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Perfusion Conversion to Concentration: Average Baseline signal
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For absolute and relative signal enhancement, the baseline signal of the time-series is used. Currently the first time frame is used as baseline, which leads to errors and statistical variations.
Implementation of a feature that allows to average the S(0) image from several baseline timepoints (frame x to y) would help.

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No effots have been taken in this direction so far. For automatic determination of the number of frames to be averaged, a robust and accurate method for BAT (bolus arrival time, initial rise of concentration-time-curve) would be needed. So far this is not existing (linear-linear model exists, but is strongly dependent on curve shape).
Hence, implementation should give the user the option to define a certain number of frames (or even better a range of frames, so that 1st frame could be excluded, in case of not reachesd steady-state e.g.) from which the baseline signal is then averaged. This could then be included in the conversion to relative/absolute signal enhancement.

floca raised the priority of this task from Wishlist to Low.Nov 22 2019, 10:00 PM
floca added a subscriber: bendinge.

In a meeting with Alina Bendinger (27.11.2019) we concluded that a sufficient solution for now is to allow the user to choose a range of timepoints from which the baseline will be calculated as average value.

This will be implemented as an additional option for relative and absolute conversion from signal to concentration.

kompan added a revision: Restricted Differential Revision.Jan 24 2020, 10:09 AM
kompan added a revision: Restricted Differential Revision.Feb 14 2020, 1:02 PM
kompan raised the priority of this task from Low to Normal.
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floca moved this task from Restricted Project Column to Restricted Project Column on the Restricted Project board.Apr 26 2020, 1:31 PM