batch_scores[ix]
         deltas = batch_deltas[ix]
 
         # improve performance by trimming to top anchors by score
         # and doing the rest on the smaller subset.
         pre_nms_limit = min(cf.pre_nms_limit, anchors.size()[0])
         scores, order = scores.sort(descending=True)
         order = order[:pre_nms_limit]
         scores = scores[:pre_nms_limit]
         deltas = deltas[order, :]
 
         # apply deltas to anchors to get refined anchors and filter with non-maximum suppression.
         if batch_deltas.shape[-1] == 4:
             boxes = apply_box_deltas_2D(anchors[order, :], deltas)
             boxes = clip_boxes_2D(boxes, cf.window)
         else:
             boxes = apply_box_deltas_3D(anchors[order, :], deltas)
             boxes = clip_boxes_3D(boxes, cf.window)
         # boxes are y1,x1,y2,x2, torchvision-nms requires x1,y1,x2,y2, but consistent swap x<->y is irrelevant.
         keep = nms.nms(boxes, scores, cf.rpn_nms_threshold)
 
 
         keep = keep[:proposal_count]
         boxes = boxes[keep, :]
         rpn_scores = scores[keep][:, None]
 
         # pad missing boxes with 0.
         if boxes.shape[0] < proposal_count:
             n_pad_boxes = proposal_count - boxes.shape[0]
             zeros = torch.zeros([n_pad_boxes, boxes.shape[1]]).cuda()
             boxes = torch.cat([boxes, zeros], dim=0)
             zeros = torch.zeros([n_pad_boxes, rpn_scores.shape[1]]).cuda()
             rpn_scores = torch.cat([rpn_scores, zeros], dim=0)
 
         # concat box and score info for monitoring/plotting.
         batch_out_proposals.append(torch.cat((boxes, rpn_scores), 1).cpu().data.numpy())
         # normalize dimensions to range of 0 to 1.
         normalized_boxes = boxes / norm
         where = normalized_boxes <=1
         assert torch.all(where), "normalized box coords >1 found:\n {}\n".format(normalized_boxes[where])
         #assert torch.all(normalized_boxes <= 1), "normalized box coords >1 found"
 
         # add again batch dimension
         batch_normalized_props.append(torch.cat((normalized_boxes, rpn_scores), 1).unsqueeze(0))
 
     batch_normalized_props = torch.cat(batch_normalized_props)
     batch_out_proposals = np.array(batch_out_proposals)
 
     return batch_normalized_props, batch_out_proposals
 
 def pyramid_roi_align(feature_maps, rois, pool_size, pyramid_levels, dim):
     """
     Implements ROI Pooling on multiple levels of the feature pyramid.
     :param feature_maps: list of feature maps, each of shape (b, c, y, x , (z))
     :param rois: proposals (normalized coords.) as returned by RPN. contain info about original batch element allocation.
     (n_proposals, (y1, x1, y2, x2, (z1), (z2), batch_ixs)
     :param pool_size: list of poolsizes in dims: [x, y, (z)]
     :param pyramid_levels: list. [0, 1, 2, ...]
     :return: pooled: pooled feature map rois (n_proposals, c, poolsize_y, poolsize_x, (poolsize_z))
 
     Output:
     Pooled regions in the shape: [num_boxes, height, width, channels].
     The width and height are those specific in the pool_shape in the layer
     constructor.
     """
     boxes = rois[:, :dim*2]
     batch_ixs = rois[:, dim*2]
 
     # Assign each ROI to a level in the pyramid based on the ROI area.
     if dim == 2:
         y1, x1, y2, x2 = boxes.chunk(4, dim=1)
     else:
         y1, x1, y2, x2, z1, z2 = boxes.chunk(6, dim=1)
 
     h = y2 - y1
     w = x2 - x1
 
     # Equation 1 in https://arxiv.org/abs/1612.03144. Account for
     # the fact that our coordinates are normalized here.
     # divide sqrt(h*w) by 1 instead image_area.
     roi_level = (4 + torch.log2(torch.sqrt(h*w))).round().int().clamp(pyramid_levels[0], pyramid_levels[-1])
     # if Pyramid contains additional level P6, adapt the roi_level assignment accordingly.
     if len(pyramid_levels) == 5:
         roi_level[h*w > 0.65] = 5
 
     # Loop through levels and apply ROI pooling to each.
     pooled = []
     box_to_level = []
     fmap_shapes = [f.shape for f in feature_maps]
     for level_ix, level in enumerate(pyramid_levels):
         ix = roi_level == level
         if not ix.any():
             continue
         ix = torch.nonzero(ix)[:, 0]
         level_boxes = boxes[ix, :]
         # re-assign rois to feature map of original batch element.
         ind = batch_ixs[ix].int()
 
         # Keep track of which box is mapped to which level
         box_to_level.append(ix)
 
         # Stop gradient propogation to ROI proposals
         level_boxes = level_boxes.detach()
         if len(pool_size) == 2:
             # remap to feature map coordinate system
             y_exp, x_exp = fmap_shapes[level_ix][2:]  # exp = expansion
             level_boxes.mul_(torch.tensor([y_exp, x_exp, y_exp, x_exp], dtype=torch.float32).cuda())
             pooled_features = roi_align.roi_align_2d(feature_maps[level_ix],
                                                      torch.cat((ind.unsqueeze(1).float(), level_boxes), dim=1),
                                                      pool_size)
         else:
             y_exp, x_exp, z_exp = fmap_shapes[level_ix][2:]
             level_boxes.mul_(torch.tensor([y_exp, x_exp, y_exp, x_exp, z_exp, z_exp], dtype=torch.float32).cuda())
             pooled_features = roi_align.roi_align_3d(feature_maps[level_ix],
                                                      torch.cat((ind.unsqueeze(1).float(), level_boxes), dim=1),
                                                      pool_size)
         pooled.append(pooled_features)
 
 
     # Pack pooled features into one tensor
     pooled = torch.cat(pooled, dim=0)
 
     # Pack box_to_level mapping into one array and add another
     # column representing the order of pooled boxes
     box_to_level = torch.cat(box_to_level, dim=0)
 
     # Rearrange pooled features to match the order of the original boxes
     _, box_to_level = torch.sort(box_to_level)
     pooled = pooled[box_to_level, :, :]
 
     return pooled
 
 
 def roi_align_3d_numpy(input: np.ndarray, rois, output_size: tuple,
                        spatial_scale: float = 1., sampling_ratio: int = -1) -> np.ndarray:
     """ This fct mainly serves as a verification method for 3D CUDA implementation of RoIAlign, it's highly
         inefficient due to the nested loops.
     :param input:  (ndarray[N, C, H, W, D]): input feature map
     :param rois: list (N,K(n), 6), K(n) = nr of rois in batch-element n, single roi of format (y1,x1,y2,x2,z1,z2)
     :param output_size:
     :param spatial_scale:
     :param sampling_ratio:
     :return: (List[N, K(n), C, output_size[0], output_size[1], output_size[2]])
     """
 
     out_height, out_width, out_depth = output_size
 
     coord_grid = tuple([np.linspace(0, input.shape[dim] - 1, num=input.shape[dim]) for dim in range(2, 5)])
     pooled_rois = [[]] * len(rois)
     assert len(rois) == input.shape[0], "batch dim mismatch, rois: {}, input: {}".format(len(rois), input.shape[0])
     print("Numpy 3D RoIAlign progress:", end="\n")
     for b in range(input.shape[0]):
         for roi in tqdm.tqdm(rois[b]):
             y1, x1, y2, x2, z1, z2 = np.array(roi) * spatial_scale
             roi_height = max(float(y2 - y1), 1.)
             roi_width = max(float(x2 - x1), 1.)
             roi_depth = max(float(z2 - z1), 1.)
 
             if sampling_ratio <= 0:
                 sampling_ratio_h = int(np.ceil(roi_height / out_height))
                 sampling_ratio_w = int(np.ceil(roi_width / out_width))
                 sampling_ratio_d = int(np.ceil(roi_depth / out_depth))
             else:
                 sampling_ratio_h = sampling_ratio_w = sampling_ratio_d = sampling_ratio  # == n points per bin
 
             bin_height = roi_height / out_height
             bin_width = roi_width / out_width
             bin_depth = roi_depth / out_depth
 
             n_points = sampling_ratio_h * sampling_ratio_w * sampling_ratio_d
             pooled_roi = np.empty((input.shape[1], out_height, out_width, out_depth), dtype="float32")
             for chan in range(input.shape[1]):
                 lin_interpolator = scipy.interpolate.RegularGridInterpolator(coord_grid, input[b, chan],
                                                                              method="linear")
                 for bin_iy in range(out_height):
                     for bin_ix in range(out_width):
                         for bin_iz in range(out_depth):
 
                             bin_val = 0.
                             for i in range(sampling_ratio_h):
                                 for j in range(sampling_ratio_w):
                                     for k in range(sampling_ratio_d):
                                         loc_ijk = [
-                                            y1 + bin_iy * bin_height + (i + 0.5)* ((bin_height -1) / sampling_ratio_h),
-                                            x1 + bin_ix * bin_width + (j + 0.5) * ((bin_width -1) / sampling_ratio_w),
-                                            z1 + bin_iz * bin_depth + (k + 0.5) * ((bin_depth -1) / sampling_ratio_d)]
+                                            y1 + bin_iy * bin_height + (i + 0.5) * (bin_height / sampling_ratio_h),
+                                            x1 + bin_ix * bin_width +  (j + 0.5) * (bin_width / sampling_ratio_w),
+                                            z1 + bin_iz * bin_depth +  (k + 0.5) * (bin_depth / sampling_ratio_d)]
                                         # print("loc_ijk", loc_ijk)
                                         if not (np.any([c < -1.0 for c in loc_ijk]) or loc_ijk[0] > input.shape[2] or
                                                 loc_ijk[1] > input.shape[3] or loc_ijk[2] > input.shape[4]):
                                             for catch_case in range(3):
                                                 # catch on-border cases
                                                 if int(loc_ijk[catch_case]) == input.shape[catch_case + 2] - 1:
                                                     loc_ijk[catch_case] = input.shape[catch_case + 2] - 1
                                             bin_val += lin_interpolator(loc_ijk)
                             pooled_roi[chan, bin_iy, bin_ix, bin_iz] = bin_val / n_points
 
             pooled_rois[b].append(pooled_roi)
 
     return np.array(pooled_rois)
 
 def refine_detections(cf, batch_ixs, rois, deltas, scores, regressions):
     """
     Refine classified proposals (apply deltas to rpn rois), filter overlaps (nms) and return final detections.
 
     :param rois: (n_proposals, 2 * dim) normalized boxes as proposed by RPN. n_proposals = batch_size * POST_NMS_ROIS
     :param deltas: (n_proposals, n_classes, 2 * dim) box refinement deltas as predicted by mrcnn bbox regressor.
     :param batch_ixs: (n_proposals) batch element assignment info for re-allocation.
     :param scores: (n_proposals, n_classes) probabilities for all classes per roi as predicted by mrcnn classifier.
     :param regressions: (n_proposals, n_classes, regression_features (+1 for uncertainty if predicted) regression vector
     :return: result: (n_final_detections, (y1, x1, y2, x2, (z1), (z2), batch_ix, pred_class_id, pred_score, *regression vector features))
     """
     # class IDs per ROI. Since scores of all classes are of interest (not just max class), all are kept at this point.
     class_ids = []
     fg_classes = cf.head_classes - 1
     # repeat vectors to fill in predictions for all foreground classes.
     for ii in range(1, fg_classes + 1):
         class_ids += [ii] * rois.shape[0]
     class_ids = torch.from_numpy(np.array(class_ids)).cuda()
 
     batch_ixs = batch_ixs.repeat(fg_classes)
     rois = rois.repeat(fg_classes, 1)
     deltas = deltas.repeat(fg_classes, 1, 1)
     scores = scores.repeat(fg_classes, 1)
     regressions = regressions.repeat(fg_classes, 1, 1)
 
     # get class-specific scores and  bounding box deltas
     idx = torch.arange(class_ids.size()[0]).long().cuda()
     # using idx instead of slice [:,] squashes first dimension.
     #len(class_ids)>scores.shape[1] --> probs is broadcasted by expansion from fg_classes-->len(class_ids)
     batch_ixs = batch_ixs[idx]
     deltas_specific = deltas[idx, class_ids]
     class_scores = scores[idx, class_ids]
     regressions = regressions[idx, class_ids]
 
     # apply bounding box deltas. re-scale to image coordinates.
     std_dev = torch.from_numpy(np.reshape(cf.rpn_bbox_std_dev, [1, cf.dim * 2])).float().cuda()
     scale = torch.from_numpy(cf.scale).float().cuda()
     refined_rois = apply_box_deltas_2D(rois, deltas_specific * std_dev) * scale if cf.dim == 2 else \
         apply_box_deltas_3D(rois, deltas_specific * std_dev) * scale
 
     # round and cast to int since we're dealing with pixels now
     refined_rois = clip_to_window(cf.window, refined_rois)
     refined_rois = torch.round(refined_rois)
 
     # filter out low confidence boxes
     keep = idx
     keep_bool = (class_scores >= cf.model_min_confidence)
     if not 0 in torch.nonzero(keep_bool).size():
 
         score_keep = torch.nonzero(keep_bool)[:, 0]
         pre_nms_class_ids = class_ids[score_keep]
         pre_nms_rois = refined_rois[score_keep]
         pre_nms_scores = class_scores[score_keep]
         pre_nms_batch_ixs = batch_ixs[score_keep]
 
         for j, b in enumerate(unique1d(pre_nms_batch_ixs)):
 
             bixs = torch.nonzero(pre_nms_batch_ixs == b)[:, 0]
             bix_class_ids = pre_nms_class_ids[bixs]
             bix_rois = pre_nms_rois[bixs]
             bix_scores = pre_nms_scores[bixs]
 
             for i, class_id in enumerate(unique1d(bix_class_ids)):
 
                 ixs = torch.nonzero(bix_class_ids == class_id)[:, 0]
                 # nms expects boxes sorted by score.
                 ix_rois = bix_rois[ixs]
                 ix_scores = bix_scores[ixs]
                 ix_scores, order = ix_scores.sort(descending=True)
                 ix_rois = ix_rois[order, :]
 
                 class_keep = nms.nms(ix_rois, ix_scores, cf.detection_nms_threshold)
 
                 # map indices back.
                 class_keep = keep[score_keep[bixs[ixs[order[class_keep]]]]]
                 # merge indices over classes for current batch element
                 b_keep = class_keep if i == 0 else unique1d(torch.cat((b_keep, class_keep)))
 
             # only keep top-k boxes of current batch-element
             top_ids = class_scores[b_keep].sort(descending=True)[1][:cf.model_max_instances_per_batch_element]
             b_keep = b_keep[top_ids]
 
             # merge indices over batch elements.
             batch_keep = b_keep  if j == 0 else unique1d(torch.cat((batch_keep, b_keep)))
 
         keep = batch_keep
 
     else:
         keep = torch.tensor([0]).long().cuda()
 
     # arrange output
     output = [refined_rois[keep], batch_ixs[keep].unsqueeze(1)]
     output += [class_ids[keep].unsqueeze(1).float(), class_scores[keep].unsqueeze(1)]
     output += [regressions[keep]]
 
     result = torch.cat(output, dim=1)
     # shape: (n_keeps, catted feats), catted feats: [0:dim*2] are box_coords, [dim*2] are batch_ics,
     # [dim*2+1] are class_ids, [dim*2+2] are scores, [dim*2+3:] are regression vector features (incl uncertainty)
     return result
 
 
 def loss_example_mining(cf, batch_proposals, batch_gt_boxes, batch_gt_masks, batch_roi_scores,
                            batch_gt_class_ids, batch_gt_regressions):
     """
     Subsamples proposals for mrcnn losses and generates targets. Sampling is done per batch element, seems to have positive
     effects on training, as opposed to sampling over entire batch. Negatives are sampled via stochastic hard-example mining
     (SHEM), where a number of negative proposals is drawn from larger pool of highest scoring proposals for stochasticity.
     Scoring is obtained here as the max over all foreground probabilities as returned by mrcnn_classifier (worked better than
     loss-based class-balancing methods like "online hard-example mining" or "focal loss".)
 
     Classification-regression duality: regressions can be given along with classes (at least fg/bg, only class scores
     are used for ranking).
 
     :param batch_proposals: (n_proposals, (y1, x1, y2, x2, (z1), (z2), batch_ixs).
     boxes as proposed by RPN. n_proposals here is determined by batch_size * POST_NMS_ROIS.
     :param mrcnn_class_logits: (n_proposals, n_classes)
     :param batch_gt_boxes: list over batch elements. Each element is a list over the corresponding roi target coordinates.
     :param batch_gt_masks: list over batch elements. Each element is binary mask of shape (n_gt_rois, c, y, x, (z))
     :param batch_gt_class_ids: list over batch elements. Each element is a list over the corresponding roi target labels.
         if no classes predicted (only fg/bg from RPN): expected as pseudo classes [0, 1] for bg, fg.
     :param batch_gt_regressions: list over b elements. Each element is a regression target vector. if None--> pseudo
     :return: sample_indices: (n_sampled_rois) indices of sampled proposals to be used for loss functions.
     :return: target_class_ids: (n_sampled_rois)containing target class labels of sampled proposals.
     :return: target_deltas: (n_sampled_rois, 2 * dim) containing target deltas of sampled proposals for box refinement.
     :return: target_masks: (n_sampled_rois, y, x, (z)) containing target masks of sampled proposals.
     """
     # normalization of target coordinates
     #global sample_regressions
     if cf.dim == 2:
         h, w = cf.patch_size
         scale = torch.from_numpy(np.array([h, w, h, w])).float().cuda()
     else:
         h, w, z = cf.patch_size
         scale = torch.from_numpy(np.array([h, w, h, w, z, z])).float().cuda()
 
     positive_count = 0
     negative_count = 0
     sample_positive_indices = []
     sample_negative_indices = []
     sample_deltas = []
     sample_masks = []
     sample_class_ids = []
     if batch_gt_regressions is not None:
         sample_regressions = []
     else:
         target_regressions = torch.FloatTensor().cuda()
 
     std_dev = torch.from_numpy(cf.bbox_std_dev).float().cuda()
 
     # loop over batch and get positive and negative sample rois.
     for b in range(len(batch_gt_boxes)):
 
         gt_masks = torch.from_numpy(batch_gt_masks[b]).float().cuda()
         gt_class_ids = torch.from_numpy(batch_gt_class_ids[b]).int().cuda()
         if batch_gt_regressions is not None:
             gt_regressions = torch.from_numpy(batch_gt_regressions[b]).float().cuda()
 
         #if np.any(batch_gt_class_ids[b] > 0):  # skip roi selection for no gt images.
         if np.any([len(coords)>0 for coords in batch_gt_boxes[b]]):
             gt_boxes = torch.from_numpy(batch_gt_boxes[b]).float().cuda() / scale
         else:
             gt_boxes = torch.FloatTensor().cuda()
 
         # get proposals and indices of current batch element.
         proposals = batch_proposals[batch_proposals[:, -1] == b][:, :-1]
         batch_element_indices = torch.nonzero(batch_proposals[:, -1] == b).squeeze(1)
 
         # Compute overlaps matrix [proposals, gt_boxes]
         if not 0 in gt_boxes.size():
             if gt_boxes.shape[1] == 4:
                 assert cf.dim == 2, "gt_boxes shape {} doesnt match cf.dim{}".format(gt_boxes.shape, cf.dim)
                 overlaps = bbox_overlaps_2D(proposals, gt_boxes)
             else:
                 assert cf.dim == 3, "gt_boxes shape {} doesnt match cf.dim{}".format(gt_boxes.shape, cf.dim)
                 overlaps = bbox_overlaps_3D(proposals, gt_boxes)
 
             # Determine positive and negative ROIs
             roi_iou_max = torch.max(overlaps, dim=1)[0]
             # 1. Positive ROIs are those with >= 0.5 IoU with a GT box
             positive_roi_bool = roi_iou_max >= (0.5 if cf.dim == 2 else 0.3)
             # 2. Negative ROIs are those with < 0.1 with every GT box.
             negative_roi_bool = roi_iou_max < (0.1 if cf.dim == 2 else 0.01)
         else:
             positive_roi_bool = torch.FloatTensor().cuda()
             negative_roi_bool = torch.from_numpy(np.array([1]*proposals.shape[0])).cuda()
 
         # Sample Positive ROIs
         if not 0 in torch.nonzero(positive_roi_bool).size():
             positive_indices = torch.nonzero(positive_roi_bool).squeeze(1)
             positive_samples = int(cf.train_rois_per_image * cf.roi_positive_ratio)
             rand_idx = torch.randperm(positive_indices.size()[0])
             rand_idx = rand_idx[:positive_samples].cuda()
             positive_indices = positive_indices[rand_idx]
             positive_samples = positive_indices.size()[0]
             positive_rois = proposals[positive_indices, :]
             # Assign positive ROIs to GT boxes.
             positive_overlaps = overlaps[positive_indices, :]
             roi_gt_box_assignment = torch.max(positive_overlaps, dim=1)[1]
             roi_gt_boxes = gt_boxes[roi_gt_box_assignment, :]
             roi_gt_class_ids = gt_class_ids[roi_gt_box_assignment]
             if batch_gt_regressions is not None:
                 roi_gt_regressions = gt_regressions[roi_gt_box_assignment]
 
             # Compute bbox refinement targets for positive ROIs
             deltas = box_refinement(positive_rois, roi_gt_boxes)
             deltas /= std_dev
 
             roi_masks = gt_masks[roi_gt_box_assignment]
             assert roi_masks.shape[1] == 1, "gt masks have more than one channel --> is this desired?"
             # Compute mask targets
             boxes = positive_rois
             box_ids = torch.arange(roi_masks.shape[0]).cuda().unsqueeze(1).float()
 
             if len(cf.mask_shape) == 2:
                 y_exp, x_exp = roi_masks.shape[2:]  # exp = expansion
                 boxes.mul_(torch.tensor([y_exp, x_exp, y_exp, x_exp], dtype=torch.float32).cuda())
                 masks = roi_align.roi_align_2d(roi_masks,
                                                torch.cat((box_ids, boxes), dim=1),
                                                cf.mask_shape)
             else:
                 y_exp, x_exp, z_exp = roi_masks.shape[2:]  # exp = expansion
                 boxes.mul_(torch.tensor([y_exp, x_exp, y_exp, x_exp, z_exp, z_exp], dtype=torch.float32).cuda())
                 masks = roi_align.roi_align_3d(roi_masks,
                                                torch.cat((box_ids, boxes), dim=1),
                                                cf.mask_shape)
 
             masks = masks.squeeze(1)
             # Threshold mask pixels at 0.5 to have GT masks be 0 or 1 to use with
             # binary cross entropy loss.
             masks = torch.round(masks)
 
             sample_positive_indices.append(batch_element_indices[positive_indices])
             sample_deltas.append(deltas)
             sample_masks.append(masks)
             sample_class_ids.append(roi_gt_class_ids)
             if batch_gt_regressions is not None:
                 sample_regressions.append(roi_gt_regressions)
             positive_count += positive_samples
         else:
             positive_samples = 0
 
         # Sample negative ROIs. Add enough to maintain positive:negative ratio, but at least 1. Sample via SHEM.
         if not 0 in torch.nonzero(negative_roi_bool).size():
             negative_indices = torch.nonzero(negative_roi_bool).squeeze(1)
             r = 1.0 / cf.roi_positive_ratio
             b_neg_count = np.max((int(r * positive_samples - positive_samples), 1))
             roi_scores_neg = batch_roi_scores[batch_element_indices[negative_indices]]
             raw_sampled_indices = shem(roi_scores_neg, b_neg_count, cf.shem_poolsize)
             sample_negative_indices.append(batch_element_indices[negative_indices[raw_sampled_indices]])
             negative_count  += raw_sampled_indices.size()[0]
 
     if len(sample_positive_indices) > 0:
         target_deltas = torch.cat(sample_deltas)
         target_masks = torch.cat(sample_masks)
         target_class_ids = torch.cat(sample_class_ids)
         if batch_gt_regressions is not None:
             target_regressions = torch.cat(sample_regressions)
 
     # Pad target information with zeros for negative ROIs.
     if positive_count > 0 and negative_count > 0:
         sample_indices = torch.cat((torch.cat(sample_positive_indices), torch.cat(sample_negative_indices)), dim=0)
         zeros = torch.zeros(negative_count, cf.dim * 2).cuda()
         target_deltas = torch.cat([target_deltas, zeros], dim=0)
         zeros = torch.zeros(negative_count, *cf.mask_shape).cuda()
         target_masks = torch.cat([target_masks, zeros], dim=0)
         zeros = torch.zeros(negative_count).int().cuda()
         target_class_ids = torch.cat([target_class_ids, zeros], dim=0)
         if batch_gt_regressions is not None:
             # regression targets need to have 0 as background/negative with below practice
             if 'regression_bin' in cf.prediction_tasks:
                 zeros = torch.zeros(negative_count, dtype=torch.float).cuda()
             else:
                 zeros = torch.zeros(negative_count, cf.regression_n_features, dtype=torch.float).cuda()
             target_regressions = torch.cat([target_regressions, zeros], dim=0)
 
     elif positive_count > 0:
         sample_indices = torch.cat(sample_positive_indices)
     elif negative_count > 0:
         sample_indices = torch.cat(sample_negative_indices)
         target_deltas = torch.zeros(negative_count, cf.dim * 2).cuda()
         target_masks = torch.zeros(negative_count, *cf.mask_shape).cuda()
         target_class_ids = torch.zeros(negative_count).int().cuda()
         if batch_gt_regressions is not None:
             if 'regression_bin' in cf.prediction_tasks:
                 target_regressions = torch.zeros(negative_count, dtype=torch.float).cuda()
             else:
                 target_regressions = torch.zeros(negative_count, cf.regression_n_features, dtype=torch.float).cuda()
     else:
         sample_indices = torch.LongTensor().cuda()
         target_class_ids = torch.IntTensor().cuda()
         target_deltas = torch.FloatTensor().cuda()
         target_masks = torch.FloatTensor().cuda()
         target_regressions = torch.FloatTensor().cuda()
 
     return sample_indices, target_deltas, target_masks, target_class_ids, target_regressions
 
 ############################################################
 #  Anchors
 ############################################################
 
 def generate_anchors(scales, ratios, shape, feature_stride, anchor_stride):
     """
     scales: 1D array of anchor sizes in pixels. Example: [32, 64, 128]
     ratios: 1D array of anchor ratios of width/height. Example: [0.5, 1, 2]
     shape: [height, width] spatial shape of the feature map over which
             to generate anchors.
     feature_stride: Stride of the feature map relative to the image in pixels.
     anchor_stride: Stride of anchors on the feature map. For example, if the
         value is 2 then generate anchors for every other feature map pixel.
     """
     # Get all combinations of scales and ratios
     scales, ratios = np.meshgrid(np.array(scales), np.array(ratios))
     scales = scales.flatten()
     ratios = ratios.flatten()
 
     # Enumerate heights and widths from scales and ratios
     heights = scales / np.sqrt(ratios)
     widths = scales * np.sqrt(ratios)
 
     # Enumerate shifts in feature space
     shifts_y = np.arange(0, shape[0], anchor_stride) * feature_stride
     shifts_x = np.arange(0, shape[1], anchor_stride) * feature_stride
     shifts_x, shifts_y = np.meshgrid(shifts_x, shifts_y)
 
     # Enumerate combinations of shifts, widths, and heights
     box_widths, box_centers_x = np.meshgrid(widths, shifts_x)
     box_heights, box_centers_y = np.meshgrid(heights, shifts_y)
 
     # Reshape to get a list of (y, x) and a list of (h, w)
     box_centers = np.stack([box_centers_y, box_centers_x], axis=2).reshape([-1, 2])
     box_sizes = np.stack([box_heights, box_widths], axis=2).reshape([-1, 2])
 
     # Convert to corner coordinates (y1, x1, y2, x2)
     boxes = np.concatenate([box_centers - 0.5 * box_sizes, box_centers + 0.5 * box_sizes], axis=1)
     return boxes
 
 
 
 def generate_anchors_3D(scales_xy, scales_z, ratios, shape, feature_stride_xy, feature_stride_z, anchor_stride):
     """
     scales: 1D array of anchor sizes in pixels. Example: [32, 64, 128]
     ratios: 1D array of anchor ratios of width/height. Example: [0.5, 1, 2]
     shape: [height, width] spatial shape of the feature map over which
             to generate anchors.
     feature_stride: Stride of the feature map relative to the image in pixels.
     anchor_stride: Stride of anchors on the feature map. For example, if the
         value is 2 then generate anchors for every other feature map pixel.
     """
     # Get all combinations of scales and ratios
 
     scales_xy, ratios_meshed = np.meshgrid(np.array(scales_xy), np.array(ratios))
     scales_xy = scales_xy.flatten()
     ratios_meshed = ratios_meshed.flatten()
 
     # Enumerate heights and widths from scales and ratios
     heights = scales_xy / np.sqrt(ratios_meshed)
     widths = scales_xy * np.sqrt(ratios_meshed)
     depths = np.tile(np.array(scales_z), len(ratios_meshed)//np.array(scales_z)[..., None].shape[0])
 
     # Enumerate shifts in feature space
     shifts_y = np.arange(0, shape[0], anchor_stride) * feature_stride_xy #translate from fm positions to input coords.
     shifts_x = np.arange(0, shape[1], anchor_stride) * feature_stride_xy
     shifts_z = np.arange(0, shape[2], anchor_stride) * (feature_stride_z)
     shifts_x, shifts_y, shifts_z = np.meshgrid(shifts_x, shifts_y, shifts_z)
 
     # Enumerate combinations of shifts, widths, and heights
     box_widths, box_centers_x = np.meshgrid(widths, shifts_x)
     box_heights, box_centers_y = np.meshgrid(heights, shifts_y)
     box_depths, box_centers_z = np.meshgrid(depths, shifts_z)
 
     # Reshape to get a list of (y, x, z) and a list of (h, w, d)
     box_centers = np.stack(
         [box_centers_y, box_centers_x, box_centers_z], axis=2).reshape([-1, 3])
     box_sizes = np.stack([box_heights, box_widths, box_depths], axis=2).reshape([-1, 3])
 
     # Convert to corner coordinates (y1, x1, y2, x2, z1, z2)
     boxes = np.concatenate([box_centers - 0.5 * box_sizes,
                             box_centers + 0.5 * box_sizes], axis=1)
 
     boxes = np.transpose(np.array([boxes[:, 0], boxes[:, 1], boxes[:, 3], boxes[:, 4], boxes[:, 2], boxes[:, 5]]), axes=(1, 0))
     return boxes
 
 
 def generate_pyramid_anchors(logger, cf):
     """Generate anchors at different levels of a feature pyramid. Each scale
     is associated with a level of the pyramid, but each ratio is used in
     all levels of the pyramid.
 
     from configs:
     :param scales: cf.RPN_ANCHOR_SCALES , for conformity with retina nets: scale entries need to be list, e.g. [[4], [8], [16], [32]]
     :param ratios: cf.RPN_ANCHOR_RATIOS , e.g. [0.5, 1, 2]
     :param feature_shapes: cf.BACKBONE_SHAPES , e.g.  [array of shapes per feature map] [80, 40, 20, 10, 5]
     :param feature_strides: cf.BACKBONE_STRIDES , e.g. [2, 4, 8, 16, 32, 64]
     :param anchors_stride: cf.RPN_ANCHOR_STRIDE , e.g. 1
     :return anchors: (N, (y1, x1, y2, x2, (z1), (z2)). All generated anchors in one array. Sorted
     with the same order of the given scales. So, anchors of scale[0] come first, then anchors of scale[1], and so on.
     """
     scales = cf.rpn_anchor_scales
     ratios = cf.rpn_anchor_ratios
     feature_shapes = cf.backbone_shapes
     anchor_stride = cf.rpn_anchor_stride
     pyramid_levels = cf.pyramid_levels
     feature_strides = cf.backbone_strides
 
     logger.info("anchor scales {} and feature map shapes {}".format(scales, feature_shapes))
     expected_anchors = [np.prod(feature_shapes[level]) * len(ratios) * len(scales['xy'][level]) for level in pyramid_levels]
 
     anchors = []
     for lix, level in enumerate(pyramid_levels):
         if len(feature_shapes[level]) == 2:
             anchors.append(generate_anchors(scales['xy'][level], ratios, feature_shapes[level],
                                             feature_strides['xy'][level], anchor_stride))
         elif len(feature_shapes[level]) == 3:
             anchors.append(generate_anchors_3D(scales['xy'][level], scales['z'][level], ratios, feature_shapes[level],
                                             feature_strides['xy'][level], feature_strides['z'][level], anchor_stride))
         else:
             raise Exception("invalid feature_shapes[{}] size {}".format(level, feature_shapes[level]))
         logger.info("level {}: expected anchors {}, built anchors {}.".format(level, expected_anchors[lix], anchors[-1].shape))
 
     out_anchors = np.concatenate(anchors, axis=0)
     logger.info("Total: expected anchors {}, built anchors {}.".format(np.sum(expected_anchors), out_anchors.shape))
 
     return out_anchors
 
 
 
 def apply_box_deltas_2D(boxes, deltas):
     """Applies the given deltas to the given boxes.
     boxes: [N, 4] where each row is y1, x1, y2, x2
     deltas: [N, 4] where each row is [dy, dx, log(dh), log(dw)]
     """
     # Convert to y, x, h, w
     height = boxes[:, 2] - boxes[:, 0]
     width = boxes[:, 3] - boxes[:, 1]
     center_y = boxes[:, 0] + 0.5 * height
     center_x = boxes[:, 1] + 0.5 * width
     # Apply deltas
     center_y += deltas[:, 0] * height
     center_x += deltas[:, 1] * width
     height *= torch.exp(deltas[:, 2])
     width *= torch.exp(deltas[:, 3])
     # Convert back to y1, x1, y2, x2
     y1 = center_y - 0.5 * height
     x1 = center_x - 0.5 * width
     y2 = y1 + height
     x2 = x1 + width
     result = torch.stack([y1, x1, y2, x2], dim=1)
     return result
 
 
 
 def apply_box_deltas_3D(boxes, deltas):
     """Applies the given deltas to the given boxes.
     boxes: [N, 6] where each row is y1, x1, y2, x2, z1, z2
     deltas: [N, 6] where each row is [dy, dx, dz, log(dh), log(dw), log(dd)]
     """
     # Convert to y, x, h, w
     height = boxes[:, 2] - boxes[:, 0]
     width = boxes[:, 3] - boxes[:, 1]
     depth = boxes[:, 5] - boxes[:, 4]
     center_y = boxes[:, 0] + 0.5 * height
     center_x = boxes[:, 1] + 0.5 * width
     center_z = boxes[:, 4] + 0.5 * depth
     # Apply deltas
     center_y += deltas[:, 0] * height
     center_x += deltas[:, 1] * width
     center_z += deltas[:, 2] * depth
     height *= torch.exp(deltas[:, 3])
     width *= torch.exp(deltas[:, 4])
     depth *= torch.exp(deltas[:, 5])
     # Convert back to y1, x1, y2, x2
     y1 = center_y - 0.5 * height
     x1 = center_x - 0.5 * width
     z1 = center_z - 0.5 * depth
     y2 = y1 + height
     x2 = x1 + width
     z2 = z1 + depth
     result = torch.stack([y1, x1, y2, x2, z1, z2], dim=1)
     return result
 
 
 
 def clip_boxes_2D(boxes, window):
     """
     boxes: [N, 4] each col is y1, x1, y2, x2
     window: [4] in the form y1, x1, y2, x2
     """
     boxes = torch.stack( \
         [boxes[:, 0].clamp(float(window[0]), float(window[2])),
          boxes[:, 1].clamp(float(window[1]), float(window[3])),
          boxes[:, 2].clamp(float(window[0]), float(window[2])),
          boxes[:, 3].clamp(float(window[1]), float(window[3]))], 1)
     return boxes
 
 def clip_boxes_3D(boxes, window):
     """
     boxes: [N, 6] each col is y1, x1, y2, x2, z1, z2
     window: [6] in the form y1, x1, y2, x2, z1, z2
     """
     boxes = torch.stack( \
         [boxes[:, 0].clamp(float(window[0]), float(window[2])),
          boxes[:, 1].clamp(float(window[1]), float(window[3])),
          boxes[:, 2].clamp(float(window[0]), float(window[2])),
          boxes[:, 3].clamp(float(window[1]), float(window[3])),
          boxes[:, 4].clamp(float(window[4]), float(window[5])),
          boxes[:, 5].clamp(float(window[4]), float(window[5]))], 1)
     return boxes
 
 from matplotlib import pyplot as plt
 
 
 def clip_boxes_numpy(boxes, window):
     """
     boxes: [N, 4] each col is y1, x1, y2, x2 / [N, 6] in 3D.
     window: iamge shape (y, x, (z))
     """
     if boxes.shape[1] == 4:
         boxes = np.concatenate(
             (np.clip(boxes[:, 0], 0, window[0])[:, None],
             np.clip(boxes[:, 1], 0, window[0])[:, None],
             np.clip(boxes[:, 2], 0, window[1])[:, None],
             np.clip(boxes[:, 3], 0, window[1])[:, None]), 1
         )
 
     else:
         boxes = np.concatenate(
             (np.clip(boxes[:, 0], 0, window[0])[:, None],
              np.clip(boxes[:, 1], 0, window[0])[:, None],
              np.clip(boxes[:, 2], 0, window[1])[:, None],
              np.clip(boxes[:, 3], 0, window[1])[:, None],
              np.clip(boxes[:, 4], 0, window[2])[:, None],
              np.clip(boxes[:, 5], 0, window[2])[:, None]), 1
         )
 
     return boxes
 
 
 
 def bbox_overlaps_2D(boxes1, boxes2):
     """Computes IoU overlaps between two sets of boxes.
     boxes1, boxes2: [N, (y1, x1, y2, x2)].
     """
     # 1. Tile boxes2 and repeate boxes1. This allows us to compare
     # every boxes1 against every boxes2 without loops.
     # TF doesn't have an equivalent to np.repeate() so simulate it
     # using tf.tile() and tf.reshape.
 
     boxes1_repeat = boxes2.size()[0]
     boxes2_repeat = boxes1.size()[0]
 
     boxes1 = boxes1.repeat(1,boxes1_repeat).view(-1,4)
     boxes2 = boxes2.repeat(boxes2_repeat,1)
 
     # 2. Compute intersections
     b1_y1, b1_x1, b1_y2, b1_x2 = boxes1.chunk(4, dim=1)
     b2_y1, b2_x1, b2_y2, b2_x2 = boxes2.chunk(4, dim=1)
     y1 = torch.max(b1_y1, b2_y1)[:, 0]
     x1 = torch.max(b1_x1, b2_x1)[:, 0]
     y2 = torch.min(b1_y2, b2_y2)[:, 0]
     x2 = torch.min(b1_x2, b2_x2)[:, 0]
     #--> expects x1<x2 & y1<y2
     zeros = torch.zeros(y1.size()[0], requires_grad=False)
     if y1.is_cuda:
         zeros = zeros.cuda()
     intersection = torch.max(x2 - x1, zeros) * torch.max(y2 - y1, zeros)
 
     # 3. Compute unions
     b1_area = (b1_y2 - b1_y1) * (b1_x2 - b1_x1)
     b2_area = (b2_y2 - b2_y1) * (b2_x2 - b2_x1)
     union = b1_area[:,0] + b2_area[:,0] - intersection
 
     # 4. Compute IoU and reshape to [boxes1, boxes2]
     iou = intersection / union
     assert torch.all(iou<=1), "iou score>1 produced in bbox_overlaps_2D"
     overlaps = iou.view(boxes2_repeat, boxes1_repeat) #--> per gt box: ious of all proposal boxes with that gt box
 
     return overlaps
 
 def bbox_overlaps_3D(boxes1, boxes2):
     """Computes IoU overlaps between two sets of boxes.
     boxes1, boxes2: [N, (y1, x1, y2, x2, z1, z2)].
     """
     # 1. Tile boxes2 and repeate boxes1. This allows us to compare
     # every boxes1 against every boxes2 without loops.
     # TF doesn't have an equivalent to np.repeate() so simulate it
     # using tf.tile() and tf.reshape.
     boxes1_repeat = boxes2.size()[0]
     boxes2_repeat = boxes1.size()[0]
     boxes1 = boxes1.repeat(1,boxes1_repeat).view(-1,6)
     boxes2 = boxes2.repeat(boxes2_repeat,1)
 
     # 2. Compute intersections
     b1_y1, b1_x1, b1_y2, b1_x2, b1_z1, b1_z2 = boxes1.chunk(6, dim=1)
     b2_y1, b2_x1, b2_y2, b2_x2, b2_z1, b2_z2 = boxes2.chunk(6, dim=1)
     y1 = torch.max(b1_y1, b2_y1)[:, 0]
     x1 = torch.max(b1_x1, b2_x1)[:, 0]
     y2 = torch.min(b1_y2, b2_y2)[:, 0]
     x2 = torch.min(b1_x2, b2_x2)[:, 0]
     z1 = torch.max(b1_z1, b2_z1)[:, 0]
     z2 = torch.min(b1_z2, b2_z2)[:, 0]
     zeros = torch.zeros(y1.size()[0], requires_grad=False)
     if y1.is_cuda:
         zeros = zeros.cuda()
     intersection = torch.max(x2 - x1, zeros) * torch.max(y2 - y1, zeros) * torch.max(z2 - z1, zeros)
 
     # 3. Compute unions
     b1_volume = (b1_y2 - b1_y1) * (b1_x2 - b1_x1)  * (b1_z2 - b1_z1)
     b2_volume = (b2_y2 - b2_y1) * (b2_x2 - b2_x1)  * (b2_z2 - b2_z1)
     union = b1_volume[:,0] + b2_volume[:,0] - intersection
 
     # 4. Compute IoU and reshape to [boxes1, boxes2]
     iou = intersection / union
     overlaps = iou.view(boxes2_repeat, boxes1_repeat)
     return overlaps
 
 def gt_anchor_matching(cf, anchors, gt_boxes, gt_class_ids=None):
     """Given the anchors and GT boxes, compute overlaps and identify positive
     anchors and deltas to refine them to match their corresponding GT boxes.
 
     anchors: [num_anchors, (y1, x1, y2, x2, (z1), (z2))]
     gt_boxes: [num_gt_boxes, (y1, x1, y2, x2, (z1), (z2))]
     gt_class_ids (optional): [num_gt_boxes] Integer class IDs for one stage detectors. in RPN case of Mask R-CNN,
     set all positive matches to 1 (foreground)
 
     Returns:
     anchor_class_matches: [N] (int32) matches between anchors and GT boxes.
                1 = positive anchor, -1 = negative anchor, 0 = neutral
     anchor_delta_targets: [N, (dy, dx, (dz), log(dh), log(dw), (log(dd)))] Anchor bbox deltas.
     """
 
     anchor_class_matches = np.zeros([anchors.shape[0]], dtype=np.int32)
     anchor_delta_targets = np.zeros((cf.rpn_train_anchors_per_image, 2*cf.dim))
     anchor_matching_iou = cf.anchor_matching_iou
 
     if gt_boxes is None:
         anchor_class_matches = np.full(anchor_class_matches.shape, fill_value=-1)
         return anchor_class_matches, anchor_delta_targets
 
     # for mrcnn: anchor matching is done for RPN loss, so positive labels are all 1 (foreground)
     if gt_class_ids is None:
         gt_class_ids = np.array([1] * len(gt_boxes))
 
     # Compute overlaps [num_anchors, num_gt_boxes]
     overlaps = compute_overlaps(anchors, gt_boxes)
 
     # Match anchors to GT Boxes
     # If an anchor overlaps a GT box with IoU >= anchor_matching_iou then it's positive.
     # If an anchor overlaps a GT box with IoU < 0.1 then it's negative.
     # Neutral anchors are those that don't match the conditions above,
     # and they don't influence the loss function.
     # However, don't keep any GT box unmatched (rare, but happens). Instead,
     # match it to the closest anchor (even if its max IoU is < 0.1).
 
     # 1. Set negative anchors first. They get overwritten below if a GT box is
     # matched to them. Skip boxes in crowd areas.
     anchor_iou_argmax = np.argmax(overlaps, axis=1)
     anchor_iou_max = overlaps[np.arange(overlaps.shape[0]), anchor_iou_argmax]
     if anchors.shape[1] == 4:
         anchor_class_matches[(anchor_iou_max < 0.1)] = -1
     elif anchors.shape[1] == 6:
         anchor_class_matches[(anchor_iou_max < 0.01)] = -1
     else:
         raise ValueError('anchor shape wrong {}'.format(anchors.shape))
 
     # 2. Set an anchor for each GT box (regardless of IoU value).
     gt_iou_argmax = np.argmax(overlaps, axis=0)
     for ix, ii in enumerate(gt_iou_argmax):
         anchor_class_matches[ii] = gt_class_ids[ix]
 
     # 3. Set anchors with high overlap as positive.
     above_thresh_ixs = np.argwhere(anchor_iou_max >= anchor_matching_iou)
     anchor_class_matches[above_thresh_ixs] = gt_class_ids[anchor_iou_argmax[above_thresh_ixs]]
 
     # Subsample to balance positive anchors.
     ids = np.where(anchor_class_matches > 0)[0]
     extra = len(ids) - (cf.rpn_train_anchors_per_image // 2)
     if extra > 0:
         # Reset the extra ones to neutral
         ids = np.random.choice(ids, extra, replace=False)
         anchor_class_matches[ids] = 0
 
     # Leave all negative proposals negative for now and sample from them later in online hard example mining.
     # For positive anchors, compute shift and scale needed to transform them to match the corresponding GT boxes.
     ids = np.where(anchor_class_matches > 0)[0]
     ix = 0  # index into anchor_delta_targets
     for i, a in zip(ids, anchors[ids]):
         # closest gt box (it might have IoU < anchor_matching_iou)
         gt = gt_boxes[anchor_iou_argmax[i]]
 
         # convert coordinates to center plus width/height.
         gt_h = gt[2] - gt[0]
         gt_w = gt[3] - gt[1]
         gt_center_y = gt[0] + 0.5 * gt_h
         gt_center_x = gt[1] + 0.5 * gt_w
         # Anchor
         a_h = a[2] - a[0]
         a_w = a[3] - a[1]
         a_center_y = a[0] + 0.5 * a_h
         a_center_x = a[1] + 0.5 * a_w
 
         if cf.dim == 2:
             anchor_delta_targets[ix] = [
                 (gt_center_y - a_center_y) / a_h,
                 (gt_center_x - a_center_x) / a_w,
                 np.log(gt_h / a_h),
                 np.log(gt_w / a_w),
             ]
 
         else:
             gt_d = gt[5] - gt[4]
             gt_center_z = gt[4] + 0.5 * gt_d
             a_d = a[5] - a[4]
             a_center_z = a[4] + 0.5 * a_d
 
             anchor_delta_targets[ix] = [
                 (gt_center_y - a_center_y) / a_h,
                 (gt_center_x - a_center_x) / a_w,
                 (gt_center_z - a_center_z) / a_d,
                 np.log(gt_h / a_h),
                 np.log(gt_w / a_w),
                 np.log(gt_d / a_d)
             ]
 
         # normalize.
         anchor_delta_targets[ix] /= cf.rpn_bbox_std_dev
         ix += 1
 
     return anchor_class_matches, anchor_delta_targets
 
 
 
 def clip_to_window(window, boxes):
     """
         window: (y1, x1, y2, x2) / 3D: (z1, z2). The window in the image we want to clip to.
         boxes: [N, (y1, x1, y2, x2)]  / 3D: (z1, z2)
     """
     boxes[:, 0] = boxes[:, 0].clamp(float(window[0]), float(window[2]))
     boxes[:, 1] = boxes[:, 1].clamp(float(window[1]), float(window[3]))
     boxes[:, 2] = boxes[:, 2].clamp(float(window[0]), float(window[2]))
     boxes[:, 3] = boxes[:, 3].clamp(float(window[1]), float(window[3]))
 
     if boxes.shape[1] > 5:
         boxes[:, 4] = boxes[:, 4].clamp(float(window[4]), float(window[5]))
         boxes[:, 5] = boxes[:, 5].clamp(float(window[4]), float(window[5]))
 
     return boxes
 
 ############################################################
 #  Connected Componenent Analysis
 ############################################################
 
 def get_coords(binary_mask, n_components, dim):
     """
     loops over batch to perform connected component analysis on binary input mask. computes box coordinates around
     n_components - biggest components (rois).
     :param binary_mask: (b, y, x, (z)). binary mask for one specific foreground class.
     :param n_components: int. number of components to extract per batch element and class.
     :return: coords (b, n, (y1, x1, y2, x2 (,z1, z2))
     :return: batch_components (b, n, (y1, x1, y2, x2, (z1), (z2))
     """
     assert len(binary_mask.shape)==dim+1
     binary_mask = binary_mask.astype('uint8')
     batch_coords = []
     batch_components = []
     for ix,b in enumerate(binary_mask):
         clusters, n_cands = lb(b)  # performs connected component analysis.
         uniques, counts = np.unique(clusters, return_counts=True)
         keep_uniques = uniques[1:][np.argsort(counts[1:])[::-1]][:n_components] #only keep n_components largest components
         p_components = np.array([(clusters == ii) * 1 for ii in keep_uniques])  # separate clusters and concat
         p_coords = []
         if p_components.shape[0] > 0:
             for roi in p_components:
                 mask_ixs = np.argwhere(roi != 0)
 
                 # get coordinates around component.
                 roi_coords = [np.min(mask_ixs[:, 0]) - 1, np.min(mask_ixs[:, 1]) - 1, np.max(mask_ixs[:, 0]) + 1,
                                np.max(mask_ixs[:, 1]) + 1]
                 if dim == 3:
                     roi_coords += [np.min(mask_ixs[:, 2]), np.max(mask_ixs[:, 2])+1]
                 p_coords.append(roi_coords)
 
             p_coords = np.array(p_coords)
 
             #clip coords.
             p_coords[p_coords < 0] = 0
             p_coords[:, :4][p_coords[:, :4] > binary_mask.shape[-2]] = binary_mask.shape[-2]
             if dim == 3:
                 p_coords[:, 4:][p_coords[:, 4:] > binary_mask.shape[-1]] = binary_mask.shape[-1]
 
         batch_coords.append(p_coords)
         batch_components.append(p_components)
     return batch_coords, batch_components
 
 
 # noinspection PyCallingNonCallable
 def get_coords_gpu(binary_mask, n_components, dim):
     """
     loops over batch to perform connected component analysis on binary input mask. computes box coordiantes around
     n_components - biggest components (rois).
     :param binary_mask: (b, y, x, (z)). binary mask for one specific foreground class.
     :param n_components: int. number of components to extract per batch element and class.
     :return: coords (b, n, (y1, x1, y2, x2 (,z1, z2))
     :return: batch_components (b, n, (y1, x1, y2, x2, (z1), (z2))
     """
     raise Exception("throws floating point exception")
     assert len(binary_mask.shape)==dim+1
     binary_mask = binary_mask.type(torch.uint8)
     batch_coords = []
     batch_components = []
     for ix,b in enumerate(binary_mask):
         clusters, n_cands = lb(b.cpu().data.numpy())  # peforms connected component analysis.
         clusters = torch.from_numpy(clusters).cuda()
         uniques = torch.unique(clusters)
         counts = torch.stack([(clusters==unique).sum() for unique in uniques])
         keep_uniques = uniques[1:][torch.sort(counts[1:])[1].flip(0)][:n_components] #only keep n_components largest components
         p_components = torch.cat([(clusters == ii).unsqueeze(0) for ii in keep_uniques]).cuda()  # separate clusters and concat
         p_coords = []
         if p_components.shape[0] > 0:
             for roi in p_components:
                 mask_ixs = torch.nonzero(roi)
 
                 # get coordinates around component.
                 roi_coords = [torch.min(mask_ixs[:, 0]) - 1, torch.min(mask_ixs[:, 1]) - 1,
                               torch.max(mask_ixs[:, 0]) + 1,
                               torch.max(mask_ixs[:, 1]) + 1]
                 if dim == 3:
                     roi_coords += [torch.min(mask_ixs[:, 2]), torch.max(mask_ixs[:, 2])+1]
                 p_coords.append(roi_coords)
 
             p_coords = torch.tensor(p_coords)
 
             #clip coords.
             p_coords[p_coords < 0] = 0
             p_coords[:, :4][p_coords[:, :4] > binary_mask.shape[-2]] = binary_mask.shape[-2]
             if dim == 3:
                 p_coords[:, 4:][p_coords[:, 4:] > binary_mask.shape[-1]] = binary_mask.shape[-1]
 
         batch_coords.append(p_coords)
         batch_components.append(p_components)
     return batch_coords, batch_components
 
 
 ############################################################
 #  Pytorch Utility Functions
 ############################################################
 
 def unique1d(tensor):
     """discard all elements of tensor that occur more than once; make tensor unique.
     :param tensor:
     :return:
     """
     if tensor.size()[0] == 0 or tensor.size()[0] == 1:
         return tensor
     tensor = tensor.sort()[0]
     unique_bool = tensor[1:] != tensor[:-1]
     first_element = torch.tensor([True], dtype=torch.bool, requires_grad=False)
     if tensor.is_cuda:
         first_element = first_element.cuda()
     unique_bool = torch.cat((first_element, unique_bool), dim=0)
     return tensor[unique_bool.data]
 
 
 def intersect1d(tensor1, tensor2):
     aux = torch.cat((tensor1, tensor2), dim=0)
     aux = aux.sort(descending=True)[0]
     return aux[:-1][(aux[1:] == aux[:-1]).data]
 
 
 
 def shem(roi_probs_neg, negative_count, poolsize):
     """
     stochastic hard example mining: from a list of indices (referring to non-matched predictions),
     determine a pool of highest scoring (worst false positives) of size negative_count*poolsize.
     Then, sample n (= negative_count) predictions of this pool as negative examples for loss.
     :param roi_probs_neg: tensor of shape (n_predictions, n_classes).
     :param negative_count: int.
     :param poolsize: int.
     :return: (negative_count).  indices refer to the positions in roi_probs_neg. If pool smaller than expected due to
     limited negative proposals availabel, this function will return sampled indices of number < negative_count without
     throwing an error.
     """
     # sort according to higehst foreground score.
     probs, order = roi_probs_neg[:, 1:].max(1)[0].sort(descending=True)
     select = torch.tensor((poolsize * int(negative_count), order.size()[0])).min().int()
 
     pool_indices = order[:select]
     rand_idx = torch.randperm(pool_indices.size()[0])
     return pool_indices[rand_idx[:negative_count].cuda()]
 
 
 ############################################################
 #  Weight Init
 ############################################################
 
 
 def initialize_weights(net):
     """Initialize model weights. Current Default in Pytorch (version 0.4.1) is initialization from a uniform distriubtion.
     Will expectably be changed to kaiming_uniform in future versions.
     """
     init_type = net.cf.weight_init
 
     for m in [module for module in net.modules() if type(module) in [torch.nn.Conv2d, torch.nn.Conv3d,
                                                                      torch.nn.ConvTranspose2d,
                                                                      torch.nn.ConvTranspose3d,
                                                                      torch.nn.Linear]]:
         if init_type == 'xavier_uniform':
             torch.nn.init.xavier_uniform_(m.weight.data)
             if m.bias is not None:
                 m.bias.data.zero_()
 
         elif init_type == 'xavier_normal':
             torch.nn.init.xavier_normal_(m.weight.data)
             if m.bias is not None:
                 m.bias.data.zero_()
 
         elif init_type == "kaiming_uniform":
             torch.nn.init.kaiming_uniform_(m.weight.data, mode='fan_out', nonlinearity=net.cf.relu, a=0)
             if m.bias is not None:
                 fan_in, fan_out = torch.nn.init._calculate_fan_in_and_fan_out(m.weight.data)
                 bound = 1 / np.sqrt(fan_out)
                 torch.nn.init.uniform_(m.bias, -bound, bound)
 
         elif init_type == "kaiming_normal":
             torch.nn.init.kaiming_normal_(m.weight.data, mode='fan_out', nonlinearity=net.cf.relu, a=0)
             if m.bias is not None:
                 fan_in, fan_out = torch.nn.init._calculate_fan_in_and_fan_out(m.weight.data)
                 bound = 1 / np.sqrt(fan_out)
                 torch.nn.init.normal_(m.bias, -bound, bound)
     net.logger.info("applied {} weight init.".format(init_type))
\ No newline at end of file