There seems to be some inconsistency in the geometry-checking of the Statistics View. Normally, it is not possible to select an image and ROI with mismatched geometries. But when a line is drawn between two images with different geometries, this can lead to errors or even a crash, although I am not able to reproduce this consistently.
Broadly speaking, the problem happens when both images are shown (via a global reinit).

For example:

• loaded brain and Pic3D (Pic3D being higher in the Data Manager)
• did a global reinit
• with brain selected in the Measurement view, drew a line from the far corner of brain to the far corner of Pic3D, outside of the respective other image
• in the Statistics view, selected Pic3D and the line
• -> crash

Interesting about this is that even though I had brain selected in the Measurement view, the Statistics view only allows me to select Pic3D + the line, not brain + the line.